Conserved oligomeric Golgi complex subunit 7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYC7_LEIMU

TriTrypDb:

LmxM.26.1480

Length:

1006

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	10
GO:0016020	membrane	2	10
GO:0017119	Golgi transport complex	3	10
GO:0031090	organelle membrane	3	10
GO:0032991	protein-containing complex	1	10
GO:0098588	bounding membrane of organelle	4	10
GO:0099023	vesicle tethering complex	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AYC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYC7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0006886	intracellular protein transport	4	10
GO:0008104	protein localization	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0033036	macromolecule localization	2	10
GO:0045184	establishment of protein localization	3	10
GO:0046907	intracellular transport	3	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0048193	Golgi vesicle transport	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	861	865	PF00656	0.590
CLV_NRD_NRD_1	112	114	PF00675	0.622
CLV_NRD_NRD_1	405	407	PF00675	0.434
CLV_NRD_NRD_1	428	430	PF00675	0.470
CLV_NRD_NRD_1	702	704	PF00675	0.499
CLV_NRD_NRD_1	847	849	PF00675	0.518
CLV_NRD_NRD_1	933	935	PF00675	0.368
CLV_PCSK_KEX2_1	209	211	PF00082	0.487
CLV_PCSK_KEX2_1	405	407	PF00082	0.434
CLV_PCSK_KEX2_1	428	430	PF00082	0.470
CLV_PCSK_KEX2_1	67	69	PF00082	0.503
CLV_PCSK_KEX2_1	701	703	PF00082	0.465
CLV_PCSK_KEX2_1	847	849	PF00082	0.518
CLV_PCSK_KEX2_1	933	935	PF00082	0.368
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.421
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.503
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.429
CLV_PCSK_SKI1_1	161	165	PF00082	0.433
CLV_PCSK_SKI1_1	276	280	PF00082	0.479
CLV_PCSK_SKI1_1	299	303	PF00082	0.496
CLV_PCSK_SKI1_1	345	349	PF00082	0.507
CLV_PCSK_SKI1_1	418	422	PF00082	0.550
CLV_PCSK_SKI1_1	584	588	PF00082	0.479
CLV_PCSK_SKI1_1	760	764	PF00082	0.506
CLV_PCSK_SKI1_1	768	772	PF00082	0.526
CLV_PCSK_SKI1_1	950	954	PF00082	0.362
CLV_Separin_Metazoa	402	406	PF03568	0.505
DEG_APCC_DBOX_1	294	302	PF00400	0.429
DEG_APCC_DBOX_1	767	775	PF00400	0.436
DEG_APCC_DBOX_1	949	957	PF00400	0.481
DEG_Nend_UBRbox_2	1	3	PF02207	0.625
DEG_SCF_FBW7_1	682	689	PF00400	0.474
DEG_SIAH_1	903	911	PF03145	0.394
DEG_SPOP_SBC_1	454	458	PF00917	0.642
DEG_SPOP_SBC_1	562	566	PF00917	0.474
DOC_CKS1_1	465	470	PF01111	0.507
DOC_CKS1_1	568	573	PF01111	0.575
