Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYC3_LEIMU

TriTrypDb:

LmxM.26.1440

Length:

775

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.473
CLV_C14_Caspase3-7	525	529	PF00656	0.588
CLV_C14_Caspase3-7	536	540	PF00656	0.624
CLV_C14_Caspase3-7	552	556	PF00656	0.479
CLV_C14_Caspase3-7	672	676	PF00656	0.684
CLV_NRD_NRD_1	132	134	PF00675	0.639
CLV_NRD_NRD_1	476	478	PF00675	0.611
CLV_NRD_NRD_1	579	581	PF00675	0.543
CLV_NRD_NRD_1	684	686	PF00675	0.670
CLV_NRD_NRD_1	744	746	PF00675	0.427
CLV_NRD_NRD_1	82	84	PF00675	0.686
CLV_PCSK_FUR_1	132	136	PF00082	0.680
CLV_PCSK_KEX2_1	131	133	PF00082	0.638
CLV_PCSK_KEX2_1	134	136	PF00082	0.647
CLV_PCSK_KEX2_1	476	478	PF00082	0.611
CLV_PCSK_KEX2_1	684	686	PF00082	0.670
CLV_PCSK_KEX2_1	746	748	PF00082	0.424
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.549
CLV_PCSK_PC1ET2_1	746	748	PF00082	0.415
CLV_PCSK_SKI1_1	34	38	PF00082	0.438
CLV_PCSK_SKI1_1	420	424	PF00082	0.361
CLV_PCSK_SKI1_1	443	447	PF00082	0.437
CLV_PCSK_SKI1_1	466	470	PF00082	0.408
CLV_PCSK_SKI1_1	482	486	PF00082	0.434
CLV_PCSK_SKI1_1	511	515	PF00082	0.506
CLV_PCSK_SKI1_1	716	720	PF00082	0.388
CLV_PCSK_SKI1_1	729	733	PF00082	0.343
CLV_PCSK_SKI1_1	771	775	PF00082	0.478
CLV_Separin_Metazoa	717	721	PF03568	0.413
DEG_MDM2_SWIB_1	230	238	PF02201	0.408
DEG_SCF_FBW7_1	398	403	PF00400	0.483
DEG_SPOP_SBC_1	347	351	PF00917	0.684
DEG_SPOP_SBC_1	382	386	PF00917	0.648
DOC_CYCLIN_RxL_1	30	38	PF00134	0.448
DOC_CYCLIN_RxL_1	476	489	PF00134	0.435
DOC_CYCLIN_yCln2_LP_2	93	99	PF00134	0.584
DOC_MAPK_gen_1	205	215	PF00069	0.404
DOC_MAPK_gen_1	273	282	PF00069	0.633
DOC_MAPK_gen_1	729	737	PF00069	0.405
DOC_MAPK_MEF2A_6	276	284	PF00069	0.593
DOC_MAPK_MEF2A_6	30	39	PF00069	0.609
DOC_MAPK_MEF2A_6	48	57	PF00069	0.298
DOC_MAPK_MEF2A_6	729	737	PF00069	0.457
DOC_PP1_RVXF_1	441	448	PF00149	0.426
DOC_PP2B_LxvP_1	170	173	PF13499	0.711
DOC_PP2B_LxvP_1	344	347	PF13499	0.477
DOC_PP2B_LxvP_1	446	449	PF13499	0.432
DOC_USP7_MATH_1	139	143	PF00917	0.560
DOC_USP7_MATH_1	156	160	PF00917	0.748
DOC_USP7_MATH_1	181	185	PF00917	0.591
DOC_USP7_MATH_1	187	191	PF00917	0.694
DOC_USP7_MATH_1	255	259	PF00917	0.661
DOC_USP7_MATH_1	309	313	PF00917	0.564
DOC_USP7_MATH_1	331	335	PF00917	0.663
DOC_USP7_MATH_1	347	351	PF00917	0.706
DOC_USP7_MATH_1	360	364	PF00917	0.778
DOC_USP7_MATH_1	381	385	PF00917	0.657
DOC_USP7_MATH_1	402	406	PF00917	0.537
