Putative DNA ligase k alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA ligase k alpha, putative

Species:

Leishmania mexicana

UniProt:

E9AYB3_LEIMU

TriTrypDb:

LmxM.26.1340

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AYB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYB3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	16
GO:0006259	DNA metabolic process	4	16
GO:0006281	DNA repair	5	16
GO:0006310	DNA recombination	5	16
GO:0006725	cellular aromatic compound metabolic process	3	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0006950	response to stress	2	16
GO:0006974	DNA damage response	4	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0033554	cellular response to stress	3	16
GO:0034641	cellular nitrogen compound metabolic process	3	16
GO:0043170	macromolecule metabolic process	3	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044260	obsolete cellular macromolecule metabolic process	3	16
GO:0046483	heterocycle metabolic process	3	16
GO:0050896	response to stimulus	1	16
GO:0051716	cellular response to stimulus	2	16
GO:0071704	organic substance metabolic process	2	16
GO:0090304	nucleic acid metabolic process	4	16
GO:1901360	organic cyclic compound metabolic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0003909	DNA ligase activity	4	16
GO:0003910	DNA ligase (ATP) activity	5	16
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0016874	ligase activity	2	16
GO:0016886	ligase activity, forming phosphoric ester bonds	3	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0140097	catalytic activity, acting on DNA	3	16
GO:0140640	catalytic activity, acting on a nucleic acid	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.492
CLV_C14_Caspase3-7	453	457	PF00656	0.502
CLV_NRD_NRD_1	308	310	PF00675	0.400
CLV_NRD_NRD_1	443	445	PF00675	0.427
CLV_NRD_NRD_1	473	475	PF00675	0.336
CLV_NRD_NRD_1	584	586	PF00675	0.361
CLV_NRD_NRD_1	91	93	PF00675	0.337
CLV_PCSK_KEX2_1	108	110	PF00082	0.337
CLV_PCSK_KEX2_1	27	29	PF00082	0.588
CLV_PCSK_KEX2_1	443	445	PF00082	0.456
CLV_PCSK_KEX2_1	473	475	PF00082	0.336
CLV_PCSK_KEX2_1	499	501	PF00082	0.711
CLV_PCSK_KEX2_1	583	585	PF00082	0.304
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.388
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.704
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.711
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.324
CLV_PCSK_SKI1_1	209	213	PF00082	0.430
CLV_PCSK_SKI1_1	24	28	PF00082	0.600
CLV_PCSK_SKI1_1	252	256	PF00082	0.414
CLV_PCSK_SKI1_1	276	280	PF00082	0.430
CLV_PCSK_SKI1_1	309	313	PF00082	0.433
CLV_PCSK_SKI1_1	477	481	PF00082	0.517
CLV_PCSK_SKI1_1	496	500	PF00082	0.704
CLV_PCSK_SKI1_1	555	559	PF00082	0.416
CLV_PCSK_SKI1_1	597	601	PF00082	0.334
DEG_APCC_DBOX_1	208	216	PF00400	0.369
DEG_Nend_UBRbox_1	1	4	PF02207	0.659
DEG_SCF_FBW7_1	574	579	PF00400	0.402
DOC_ANK_TNKS_1	620	627	PF00023	0.525
DOC_CKS1_1	377	382	PF01111	0.525
DOC_CYCLIN_RxL_1	273	282	PF00134	0.389
DOC_CYCLIN_yClb5_NLxxxL_5	209	215	PF00134	0.402
DOC_MAPK_gen_1	108	114	PF00069	0.381
DOC_MAPK_RevD_3	461	474	PF00069	0.446
DOC_PP1_RVXF_1	250	257	PF00149	0.430
DOC_PP1_RVXF_1	90	97	PF00149	0.311
DOC_SPAK_OSR1_1	571	575	PF12202	0.402
DOC_USP7_MATH_1	135	139	PF00917	0.616
DOC_USP7_MATH_1	502	506	PF00917	0.572
DOC_USP7_MATH_1	511	515	PF00917	0.698