DOC_CKS1_1	683	688	PF01111	0.485
DOC_CYCLIN_RxL_1	111	120	PF00134	0.586
DOC_CYCLIN_RxL_1	415	425	PF00134	0.422
DOC_MAPK_gen_1	151	159	PF00069	0.449
DOC_MAPK_gen_1	894	902	PF00069	0.495
DOC_MAPK_MEF2A_6	894	902	PF00069	0.401
DOC_PP1_RVXF_1	416	423	PF00149	0.417
DOC_PP2B_LxvP_1	150	153	PF13499	0.362
DOC_PP2B_LxvP_1	24	27	PF13499	0.634
DOC_PP2B_LxvP_1	743	746	PF13499	0.309
DOC_PP4_FxxP_1	568	571	PF00568	0.584
DOC_USP7_MATH_1	103	107	PF00917	0.593
DOC_USP7_MATH_1	17	21	PF00917	0.637
DOC_USP7_MATH_1	200	204	PF00917	0.537
DOC_USP7_MATH_1	33	37	PF00917	0.641
DOC_USP7_MATH_1	381	385	PF00917	0.529
DOC_USP7_MATH_1	39	43	PF00917	0.654
DOC_USP7_MATH_1	414	418	PF00917	0.432
DOC_USP7_MATH_1	439	443	PF00917	0.731
DOC_USP7_MATH_1	463	467	PF00917	0.762
DOC_USP7_MATH_1	5	9	PF00917	0.746
DOC_USP7_MATH_1	512	516	PF00917	0.338
DOC_USP7_MATH_1	562	566	PF00917	0.685
DOC_USP7_MATH_1	684	688	PF00917	0.533
DOC_USP7_MATH_1	711	715	PF00917	0.440
DOC_USP7_MATH_1	754	758	PF00917	0.490
DOC_USP7_MATH_1	776	780	PF00917	0.408
DOC_USP7_MATH_1	790	794	PF00917	0.635
DOC_USP7_MATH_1	801	805	PF00917	0.690
DOC_USP7_MATH_1	815	819	PF00917	0.597
DOC_USP7_MATH_1	86	90	PF00917	0.552
DOC_USP7_MATH_1	904	908	PF00917	0.610
DOC_USP7_MATH_1	923	927	PF00917	0.580
DOC_USP7_MATH_2	477	483	PF00917	0.483
DOC_WW_Pin1_4	270	275	PF00397	0.574
DOC_WW_Pin1_4	3	8	PF00397	0.532
DOC_WW_Pin1_4	435	440	PF00397	0.547
DOC_WW_Pin1_4	464	469	PF00397	0.636
DOC_WW_Pin1_4	567	572	PF00397	0.586
DOC_WW_Pin1_4	629	634	PF00397	0.396
DOC_WW_Pin1_4	682	687	PF00397	0.488
DOC_WW_Pin1_4	794	799	PF00397	0.716
DOC_WW_Pin1_4	9	14	PF00397	0.732
DOC_WW_Pin1_4	90	95	PF00397	0.594
LIG_14-3-3_CanoR_1	129	137	PF00244	0.440
LIG_14-3-3_CanoR_1	151	159	PF00244	0.488
LIG_14-3-3_CanoR_1	161	169	PF00244	0.404
LIG_14-3-3_CanoR_1	198	205	PF00244	0.557
LIG_14-3-3_CanoR_1	345	351	PF00244	0.504
LIG_14-3-3_CanoR_1	380	390	PF00244	0.622
LIG_14-3-3_CanoR_1	428	432	PF00244	0.553
LIG_14-3-3_CanoR_1	625	633	PF00244	0.426
LIG_14-3-3_CanoR_1	68	78	PF00244	0.492
LIG_14-3-3_CanoR_1	710	716	PF00244	0.420
LIG_14-3-3_CanoR_1	727	735	PF00244	0.451
LIG_14-3-3_CanoR_1	933	942	PF00244	0.395
LIG_14-3-3_CanoR_1	990	995	PF00244	0.441
LIG_Actin_WH2_2	283	301	PF00022	0.483
LIG_APCC_ABBAyCdc20_2	113	119	PF00400	0.543
LIG_BRCT_BRCA1_1	564	568	PF00533	0.594
LIG_FHA_1	154	160	PF00498	0.504
LIG_FHA_1	168	174	PF00498	0.554
LIG_FHA_1	568	574	PF00498	0.572
LIG_FHA_1	643	649	PF00498	0.441
