Putative DNA ligase (Putative mitochondrial dna ligase homolog)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial DNA ligase homolog, putative

Species:

Leishmania mexicana

UniProt:

E9AYB4_LEIMU

TriTrypDb:

LmxM.26.1350

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AYB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYB4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	21
GO:0006259	DNA metabolic process	4	21
GO:0006281	DNA repair	5	21
GO:0006310	DNA recombination	5	21
GO:0006725	cellular aromatic compound metabolic process	3	21
GO:0006807	nitrogen compound metabolic process	2	21
GO:0006950	response to stress	2	21
GO:0006974	DNA damage response	4	21
GO:0008152	metabolic process	1	21
GO:0009987	cellular process	1	21
GO:0033554	cellular response to stress	3	21
GO:0034641	cellular nitrogen compound metabolic process	3	21
GO:0043170	macromolecule metabolic process	3	21
GO:0044237	cellular metabolic process	2	21
GO:0044238	primary metabolic process	2	21
GO:0044260	obsolete cellular macromolecule metabolic process	3	21
GO:0046483	heterocycle metabolic process	3	21
GO:0050896	response to stimulus	1	21
GO:0051716	cellular response to stimulus	2	21
GO:0071704	organic substance metabolic process	2	21
GO:0090304	nucleic acid metabolic process	4	21
GO:1901360	organic cyclic compound metabolic process	3	21