DOC_USP7_MATH_1	75	79	PF00917	0.419
DOC_USP7_UBL2_3	122	126	PF12436	0.518
DOC_USP7_UBL2_3	217	221	PF12436	0.385
DOC_USP7_UBL2_3	306	310	PF12436	0.469
DOC_USP7_UBL2_3	340	344	PF12436	0.674
DOC_USP7_UBL2_3	591	595	PF12436	0.477
DOC_WW_Pin1_4	147	152	PF00397	0.718
DOC_WW_Pin1_4	232	237	PF00397	0.353
DOC_WW_Pin1_4	309	314	PF00397	0.730
DOC_WW_Pin1_4	376	381	PF00397	0.438
DOC_WW_Pin1_4	562	567	PF00397	0.343
DOC_WW_Pin1_4	572	577	PF00397	0.297
LIG_14-3-3_CanoR_1	177	183	PF00244	0.613
LIG_14-3-3_CanoR_1	421	431	PF00244	0.357
LIG_14-3-3_CanoR_1	527	532	PF00244	0.404
LIG_14-3-3_CanoR_1	571	575	PF00244	0.367
LIG_14-3-3_CanoR_1	585	591	PF00244	0.250
LIG_Actin_WH2_2	427	445	PF00022	0.483
LIG_BRCT_BRCA1_1	398	402	PF00533	0.547
LIG_FHA_1	206	212	PF00498	0.477
LIG_FHA_1	249	255	PF00498	0.498
LIG_FHA_1	315	321	PF00498	0.613
LIG_FHA_1	366	372	PF00498	0.462
LIG_FHA_1	377	383	PF00498	0.386
LIG_FHA_1	493	499	PF00498	0.718
LIG_FHA_1	513	519	PF00498	0.399
LIG_FHA_2	260	266	PF00498	0.357
LIG_FHA_2	577	583	PF00498	0.328
LIG_LIR_Apic_2	374	380	PF02991	0.541
LIG_LIR_Gen_1	199	207	PF02991	0.534
LIG_LIR_Gen_1	327	338	PF02991	0.533
LIG_LIR_Gen_1	539	548	PF02991	0.411
LIG_LIR_Gen_1	560	566	PF02991	0.402
LIG_LIR_Gen_1	600	611	PF02991	0.322
LIG_LIR_Nem_3	199	205	PF02991	0.559
LIG_LIR_Nem_3	327	333	PF02991	0.515
LIG_LIR_Nem_3	413	419	PF02991	0.363
LIG_LIR_Nem_3	435	440	PF02991	0.517
LIG_LIR_Nem_3	539	545	PF02991	0.395
LIG_LIR_Nem_3	551	557	PF02991	0.317
LIG_LIR_Nem_3	560	564	PF02991	0.294
LIG_LIR_Nem_3	589	593	PF02991	0.379
LIG_LIR_Nem_3	600	606	PF02991	0.319
LIG_LIR_Nem_3	64	69	PF02991	0.422
LIG_LYPXL_S_1	65	69	PF13949	0.175
LIG_LYPXL_yS_3	66	69	PF13949	0.175
LIG_NRBOX	418	424	PF00104	0.453
LIG_PDZ_Class_3	625	630	PF00595	0.515
LIG_PDZ_Wminus1_1	628	630	PF00595	0.515
LIG_Pex14_1	590	594	PF04695	0.402
LIG_Pex14_2	557	561	PF04695	0.291
LIG_REV1ctd_RIR_1	254	263	PF16727	0.410
LIG_SH2_CRK	330	334	PF00017	0.550
LIG_SH2_CRK	437	441	PF00017	0.500
LIG_SH2_PTP2	542	545	PF00017	0.459
LIG_SH2_SRC	542	545	PF00017	0.349
LIG_SH2_SRC	603	606	PF00017	0.291
LIG_SH2_STAP1	398	402	PF00017	0.424
LIG_SH2_STAP1	448	452	PF00017	0.412
LIG_SH2_STAT5	202	205	PF00017	0.560
LIG_SH2_STAT5	542	545	PF00017	0.367
LIG_SH3_1	310	316	PF00018	0.605
LIG_SH3_2	148	153	PF14604	0.572
LIG_SH3_3	145	151	PF00018	0.796
LIG_SH3_3	310	316	PF00018	0.605
LIG_SH3_3	609	615	PF00018	0.308
LIG_TYR_ITIM	414	419	PF00017	0.440
LIG_TYR_ITIM	465	470	PF00017	0.452
LIG_TYR_ITIM	601	606	PF00017	0.343
LIG_UBA3_1	20	27	PF00899	0.548
LIG_UBA3_1	211	217	PF00899	0.426
LIG_WRC_WIRS_1	558	563	PF05994	0.402
MOD_CDC14_SPxK_1	150	153	PF00782	0.574
MOD_CDK_SPK_2	232	237	PF00069	0.357
MOD_CDK_SPxK_1	147	153	PF00069	0.574
MOD_CDK_SPxK_1	562	568	PF00069	0.428
MOD_CDK_SPxxK_3	147	154	PF00069	0.575
MOD_CDK_SPxxK_3	562	569	PF00069	0.370
MOD_CK1_1	138	144	PF00069	0.756
MOD_CK1_1	158	164	PF00069	0.725
MOD_CK1_1	504	510	PF00069	0.659
MOD_CK1_1	589	595	PF00069	0.451
MOD_CK2_1	158	164	PF00069	0.605
MOD_CK2_1	259	265	PF00069	0.368
MOD_CMANNOS	587	590	PF00535	0.402
MOD_Cter_Amidation	338	341	PF01082	0.457
MOD_GlcNHglycan	133	136	PF01048	0.595
MOD_GlcNHglycan	157	160	PF01048	0.657
MOD_GlcNHglycan	259	262	PF01048	0.446
MOD_GlcNHglycan	320	323	PF01048	0.659
MOD_GlcNHglycan	326	329	PF01048	0.489
MOD_GlcNHglycan	346	349	PF01048	0.493