LIG_FHA_1	719	725	PF00498	0.488
LIG_FHA_1	765	771	PF00498	0.476
LIG_FHA_1	795	801	PF00498	0.503
LIG_FHA_1	934	940	PF00498	0.435
LIG_FHA_1	941	947	PF00498	0.452
LIG_FHA_2	153	159	PF00498	0.430
LIG_FHA_2	197	203	PF00498	0.601
LIG_FHA_2	300	306	PF00498	0.549
LIG_FHA_2	428	434	PF00498	0.624
LIG_FHA_2	526	532	PF00498	0.515
LIG_FHA_2	555	561	PF00498	0.660
LIG_FHA_2	572	578	PF00498	0.689
LIG_FHA_2	633	639	PF00498	0.681
LIG_FHA_2	721	727	PF00498	0.541
LIG_FHA_2	942	948	PF00498	0.483
LIG_GBD_Chelix_1	332	340	PF00786	0.439
LIG_LIR_Apic_2	565	571	PF02991	0.587
LIG_LIR_Nem_3	317	322	PF02991	0.531
LIG_LIR_Nem_3	741	747	PF02991	0.371
LIG_LRP6_Inhibitor_1	984	990	PF00058	0.291
LIG_MAD2	625	633	PF02301	0.355
LIG_MAD2	896	904	PF02301	0.442
LIG_NRBOX	121	127	PF00104	0.527
LIG_PCNA_PIPBox_1	690	699	PF02747	0.383
LIG_PCNA_yPIPBox_3	67	78	PF02747	0.520
LIG_PCNA_yPIPBox_3	690	703	PF02747	0.561
LIG_PCNA_yPIPBox_3	705	719	PF02747	0.481
LIG_Pex14_2	594	598	PF04695	0.461
LIG_PTB_Apo_2	221	228	PF02174	0.482
LIG_PTB_Phospho_1	221	227	PF10480	0.481
LIG_RPA_C_Fungi	387	399	PF08784	0.494
LIG_SH2_CRK	777	781	PF00017	0.509
LIG_SH2_NCK_1	510	514	PF00017	0.378
LIG_SH2_SRC	322	325	PF00017	0.456
LIG_SH2_SRC	510	513	PF00017	0.316
LIG_SH2_SRC	696	699	PF00017	0.370
LIG_SH2_STAP1	607	611	PF00017	0.460
LIG_SH2_STAP1	935	939	PF00017	0.491
LIG_SH2_STAT3	312	315	PF00017	0.527
LIG_SH2_STAT3	363	366	PF00017	0.502
LIG_SH2_STAT5	191	194	PF00017	0.432
LIG_SH2_STAT5	211	214	PF00017	0.303
LIG_SH2_STAT5	227	230	PF00017	0.514
LIG_SH2_STAT5	322	325	PF00017	0.513
LIG_SH2_STAT5	696	699	PF00017	0.497
LIG_SH2_STAT5	777	780	PF00017	0.586
LIG_SH2_STAT5	810	813	PF00017	0.580
LIG_SH2_STAT5	935	938	PF00017	0.417
LIG_SH2_STAT5	948	951	PF00017	0.368
LIG_SH3_1	459	465	PF00018	0.512
LIG_SH3_3	13	19	PF00018	0.727
LIG_SH3_3	459	465	PF00018	0.529
LIG_SH3_3	608	614	PF00018	0.432
LIG_SH3_3	627	633	PF00018	0.407
LIG_SH3_3	654	660	PF00018	0.503
LIG_SH3_3	92	98	PF00018	0.503
LIG_SUMO_SIM_anti_2	500	506	PF11976	0.460
LIG_SUMO_SIM_par_1	830	837	PF11976	0.411
LIG_TRAF2_1	326	329	PF00917	0.479
LIG_TRAF2_1	430	433	PF00917	0.494
LIG_TRAF2_1	450	453	PF00917	0.631
LIG_TRAF2_1	651	654	PF00917	0.482
LIG_TYR_ITIM	694	699	PF00017	0.374
LIG_UBA3_1	693	701	PF00899	0.492
LIG_WRC_WIRS_1	889	894	PF05994	0.409
MOD_CDC14_SPxK_1	273	276	PF00782	0.471
MOD_CDC14_SPxK_1	438	441	PF00782	0.582
MOD_CDK_SPxK_1	270	276	PF00069	0.480
MOD_CDK_SPxK_1	435	441	PF00069	0.555