DOC_USP7_MATH_1	412	416	PF00917	0.549
DOC_USP7_MATH_1	449	453	PF00917	0.558
DOC_USP7_MATH_1	517	521	PF00917	0.549
DOC_USP7_MATH_1	538	542	PF00917	0.580
DOC_USP7_MATH_1	667	671	PF00917	0.644
DOC_USP7_MATH_1	78	82	PF00917	0.746
DOC_USP7_UBL2_3	134	138	PF12436	0.551
DOC_USP7_UBL2_3	30	34	PF12436	0.535
DOC_WW_Pin1_4	161	166	PF00397	0.646
DOC_WW_Pin1_4	333	338	PF00397	0.723
DOC_WW_Pin1_4	342	347	PF00397	0.594
DOC_WW_Pin1_4	385	390	PF00397	0.683
DOC_WW_Pin1_4	396	401	PF00397	0.603
DOC_WW_Pin1_4	466	471	PF00397	0.536
DOC_WW_Pin1_4	580	585	PF00397	0.611
DOC_WW_Pin1_4	619	624	PF00397	0.466
DOC_WW_Pin1_4	665	670	PF00397	0.743
DOC_WW_Pin1_4	68	73	PF00397	0.709
DOC_WW_Pin1_4	92	97	PF00397	0.808
LIG_14-3-3_CanoR_1	223	227	PF00244	0.390
LIG_14-3-3_CanoR_1	420	425	PF00244	0.361
LIG_14-3-3_CanoR_1	52	56	PF00244	0.609
LIG_14-3-3_CanoR_1	580	584	PF00244	0.521
LIG_14-3-3_CanoR_1	631	636	PF00244	0.475
LIG_14-3-3_CanoR_1	720	724	PF00244	0.486
LIG_Actin_RPEL_3	269	288	PF02755	0.476
LIG_BIR_III_2	467	471	PF00653	0.470
LIG_BIR_III_2	666	670	PF00653	0.630
LIG_BIR_III_4	115	119	PF00653	0.665
LIG_BIR_III_4	526	530	PF00653	0.617
LIG_BRCT_BRCA1_1	271	275	PF00533	0.623
LIG_BRCT_BRCA1_1	420	424	PF00533	0.361
LIG_Clathr_ClatBox_1	298	302	PF01394	0.509
LIG_Clathr_ClatBox_1	698	702	PF01394	0.596
LIG_CSL_BTD_1	446	449	PF09270	0.432
LIG_deltaCOP1_diTrp_1	456	463	PF00928	0.405
LIG_deltaCOP1_diTrp_1	587	595	PF00928	0.253
LIG_EVH1_2	733	737	PF00568	0.497
LIG_FHA_1	117	123	PF00498	0.540
LIG_FHA_1	210	216	PF00498	0.275
LIG_FHA_1	279	285	PF00498	0.555
LIG_FHA_1	305	311	PF00498	0.462
LIG_FHA_1	405	411	PF00498	0.521
LIG_FHA_1	421	427	PF00498	0.271
LIG_FHA_1	429	435	PF00498	0.396
LIG_FHA_1	52	58	PF00498	0.483
LIG_FHA_1	580	586	PF00498	0.486
LIG_FHA_1	660	666	PF00498	0.638
LIG_FHA_2	467	473	PF00498	0.417
LIG_FHA_2	523	529	PF00498	0.609
LIG_FHA_2	670	676	PF00498	0.683
LIG_FXI_DFP_1	47	51	PF00024	0.411
LIG_LIR_Apic_2	159	165	PF02991	0.687
LIG_LIR_Apic_2	528	533	PF02991	0.630
LIG_LIR_Apic_2	543	548	PF02991	0.474
LIG_LIR_Gen_1	231	239	PF02991	0.418
LIG_LIR_Gen_1	421	430	PF02991	0.357
LIG_LIR_Gen_1	657	667	PF02991	0.544
LIG_LIR_Nem_3	231	237	PF02991	0.408
LIG_LIR_Nem_3	657	663	PF02991	0.541
LIG_LIR_Nem_3	68	73	PF02991	0.707
LIG_LIR_Nem_3	736	740	PF02991	0.530
LIG_LIR_Nem_3	94	100	PF02991	0.606
LIG_MYND_1	169	173	PF01753	0.657
LIG_Pex14_1	459	463	PF04695	0.396
