Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WWE domain/WD domain, G-beta repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AYB9_LEIMU

TriTrypDb:

LmxM.26.1400

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	14
GO:0032991	protein-containing complex	1	14
GO:0043226	organelle	2	14
GO:0043228	non-membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043232	intracellular non-membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	14
GO:1990904	ribonucleoprotein complex	2	14
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0036064	ciliary basal body	3	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AYB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYB9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	525	529	PF00656	0.255
CLV_PCSK_KEX2_1	192	194	PF00082	0.251
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.246
CLV_PCSK_SKI1_1	189	193	PF00082	0.238
CLV_PCSK_SKI1_1	520	524	PF00082	0.338
CLV_PCSK_SKI1_1	75	79	PF00082	0.674
DEG_SPOP_SBC_1	331	335	PF00917	0.579
DEG_SPOP_SBC_1	522	526	PF00917	0.226
DOC_ANK_TNKS_1	360	367	PF00023	0.449
DOC_MAPK_DCC_7	189	199	PF00069	0.493
DOC_MAPK_gen_1	155	163	PF00069	0.428
DOC_MAPK_gen_1	187	196	PF00069	0.424
DOC_MAPK_gen_1	65	72	PF00069	0.587
DOC_MAPK_MEF2A_6	192	199	PF00069	0.552
DOC_MAPK_RevD_3	142	156	PF00069	0.452
DOC_PP4_FxxP_1	199	202	PF00568	0.400
DOC_USP7_MATH_1	106	110	PF00917	0.720
DOC_USP7_MATH_1	132	136	PF00917	0.484
DOC_USP7_MATH_1	170	174	PF00917	0.499
DOC_USP7_MATH_1	418	422	PF00917	0.541
DOC_USP7_MATH_1	44	48	PF00917	0.646
DOC_USP7_MATH_1	493	497	PF00917	0.521
DOC_USP7_MATH_1	509	513	PF00917	0.470
DOC_USP7_MATH_2	79	85	PF00917	0.534
DOC_WW_Pin1_4	272	277	PF00397	0.411
DOC_WW_Pin1_4	280	285	PF00397	0.391
DOC_WW_Pin1_4	4	9	PF00397	0.681
DOC_WW_Pin1_4	513	518	PF00397	0.436
LIG_14-3-3_CanoR_1	11	17	PF00244	0.627
LIG_14-3-3_CanoR_1	147	153	PF00244	0.544
LIG_14-3-3_CanoR_1	414	418	PF00244	0.420
LIG_14-3-3_CanoR_1	451	457	PF00244	0.508
LIG_14-3-3_CanoR_1	494	503	PF00244	0.513
LIG_14-3-3_CanoR_1	520	530	PF00244	0.394
LIG_AP2alpha_2	218	220	PF02296	0.382
LIG_APCC_ABBA_1	217	222	PF00400	0.475
LIG_BIR_III_4	248	252	PF00653	0.499
LIG_BRCT_BRCA1_1	420	424	PF00533	0.436
LIG_deltaCOP1_diTrp_1	469	479	PF00928	0.533
LIG_deltaCOP1_diTrp_1	538	543	PF00928	0.279
LIG_eIF4E_1	382	388	PF01652	0.518
LIG_FHA_1	147	153	PF00498	0.450
LIG_FHA_1	186	192	PF00498	0.587
LIG_FHA_1	202	208	PF00498	0.659
LIG_FHA_1	251	257	PF00498	0.524
LIG_FHA_1	319	325	PF00498	0.415
LIG_FHA_1	357	363	PF00498	0.437
LIG_FHA_1	376	382	PF00498	0.378
LIG_FHA_1	485	491	PF00498	0.525
LIG_FHA_1	495	501	PF00498	0.452
LIG_FHA_1	67	73	PF00498	0.681
LIG_FHA_2	106	112	PF00498	0.632
LIG_FHA_2	196	202	PF00498	0.523
LIG_FHA_2	324	330	PF00498	0.502
LIG_FHA_2	436	442	PF00498	0.402
LIG_FHA_2	459	465	PF00498	0.552
LIG_LIR_Apic_2	198	202	PF02991	0.511
LIG_LIR_Apic_2	326	331	PF02991	0.518
LIG_LIR_Gen_1	528	534	PF02991	0.347
LIG_LIR_Nem_3	113	118	PF02991	0.416
LIG_LIR_Nem_3	127	131	PF02991	0.403
LIG_LIR_Nem_3	528	533	PF02991	0.413
LIG_LIR_Nem_3	577	581	PF02991	0.526
LIG_PCNA_yPIPBox_3	208	217	PF02747	0.438
LIG_SH2_NCK_1	328	332	PF00017	0.518
LIG_SH2_SRC	363	366	PF00017	0.345
LIG_SH2_STAP1	344	348	PF00017	0.453
LIG_SH2_STAT3	180	183	PF00017	0.426
