LeishMANIAdb
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J domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
J domain-containing protein
Gene product:
DnaJ domain containing protein, putative
Species:
Leishmania mexicana
UniProt:
E9AYC0_LEIMU
TriTrypDb:
LmxM.26.1410
Length:
536

Annotations

LeishMANIAdb annotations

These kinetoplastid-specific proteins contain a conserved DnaJ domain at their C-termini and a completely unique structure before and after that.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9AYC0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYC0

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 1
GO:0009987 cellular process 1 1
GO:0061077 chaperone-mediated protein folding 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0044183 protein folding chaperone 1 1
GO:0051082 unfolded protein binding 3 1
GO:0051087 protein-folding chaperone binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 460 464 PF00656 0.530
CLV_NRD_NRD_1 329 331 PF00675 0.422
CLV_NRD_NRD_1 375 377 PF00675 0.446
CLV_NRD_NRD_1 474 476 PF00675 0.388
CLV_PCSK_FUR_1 247 251 PF00082 0.408
CLV_PCSK_KEX2_1 249 251 PF00082 0.472
CLV_PCSK_KEX2_1 329 331 PF00082 0.422
CLV_PCSK_KEX2_1 342 344 PF00082 0.387
CLV_PCSK_KEX2_1 375 377 PF00082 0.446
CLV_PCSK_KEX2_1 466 468 PF00082 0.242
CLV_PCSK_KEX2_1 474 476 PF00082 0.379
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.472
CLV_PCSK_PC1ET2_1 342 344 PF00082 0.465
CLV_PCSK_PC1ET2_1 466 468 PF00082 0.273
CLV_PCSK_SKI1_1 153 157 PF00082 0.586
CLV_PCSK_SKI1_1 255 259 PF00082 0.320
CLV_PCSK_SKI1_1 428 432 PF00082 0.301
CLV_PCSK_SKI1_1 5 9 PF00082 0.253
CLV_PCSK_SKI1_1 70 74 PF00082 0.574
DEG_APCC_DBOX_1 27 35 PF00400 0.298
DEG_APCC_DBOX_1 301 309 PF00400 0.336
DEG_Nend_Nbox_1 1 3 PF02207 0.672
DEG_SPOP_SBC_1 140 144 PF00917 0.408
DOC_CYCLIN_RxL_1 422 435 PF00134 0.496
DOC_MAPK_gen_1 190 199 PF00069 0.334
DOC_PP1_RVXF_1 115 122 PF00149 0.408
DOC_USP7_MATH_1 140 144 PF00917 0.502
DOC_USP7_MATH_1 186 190 PF00917 0.497
DOC_USP7_MATH_1 364 368 PF00917 0.711
DOC_USP7_MATH_1 495 499 PF00917 0.395
DOC_WW_Pin1_4 162 167 PF00397 0.468
DOC_WW_Pin1_4 306 311 PF00397 0.297
DOC_WW_Pin1_4 8 13 PF00397 0.336
LIG_14-3-3_CanoR_1 149 155 PF00244 0.524
LIG_14-3-3_CanoR_1 247 257 PF00244 0.559
LIG_14-3-3_CanoR_1 28 32 PF00244 0.418
LIG_14-3-3_CanoR_1 302 306 PF00244 0.352
LIG_14-3-3_CanoR_1 314 318 PF00244 0.330
LIG_14-3-3_CanoR_1 330 336 PF00244 0.656
LIG_14-3-3_CanoR_1 448 458 PF00244 0.528
LIG_14-3-3_CanoR_1 474 483 PF00244 0.640
LIG_14-3-3_CanoR_1 523 528 PF00244 0.440
LIG_14-3-3_CanoR_1 65 73 PF00244 0.361
LIG_Actin_WH2_2 118 134 PF00022 0.370
LIG_Actin_WH2_2 14 30 PF00022 0.246
LIG_BRCT_BRCA1_1 213 217 PF00533 0.412
LIG_Clathr_ClatBox_1 174 178 PF01394 0.378
LIG_Clathr_ClatBox_1 231 235 PF01394 0.173
LIG_Clathr_ClatBox_1 31 35 PF01394 0.404
LIG_EH1_1 231 239 PF00400 0.261
LIG_eIF4E_1 26 32 PF01652 0.410
