Protein farnesyltransferase subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

farnesyltransferase beta subunit

Species:

Leishmania mexicana

UniProt:

E9AYC6_LEIMU

TriTrypDb:

LmxM.26.1470

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005965	protein farnesyltransferase complex	4	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

Expansion

Sequence features

E9AYC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYC6

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0018342	protein prenylation	4	12
GO:0018343	protein farnesylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0097354	prenylation	3	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004659	prenyltransferase activity	4	12
GO:0004660	protein farnesyltransferase activity	4	12
GO:0005488	binding	1	12
GO:0008318	protein prenyltransferase activity	3	12
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0008270	zinc ion binding	6	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.571
CLV_C14_Caspase3-7	452	456	PF00656	0.639
CLV_C14_Caspase3-7	485	489	PF00656	0.338
CLV_NRD_NRD_1	315	317	PF00675	0.428
CLV_NRD_NRD_1	382	384	PF00675	0.256
CLV_NRD_NRD_1	579	581	PF00675	0.233
CLV_PCSK_KEX2_1	265	267	PF00082	0.247
CLV_PCSK_KEX2_1	315	317	PF00082	0.428
CLV_PCSK_KEX2_1	382	384	PF00082	0.249
CLV_PCSK_KEX2_1	521	523	PF00082	0.569
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.242
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.469
CLV_PCSK_PC7_1	261	267	PF00082	0.281
CLV_PCSK_SKI1_1	266	270	PF00082	0.242
CLV_PCSK_SKI1_1	323	327	PF00082	0.420
CLV_PCSK_SKI1_1	564	568	PF00082	0.551
DEG_Nend_UBRbox_3	1	3	PF02207	0.547
DEG_SPOP_SBC_1	45	49	PF00917	0.623
DEG_SPOP_SBC_1	50	54	PF00917	0.613
DOC_CYCLIN_RxL_1	261	270	PF00134	0.360
DOC_CYCLIN_yCln2_LP_2	202	205	PF00134	0.634
DOC_CYCLIN_yCln2_LP_2	78	84	PF00134	0.430
DOC_MAPK_gen_1	265	271	PF00069	0.442
DOC_MAPK_gen_1	461	471	PF00069	0.417
DOC_MAPK_gen_1	88	97	PF00069	0.522
DOC_MAPK_MEF2A_6	323	330	PF00069	0.450
DOC_MAPK_NFAT4_5	323	331	PF00069	0.229
DOC_PP2B_LxvP_1	202	205	PF13499	0.507
DOC_PP2B_LxvP_1	671	674	PF13499	0.565
DOC_USP7_MATH_1	132	136	PF00917	0.332
DOC_USP7_MATH_1	171	175	PF00917	0.618
DOC_USP7_MATH_1	350	354	PF00917	0.547
DOC_USP7_MATH_1	45	49	PF00917	0.623
DOC_USP7_MATH_1	50	54	PF00917	0.613
DOC_USP7_MATH_1	59	63	PF00917	0.494
DOC_USP7_MATH_1	636	640	PF00917	0.617
DOC_USP7_MATH_1	67	71	PF00917	0.568
DOC_USP7_MATH_1	674	678	PF00917	0.575
DOC_USP7_MATH_1	679	683	PF00917	0.485
DOC_WW_Pin1_4	102	107	PF00397	0.612
DOC_WW_Pin1_4	138	143	PF00397	0.397
DOC_WW_Pin1_4	346	351	PF00397	0.522
DOC_WW_Pin1_4	455	460	PF00397	0.509
LIG_14-3-3_CanoR_1	14	21	PF00244	0.477
LIG_14-3-3_CanoR_1	266	272	PF00244	0.490
LIG_14-3-3_CanoR_1	289	293	PF00244	0.431
LIG_14-3-3_CanoR_1	627	637	PF00244	0.557
LIG_14-3-3_CanoR_1	698	706	PF00244	0.423
LIG_Actin_WH2_2	501	518	PF00022	0.508
LIG_BIR_III_4	441	445	PF00653	0.468
