Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYB5_LEIMU

TriTrypDb:

LmxM.26.1360

Length:

590

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.471
CLV_C14_Caspase3-7	479	483	PF00656	0.358
CLV_C14_Caspase3-7	524	528	PF00656	0.784
CLV_NRD_NRD_1	31	33	PF00675	0.620
CLV_NRD_NRD_1	313	315	PF00675	0.484
CLV_NRD_NRD_1	339	341	PF00675	0.436
CLV_NRD_NRD_1	389	391	PF00675	0.385
CLV_NRD_NRD_1	406	408	PF00675	0.317
CLV_NRD_NRD_1	53	55	PF00675	0.795
CLV_NRD_NRD_1	7	9	PF00675	0.697
CLV_PCSK_KEX2_1	31	33	PF00082	0.635
CLV_PCSK_KEX2_1	313	315	PF00082	0.567
CLV_PCSK_KEX2_1	339	341	PF00082	0.436
CLV_PCSK_KEX2_1	389	391	PF00082	0.339
CLV_PCSK_KEX2_1	406	408	PF00082	0.361
CLV_PCSK_KEX2_1	53	55	PF00082	0.795
CLV_PCSK_KEX2_1	549	551	PF00082	0.562
CLV_PCSK_KEX2_1	7	9	PF00082	0.697
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.559
CLV_PCSK_PC7_1	3	9	PF00082	0.556
CLV_PCSK_SKI1_1	32	36	PF00082	0.436
CLV_PCSK_SKI1_1	339	343	PF00082	0.432
CLV_PCSK_SKI1_1	406	410	PF00082	0.441
CLV_PCSK_SKI1_1	453	457	PF00082	0.360
CLV_PCSK_SKI1_1	471	475	PF00082	0.313
CLV_PCSK_SKI1_1	505	509	PF00082	0.346
CLV_PCSK_SKI1_1	549	553	PF00082	0.423
DEG_APCC_DBOX_1	405	413	PF00400	0.434
DEG_APCC_DBOX_1	452	460	PF00400	0.390
DEG_APCC_DBOX_1	470	478	PF00400	0.229
DEG_APCC_DBOX_1	581	589	PF00400	0.381
DEG_APCC_DBOX_1	6	14	PF00400	0.442
DEG_Nend_Nbox_1	1	3	PF02207	0.588
DEG_SPOP_SBC_1	126	130	PF00917	0.636
DEG_SPOP_SBC_1	42	46	PF00917	0.675
DOC_ANK_TNKS_1	53	60	PF00023	0.537
DOC_CYCLIN_RxL_1	404	413	PF00134	0.439
DOC_CYCLIN_RxL_1	502	512	PF00134	0.269
DOC_MAPK_gen_1	177	186	PF00069	0.539
DOC_MAPK_gen_1	406	414	PF00069	0.288
DOC_MAPK_gen_1	7	13	PF00069	0.442
DOC_MAPK_MEF2A_6	141	148	PF00069	0.477
DOC_MAPK_MEF2A_6	231	239	PF00069	0.547
DOC_MAPK_MEF2A_6	407	416	PF00069	0.284
DOC_USP7_MATH_1	137	141	PF00917	0.512
DOC_USP7_MATH_1	268	272	PF00917	0.711
DOC_USP7_MATH_1	41	45	PF00917	0.498
DOC_USP7_MATH_1	49	53	PF00917	0.616
DOC_USP7_MATH_1	531	535	PF00917	0.709
DOC_USP7_UBL2_3	107	111	PF12436	0.506
DOC_USP7_UBL2_3	504	508	PF12436	0.434
DOC_WW_Pin1_4	164	169	PF00397	0.734
DOC_WW_Pin1_4	264	269	PF00397	0.587
LIG_14-3-3_CanoR_1	195	203	PF00244	0.395
LIG_14-3-3_CanoR_1	207	213	PF00244	0.324
LIG_14-3-3_CanoR_1	231	239	PF00244	0.474
LIG_14-3-3_CanoR_1	31	37	PF00244	0.674
LIG_14-3-3_CanoR_1	313	317	PF00244	0.533
LIG_14-3-3_CanoR_1	339	346	PF00244	0.447
LIG_14-3-3_CanoR_1	372	378	PF00244	0.478
LIG_14-3-3_CanoR_1	48	55	PF00244	0.766
LIG_14-3-3_CanoR_1	584	589	PF00244	0.388
LIG_14-3-3_CanoR_1	69	74	PF00244	0.658