MOD_CK1_1	106	112	PF00069	0.504
MOD_CK1_1	201	207	PF00069	0.496
MOD_CK1_1	25	31	PF00069	0.610
MOD_CK1_1	466	472	PF00069	0.744
MOD_CK1_1	545	551	PF00069	0.586
MOD_CK1_1	563	569	PF00069	0.608
MOD_CK1_1	632	638	PF00069	0.658
MOD_CK1_1	643	649	PF00069	0.514
MOD_CK1_1	689	695	PF00069	0.432
MOD_CK1_1	720	726	PF00069	0.499
MOD_CK1_1	793	799	PF00069	0.667
MOD_CK1_1	855	861	PF00069	0.458
MOD_CK1_1	960	966	PF00069	0.529
MOD_CK2_1	152	158	PF00069	0.431
MOD_CK2_1	196	202	PF00069	0.566
MOD_CK2_1	304	310	PF00069	0.465
MOD_CK2_1	427	433	PF00069	0.484
MOD_CK2_1	554	560	PF00069	0.651
MOD_CK2_1	632	638	PF00069	0.603
MOD_CK2_1	720	726	PF00069	0.511
MOD_CK2_1	923	929	PF00069	0.481
MOD_GlcNHglycan	105	108	PF01048	0.536
MOD_GlcNHglycan	136	140	PF01048	0.487
MOD_GlcNHglycan	240	243	PF01048	0.754
MOD_GlcNHglycan	270	273	PF01048	0.638
MOD_GlcNHglycan	384	387	PF01048	0.555
MOD_GlcNHglycan	441	444	PF01048	0.742
MOD_GlcNHglycan	469	472	PF01048	0.757
MOD_GlcNHglycan	481	484	PF01048	0.700
MOD_GlcNHglycan	536	539	PF01048	0.491
MOD_GlcNHglycan	544	547	PF01048	0.454
MOD_GlcNHglycan	627	630	PF01048	0.499
MOD_GlcNHglycan	730	733	PF01048	0.521
MOD_GlcNHglycan	788	791	PF01048	0.600
MOD_GlcNHglycan	818	821	PF01048	0.540
MOD_GlcNHglycan	840	843	PF01048	0.516
MOD_GlcNHglycan	857	860	PF01048	0.516
MOD_GlcNHglycan	925	928	PF01048	0.590
MOD_GlcNHglycan	953	956	PF01048	0.499
MOD_GlcNHglycan	995	999	PF01048	0.690
MOD_GSK3_1	103	110	PF00069	0.454
MOD_GSK3_1	131	138	PF00069	0.477
MOD_GSK3_1	153	160	PF00069	0.501
MOD_GSK3_1	196	203	PF00069	0.451
MOD_GSK3_1	232	239	PF00069	0.707
MOD_GSK3_1	260	267	PF00069	0.721
MOD_GSK3_1	34	41	PF00069	0.609
MOD_GSK3_1	341	348	PF00069	0.518
MOD_GSK3_1	414	421	PF00069	0.515
MOD_GSK3_1	435	442	PF00069	0.683
MOD_GSK3_1	453	460	PF00069	0.767
MOD_GSK3_1	463	470	PF00069	0.758
MOD_GSK3_1	5	12	PF00069	0.788
MOD_GSK3_1	563	570	PF00069	0.673
MOD_GSK3_1	621	628	PF00069	0.546
MOD_GSK3_1	642	649	PF00069	0.578
MOD_GSK3_1	661	668	PF00069	0.519
MOD_GSK3_1	682	689	PF00069	0.498
MOD_GSK3_1	734	741	PF00069	0.385
MOD_GSK3_1	754	761	PF00069	0.539
MOD_GSK3_1	786	793	PF00069	0.592
MOD_GSK3_1	834	841	PF00069	0.491
MOD_GSK3_1	86	93	PF00069	0.706
MOD_GSK3_1	883	890	PF00069	0.376
MOD_GSK3_1	904	911	PF00069	0.707
MOD_GSK3_1	917	924	PF00069	0.636
MOD_GSK3_1	990	997	PF00069	0.662
MOD_LATS_1	127	133	PF00433	0.570
MOD_N-GLC_1	236	241	PF02516	0.600
MOD_N-GLC_1	242	247	PF02516	0.594
MOD_N-GLC_1	268	273	PF02516	0.656