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	21
GO:0003824	catalytic activity	1	21
GO:0003909	DNA ligase activity	4	21
GO:0003910	DNA ligase (ATP) activity	5	21
GO:0005488	binding	1	21
GO:0005524	ATP binding	5	21
GO:0016874	ligase activity	2	21
GO:0016886	ligase activity, forming phosphoric ester bonds	3	21
GO:0017076	purine nucleotide binding	4	21
GO:0030554	adenyl nucleotide binding	5	21
GO:0032553	ribonucleotide binding	3	21
GO:0032555	purine ribonucleotide binding	4	21
GO:0032559	adenyl ribonucleotide binding	5	21
GO:0035639	purine ribonucleoside triphosphate binding	4	21
GO:0036094	small molecule binding	2	21
GO:0043167	ion binding	2	21
GO:0043168	anion binding	3	21
GO:0097159	organic cyclic compound binding	2	21
GO:0097367	carbohydrate derivative binding	2	21
GO:0140097	catalytic activity, acting on DNA	3	21
GO:0140640	catalytic activity, acting on a nucleic acid	2	21
GO:1901265	nucleoside phosphate binding	3	21
GO:1901363	heterocyclic compound binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.416
CLV_NRD_NRD_1	200	202	PF00675	0.268
CLV_NRD_NRD_1	203	205	PF00675	0.260
CLV_NRD_NRD_1	265	267	PF00675	0.292
CLV_NRD_NRD_1	384	386	PF00675	0.329
CLV_NRD_NRD_1	392	394	PF00675	0.334
CLV_NRD_NRD_1	427	429	PF00675	0.504
CLV_PCSK_KEX2_1	200	202	PF00082	0.279
CLV_PCSK_KEX2_1	255	257	PF00082	0.312
CLV_PCSK_KEX2_1	329	331	PF00082	0.284
CLV_PCSK_KEX2_1	383	385	PF00082	0.312
CLV_PCSK_KEX2_1	392	394	PF00082	0.304
CLV_PCSK_KEX2_1	427	429	PF00082	0.479
CLV_PCSK_PC1ET2_1	255	257	PF00082	0.321
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.291
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.322
CLV_PCSK_SKI1_1	124	128	PF00082	0.349
CLV_PCSK_SKI1_1	241	245	PF00082	0.296
CLV_PCSK_SKI1_1	358	362	PF00082	0.445
CLV_PCSK_SKI1_1	398	402	PF00082	0.331
CLV_PCSK_SKI1_1	81	85	PF00082	0.392
DEG_Kelch_Keap1_1	112	117	PF01344	0.136
DEG_Nend_UBRbox_3	1	3	PF02207	0.449
DEG_SIAH_1	291	299	PF03145	0.379
DOC_CKS1_1	1	6	PF01111	0.307
DOC_MAPK_gen_1	48	55	PF00069	0.656
DOC_PP1_RVXF_1	344	351	PF00149	0.390
DOC_PP1_RVXF_1	79	86	PF00149	0.526
DOC_PP2B_LxvP_1	185	188	PF13499	0.307
DOC_PP2B_LxvP_1	234	237	PF13499	0.219
DOC_PP4_FxxP_1	85	88	PF00568	0.529
DOC_USP7_MATH_1	378	382	PF00917	0.438
DOC_USP7_UBL2_3	379	383	PF12436	0.410
DOC_WW_Pin1_4	127	132	PF00397	0.293
DOC_WW_Pin1_4	42	47	PF00397	0.556
DOC_WW_Pin1_4	5	10	PF00397	0.328
LIG_14-3-3_CanoR_1	18	26	PF00244	0.307
LIG_14-3-3_CanoR_1	204	208	PF00244	0.246
LIG_14-3-3_CanoR_1	271	277	PF00244	0.448
LIG_BRCT_BRCA1_1	234	238	PF00533	0.391
LIG_BRCT_BRCA1_1	309	313	PF00533	0.349
LIG_BRCT_BRCA1_1	81	85	PF00533	0.517
LIG_FHA_1	176	182	PF00498	0.353
LIG_FHA_2	118	124	PF00498	0.291
LIG_FHA_2	365	371	PF00498	0.403
LIG_LIR_Apic_2	82	88	PF02991	0.511
LIG_LIR_Gen_1	189	199	PF02991	0.349
LIG_LIR_Gen_1	239	250	PF02991	0.317
LIG_LIR_Gen_1	25	34	PF02991	0.291
LIG_LIR_Gen_1	401	412	PF02991	0.324
LIG_LIR_LC3C_4	104	107	PF02991	0.178
LIG_LIR_Nem_3	189	195	PF02991	0.331
LIG_LIR_Nem_3	219	223	PF02991	0.268
LIG_LIR_Nem_3	239	245	PF02991	0.315
LIG_LIR_Nem_3	25	29	PF02991	0.291
LIG_LIR_Nem_3	310	316	PF02991	0.277
LIG_LIR_Nem_3	331	335	PF02991	0.331
LIG_LIR_Nem_3	342	348	PF02991	0.380
LIG_LIR_Nem_3	401	407	PF02991	0.328
LIG_LIR_Nem_3	78	83	PF02991	0.400
LIG_MYND_1	167	171	PF01753	0.307
LIG_PCNA_PIPBox_1	214	223	PF02747	0.307
LIG_PDZ_Class_3	426	431	PF00595	0.547
LIG_PDZ_Wminus1_1	429	431	PF00595	0.535
LIG_REV1ctd_RIR_1	149	158	PF16727	0.321