LIG_Actin_WH2_2	392	408	PF00022	0.554
LIG_Actin_WH2_2	409	424	PF00022	0.347
LIG_Actin_WH2_2	492	510	PF00022	0.409
LIG_BIR_III_4	14	18	PF00653	0.505
LIG_BRCT_BRCA1_1	281	285	PF00533	0.445
LIG_BRCT_MDC1_1	586	590	PF00533	0.414
LIG_Clathr_ClatBox_1	10	14	PF01394	0.444
LIG_FHA_1	118	124	PF00498	0.480
LIG_FHA_1	143	149	PF00498	0.614
LIG_FHA_1	209	215	PF00498	0.331
LIG_FHA_1	259	265	PF00498	0.579
LIG_FHA_1	272	278	PF00498	0.515
LIG_FHA_1	281	287	PF00498	0.433
LIG_FHA_1	31	37	PF00498	0.567
LIG_FHA_1	442	448	PF00498	0.556
LIG_FHA_2	216	222	PF00498	0.386
LIG_FHA_2	313	319	PF00498	0.447
LIG_FHA_2	340	346	PF00498	0.439
LIG_FHA_2	374	380	PF00498	0.444
LIG_GBD_Chelix_1	495	503	PF00786	0.391
LIG_LIR_Gen_1	182	191	PF02991	0.486
LIG_LIR_Gen_1	395	404	PF02991	0.387
LIG_LIR_Gen_1	497	507	PF02991	0.340
LIG_LIR_Nem_3	182	186	PF02991	0.508
LIG_LIR_Nem_3	395	399	PF02991	0.397
LIG_LIR_Nem_3	497	503	PF02991	0.369
LIG_LYPXL_SIV_4	104	112	PF13949	0.386
LIG_NRBOX	498	504	PF00104	0.393
LIG_NRBOX	584	590	PF00104	0.413
LIG_Pex14_1	2	6	PF04695	0.548
LIG_RPA_C_Fungi	14	26	PF08784	0.447
LIG_SH2_STAT5	105	108	PF00017	0.317
LIG_SH2_STAT5	212	215	PF00017	0.334
LIG_SH2_STAT5	350	353	PF00017	0.449
LIG_SH2_STAT5	369	372	PF00017	0.309
LIG_SH2_STAT5	469	472	PF00017	0.407
LIG_SH2_STAT5	73	76	PF00017	0.457
LIG_SH2_STAT5	96	99	PF00017	0.378
LIG_SH3_3	348	354	PF00018	0.312
LIG_SH3_3	570	576	PF00018	0.544
LIG_SUMO_SIM_par_1	407	413	PF11976	0.316
LIG_TRAF2_1	315	318	PF00917	0.509
LIG_TRAF2_1	530	533	PF00917	0.692
LIG_UBA3_1	499	508	PF00899	0.400
MOD_CK1_1	128	134	PF00069	0.675
MOD_CK1_1	142	148	PF00069	0.733
MOD_CK1_1	164	170	PF00069	0.724
MOD_CK1_1	199	205	PF00069	0.398
MOD_CK1_1	271	277	PF00069	0.453
MOD_CK1_1	279	285	PF00069	0.393
MOD_CK1_1	373	379	PF00069	0.514
MOD_CK1_1	515	521	PF00069	0.661
MOD_CK1_1	72	78	PF00069	0.442
MOD_CK2_1	137	143	PF00069	0.732
MOD_CK2_1	312	318	PF00069	0.527
MOD_CK2_1	339	345	PF00069	0.451
MOD_CK2_1	527	533	PF00069	0.676
MOD_GlcNHglycan	102	105	PF01048	0.427
MOD_GlcNHglycan	131	134	PF01048	0.713
MOD_GlcNHglycan	163	166	PF01048	0.596
MOD_GlcNHglycan	169	172	PF01048	0.732
MOD_GlcNHglycan	198	201	PF01048	0.397
MOD_GlcNHglycan	258	261	PF01048	0.614
MOD_GlcNHglycan	263	267	PF01048	0.632
MOD_GlcNHglycan	270	273	PF01048	0.566
MOD_GlcNHglycan	278	281	PF01048	0.377
MOD_GlcNHglycan	529	532	PF01048	0.712
MOD_GSK3_1	118	125	PF00069	0.595
MOD_GSK3_1	127	134	PF00069	0.679
MOD_GSK3_1	258	265	PF00069	0.635
MOD_GSK3_1	268	275	PF00069	0.535
MOD_GSK3_1	276	283	PF00069	0.374
MOD_GSK3_1	30	37	PF00069	0.594