LIG_Pex14_2	226	230	PF04695	0.373
LIG_SH2_CRK	70	74	PF00017	0.670
LIG_SH2_NCK_1	611	615	PF00017	0.508
LIG_SH2_NCK_1	660	664	PF00017	0.549
LIG_SH2_NCK_1	70	74	PF00017	0.620
LIG_SH2_STAP1	586	590	PF00017	0.368
LIG_SH2_STAP1	611	615	PF00017	0.508
LIG_SH2_STAT3	759	762	PF00017	0.488
LIG_SH2_STAT5	417	420	PF00017	0.375
LIG_SH2_STAT5	574	577	PF00017	0.425
LIG_SH2_STAT5	753	756	PF00017	0.367
LIG_SH3_2	626	631	PF14604	0.541
LIG_SH3_3	170	176	PF00018	0.645
LIG_SH3_3	257	263	PF00018	0.489
LIG_SH3_3	323	329	PF00018	0.587
LIG_SH3_3	620	626	PF00018	0.556
LIG_SH3_3	644	650	PF00018	0.623
LIG_SH3_3	680	686	PF00018	0.693
LIG_SH3_3	93	99	PF00018	0.655
LIG_SH3_4	84	91	PF00018	0.658
LIG_SUMO_SIM_anti_2	211	218	PF11976	0.384
LIG_SUMO_SIM_anti_2	42	49	PF11976	0.417
LIG_SUMO_SIM_anti_2	560	566	PF11976	0.276
LIG_SUMO_SIM_anti_2	722	727	PF11976	0.399
LIG_SUMO_SIM_par_1	211	218	PF11976	0.384
LIG_SUMO_SIM_par_1	278	283	PF11976	0.644
LIG_SUMO_SIM_par_1	294	303	PF11976	0.366
LIG_SUMO_SIM_par_1	685	691	PF11976	0.588
MOD_CK1_1	161	167	PF00069	0.754
MOD_CK1_1	229	235	PF00069	0.516
MOD_CK1_1	3	9	PF00069	0.607
MOD_CK1_1	350	356	PF00069	0.700
MOD_CK1_1	363	369	PF00069	0.518
MOD_CK1_1	377	383	PF00069	0.719
MOD_CK1_1	384	390	PF00069	0.629
MOD_CK1_1	495	501	PF00069	0.604
MOD_CK1_1	630	636	PF00069	0.586
MOD_CK1_1	645	651	PF00069	0.698
MOD_CK1_1	71	77	PF00069	0.737
MOD_CK2_1	3	9	PF00069	0.654
MOD_CK2_1	71	77	PF00069	0.688
MOD_CMANNOS	447	450	PF00535	0.431
MOD_GlcNHglycan	139	142	PF01048	0.802
MOD_GlcNHglycan	152	155	PF01048	0.658
MOD_GlcNHglycan	157	161	PF01048	0.658
MOD_GlcNHglycan	189	192	PF01048	0.655
MOD_GlcNHglycan	2	5	PF01048	0.565
MOD_GlcNHglycan	231	234	PF01048	0.583
MOD_GlcNHglycan	257	260	PF01048	0.661
MOD_GlcNHglycan	294	297	PF01048	0.441
MOD_GlcNHglycan	311	314	PF01048	0.675
MOD_GlcNHglycan	322	325	PF01048	0.510
MOD_GlcNHglycan	350	353	PF01048	0.708
MOD_GlcNHglycan	379	382	PF01048	0.744
MOD_GlcNHglycan	420	423	PF01048	0.364
MOD_GlcNHglycan	489	492	PF01048	0.571
MOD_GlcNHglycan	494	497	PF01048	0.579
MOD_GlcNHglycan	535	538	PF01048	0.729
MOD_GlcNHglycan	539	543	PF01048	0.495
MOD_GlcNHglycan	73	76	PF01048	0.542
MOD_GSK3_1	146	153	PF00069	0.594
MOD_GSK3_1	161	168	PF00069	0.636
MOD_GSK3_1	222	229	PF00069	0.482
MOD_GSK3_1	342	349	PF00069	0.602
MOD_GSK3_1	360	367	PF00069	0.698
MOD_GSK3_1	377	384	PF00069	0.697
MOD_GSK3_1	396	403	PF00069	0.706