MOD_NEK2_1	144	149	PF00069	0.577
MOD_NEK2_1	157	162	PF00069	0.420
MOD_NEK2_1	346	351	PF00069	0.498
MOD_NEK2_1	422	427	PF00069	0.432
MOD_NEK2_1	554	559	PF00069	0.760
MOD_NEK2_1	838	843	PF00069	0.518
MOD_PIKK_1	131	137	PF00454	0.499
MOD_PIKK_1	366	372	PF00454	0.418
MOD_PIKK_1	686	692	PF00454	0.558
MOD_PIKK_1	808	814	PF00454	0.670
MOD_PIKK_1	908	914	PF00454	0.684
MOD_PIKK_1	917	923	PF00454	0.680
MOD_PK_1	175	181	PF00069	0.340
MOD_PKA_1	933	939	PF00069	0.341
MOD_PKA_2	153	159	PF00069	0.562
MOD_PKA_2	231	237	PF00069	0.528
MOD_PKA_2	252	258	PF00069	0.669
MOD_PKA_2	341	347	PF00069	0.490
MOD_PKA_2	427	433	PF00069	0.548
MOD_PKA_2	665	671	PF00069	0.481
MOD_PKA_2	933	939	PF00069	0.366
MOD_PKB_1	725	733	PF00069	0.371
MOD_Plk_1	157	163	PF00069	0.497
MOD_Plk_1	201	207	PF00069	0.520
MOD_Plk_1	299	305	PF00069	0.487
MOD_Plk_1	418	424	PF00069	0.382
MOD_Plk_1	640	646	PF00069	0.553
MOD_Plk_1	758	764	PF00069	0.282
MOD_Plk_1	957	963	PF00069	0.487
MOD_Plk_4	145	151	PF00069	0.553
MOD_Plk_4	175	181	PF00069	0.427
MOD_Plk_4	346	352	PF00069	0.609
MOD_Plk_4	418	424	PF00069	0.382
MOD_Plk_4	643	649	PF00069	0.479
MOD_Plk_4	689	695	PF00069	0.387
MOD_Plk_4	758	764	PF00069	0.441
MOD_Plk_4	880	886	PF00069	0.462
MOD_Plk_4	888	894	PF00069	0.480
MOD_ProDKin_1	270	276	PF00069	0.572
MOD_ProDKin_1	3	9	PF00069	0.534
MOD_ProDKin_1	435	441	PF00069	0.555
MOD_ProDKin_1	464	470	PF00069	0.637
MOD_ProDKin_1	567	573	PF00069	0.580
MOD_ProDKin_1	629	635	PF00069	0.401
MOD_ProDKin_1	682	688	PF00069	0.480
MOD_ProDKin_1	794	800	PF00069	0.716
MOD_ProDKin_1	90	96	PF00069	0.585
MOD_SUMO_for_1	747	750	PF00179	0.487
MOD_SUMO_rev_2	296	301	PF00179	0.471
TRG_DiLeu_BaLyEn_6	516	521	PF01217	0.497
TRG_ENDOCYTIC_2	510	513	PF00928	0.415
TRG_ENDOCYTIC_2	696	699	PF00928	0.370
TRG_ENDOCYTIC_2	777	780	PF00928	0.496
TRG_ER_diArg_1	404	406	PF00400	0.413
TRG_ER_diArg_1	427	429	PF00400	0.462
TRG_ER_diArg_1	702	705	PF00400	0.507
TRG_ER_diArg_1	933	935	PF00400	0.368
TRG_NLS_MonoExtC_3	700	705	PF00514	0.420
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	870	874	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8B9	Leptomonas seymouri	53%	98%
A0A1X0NS38	Trypanosomatidae	24%	100%
A0A3Q8IP82	Leishmania donovani	89%	99%
A0A422NIU2	Trypanosoma rangeli	26%	100%
A4HF03	Leishmania braziliensis	73%	100%
A4I282	Leishmania infantum	89%	99%
C9ZRR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4Q946	Leishmania major	88%	100%