LIG_Clathr_ClatBox_1	18	22	PF01394	0.516
LIG_Clathr_ClatBox_1	300	304	PF01394	0.363
LIG_deltaCOP1_diTrp_1	559	567	PF00928	0.456
LIG_FHA_1	14	20	PF00498	0.475
LIG_FHA_1	185	191	PF00498	0.771
LIG_FHA_1	296	302	PF00498	0.491
LIG_FHA_1	398	404	PF00498	0.470
LIG_FHA_1	5	11	PF00498	0.513
LIG_FHA_1	686	692	PF00498	0.379
LIG_FHA_1	703	709	PF00498	0.316
LIG_FHA_2	226	232	PF00498	0.392
LIG_FHA_2	305	311	PF00498	0.530
LIG_FHA_2	349	355	PF00498	0.535
LIG_FHA_2	497	503	PF00498	0.537
LIG_FHA_2	602	608	PF00498	0.535
LIG_FHA_2	638	644	PF00498	0.433
LIG_FHA_2	75	81	PF00498	0.483
LIG_GBD_Chelix_1	146	154	PF00786	0.373
LIG_Integrin_isoDGR_2	397	399	PF01839	0.231
LIG_LIR_Gen_1	426	437	PF02991	0.505
LIG_LIR_Nem_3	115	121	PF02991	0.390
LIG_LIR_Nem_3	426	432	PF02991	0.463
LIG_LIR_Nem_3	505	510	PF02991	0.351
LIG_NRBOX	363	369	PF00104	0.474
LIG_PCNA_yPIPBox_3	361	371	PF02747	0.456
LIG_PCNA_yPIPBox_3	378	388	PF02747	0.478
LIG_PCNA_yPIPBox_3	579	588	PF02747	0.498
LIG_PTB_Apo_2	686	693	PF02174	0.266
LIG_SH2_GRB2like	576	579	PF00017	0.325
LIG_SH2_NCK_1	569	573	PF00017	0.549
LIG_SH2_SRC	250	253	PF00017	0.434
LIG_SH2_SRC	569	572	PF00017	0.547
LIG_SH2_SRC	650	653	PF00017	0.523
LIG_SH2_SRC	84	87	PF00017	0.378
LIG_SH2_STAP1	408	412	PF00017	0.449
LIG_SH2_STAP1	425	429	PF00017	0.424
LIG_SH2_STAT3	576	579	PF00017	0.325
LIG_SH2_STAT5	23	26	PF00017	0.476
LIG_SH2_STAT5	292	295	PF00017	0.453
LIG_SH2_STAT5	359	362	PF00017	0.431
LIG_SH2_STAT5	425	428	PF00017	0.523
LIG_SH2_STAT5	576	579	PF00017	0.280
LIG_SH2_STAT5	585	588	PF00017	0.419
LIG_SH2_STAT5	641	644	PF00017	0.410
LIG_SH2_STAT5	650	653	PF00017	0.437
LIG_SH3_3	111	117	PF00018	0.483
LIG_SH3_3	213	219	PF00018	0.654
LIG_SUMO_SIM_anti_2	16	22	PF11976	0.404
LIG_SUMO_SIM_anti_2	324	329	PF11976	0.225
LIG_SUMO_SIM_anti_2	467	472	PF11976	0.387
LIG_SUMO_SIM_anti_2	499	505	PF11976	0.334
LIG_SUMO_SIM_par_1	16	22	PF11976	0.488
LIG_SUMO_SIM_par_1	324	329	PF11976	0.373
LIG_SUMO_SIM_par_1	467	472	PF11976	0.399
LIG_SUMO_SIM_par_1	6	11	PF11976	0.589
LIG_SUMO_SIM_par_1	669	677	PF11976	0.445
LIG_TRAF2_1	228	231	PF00917	0.411
LIG_TYR_ITIM	119	124	PF00017	0.349
LIG_UBA3_1	367	371	PF00899	0.498
MOD_CDC14_SPxK_1	458	461	PF00782	0.385
MOD_CDK_SPxK_1	455	461	PF00069	0.405
MOD_CK1_1	406	412	PF00069	0.442
MOD_CK1_1	46	52	PF00069	0.729
MOD_CK1_1	53	59	PF00069	0.727
MOD_CK1_1	616	622	PF00069	0.431
MOD_CK1_1	656	662	PF00069	0.745
MOD_CK1_1	672	678	PF00069	0.404
MOD_CK1_1	70	76	PF00069	0.729
MOD_CK2_1	128	134	PF00069	0.339
MOD_CK2_1	171	177	PF00069	0.686
MOD_CK2_1	225	231	PF00069	0.398
MOD_CK2_1	348	354	PF00069	0.535
MOD_CK2_1	637	643	PF00069	0.445
MOD_CK2_1	657	663	PF00069	0.651
MOD_CK2_1	74	80	PF00069	0.702
MOD_Cter_Amidation	313	316	PF01082	0.420
MOD_Cter_Amidation	519	522	PF01082	0.457
MOD_GlcNHglycan	130	133	PF01048	0.536
MOD_GlcNHglycan	143	146	PF01048	0.531
MOD_GlcNHglycan	173	176	PF01048	0.659
MOD_GlcNHglycan	193	196	PF01048	0.603
MOD_GlcNHglycan	198	201	PF01048	0.585