LIG_SH2_STAT5	159	162	PF00017	0.513
LIG_SH2_STAT5	278	281	PF00017	0.453
LIG_SH2_STAT5	372	375	PF00017	0.459
LIG_SH2_STAT5	515	518	PF00017	0.451
LIG_SH3_1	427	433	PF00018	0.362
LIG_SH3_3	293	299	PF00018	0.432
LIG_SH3_3	427	433	PF00018	0.460
LIG_SH3_3	99	105	PF00018	0.655
LIG_Sin3_3	293	300	PF02671	0.384
LIG_SUMO_SIM_par_1	158	165	PF11976	0.468
LIG_SUMO_SIM_par_1	252	259	PF11976	0.458
LIG_SUMO_SIM_par_1	94	100	PF11976	0.542
LIG_SxIP_EBH_1	268	277	PF03271	0.421
LIG_TRFH_1	424	428	PF08558	0.451
LIG_WRC_WIRS_1	196	201	PF05994	0.383
MOD_CDK_SPxxK_3	4	11	PF00069	0.545
MOD_CDK_SPxxK_3	513	520	PF00069	0.440
MOD_CK1_1	173	179	PF00069	0.480
MOD_CK1_1	318	324	PF00069	0.526
MOD_CK1_1	335	341	PF00069	0.456
MOD_CK1_1	526	532	PF00069	0.484
MOD_CK1_1	569	575	PF00069	0.492
MOD_CK1_1	7	13	PF00069	0.593
MOD_CK2_1	105	111	PF00069	0.575
MOD_CK2_1	323	329	PF00069	0.504
MOD_CK2_1	435	441	PF00069	0.455
MOD_GlcNHglycan	134	137	PF01048	0.313
MOD_GlcNHglycan	172	175	PF01048	0.296
MOD_GlcNHglycan	307	310	PF01048	0.453
MOD_GlcNHglycan	46	49	PF01048	0.742
MOD_GSK3_1	106	113	PF00069	0.632
MOD_GSK3_1	12	19	PF00069	0.714
MOD_GSK3_1	197	204	PF00069	0.603
MOD_GSK3_1	272	279	PF00069	0.393
MOD_GSK3_1	315	322	PF00069	0.468
MOD_GSK3_1	331	338	PF00069	0.402
MOD_GSK3_1	509	516	PF00069	0.441
MOD_GSK3_1	522	529	PF00069	0.370
MOD_GSK3_1	533	540	PF00069	0.415
MOD_GSK3_1	559	566	PF00069	0.555
MOD_N-GLC_1	342	347	PF02516	0.459
MOD_N-GLC_1	475	480	PF02516	0.406
MOD_NEK2_1	146	151	PF00069	0.510
MOD_NEK2_1	16	21	PF00069	0.550
MOD_NEK2_1	266	271	PF00069	0.450
MOD_NEK2_1	304	309	PF00069	0.335
MOD_NEK2_1	315	320	PF00069	0.326
MOD_NEK2_1	502	507	PF00069	0.546
MOD_NEK2_2	12	17	PF00069	0.565
MOD_NEK2_2	509	514	PF00069	0.348
MOD_PKA_1	155	161	PF00069	0.536
MOD_PKA_2	146	152	PF00069	0.547
MOD_PKA_2	413	419	PF00069	0.414
MOD_PKA_2	493	499	PF00069	0.498
MOD_Plk_1	315	321	PF00069	0.435
MOD_Plk_1	356	362	PF00069	0.337
MOD_Plk_1	463	469	PF00069	0.525
MOD_Plk_1	475	481	PF00069	0.536
MOD_Plk_1	537	543	PF00069	0.451
MOD_Plk_1	569	575	PF00069	0.465
MOD_Plk_4	110	116	PF00069	0.531
MOD_Plk_4	12	18	PF00069	0.514
MOD_Plk_4	148	154	PF00069	0.508
MOD_Plk_4	155	161	PF00069	0.518
MOD_Plk_4	320	326	PF00069	0.469
MOD_Plk_4	335	341	PF00069	0.331
MOD_Plk_4	526	532	PF00069	0.352
MOD_Plk_4	548	554	PF00069	0.407
MOD_Plk_4	559	565	PF00069	0.443
MOD_ProDKin_1	272	278	PF00069	0.408
MOD_ProDKin_1	280	286	PF00069	0.397
MOD_ProDKin_1	4	10	PF00069	0.681
MOD_ProDKin_1	513	519	PF00069	0.435
MOD_SUMO_rev_2	201	209	PF00179	0.685
MOD_SUMO_rev_2	441	445	PF00179	0.324
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.562
TRG_ER_diArg_1	553	556	PF00400	0.331
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUB1	Leptomonas seymouri	61%	100%
A0A0S4KLR3	Bodo saltans	25%	100%
A0A1X0NS60	Trypanosomatidae	32%	100%
A0A3S7WR72	Leishmania donovani	23%	100%
A0A3S7WZV3	Leishmania donovani	88%	100%
A0A422NIT0	Trypanosoma rangeli	35%	100%
A4H666	Leishmania braziliensis	23%	100%
A4HEZ5	Leishmania braziliensis	71%	100%
A4HUJ0	Leishmania infantum	23%	100%
A4I269	Leishmania infantum	88%	100%
C9ZRS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4Q954	Leishmania major	87%	99%
Q4QHD6	Leishmania major	23%	100%
V5BEB9	Trypanosoma cruzi	32%	100%