Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYB8_LEIMU

TriTrypDb:

LmxM.26.1390

Length:

1093

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1011	1015	PF00656	0.609
CLV_C14_Caspase3-7	773	777	PF00656	0.628
CLV_C14_Caspase3-7	885	889	PF00656	0.721
CLV_C14_Caspase3-7	972	976	PF00656	0.692
CLV_NRD_NRD_1	1003	1005	PF00675	0.606
CLV_NRD_NRD_1	1064	1066	PF00675	0.694
CLV_NRD_NRD_1	331	333	PF00675	0.753
CLV_NRD_NRD_1	536	538	PF00675	0.462
CLV_NRD_NRD_1	632	634	PF00675	0.745
CLV_NRD_NRD_1	736	738	PF00675	0.744
CLV_NRD_NRD_1	77	79	PF00675	0.806
CLV_NRD_NRD_1	831	833	PF00675	0.736
CLV_NRD_NRD_1	860	862	PF00675	0.681
CLV_NRD_NRD_1	932	934	PF00675	0.606
CLV_PCSK_KEX2_1	1003	1005	PF00082	0.639
CLV_PCSK_KEX2_1	2	4	PF00082	0.772
CLV_PCSK_KEX2_1	536	538	PF00082	0.462
CLV_PCSK_KEX2_1	632	634	PF00082	0.745
CLV_PCSK_KEX2_1	736	738	PF00082	0.584
CLV_PCSK_KEX2_1	77	79	PF00082	0.806
CLV_PCSK_KEX2_1	831	833	PF00082	0.740
CLV_PCSK_KEX2_1	860	862	PF00082	0.681
CLV_PCSK_KEX2_1	932	934	PF00082	0.606
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.714
CLV_PCSK_SKI1_1	366	370	PF00082	0.614
CLV_PCSK_SKI1_1	485	489	PF00082	0.668
CLV_PCSK_SKI1_1	547	551	PF00082	0.444
CLV_PCSK_SKI1_1	691	695	PF00082	0.672
CLV_PCSK_SKI1_1	758	762	PF00082	0.478
CLV_PCSK_SKI1_1	852	856	PF00082	0.606
CLV_PCSK_SKI1_1	935	939	PF00082	0.596
DEG_APCC_DBOX_1	365	373	PF00400	0.604
DEG_APCC_DBOX_1	763	771	PF00400	0.611
DEG_Nend_UBRbox_1	1	4	PF02207	0.716
DEG_SPOP_SBC_1	1045	1049	PF00917	0.521
DEG_SPOP_SBC_1	110	114	PF00917	0.835
DEG_SPOP_SBC_1	459	463	PF00917	0.502
DEG_SPOP_SBC_1	615	619	PF00917	0.647
DOC_CYCLIN_RxL_1	688	697	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	763	769	PF00134	0.663
DOC_MAPK_gen_1	2	10	PF00069	0.770
DOC_MAPK_gen_1	536	542	PF00069	0.447
DOC_MAPK_gen_1	753	762	PF00069	0.483
DOC_MAPK_gen_1	831	837	PF00069	0.742
DOC_MAPK_gen_1	860	869	PF00069	0.621
DOC_MAPK_gen_1	932	940	PF00069	0.574
DOC_MAPK_HePTP_8	368	380	PF00069	0.680
DOC_MAPK_MEF2A_6	2	10	PF00069	0.770
DOC_MAPK_MEF2A_6	371	380	PF00069	0.684
DOC_MAPK_MEF2A_6	831	839	PF00069	0.745
DOC_MAPK_MEF2A_6	932	940	PF00069	0.730
DOC_MAPK_NFAT4_5	3	11	PF00069	0.498
DOC_PP2B_LxvP_1	763	766	PF13499	0.452
DOC_USP7_MATH_1	1010	1014	PF00917	0.711
DOC_USP7_MATH_1	1015	1019	PF00917	0.647
DOC_USP7_MATH_1	103	107	PF00917	0.797
DOC_USP7_MATH_1	110	114	PF00917	0.748
DOC_USP7_MATH_1	117	121	PF00917	0.653
DOC_USP7_MATH_1	176	180	PF00917	0.705
DOC_USP7_MATH_1	196	200	PF00917	0.494
DOC_USP7_MATH_1	23	27	PF00917	0.756
DOC_USP7_MATH_1	239	243	PF00917	0.770
DOC_USP7_MATH_1	324	328	PF00917	0.751