MOD_GlcNHglycan	455	458	PF01048	0.539
MOD_GlcNHglycan	48	51	PF01048	0.650
MOD_GlcNHglycan	516	519	PF01048	0.528
MOD_GlcNHglycan	57	60	PF01048	0.530
MOD_GlcNHglycan	615	618	PF01048	0.231
MOD_GlcNHglycan	655	658	PF01048	0.664
MOD_GlcNHglycan	659	662	PF01048	0.652
MOD_GlcNHglycan	676	679	PF01048	0.459
MOD_GlcNHglycan	70	73	PF01048	0.739
MOD_GlcNHglycan	700	703	PF01048	0.427
MOD_GSK3_1	108	115	PF00069	0.580
MOD_GSK3_1	128	135	PF00069	0.218
MOD_GSK3_1	169	176	PF00069	0.506
MOD_GSK3_1	186	193	PF00069	0.698
MOD_GSK3_1	344	351	PF00069	0.521
MOD_GSK3_1	45	52	PF00069	0.716
MOD_GSK3_1	492	499	PF00069	0.552
MOD_GSK3_1	55	62	PF00069	0.656
MOD_GSK3_1	653	660	PF00069	0.709
MOD_GSK3_1	669	676	PF00069	0.402
MOD_GSK3_1	694	701	PF00069	0.430
MOD_GSK3_1	70	77	PF00069	0.738
MOD_N-GLC_1	100	105	PF02516	0.397
MOD_N-GLC_1	657	662	PF02516	0.658
MOD_N-GLC_1	67	72	PF02516	0.595
MOD_NEK2_1	149	154	PF00069	0.399
MOD_NEK2_1	190	195	PF00069	0.616
MOD_NEK2_1	24	29	PF00069	0.435
MOD_NEK2_1	326	331	PF00069	0.330
MOD_NEK2_1	403	408	PF00069	0.449
MOD_NEK2_1	532	537	PF00069	0.613
MOD_NEK2_1	646	651	PF00069	0.527
MOD_NEK2_1	684	689	PF00069	0.424
MOD_NEK2_2	108	113	PF00069	0.397
MOD_NEK2_2	267	272	PF00069	0.456
MOD_NEK2_2	608	613	PF00069	0.474
MOD_OFUCOSY	153	160	PF10250	0.383
MOD_PIKK_1	357	363	PF00454	0.442
MOD_PIKK_1	496	502	PF00454	0.482
MOD_PK_1	704	710	PF00069	0.383
MOD_PKA_2	13	19	PF00069	0.483
MOD_PKA_2	191	197	PF00069	0.551
MOD_PKA_2	24	30	PF00069	0.495
MOD_PKA_2	288	294	PF00069	0.431
MOD_PKA_2	653	659	PF00069	0.615
MOD_PKA_2	685	691	PF00069	0.364
MOD_Plk_1	100	106	PF00069	0.401
MOD_Plk_2-3	305	311	PF00069	0.550
MOD_Plk_2-3	6	12	PF00069	0.519
MOD_Plk_4	108	114	PF00069	0.471
MOD_Plk_4	186	192	PF00069	0.531
MOD_Plk_4	198	204	PF00069	0.574
MOD_Plk_4	245	251	PF00069	0.390
MOD_Plk_4	296	302	PF00069	0.449
MOD_Plk_4	637	643	PF00069	0.461
MOD_Plk_4	679	685	PF00069	0.569
MOD_ProDKin_1	102	108	PF00069	0.614
MOD_ProDKin_1	138	144	PF00069	0.397
MOD_ProDKin_1	346	352	PF00069	0.522
MOD_ProDKin_1	455	461	PF00069	0.498
MOD_SUMO_rev_2	174	184	PF00179	0.537
MOD_SUMO_rev_2	517	523	PF00179	0.526
TRG_DiLeu_BaEn_1	594	599	PF01217	0.456
TRG_ENDOCYTIC_2	121	124	PF00928	0.315
TRG_ENDOCYTIC_2	529	532	PF00928	0.543
TRG_ENDOCYTIC_2	569	572	PF00928	0.547
TRG_ER_diArg_1	381	383	PF00400	0.456
TRG_ER_diArg_1	463	466	PF00400	0.420
TRG_ER_diArg_1	561	564	PF00400	0.600
TRG_NES_CRM1_1	500	512	PF08389	0.344
TRG_Pf-PMV_PEXEL_1	388	393	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.298

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA19	Leptomonas seymouri	57%	100%
A0A0S4KLG2	Bodo saltans	36%	100%
A0A1X0NSS5	Trypanosomatidae	38%	100%
A0A3S7WZW4	Leishmania donovani	89%	98%
A0A422NJ04	Trypanosoma rangeli	39%	100%
A4HF02	Leishmania braziliensis	80%	100%
A4I281	Leishmania infantum	90%	98%
C9ZRR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q8WR00	Leishmania major	87%	100%
V5DA92	Trypanosoma cruzi	40%	100%