Expressed conserved protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AYC5_LEIMU

TriTrypDb:

LmxM.26.1460

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AYC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.392
CLV_C14_Caspase3-7	4	8	PF00656	0.765
CLV_PCSK_KEX2_1	173	175	PF00082	0.545
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.545
DEG_APCC_KENBOX_2	129	133	PF00400	0.329
DOC_CKS1_1	73	78	PF01111	0.284
DOC_MAPK_RevD_3	159	174	PF00069	0.307
DOC_PP4_FxxP_1	64	67	PF00568	0.532
DOC_USP7_MATH_1	126	130	PF00917	0.398
DOC_USP7_MATH_1	267	271	PF00917	0.622
DOC_USP7_MATH_1	290	294	PF00917	0.794
DOC_USP7_MATH_1	59	63	PF00917	0.349
DOC_USP7_MATH_1	96	100	PF00917	0.376
DOC_WW_Pin1_4	152	157	PF00397	0.414
DOC_WW_Pin1_4	22	27	PF00397	0.548
DOC_WW_Pin1_4	72	77	PF00397	0.350
DOC_WW_Pin1_4	78	83	PF00397	0.372
LIG_14-3-3_CanoR_1	18	23	PF00244	0.660
LIG_14-3-3_CanoR_1	242	248	PF00244	0.601
LIG_14-3-3_CanoR_1	258	268	PF00244	0.592
LIG_APCC_ABBA_1	275	280	PF00400	0.746
LIG_BRCT_BRCA1_1	24	28	PF00533	0.560
LIG_EVH1_2	76	80	PF00568	0.292
LIG_FHA_1	167	173	PF00498	0.451
LIG_FHA_1	201	207	PF00498	0.360
LIG_FHA_2	2	8	PF00498	0.765
LIG_LIR_Apic_2	61	67	PF02991	0.487
LIG_LIR_Gen_1	203	212	PF02991	0.377
LIG_LIR_Gen_1	311	321	PF02991	0.690
LIG_LIR_Gen_1	88	96	PF02991	0.364
LIG_LIR_Nem_3	115	119	PF02991	0.368
LIG_LIR_Nem_3	133	139	PF02991	0.278
LIG_LIR_Nem_3	203	207	PF02991	0.377
LIG_LIR_Nem_3	25	31	PF02991	0.560
LIG_LIR_Nem_3	311	317	PF02991	0.691
LIG_LIR_Nem_3	88	93	PF02991	0.353
LIG_PTB_Apo_2	186	193	PF02174	0.548
LIG_PTB_Phospho_1	186	192	PF10480	0.550
LIG_SH2_CRK	136	140	PF00017	0.301
LIG_SH2_GRB2like	53	56	PF00017	0.567
LIG_SH2_PTP2	30	33	PF00017	0.432
LIG_SH2_SRC	30	33	PF00017	0.218
LIG_SH2_SRC	53	56	PF00017	0.567
LIG_SH2_STAP1	48	52	PF00017	0.374
LIG_SH2_STAT3	316	319	PF00017	0.625
LIG_SH2_STAT5	192	195	PF00017	0.539
LIG_SH2_STAT5	251	254	PF00017	0.546
LIG_SH2_STAT5	30	33	PF00017	0.432
LIG_SH2_STAT5	316	319	PF00017	0.709
LIG_SH2_STAT5	53	56	PF00017	0.553
LIG_SH3_3	150	156	PF00018	0.380
LIG_SUMO_SIM_anti_2	104	110	PF11976	0.346
MOD_CK1_1	10	16	PF00069	0.779
MOD_CK1_1	104	110	PF00069	0.356
MOD_CK1_1	259	265	PF00069	0.600
MOD_CK1_1	78	84	PF00069	0.417
MOD_CK2_1	121	127	PF00069	0.399