MOD_GSK3_1	480	487	PF00069	0.484
MOD_GSK3_1	513	520	PF00069	0.631
MOD_GSK3_1	575	582	PF00069	0.474
MOD_GSK3_1	627	634	PF00069	0.674
MOD_GSK3_1	665	672	PF00069	0.729
MOD_N-GLC_1	304	309	PF02516	0.431
MOD_N-GLC_1	485	490	PF02516	0.445
MOD_N-GLC_1	631	636	PF02516	0.470
MOD_N-GLC_1	675	680	PF02516	0.632
MOD_N-GLC_2	290	292	PF02516	0.389
MOD_NEK2_1	410	415	PF00069	0.423
MOD_NEK2_1	513	518	PF00069	0.581
MOD_NEK2_1	557	562	PF00069	0.352
MOD_NEK2_1	56	61	PF00069	0.589
MOD_NEK2_1	739	744	PF00069	0.464
MOD_NEK2_2	271	276	PF00069	0.483
MOD_NEK2_2	51	56	PF00069	0.574
MOD_NEK2_2	690	695	PF00069	0.516
MOD_NMyristoyl	1	7	PF02799	0.573
MOD_PIKK_1	369	375	PF00454	0.654
MOD_PIKK_1	428	434	PF00454	0.381
MOD_PKA_2	181	187	PF00069	0.524
MOD_PKA_2	209	215	PF00069	0.277
MOD_PKA_2	222	228	PF00069	0.385
MOD_PKA_2	320	326	PF00069	0.499
MOD_PKA_2	377	383	PF00069	0.728
MOD_PKA_2	393	399	PF00069	0.573
MOD_PKA_2	51	57	PF00069	0.599
MOD_PKA_2	579	585	PF00069	0.522
MOD_PKA_2	630	636	PF00069	0.465
MOD_PKA_2	719	725	PF00069	0.427
MOD_Plk_1	631	637	PF00069	0.464
MOD_Plk_1	690	696	PF00069	0.513
MOD_Plk_4	158	164	PF00069	0.576
MOD_Plk_4	209	215	PF00069	0.277
MOD_Plk_4	388	394	PF00069	0.599
MOD_Plk_4	480	486	PF00069	0.396
MOD_Plk_4	51	57	PF00069	0.590
MOD_Plk_4	590	596	PF00069	0.274
MOD_Plk_4	597	603	PF00069	0.527
MOD_Plk_4	631	637	PF00069	0.599
MOD_Plk_4	642	648	PF00069	0.742
MOD_ProDKin_1	161	167	PF00069	0.647
MOD_ProDKin_1	333	339	PF00069	0.725
MOD_ProDKin_1	342	348	PF00069	0.598
MOD_ProDKin_1	385	391	PF00069	0.682
MOD_ProDKin_1	396	402	PF00069	0.598
MOD_ProDKin_1	466	472	PF00069	0.533
MOD_ProDKin_1	580	586	PF00069	0.604
MOD_ProDKin_1	619	625	PF00069	0.474
MOD_ProDKin_1	665	671	PF00069	0.744
MOD_ProDKin_1	68	74	PF00069	0.711
MOD_ProDKin_1	92	98	PF00069	0.808
MOD_SUMO_rev_2	576	583	PF00179	0.466
TRG_DiLeu_BaEn_1	211	216	PF01217	0.327
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.659
TRG_ENDOCYTIC_2	660	663	PF00928	0.547
TRG_ENDOCYTIC_2	70	73	PF00928	0.668
TRG_ER_diArg_1	102	105	PF00400	0.682
TRG_ER_diArg_1	131	133	PF00400	0.636
TRG_ER_diArg_1	683	685	PF00400	0.669
TRG_ER_diArg_1	744	747	PF00400	0.477
TRG_ER_diLys_1	771	775	PF00400	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P8	Leptomonas seymouri	39%	98%
A0A3Q8IFV9	Leishmania donovani	85%	99%
A4HEZ9	Leishmania braziliensis	62%	98%
A4I278	Leishmania infantum	84%	99%
Q4Q950	Leishmania major	81%	99%