MOD_GlcNHglycan	368	371	PF01048	0.367
MOD_GlcNHglycan	407	410	PF01048	0.487
MOD_GlcNHglycan	424	427	PF01048	0.394
MOD_GlcNHglycan	492	495	PF01048	0.682
MOD_GlcNHglycan	504	507	PF01048	0.683
MOD_GlcNHglycan	509	512	PF01048	0.680
MOD_GlcNHglycan	52	55	PF01048	0.680
MOD_GlcNHglycan	549	553	PF01048	0.384
MOD_GSK3_1	131	138	PF00069	0.706
MOD_GSK3_1	139	146	PF00069	0.659
MOD_GSK3_1	177	184	PF00069	0.604
MOD_GSK3_1	255	262	PF00069	0.358
MOD_GSK3_1	300	307	PF00069	0.553
MOD_GSK3_1	314	321	PF00069	0.654
MOD_GSK3_1	366	373	PF00069	0.433
MOD_GSK3_1	444	451	PF00069	0.378
MOD_GSK3_1	50	57	PF00069	0.651
MOD_GSK3_1	507	514	PF00069	0.473
MOD_GSK3_1	572	579	PF00069	0.291
MOD_N-GLC_1	178	183	PF02516	0.504
MOD_N-GLC_1	292	297	PF02516	0.464
MOD_NEK2_1	1	6	PF00069	0.677
MOD_NEK2_1	193	198	PF00069	0.614
MOD_NEK2_1	255	260	PF00069	0.357
MOD_NEK2_1	422	427	PF00069	0.400
MOD_NEK2_1	512	517	PF00069	0.437
MOD_NEK2_1	557	562	PF00069	0.372
MOD_NEK2_1	586	591	PF00069	0.291
MOD_NEK2_1	9	14	PF00069	0.677
MOD_PKA_1	136	142	PF00069	0.540
MOD_PKA_1	27	33	PF00069	0.602
MOD_PKA_2	27	33	PF00069	0.622
MOD_PKA_2	371	377	PF00069	0.404
MOD_PKA_2	405	411	PF00069	0.480
MOD_PKA_2	526	532	PF00069	0.414
MOD_PKA_2	570	576	PF00069	0.370
MOD_PKB_1	175	183	PF00069	0.545
MOD_Plk_1	178	184	PF00069	0.501
MOD_Plk_1	292	298	PF00069	0.470
MOD_Plk_4	1	7	PF00069	0.622
MOD_Plk_4	16	22	PF00069	0.599
MOD_Plk_4	259	265	PF00069	0.368
MOD_Plk_4	281	287	PF00069	0.374
MOD_Plk_4	527	533	PF00069	0.418
MOD_Plk_4	557	563	PF00069	0.392
MOD_Plk_4	589	595	PF00069	0.260
MOD_ProDKin_1	147	153	PF00069	0.721
MOD_ProDKin_1	232	238	PF00069	0.351
MOD_ProDKin_1	309	315	PF00069	0.734
MOD_ProDKin_1	376	382	PF00069	0.429
MOD_ProDKin_1	562	568	PF00069	0.343
MOD_ProDKin_1	572	578	PF00069	0.297
MOD_SUMO_for_1	121	124	PF00179	0.260
TRG_DiLeu_BaEn_1	207	212	PF01217	0.459
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.453
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.445
TRG_ENDOCYTIC_2	202	205	PF00928	0.558
TRG_ENDOCYTIC_2	330	333	PF00928	0.554
TRG_ENDOCYTIC_2	391	394	PF00928	0.343
TRG_ENDOCYTIC_2	416	419	PF00928	0.353
TRG_ENDOCYTIC_2	437	440	PF00928	0.496
TRG_ENDOCYTIC_2	467	470	PF00928	0.307
TRG_ENDOCYTIC_2	534	537	PF00928	0.388
TRG_ENDOCYTIC_2	542	545	PF00928	0.356
TRG_ENDOCYTIC_2	603	606	PF00928	0.321
TRG_ENDOCYTIC_2	66	69	PF00928	0.265
TRG_ER_diArg_1	172	175	PF00400	0.690
TRG_ER_diArg_1	442	444	PF00400	0.458
TRG_ER_diArg_1	472	474	PF00400	0.294
TRG_ER_diArg_1	584	586	PF00400	0.346
TRG_NLS_Bipartite_1	136	157	PF00514	0.580
TRG_NLS_MonoExtC_3	339	344	PF00514	0.478
TRG_NLS_MonoExtC_3	495	500	PF00514	0.690
TRG_NLS_MonoExtN_4	151	157	PF00514	0.732
TRG_NLS_MonoExtN_4	340	345	PF00514	0.526
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYQ3	Leptomonas seymouri	59%	97%
A0A0S4KIC5	Bodo saltans	29%	100%
A0A0S4KP75	Bodo saltans	27%	100%
A0A1X0NS61	Trypanosomatidae	45%	100%
A0A3Q8IDN6	Leishmania donovani	30%	100%
A0A3Q8IDV4	Leishmania donovani	92%	100%
A4HEY9	Leishmania braziliensis	81%	100%
A4I263	Leishmania infantum	92%	100%
A4I264	Leishmania infantum	30%	100%
C9ZRT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AYB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q959	Leishmania major	30%	100%
Q4Q960	Leishmania major	91%	100%
V5AUB9	Trypanosoma cruzi	25%	100%