MOD_CK2_1	152	158	PF00069	0.352
MOD_CK2_1	267	273	PF00069	0.590
MOD_GlcNHglycan	145	148	PF01048	0.688
MOD_GlcNHglycan	43	46	PF01048	0.726
MOD_GSK3_1	1	8	PF00069	0.765
MOD_GSK3_1	115	122	PF00069	0.398
MOD_GSK3_1	143	150	PF00069	0.451
MOD_GSK3_1	18	25	PF00069	0.537
MOD_GSK3_1	183	190	PF00069	0.394
MOD_GSK3_1	304	311	PF00069	0.662
MOD_GSK3_1	37	44	PF00069	0.345
MOD_GSK3_1	91	98	PF00069	0.351
MOD_N-GLC_1	101	106	PF02516	0.694
MOD_N-GLC_1	119	124	PF02516	0.524
MOD_N-GLC_1	159	164	PF02516	0.580
MOD_N-GLC_1	182	187	PF02516	0.726
MOD_N-GLC_1	188	193	PF02516	0.712
MOD_N-GLC_1	194	199	PF02516	0.622
MOD_N-GLC_1	235	240	PF02516	0.496
MOD_N-GLC_1	283	288	PF02516	0.495
MOD_N-GLC_1	297	302	PF02516	0.464
MOD_N-GLC_1	303	308	PF02516	0.427
MOD_N-GLC_1	78	83	PF02516	0.502
MOD_N-GLC_2	110	112	PF02516	0.535
MOD_NEK2_1	1	6	PF00069	0.761
MOD_NEK2_1	119	124	PF00069	0.343
MOD_NEK2_1	175	180	PF00069	0.517
MOD_NEK2_1	187	192	PF00069	0.441
MOD_NEK2_1	227	232	PF00069	0.656
MOD_NEK2_1	37	42	PF00069	0.330
MOD_NEK2_2	243	248	PF00069	0.530
MOD_NEK2_2	48	53	PF00069	0.527
MOD_NEK2_2	59	64	PF00069	0.361
MOD_NEK2_2	96	101	PF00069	0.319
MOD_OFUCOSY	38	43	PF10250	0.432
MOD_PIKK_1	259	265	PF00454	0.592
MOD_PIKK_1	290	296	PF00454	0.704
MOD_PKA_2	304	310	PF00069	0.678
MOD_PKB_1	16	24	PF00069	0.725
MOD_Plk_1	159	165	PF00069	0.435
MOD_Plk_1	182	188	PF00069	0.502
MOD_Plk_1	235	241	PF00069	0.695
MOD_Plk_1	48	54	PF00069	0.551
MOD_Plk_1	96	102	PF00069	0.474
MOD_Plk_4	104	110	PF00069	0.323
MOD_Plk_4	166	172	PF00069	0.509
MOD_Plk_4	188	194	PF00069	0.546
MOD_Plk_4	235	241	PF00069	0.620
MOD_Plk_4	48	54	PF00069	0.526
MOD_Plk_4	59	65	PF00069	0.363
MOD_Plk_4	67	73	PF00069	0.290
MOD_ProDKin_1	152	158	PF00069	0.415
MOD_ProDKin_1	22	28	PF00069	0.546
MOD_ProDKin_1	72	78	PF00069	0.355
TRG_DiLeu_BaEn_2	133	139	PF01217	0.303
TRG_ENDOCYTIC_2	136	139	PF00928	0.295
TRG_ENDOCYTIC_2	204	207	PF00928	0.326
TRG_ENDOCYTIC_2	278	281	PF00928	0.759
TRG_ENDOCYTIC_2	30	33	PF00928	0.432
TRG_ENDOCYTIC_2	90	93	PF00928	0.431
TRG_ER_diArg_1	15	18	PF00400	0.777
TRG_NES_CRM1_1	266	280	PF08389	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM62	Leptomonas seymouri	32%	100%
A0A3Q8ICZ0	Leishmania donovani	73%	99%
A4I280	Leishmania infantum	72%	99%
Q4Q948	Leishmania major	71%	100%