DOC_USP7_MATH_1	389	393	PF00917	0.797
DOC_USP7_MATH_1	40	44	PF00917	0.579
DOC_USP7_MATH_1	475	479	PF00917	0.736
DOC_USP7_MATH_1	55	59	PF00917	0.554
DOC_USP7_MATH_1	615	619	PF00917	0.823
DOC_USP7_MATH_1	714	718	PF00917	0.631
DOC_USP7_MATH_1	785	789	PF00917	0.683
DOC_USP7_MATH_1	913	917	PF00917	0.747
DOC_WW_Pin1_4	1027	1032	PF00397	0.755
DOC_WW_Pin1_4	123	128	PF00397	0.697
DOC_WW_Pin1_4	142	147	PF00397	0.494
DOC_WW_Pin1_4	283	288	PF00397	0.717
DOC_WW_Pin1_4	296	301	PF00397	0.564
DOC_WW_Pin1_4	32	37	PF00397	0.635
DOC_WW_Pin1_4	461	466	PF00397	0.747
DOC_WW_Pin1_4	469	474	PF00397	0.686
DOC_WW_Pin1_4	550	555	PF00397	0.729
DOC_WW_Pin1_4	560	565	PF00397	0.726
DOC_WW_Pin1_4	61	66	PF00397	0.789
DOC_WW_Pin1_4	611	616	PF00397	0.792
DOC_WW_Pin1_4	647	652	PF00397	0.622
DOC_WW_Pin1_4	745	750	PF00397	0.723
DOC_WW_Pin1_4	810	815	PF00397	0.770
DOC_WW_Pin1_4	974	979	PF00397	0.730
DOC_WW_Pin1_4	99	104	PF00397	0.649
LIG_14-3-3_CanoR_1	1004	1010	PF00244	0.535
LIG_14-3-3_CanoR_1	1065	1072	PF00244	0.667
LIG_14-3-3_CanoR_1	3	9	PF00244	0.527
LIG_14-3-3_CanoR_1	346	350	PF00244	0.522
LIG_14-3-3_CanoR_1	416	424	PF00244	0.599
LIG_14-3-3_CanoR_1	435	440	PF00244	0.504
LIG_14-3-3_CanoR_1	577	586	PF00244	0.641
LIG_14-3-3_CanoR_1	736	743	PF00244	0.752
LIG_14-3-3_CanoR_1	758	763	PF00244	0.472
LIG_14-3-3_CanoR_1	878	887	PF00244	0.753
LIG_14-3-3_CanoR_1	95	105	PF00244	0.552
LIG_Actin_WH2_2	218	233	PF00022	0.577
LIG_Actin_WH2_2	82	97	PF00022	0.549
LIG_APCC_ABBAyCdc20_2	691	697	PF00400	0.585
LIG_BRCT_BRCA1_1	445	449	PF00533	0.723
LIG_CaM_NSCaTE_8	771	778	PF13499	0.707
LIG_Clathr_ClatBox_1	421	425	PF01394	0.687
LIG_deltaCOP1_diTrp_1	223	227	PF00928	0.663
LIG_DLG_GKlike_1	435	443	PF00625	0.458
LIG_FHA_1	127	133	PF00498	0.490
LIG_FHA_1	216	222	PF00498	0.675
LIG_FHA_1	310	316	PF00498	0.701
LIG_FHA_1	321	327	PF00498	0.543
LIG_FHA_1	398	404	PF00498	0.762
LIG_FHA_1	40	46	PF00498	0.812
LIG_FHA_1	416	422	PF00498	0.481
LIG_FHA_1	706	712	PF00498	0.839
LIG_FHA_1	722	728	PF00498	0.473
LIG_FHA_1	811	817	PF00498	0.761
LIG_FHA_1	832	838	PF00498	0.669
LIG_FHA_2	158	164	PF00498	0.840
LIG_FHA_2	771	777	PF00498	0.632
LIG_GBD_Chelix_1	725	733	PF00786	0.732
LIG_LIR_Apic_2	611	615	PF02991	0.785
LIG_LIR_Gen_1	1082	1090	PF02991	0.714
LIG_LIR_Gen_1	222	230	PF02991	0.660
LIG_LIR_Gen_1	446	455	PF02991	0.658
LIG_LIR_Gen_1	486	496	PF02991	0.753
LIG_LIR_Nem_3	1082	1088	PF02991	0.647
LIG_LIR_Nem_3	222	227	PF02991	0.656
LIG_LIR_Nem_3	256	261	PF02991	0.662
LIG_LIR_Nem_3	446	452	PF02991	0.649
LIG_LIR_Nem_3	486	491	PF02991	0.739
LIG_MYND_1	413	417	PF01753	0.667