LIG_SH2_CRK	242	246	PF00017	0.291
LIG_SH2_CRK	289	293	PF00017	0.364
LIG_SH2_CRK	80	84	PF00017	0.401
LIG_SH2_SRC	325	328	PF00017	0.266
LIG_SH2_STAP1	227	231	PF00017	0.332
LIG_SH2_STAT3	227	230	PF00017	0.416
LIG_SH2_STAT5	220	223	PF00017	0.307
LIG_SH2_STAT5	260	263	PF00017	0.408
LIG_SH2_STAT5	395	398	PF00017	0.336
LIG_SH2_STAT5	399	402	PF00017	0.316
LIG_SH2_STAT5	69	72	PF00017	0.593
LIG_SH3_3	318	324	PF00018	0.307
LIG_SH3_3	410	416	PF00018	0.293
LIG_SH3_3	67	73	PF00018	0.571
LIG_SUMO_SIM_par_1	176	182	PF11976	0.328
LIG_TYR_ITIM	402	407	PF00017	0.311
LIG_UBA3_1	169	175	PF00899	0.416
LIG_UBA3_1	317	322	PF00899	0.291
MOD_CDC14_SPxK_1	45	48	PF00782	0.380
MOD_CDK_SPK_2	127	132	PF00069	0.293
MOD_CDK_SPxK_1	42	48	PF00069	0.370
MOD_CDK_SPxxK_3	42	49	PF00069	0.382
MOD_CK1_1	232	238	PF00069	0.337
MOD_CK1_1	5	11	PF00069	0.369
MOD_CK2_1	111	117	PF00069	0.375
MOD_CK2_1	296	302	PF00069	0.333
MOD_Cter_Amidation	327	330	PF01082	0.291
MOD_GlcNHglycan	117	120	PF01048	0.248
MOD_GlcNHglycan	227	230	PF01048	0.335
MOD_GlcNHglycan	234	237	PF01048	0.369
MOD_GlcNHglycan	358	361	PF01048	0.399
MOD_GSK3_1	111	118	PF00069	0.403
MOD_GSK3_1	225	232	PF00069	0.291
MOD_GSK3_1	75	82	PF00069	0.510
MOD_N-GLC_1	111	116	PF02516	0.274
MOD_N-GLC_1	5	10	PF02516	0.379
MOD_N-GLC_1	51	56	PF02516	0.609
MOD_NEK2_1	110	115	PF00069	0.239
MOD_NEK2_1	364	369	PF00069	0.430
MOD_NEK2_1	75	80	PF00069	0.459
MOD_PIKK_1	307	313	PF00454	0.326
MOD_PIKK_1	406	412	PF00454	0.323
MOD_PKA_1	255	261	PF00069	0.326
MOD_PKA_2	17	23	PF00069	0.291
MOD_PKA_2	203	209	PF00069	0.270
MOD_PKA_2	255	261	PF00069	0.326
MOD_PKA_2	270	276	PF00069	0.326
MOD_PKA_2	421	427	PF00069	0.521
MOD_Plk_1	51	57	PF00069	0.652
MOD_Plk_4	175	181	PF00069	0.345
MOD_ProDKin_1	127	133	PF00069	0.293
MOD_ProDKin_1	42	48	PF00069	0.566
MOD_ProDKin_1	5	11	PF00069	0.328
MOD_SUMO_rev_2	342	348	PF00179	0.485
TRG_DiLeu_BaEn_1	240	245	PF01217	0.291
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.416
TRG_ENDOCYTIC_2	220	223	PF00928	0.293
TRG_ENDOCYTIC_2	242	245	PF00928	0.311
TRG_ENDOCYTIC_2	337	340	PF00928	0.380
TRG_ENDOCYTIC_2	399	402	PF00928	0.305
TRG_ENDOCYTIC_2	404	407	PF00928	0.298
TRG_ENDOCYTIC_2	80	83	PF00928	0.404
TRG_ER_diArg_1	199	201	PF00400	0.291
TRG_ER_diArg_1	384	386	PF00400	0.357
TRG_NLS_Bipartite_1	255	270	PF00514	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAX3	Leptomonas seymouri	78%	87%
A0A0S4IPC3	Bodo saltans	27%	100%
A0A0S4KIC5	Bodo saltans	34%	76%
A0A0S4KP75	Bodo saltans	35%	95%
A0A1X0NS61	Trypanosomatidae	33%	83%
A0A1X0NSF5	Trypanosomatidae	60%	82%
A0A3Q8IDN6	Leishmania donovani	95%	100%
A0A3S5IR98	Trypanosoma rangeli	36%	88%
A0A422NIS8	Trypanosoma rangeli	58%	100%
A4HEY9	Leishmania braziliensis	26%	100%
A4HEZ0	Leishmania braziliensis	89%	100%
A4I264	Leishmania infantum	95%	100%
C9ZRT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	84%
C9ZRT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	89%
E9AYB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	68%
P0C991	African swine fever virus (isolate Warthog/Namibia/Wart80/1980)	23%	100%
P0C992	African swine fever virus (isolate Pig/Kenya/KEN-50/1950)	23%	100%
P26813	African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983)	24%	100%
P35970	African swine fever virus (strain Badajoz 1971 Vero-adapted)	24%	100%
Q4Q959	Leishmania major	93%	100%
Q4Q960	Leishmania major	30%	68%
V5AUB9	Trypanosoma cruzi	60%	82%
V5DAB4	Trypanosoma cruzi	34%	88%