LIG_eIF4E_1 425 431 PF01652 0.496
LIG_FHA_1 114 120 PF00498 0.384
LIG_FHA_1 22 28 PF00498 0.428
LIG_FHA_1 228 234 PF00498 0.209
LIG_FHA_1 269 275 PF00498 0.276
LIG_FHA_1 302 308 PF00498 0.317
LIG_FHA_1 489 495 PF00498 0.594
LIG_FHA_1 497 503 PF00498 0.306
LIG_FHA_2 332 338 PF00498 0.578
LIG_FHA_2 458 464 PF00498 0.523
LIG_LIR_Gen_1 404 414 PF02991 0.459
LIG_LIR_Gen_1 456 462 PF02991 0.536
LIG_LIR_Gen_1 519 527 PF02991 0.367
LIG_LIR_Gen_1 61 71 PF02991 0.436
LIG_LIR_LC3C_4 263 266 PF02991 0.234
LIG_LIR_Nem_3 107 113 PF02991 0.421
LIG_LIR_Nem_3 214 220 PF02991 0.279
LIG_LIR_Nem_3 251 257 PF02991 0.541
LIG_LIR_Nem_3 400 406 PF02991 0.587
LIG_LIR_Nem_3 456 461 PF02991 0.536
LIG_LIR_Nem_3 512 517 PF02991 0.425
LIG_LIR_Nem_3 61 66 PF02991 0.437
LIG_LIR_Nem_3 69 75 PF02991 0.384
LIG_LYPXL_S_1 101 105 PF13949 0.525
LIG_LYPXL_S_1 126 130 PF13949 0.607
LIG_LYPXL_yS_3 102 105 PF13949 0.328
LIG_NRBOX 17 23 PF00104 0.322
LIG_Pex14_1 239 243 PF04695 0.506
LIG_Pex14_1 46 50 PF04695 0.370
LIG_Pex14_2 126 130 PF04695 0.418
LIG_Pex14_2 217 221 PF04695 0.299
LIG_Pex14_2 50 54 PF04695 0.426
LIG_REV1ctd_RIR_1 47 55 PF16727 0.413
LIG_REV1ctd_RIR_1 70 78 PF16727 0.269
LIG_SH2_CRK 182 186 PF00017 0.503
LIG_SH2_CRK 458 462 PF00017 0.536
LIG_SH2_CRK 63 67 PF00017 0.397
LIG_SH2_GRB2like 403 406 PF00017 0.472
LIG_SH2_STAP1 218 222 PF00017 0.336
LIG_SH2_STAP1 275 279 PF00017 0.430
LIG_SH2_STAP1 403 407 PF00017 0.367
LIG_SH2_STAP1 458 462 PF00017 0.536
LIG_SH2_STAP1 63 67 PF00017 0.397
LIG_SH2_STAT3 242 245 PF00017 0.546
LIG_SH2_STAT5 208 211 PF00017 0.329
LIG_SH2_STAT5 212 215 PF00017 0.339
LIG_SH2_STAT5 242 245 PF00017 0.592
LIG_SH2_STAT5 26 29 PF00017 0.313
LIG_SH2_STAT5 403 406 PF00017 0.472
LIG_SH2_STAT5 517 520 PF00017 0.354
LIG_SH3_1 182 188 PF00018 0.506
LIG_SH3_2 185 190 PF14604 0.509
LIG_SH3_3 182 188 PF00018 0.506
LIG_SH3_3 6 12 PF00018 0.367
LIG_SUMO_SIM_anti_2 263 268 PF11976 0.345
LIG_SUMO_SIM_anti_2 301 307 PF11976 0.243
LIG_SUMO_SIM_anti_2 498 504 PF11976 0.376
LIG_SUMO_SIM_par_1 172 178 PF11976 0.381
LIG_SUMO_SIM_par_1 263 268 PF11976 0.474
LIG_SUMO_SIM_par_1 303 309 PF11976 0.362
LIG_SUMO_SIM_par_1 5 11 PF11976 0.367
LIG_SUMO_SIM_par_1 530 536 PF11976 0.428
LIG_TRAF2_1 200 203 PF00917 0.352
LIG_TYR_ITSM 402 409 PF00017 0.461
LIG_WRC_WIRS_1 127 132 PF05994 0.455
LIG_WRC_WIRS_1 59 64 PF05994 0.439
LIG_WW_3 184 188 PF00397 0.494
MOD_CK1_1 139 145 PF00069 0.559
MOD_CK1_1 148 154 PF00069 0.560
MOD_CK1_1 160 166 PF00069 0.497
MOD_CK1_1 268 274 PF00069 0.253
MOD_CK1_1 488 494 PF00069 0.645
MOD_CK1_1 61 67 PF00069 0.458
MOD_CK2_1 197 203 PF00069 0.357
MOD_GlcNHglycan 138 141 PF01048 0.696
MOD_GlcNHglycan 144 147 PF01048 0.718
MOD_GlcNHglycan 159 162 PF01048 0.673
MOD_GlcNHglycan 222 225 PF01048 0.297
MOD_GlcNHglycan 451 454 PF01048 0.292
MOD_GlcNHglycan 51 54 PF01048 0.583
MOD_GlcNHglycan 511 514 PF01048 0.548
MOD_GlcNHglycan 80 83 PF01048 0.503