LIG_NRBOX	372	378	PF00104	0.675
LIG_NRBOX	689	695	PF00104	0.668
LIG_NRBOX	758	764	PF00104	0.684
LIG_PCNA_yPIPBox_3	750	763	PF02747	0.580
LIG_SH2_CRK	1076	1080	PF00017	0.390
LIG_SH2_CRK	838	842	PF00017	0.674
LIG_SH2_GRB2like	9	12	PF00017	0.499
LIG_SH2_STAP1	310	314	PF00017	0.707
LIG_SH2_STAT5	313	316	PF00017	0.698
LIG_SH2_STAT5	367	370	PF00017	0.684
LIG_SH2_STAT5	521	524	PF00017	0.661
LIG_SH2_STAT5	612	615	PF00017	0.790
LIG_SH2_STAT5	9	12	PF00017	0.713
LIG_SH3_1	33	39	PF00018	0.524
LIG_SH3_2	36	41	PF14604	0.514
LIG_SH3_3	297	303	PF00018	0.780
LIG_SH3_3	33	39	PF00018	0.524
LIG_SH3_3	558	564	PF00018	0.710
LIG_SH3_3	620	626	PF00018	0.699
LIG_SH3_4	201	208	PF00018	0.435
LIG_Sin3_3	420	427	PF02671	0.604
LIG_SUMO_SIM_anti_2	374	379	PF11976	0.688
LIG_SUMO_SIM_anti_2	418	425	PF11976	0.691
LIG_SUMO_SIM_par_1	246	252	PF11976	0.720
LIG_SUMO_SIM_par_1	418	425	PF11976	0.614
LIG_SUMO_SIM_par_1	723	728	PF11976	0.733
LIG_TRAF2_1	907	910	PF00917	0.532
LIG_UBA3_1	131	140	PF00899	0.652
LIG_WRC_WIRS_1	451	456	PF05994	0.667
LIG_WW_3	574	578	PF00397	0.846
MOD_CDK_SPK_2	142	147	PF00069	0.637
MOD_CDK_SPK_2	299	304	PF00069	0.761
MOD_CDK_SPK_2	745	750	PF00069	0.607
MOD_CDK_SPxxK_3	550	557	PF00069	0.736
MOD_CK1_1	111	117	PF00069	0.688
MOD_CK1_1	148	154	PF00069	0.799
MOD_CK1_1	157	163	PF00069	0.738
MOD_CK1_1	167	173	PF00069	0.526
MOD_CK1_1	215	221	PF00069	0.620
MOD_CK1_1	232	238	PF00069	0.470
MOD_CK1_1	286	292	PF00069	0.820
MOD_CK1_1	299	305	PF00069	0.515
MOD_CK1_1	348	354	PF00069	0.606
MOD_CK1_1	438	444	PF00069	0.753
MOD_CK1_1	450	456	PF00069	0.561
MOD_CK1_1	461	467	PF00069	0.599
MOD_CK1_1	494	500	PF00069	0.679
MOD_CK1_1	592	598	PF00069	0.618
MOD_CK1_1	614	620	PF00069	0.671
MOD_CK1_1	739	745	PF00069	0.650
MOD_CK1_1	790	796	PF00069	0.583
MOD_CK1_1	846	852	PF00069	0.496
MOD_CK1_1	97	103	PF00069	0.725
MOD_CK1_1	974	980	PF00069	0.723
MOD_CK2_1	1045	1051	PF00069	0.708
MOD_CK2_1	898	904	PF00069	0.676
MOD_CMANNOS	1060	1063	PF00535	0.669
MOD_CMANNOS	685	688	PF00535	0.738
MOD_GlcNHglycan	1010	1013	PF01048	0.724
MOD_GlcNHglycan	1034	1037	PF01048	0.668
MOD_GlcNHglycan	119	122	PF01048	0.841
MOD_GlcNHglycan	166	169	PF01048	0.737
MOD_GlcNHglycan	185	188	PF01048	0.542
MOD_GlcNHglycan	255	258	PF01048	0.646
MOD_GlcNHglycan	288	291	PF01048	0.656
MOD_GlcNHglycan	335	338	PF01048	0.812
MOD_GlcNHglycan	353	356	PF01048	0.481
MOD_GlcNHglycan	391	394	PF01048	0.637
MOD_GlcNHglycan	42	45	PF01048	0.622
MOD_GlcNHglycan	440	443	PF01048	0.737
MOD_GlcNHglycan	444	448	PF01048	0.675
MOD_GlcNHglycan	477	480	PF01048	0.789
MOD_GlcNHglycan	494	497	PF01048	0.504
MOD_GlcNHglycan	50	53	PF01048	0.629
MOD_GlcNHglycan	501	505	PF01048	0.710
MOD_GlcNHglycan	580	583	PF01048	0.728
MOD_GlcNHglycan	588	592	PF01048	0.637
MOD_GlcNHglycan	594	597	PF01048	0.591
MOD_GlcNHglycan	619	622	PF01048	0.666
MOD_GlcNHglycan	654	657	PF01048	0.755
MOD_GlcNHglycan	661	664	PF01048	0.683
MOD_GlcNHglycan	676	679	PF01048	0.663
MOD_GlcNHglycan	705	708	PF01048	0.702
MOD_GlcNHglycan	789	792	PF01048	0.733
MOD_GlcNHglycan	881	884	PF01048	0.762
MOD_GSK3_1	108	115	PF00069	0.719
MOD_GSK3_1	119	126	PF00069	0.608
MOD_GSK3_1	190	197	PF00069	0.709
MOD_GSK3_1	215	222	PF00069	0.607
MOD_GSK3_1	229	236	PF00069	0.463
MOD_GSK3_1	281	288	PF00069	0.717
MOD_GSK3_1	320	327	PF00069	0.723
MOD_GSK3_1	328	335	PF00069	0.670
MOD_GSK3_1	389	396	PF00069	0.621
MOD_GSK3_1	411	418	PF00069	0.755
MOD_GSK3_1	434	441	PF00069	0.602
MOD_GSK3_1	443	450	PF00069	0.541
MOD_GSK3_1	455	462	PF00069	0.649
MOD_GSK3_1	469	476	PF00069	0.672
MOD_GSK3_1	487	494	PF00069	0.452
MOD_GSK3_1	587	594	PF00069	0.691
MOD_GSK3_1	61	68	PF00069	0.793
MOD_GSK3_1	611	618	PF00069	0.717
MOD_GSK3_1	647	654	PF00069	0.627
MOD_GSK3_1	703	710	PF00069	0.677
MOD_GSK3_1	721	728	PF00069	0.583
MOD_GSK3_1	796	803	PF00069	0.582
MOD_GSK3_1	939	946	PF00069	0.535
MOD_GSK3_1	99	106	PF00069	0.738
MOD_N-GLC_1	117	122	PF02516	0.844
MOD_N-GLC_1	148	153	PF02516	0.551
MOD_N-GLC_1	447	452	PF02516	0.642
MOD_N-GLC_2	787	789	PF02516	0.810
MOD_NEK2_1	1044	1049	PF00069	0.737
MOD_NEK2_1	1075	1080	PF00069	0.680
MOD_NEK2_1	130	135	PF00069	0.645
MOD_NEK2_1	183	188	PF00069	0.575
MOD_NEK2_1	189	194	PF00069	0.739
MOD_NEK2_1	210	215	PF00069	0.588
MOD_NEK2_1	230	235	PF00069	0.387
MOD_NEK2_1	384	389	PF00069	0.477
MOD_NEK2_1	4	9	PF00069	0.669
MOD_NEK2_1	455	460	PF00069	0.693
MOD_NEK2_1	492	497	PF00069	0.711
MOD_NEK2_1	524	529	PF00069	0.677
MOD_NEK2_1	559	564	PF00069	0.585
MOD_NEK2_1	608	613	PF00069	0.620
MOD_NEK2_1	646	651	PF00069	0.764
MOD_NEK2_1	652	657	PF00069	0.759
MOD_NEK2_1	725	730	PF00069	0.736
MOD_NEK2_1	94	99	PF00069	0.667
MOD_NEK2_1	994	999	PF00069	0.618
MOD_NEK2_2	943	948	PF00069	0.692
MOD_PIKK_1	130	136	PF00454	0.648
MOD_PIKK_1	194	200	PF00454	0.535
MOD_PIKK_1	230	236	PF00454	0.512
MOD_PIKK_1	736	742	PF00454	0.749
MOD_PIKK_1	796	802	PF00454	0.735
MOD_PIKK_1	825	831	PF00454	0.763
MOD_PIKK_1	846	852	PF00454	0.748
MOD_PIKK_1	919	925	PF00454	0.662
MOD_PKA_1	2	8	PF00069	0.554
MOD_PKA_1	332	338	PF00069	0.734
MOD_PKA_1	703	709	PF00069	0.535
MOD_PKA_1	736	742	PF00069	0.749
MOD_PKA_1	831	837	PF00069	0.742
MOD_PKA_2	1020	1026	PF00069	0.614
MOD_PKA_2	1064	1070	PF00069	0.606
MOD_PKA_2	157	163	PF00069	0.746
MOD_PKA_2	2	8	PF00069	0.525
MOD_PKA_2	230	236	PF00069	0.628
MOD_PKA_2	345	351	PF00069	0.518
MOD_PKA_2	40	46	PF00069	0.707
MOD_PKA_2	405	411	PF00069	0.791
MOD_PKA_2	415	421	PF00069	0.586
MOD_PKA_2	434	440	PF00069	0.420
MOD_PKA_2	736	742	PF00069	0.749
MOD_PKA_2	831	837	PF00069	0.742
MOD_PKA_2	904	910	PF00069	0.541
MOD_PKA_2	94	100	PF00069	0.603
MOD_Plk_1	1045	1051	PF00069	0.602
MOD_Plk_1	189	195	PF00069	0.638
MOD_Plk_1	447	453	PF00069	0.639
MOD_Plk_1	720	726	PF00069	0.743
MOD_Plk_1	81	87	PF00069	0.555
MOD_Plk_1	825	831	PF00069	0.763
MOD_Plk_1	846	852	PF00069	0.748
MOD_Plk_2-3	1046	1052	PF00069	0.561
MOD_Plk_4	1020	1026	PF00069	0.549
MOD_Plk_4	126	132	PF00069	0.735
MOD_Plk_4	309	315	PF00069	0.704
MOD_Plk_4	4	10	PF00069	0.713
MOD_Plk_4	435	441	PF00069	0.519
MOD_Plk_4	450	456	PF00069	0.715
MOD_Plk_4	487	493	PF00069	0.740
MOD_Plk_4	608	614	PF00069	0.712
MOD_Plk_4	721	727	PF00069	0.451
MOD_Plk_4	758	764	PF00069	0.626
MOD_Plk_4	770	776	PF00069	0.622
MOD_ProDKin_1	1027	1033	PF00069	0.754
MOD_ProDKin_1	123	129	PF00069	0.695
MOD_ProDKin_1	142	148	PF00069	0.494
MOD_ProDKin_1	283	289	PF00069	0.719
MOD_ProDKin_1	296	302	PF00069	0.558
MOD_ProDKin_1	32	38	PF00069	0.629
MOD_ProDKin_1	461	467	PF00069	0.752
MOD_ProDKin_1	469	475	PF00069	0.681
MOD_ProDKin_1	550	556	PF00069	0.728
MOD_ProDKin_1	560	566	PF00069	0.729
MOD_ProDKin_1	61	67	PF00069	0.785
MOD_ProDKin_1	611	617	PF00069	0.794
MOD_ProDKin_1	647	653	PF00069	0.624
MOD_ProDKin_1	745	751	PF00069	0.720
MOD_ProDKin_1	810	816	PF00069	0.768
MOD_ProDKin_1	974	980	PF00069	0.723
MOD_ProDKin_1	99	105	PF00069	0.647
TRG_DiLeu_BaEn_1	721	726	PF01217	0.450
TRG_DiLeu_BaEn_1	876	881	PF01217	0.805
TRG_DiLeu_BaEn_2	222	228	PF01217	0.659
TRG_DiLeu_BaLyEn_6	574	579	PF01217	0.557
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.769
TRG_DiLeu_BaLyEn_6	648	653	PF01217	0.630
TRG_ENDOCYTIC_2	1076	1079	PF00928	0.399
TRG_ENDOCYTIC_2	521	524	PF00928	0.661
TRG_ENDOCYTIC_2	838	841	PF00928	0.760
TRG_ER_diArg_1	1003	1005	PF00400	0.708
TRG_ER_diArg_1	30	33	PF00400	0.818
TRG_ER_diArg_1	364	367	PF00400	0.636
TRG_ER_diArg_1	536	538	PF00400	0.462
TRG_ER_diArg_1	59	62	PF00400	0.730
TRG_ER_diArg_1	735	737	PF00400	0.735
TRG_ER_diArg_1	830	832	PF00400	0.745
TRG_ER_diArg_1	931	933	PF00400	0.774
TRG_NES_CRM1_1	989	1002	PF08389	0.623
TRG_Pf-PMV_PEXEL_1	536	541	PF00026	0.667
TRG_Pf-PMV_PEXEL_1	691	696	PF00026	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IH22	Leishmania donovani	81%	98%
A4HEZ4	Leishmania braziliensis	63%	100%
A4I268	Leishmania infantum	81%	98%
Q4Q955	Leishmania major	78%	100%