MOD_GSK3_1	482	489	PF00069	0.539
MOD_GSK3_1	527	534	PF00069	0.696
MOD_GSK3_1	560	567	PF00069	0.383
MOD_GSK3_1	571	578	PF00069	0.503
MOD_GSK3_1	580	587	PF00069	0.358
MOD_N-GLC_1	100	105	PF02516	0.502
MOD_N-GLC_1	148	153	PF02516	0.586
MOD_N-GLC_1	49	54	PF02516	0.590
MOD_NEK2_1	1	6	PF00069	0.582
MOD_NEK2_1	112	117	PF00069	0.500
MOD_NEK2_1	215	220	PF00069	0.377
MOD_NEK2_1	278	283	PF00069	0.462
MOD_NEK2_1	312	317	PF00069	0.433
MOD_NEK2_1	370	375	PF00069	0.447
MOD_NEK2_1	507	512	PF00069	0.474
MOD_NEK2_1	514	519	PF00069	0.603
MOD_NEK2_1	544	549	PF00069	0.418
MOD_NEK2_1	564	569	PF00069	0.312
MOD_NEK2_2	531	536	PF00069	0.496
MOD_PIKK_1	148	154	PF00454	0.603
MOD_PIKK_1	172	178	PF00454	0.624
MOD_PIKK_1	329	335	PF00454	0.284
MOD_PIKK_1	512	518	PF00454	0.568
MOD_PIKK_1	575	581	PF00454	0.455
MOD_PIKK_1	84	90	PF00454	0.363
MOD_PK_1	231	237	PF00069	0.381
MOD_PK_1	434	440	PF00069	0.426
MOD_PKA_1	339	345	PF00069	0.426
MOD_PKA_2	230	236	PF00069	0.519
MOD_PKA_2	256	262	PF00069	0.567
MOD_PKA_2	30	36	PF00069	0.584
MOD_PKA_2	312	318	PF00069	0.413
MOD_PKA_2	339	345	PF00069	0.426
MOD_PKA_2	512	518	PF00069	0.587
MOD_PKB_1	582	590	PF00069	0.391
MOD_Plk_1	100	106	PF00069	0.381
MOD_Plk_1	142	148	PF00069	0.648
MOD_Plk_1	531	537	PF00069	0.513
MOD_Plk_2-3	482	488	PF00069	0.570
MOD_Plk_4	215	221	PF00069	0.398
MOD_Plk_4	231	237	PF00069	0.421
MOD_Plk_4	434	440	PF00069	0.444
MOD_Plk_4	491	497	PF00069	0.313
MOD_Plk_4	564	570	PF00069	0.466
MOD_Plk_4	584	590	PF00069	0.388
MOD_Plk_4	69	75	PF00069	0.575
MOD_ProDKin_1	164	170	PF00069	0.734
MOD_ProDKin_1	264	270	PF00069	0.582
MOD_SUMO_rev_2	534	544	PF00179	0.610
TRG_DiLeu_BaEn_1	458	463	PF01217	0.423
TRG_DiLeu_BaEn_4	304	310	PF01217	0.459
TRG_ENDOCYTIC_2	212	215	PF00928	0.334
TRG_ER_diArg_1	205	208	PF00400	0.415
TRG_ER_diArg_1	312	314	PF00400	0.543
TRG_ER_diArg_1	338	340	PF00400	0.468
TRG_ER_diArg_1	405	407	PF00400	0.352
TRG_ER_diArg_1	511	514	PF00400	0.539
TRG_ER_diArg_1	53	55	PF00400	0.793
TRG_ER_diArg_1	582	585	PF00400	0.385
TRG_ER_diArg_1	6	8	PF00400	0.590
TRG_NES_CRM1_1	326	337	PF08389	0.404
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	339	343	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P9	Leptomonas seymouri	61%	100%
A0A0S4KJS0	Bodo saltans	32%	100%
A0A1X0NTU8	Trypanosomatidae	43%	100%
A0A3Q8IDS9	Leishmania donovani	85%	98%
A4HEZ1	Leishmania braziliensis	77%	100%
A4I265	Leishmania infantum	85%	98%
C9ZRT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q958	Leishmania major	87%	100%
V5B9R8	Trypanosoma cruzi	43%	100%