MOD_GlcNHglycan 86 89 PF01048 0.502
MOD_GSK3_1 136 143 PF00069 0.546
MOD_GSK3_1 144 151 PF00069 0.551
MOD_GSK3_1 153 160 PF00069 0.543
MOD_GSK3_1 245 252 PF00069 0.638
MOD_GSK3_1 265 272 PF00069 0.440
MOD_GSK3_1 286 293 PF00069 0.361
MOD_GSK3_1 45 52 PF00069 0.393
MOD_GSK3_1 457 464 PF00069 0.518
MOD_GSK3_1 485 492 PF00069 0.647
MOD_GSK3_1 54 61 PF00069 0.407
MOD_NEK2_1 113 118 PF00069 0.371
MOD_NEK2_1 131 136 PF00069 0.351
MOD_NEK2_1 138 143 PF00069 0.447
MOD_NEK2_1 27 32 PF00069 0.339
MOD_NEK2_1 363 368 PF00069 0.681
MOD_NEK2_1 410 415 PF00069 0.526
MOD_NEK2_1 489 494 PF00069 0.557
MOD_NEK2_1 49 54 PF00069 0.379
MOD_NEK2_2 227 232 PF00069 0.258
MOD_NEK2_2 45 50 PF00069 0.391
MOD_PIKK_1 167 173 PF00454 0.444
MOD_PIKK_1 489 495 PF00454 0.483
MOD_PKA_1 249 255 PF00069 0.637
MOD_PKA_1 474 480 PF00069 0.591
MOD_PKA_2 131 137 PF00069 0.431
MOD_PKA_2 148 154 PF00069 0.526
MOD_PKA_2 186 192 PF00069 0.499
MOD_PKA_2 249 255 PF00069 0.595
MOD_PKA_2 27 33 PF00069 0.421
MOD_PKA_2 301 307 PF00069 0.319
MOD_PKA_2 313 319 PF00069 0.338
MOD_PKA_2 323 329 PF00069 0.506
MOD_PKA_2 474 480 PF00069 0.591
MOD_PKA_2 522 528 PF00069 0.457
MOD_Plk_1 227 233 PF00069 0.410
MOD_Plk_4 126 132 PF00069 0.446
MOD_Plk_4 227 233 PF00069 0.327
MOD_Plk_4 238 244 PF00069 0.649
MOD_Plk_4 269 275 PF00069 0.330
MOD_Plk_4 27 33 PF00069 0.365
MOD_Plk_4 301 307 PF00069 0.300
MOD_Plk_4 313 319 PF00069 0.312
MOD_Plk_4 457 463 PF00069 0.547
MOD_Plk_4 496 502 PF00069 0.364
MOD_Plk_4 516 522 PF00069 0.372
MOD_Plk_4 55 61 PF00069 0.373
MOD_ProDKin_1 162 168 PF00069 0.467
MOD_ProDKin_1 306 312 PF00069 0.297
MOD_ProDKin_1 8 14 PF00069 0.336
MOD_SUMO_rev_2 336 344 PF00179 0.666
MOD_SUMO_rev_2 416 424 PF00179 0.445
TRG_DiLeu_BaEn_1 17 22 PF01217 0.410
TRG_DiLeu_BaEn_1 301 306 PF01217 0.255
TRG_DiLeu_BaEn_2 477 483 PF01217 0.565
TRG_DiLeu_BaLyEn_6 114 119 PF01217 0.494
TRG_DiLeu_BaLyEn_6 62 67 PF01217 0.352
TRG_DiLeu_BaLyEn_6 71 76 PF01217 0.364
TRG_ENDOCYTIC_2 102 105 PF00928 0.376
TRG_ENDOCYTIC_2 110 113 PF00928 0.395
TRG_ENDOCYTIC_2 127 130 PF00928 0.451
TRG_ENDOCYTIC_2 218 221 PF00928 0.338
TRG_ENDOCYTIC_2 406 409 PF00928 0.444
TRG_ENDOCYTIC_2 458 461 PF00928 0.442
TRG_ENDOCYTIC_2 470 473 PF00928 0.546
TRG_ENDOCYTIC_2 517 520 PF00928 0.352
TRG_ENDOCYTIC_2 63 66 PF00928 0.397
TRG_ER_diArg_1 473 475 PF00400 0.596
TRG_NES_CRM1_1 25 38 PF08389 0.414
TRG_Pf-PMV_PEXEL_1 342 346 PF00026 0.295
TRG_Pf-PMV_PEXEL_1 396 400 PF00026 0.376
TRG_Pf-PMV_PEXEL_1 65 69 PF00026 0.603

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4K7 Leptomonas seymouri 56% 100%
A0A1X0NST5 Trypanosomatidae 33% 100%
A0A3Q8ICU0 Leishmania donovani 90% 100%
A0A3R7KCJ4 Trypanosoma rangeli 32% 100%
A4HEZ6 Leishmania braziliensis 80% 100%
A4I270 Leishmania infantum 90% 100%
C9ZRS7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
Q4Q953 Leishmania major 90% 100%
V5DAA3 Trypanosoma cruzi 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS