Guanine nucleotide-binding protein-like protein (Gtp-binding protein-like protein)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guanine nucleotide-binding protein-like protein

Species:

Leishmania mexicana

UniProt:

E9AYB6_LEIMU

TriTrypDb:

LmxM.26.1370

Length:

899

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYB6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0003924	GTPase activity	7	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.659
CLV_C14_Caspase3-7	228	232	PF00656	0.700
CLV_C14_Caspase3-7	323	327	PF00656	0.839
CLV_C14_Caspase3-7	366	370	PF00656	0.607
CLV_C14_Caspase3-7	561	565	PF00656	0.555
CLV_C14_Caspase3-7	755	759	PF00656	0.549
CLV_NRD_NRD_1	114	116	PF00675	0.716
CLV_NRD_NRD_1	145	147	PF00675	0.538
CLV_NRD_NRD_1	18	20	PF00675	0.684
CLV_NRD_NRD_1	219	221	PF00675	0.661
CLV_NRD_NRD_1	314	316	PF00675	0.526
CLV_NRD_NRD_1	430	432	PF00675	0.603
CLV_NRD_NRD_1	524	526	PF00675	0.625
CLV_NRD_NRD_1	528	530	PF00675	0.603
CLV_NRD_NRD_1	595	597	PF00675	0.563
CLV_NRD_NRD_1	616	618	PF00675	0.478
CLV_NRD_NRD_1	70	72	PF00675	0.665
CLV_NRD_NRD_1	83	85	PF00675	0.709
CLV_PCSK_FUR_1	68	72	PF00082	0.665
CLV_PCSK_KEX2_1	114	116	PF00082	0.716
CLV_PCSK_KEX2_1	16	18	PF00082	0.677
CLV_PCSK_KEX2_1	191	193	PF00082	0.813
CLV_PCSK_KEX2_1	20	22	PF00082	0.673
CLV_PCSK_KEX2_1	219	221	PF00082	0.753
CLV_PCSK_KEX2_1	314	316	PF00082	0.526
CLV_PCSK_KEX2_1	359	361	PF00082	0.470
CLV_PCSK_KEX2_1	524	526	PF00082	0.672
CLV_PCSK_KEX2_1	549	551	PF00082	0.569
CLV_PCSK_KEX2_1	595	597	PF00082	0.563
CLV_PCSK_KEX2_1	616	618	PF00082	0.478
CLV_PCSK_KEX2_1	664	666	PF00082	0.724
CLV_PCSK_KEX2_1	70	72	PF00082	0.668
CLV_PCSK_KEX2_1	831	833	PF00082	0.474
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.677
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.735
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.673
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.434
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.528
CLV_PCSK_PC1ET2_1	664	666	PF00082	0.724
CLV_PCSK_PC1ET2_1	831	833	PF00082	0.474
CLV_PCSK_SKI1_1	132	136	PF00082	0.644
CLV_PCSK_SKI1_1	209	213	PF00082	0.593
CLV_PCSK_SKI1_1	286	290	PF00082	0.639
CLV_PCSK_SKI1_1	360	364	PF00082	0.394
CLV_PCSK_SKI1_1	498	502	PF00082	0.493
CLV_PCSK_SKI1_1	832	836	PF00082	0.455
CLV_PCSK_SKI1_1	840	844	PF00082	0.453
DEG_SCF_FBW7_1	734	741	PF00400	0.546
DEG_SCF_TRCP1_1	686	692	PF00400	0.845
DEG_SPOP_SBC_1	236	240	PF00917	0.640
DEG_SPOP_SBC_1	640	644	PF00917	0.762
DOC_MAPK_FxFP_2	171	174	PF00069	0.671
DOC_MAPK_gen_1	428	437	PF00069	0.579
DOC_MAPK_gen_1	539	547	PF00069	0.619
DOC_MAPK_gen_1	595	603	PF00069	0.563
DOC_MAPK_gen_1	830	836	PF00069	0.462
DOC_MAPK_gen_1	837	845	PF00069	0.450
DOC_MAPK_gen_1	879	888	PF00069	0.509
DOC_MAPK_MEF2A_6	428	437	PF00069	0.477
DOC_MAPK_MEF2A_6	879	888	PF00069	0.509
DOC_PP2B_LxvP_1	762	765	PF13499	0.539
DOC_PP2B_LxvP_1	886	889	PF13499	0.374
DOC_PP4_FxxP_1	171	174	PF00568	0.671
DOC_PP4_FxxP_1	767	770	PF00568	0.507
DOC_PP4_FxxP_1	864	867	PF00568	0.576
DOC_USP7_MATH_1	182	186	PF00917	0.732
DOC_USP7_MATH_1	257	261	PF00917	0.717
DOC_USP7_MATH_1	264	268	PF00917	0.779
DOC_USP7_MATH_1	648	652	PF00917	0.711
DOC_USP7_MATH_1	788	792	PF00917	0.584
DOC_USP7_MATH_1	895	899	PF00917	0.461
DOC_USP7_UBL2_3	16	20	PF12436	0.635
DOC_USP7_UBL2_3	428	432	PF12436	0.508
DOC_USP7_UBL2_3	527	531	PF12436	0.763
DOC_USP7_UBL2_3	660	664	PF12436	0.683
DOC_WW_Pin1_4	286	291	PF00397	0.747
DOC_WW_Pin1_4	296	301	PF00397	0.787
DOC_WW_Pin1_4	641	646	PF00397	0.821
DOC_WW_Pin1_4	700	705	PF00397	0.682
DOC_WW_Pin1_4	734	739	PF00397	0.545
DOC_WW_Pin1_4	756	761	PF00397	0.549
LIG_14-3-3_CanoR_1	114	118	PF00244	0.838
LIG_14-3-3_CanoR_1	146	152	PF00244	0.551
LIG_14-3-3_CanoR_1	157	161	PF00244	0.672
LIG_14-3-3_CanoR_1	502	510	PF00244	0.536
LIG_14-3-3_CanoR_1	574	584	PF00244	0.584
LIG_14-3-3_CanoR_1	623	629	PF00244	0.679
LIG_APCC_ABBA_1	361	366	PF00400	0.589
LIG_APCC_ABBAyCdc20_2	360	366	PF00400	0.591
LIG_BIR_III_2	369	373	PF00653	0.518
LIG_BIR_III_2	812	816	PF00653	0.386
LIG_BIR_III_4	231	235	PF00653	0.769
LIG_BIR_III_4	471	475	PF00653	0.494
LIG_BRCT_BRCA1_1	237	241	PF00533	0.600
LIG_BRCT_BRCA1_1	485	489	PF00533	0.604
LIG_BRCT_BRCA1_1	790	794	PF00533	0.476
LIG_BRCT_BRCA1_1	892	896	PF00533	0.432
LIG_deltaCOP1_diTrp_1	169	173	PF00928	0.656
LIG_deltaCOP1_diTrp_1	390	396	PF00928	0.471
LIG_deltaCOP1_diTrp_1	480	489	PF00928	0.514
LIG_deltaCOP1_diTrp_1	816	822	PF00928	0.341
LIG_FHA_1	363	369	PF00498	0.592
LIG_FHA_1	396	402	PF00498	0.464
LIG_FHA_1	540	546	PF00498	0.695
LIG_FHA_1	607	613	PF00498	0.481
LIG_FHA_1	629	635	PF00498	0.838
LIG_FHA_1	647	653	PF00498	0.610
LIG_FHA_1	727	733	PF00498	0.546
LIG_FHA_1	744	750	PF00498	0.546
LIG_FHA_1	777	783	PF00498	0.532
LIG_FHA_2	753	759	PF00498	0.546
LIG_GBD_Chelix_1	604	612	PF00786	0.605
LIG_LIR_Apic_2	169	174	PF02991	0.661
LIG_LIR_Apic_2	369	374	PF02991	0.520
LIG_LIR_Gen_1	390	399	PF02991	0.466
LIG_LIR_Gen_1	534	545	PF02991	0.555
LIG_LIR_Gen_1	703	712	PF02991	0.548
LIG_LIR_Gen_1	816	827	PF02991	0.307
LIG_LIR_LC3C_4	402	407	PF02991	0.539
LIG_LIR_Nem_3	150	154	PF02991	0.576
LIG_LIR_Nem_3	169	173	PF02991	0.746
LIG_LIR_Nem_3	238	244	PF02991	0.663
LIG_LIR_Nem_3	390	395	PF02991	0.475
LIG_LIR_Nem_3	410	416	PF02991	0.216
LIG_LIR_Nem_3	534	540	PF02991	0.550
LIG_LIR_Nem_3	578	584	PF02991	0.462
LIG_LIR_Nem_3	703	709	PF02991	0.577
LIG_LIR_Nem_3	816	822	PF02991	0.592
LIG_LYPXL_yS_3	413	416	PF13949	0.446
LIG_MAD2	730	738	PF02301	0.546
LIG_MLH1_MIPbox_1	238	242	PF16413	0.678
LIG_NRBOX	52	58	PF00104	0.588
LIG_Pex14_2	167	171	PF04695	0.658
LIG_SH2_CRK	151	155	PF00017	0.618
LIG_SH2_NCK_1	865	869	PF00017	0.485
LIG_SH2_SRC	151	154	PF00017	0.588
LIG_SH2_SRC	706	709	PF00017	0.514
LIG_SH2_SRC	798	801	PF00017	0.495
LIG_SH2_SRC	865	868	PF00017	0.577
LIG_SH2_STAP1	364	368	PF00017	0.551
LIG_SH2_STAP1	385	389	PF00017	0.497
LIG_SH2_STAT3	805	808	PF00017	0.542
LIG_SH2_STAT5	352	355	PF00017	0.599
LIG_SH2_STAT5	364	367	PF00017	0.438
LIG_SH2_STAT5	425	428	PF00017	0.409
LIG_SH2_STAT5	459	462	PF00017	0.464
LIG_SH2_STAT5	706	709	PF00017	0.514
LIG_SH2_STAT5	798	801	PF00017	0.490
LIG_SH3_3	243	249	PF00018	0.534
LIG_SH3_3	464	470	PF00018	0.544
LIG_SH3_3	698	704	PF00018	0.674
LIG_SH3_3	754	760	PF00018	0.546
LIG_SH3_3	766	772	PF00018	0.617
LIG_Sin3_3	849	856	PF02671	0.560
LIG_SUMO_SIM_anti_2	207	214	PF11976	0.722
LIG_SUMO_SIM_anti_2	402	410	PF11976	0.436
LIG_SUMO_SIM_anti_2	600	605	PF11976	0.512
LIG_SUMO_SIM_anti_2	752	759	PF11976	0.528
LIG_SUMO_SIM_par_1	397	403	PF11976	0.467
LIG_SUMO_SIM_par_1	404	410	PF11976	0.431
LIG_SUMO_SIM_par_1	729	735	PF11976	0.546
LIG_TYR_ITIM	149	154	PF00017	0.597
LIG_TYR_ITIM	535	540	PF00017	0.376
LIG_UBA3_1	422	428	PF00899	0.461
LIG_UBA3_1	722	730	PF00899	0.546
LIG_WRC_WIRS_1	501	506	PF05994	0.515
MOD_CK1_1	175	181	PF00069	0.670
MOD_CK1_1	237	243	PF00069	0.537
MOD_CK1_1	689	695	PF00069	0.775
MOD_CK1_1	88	94	PF00069	0.692
MOD_CK1_1	96	102	PF00069	0.762
MOD_CK2_1	102	108	PF00069	0.794
MOD_CK2_1	315	321	PF00069	0.732
MOD_CK2_1	380	386	PF00069	0.502
MOD_CK2_1	684	690	PF00069	0.629
MOD_CK2_1	817	823	PF00069	0.510
MOD_Cter_Amidation	5	8	PF01082	0.693
MOD_Cter_Amidation	68	71	PF01082	0.667
MOD_GlcNHglycan	115	118	PF01048	0.696
MOD_GlcNHglycan	123	126	PF01048	0.585
MOD_GlcNHglycan	138	141	PF01048	0.476
MOD_GlcNHglycan	175	178	PF01048	0.743
MOD_GlcNHglycan	184	187	PF01048	0.628
MOD_GlcNHglycan	227	230	PF01048	0.674
MOD_GlcNHglycan	258	262	PF01048	0.716
MOD_GlcNHglycan	296	299	PF01048	0.859
MOD_GlcNHglycan	321	325	PF01048	0.765
MOD_GlcNHglycan	331	335	PF01048	0.678
MOD_GlcNHglycan	4	7	PF01048	0.703
MOD_GlcNHglycan	493	496	PF01048	0.682
MOD_GlcNHglycan	665	668	PF01048	0.583
MOD_GlcNHglycan	685	689	PF01048	0.744
MOD_GlcNHglycan	734	737	PF01048	0.330
MOD_GlcNHglycan	87	90	PF01048	0.718
MOD_GlcNHglycan	874	877	PF01048	0.506
MOD_GlcNHglycan	892	895	PF01048	0.597
MOD_GlcNHglycan	92	98	PF01048	0.791
MOD_GSK3_1	113	120	PF00069	0.539
MOD_GSK3_1	156	163	PF00069	0.670
MOD_GSK3_1	169	176	PF00069	0.655
MOD_GSK3_1	275	282	PF00069	0.802
MOD_GSK3_1	320	327	PF00069	0.812
MOD_GSK3_1	330	337	PF00069	0.682
MOD_GSK3_1	395	402	PF00069	0.574
MOD_GSK3_1	684	691	PF00069	0.614
MOD_GSK3_1	726	733	PF00069	0.513
MOD_GSK3_1	734	741	PF00069	0.519
MOD_GSK3_1	752	759	PF00069	0.546
MOD_GSK3_1	95	102	PF00069	0.839
MOD_LATS_1	83	89	PF00433	0.518
MOD_N-GLC_1	564	569	PF02516	0.551
MOD_NEK2_1	113	118	PF00069	0.737
MOD_NEK2_1	225	230	PF00069	0.694
MOD_NEK2_1	380	385	PF00069	0.512
MOD_NEK2_1	611	616	PF00069	0.597
MOD_NEK2_1	872	877	PF00069	0.513
MOD_NEK2_2	130	135	PF00069	0.654
MOD_NEK2_2	445	450	PF00069	0.478
MOD_PIKK_1	275	281	PF00454	0.846
MOD_PIKK_1	426	432	PF00454	0.301
MOD_PK_1	730	736	PF00069	0.546
MOD_PKA_1	314	320	PF00069	0.520
MOD_PKA_2	113	119	PF00069	0.836
MOD_PKA_2	156	162	PF00069	0.668
MOD_PKA_2	313	319	PF00069	0.730
MOD_PKA_2	622	628	PF00069	0.619
MOD_PKA_2	726	732	PF00069	0.546
MOD_Plk_1	264	270	PF00069	0.789
MOD_Plk_1	380	386	PF00069	0.531
MOD_Plk_2-3	381	387	PF00069	0.529
MOD_Plk_2-3	564	570	PF00069	0.667
MOD_Plk_2-3	752	758	PF00069	0.530
MOD_Plk_4	117	123	PF00069	0.821
MOD_Plk_4	237	243	PF00069	0.581
MOD_Plk_4	264	270	PF00069	0.716
MOD_Plk_4	421	427	PF00069	0.456
MOD_Plk_4	702	708	PF00069	0.599
MOD_Plk_4	718	724	PF00069	0.546
MOD_Plk_4	752	758	PF00069	0.546
MOD_ProDKin_1	286	292	PF00069	0.746
MOD_ProDKin_1	296	302	PF00069	0.783
MOD_ProDKin_1	641	647	PF00069	0.821
MOD_ProDKin_1	700	706	PF00069	0.664
MOD_ProDKin_1	734	740	PF00069	0.545
MOD_ProDKin_1	756	762	PF00069	0.549
MOD_SUMO_rev_2	355	361	PF00179	0.439
TRG_DiLeu_BaEn_1	752	757	PF01217	0.530
TRG_ENDOCYTIC_2	151	154	PF00928	0.611
TRG_ENDOCYTIC_2	413	416	PF00928	0.416
TRG_ENDOCYTIC_2	457	460	PF00928	0.439
TRG_ENDOCYTIC_2	537	540	PF00928	0.556
TRG_ENDOCYTIC_2	598	601	PF00928	0.553
TRG_ENDOCYTIC_2	706	709	PF00928	0.514
TRG_ENDOCYTIC_2	798	801	PF00928	0.495
TRG_ER_diArg_1	113	115	PF00400	0.753
TRG_ER_diArg_1	219	221	PF00400	0.753
TRG_ER_diArg_1	616	618	PF00400	0.481
TRG_ER_diArg_1	68	71	PF00400	0.654
TRG_ER_diArg_1	881	884	PF00400	0.464
TRG_NLS_MonoExtC_3	15	20	PF00514	0.631
TRG_NLS_MonoExtC_3	528	534	PF00514	0.632
TRG_NLS_MonoExtN_4	527	533	PF00514	0.750

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJA6	Leptomonas seymouri	59%	100%
A0A3S7WZV4	Leishmania donovani	89%	99%
A4HEZ2	Leishmania braziliensis	76%	99%
A4I266	Leishmania infantum	88%	99%
Q4Q957	Leishmania major	87%	99%