Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYB1_LEIMU

TriTrypDb:

LmxM.26.1320

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AYB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.425
CLV_NRD_NRD_1	209	211	PF00675	0.409
CLV_NRD_NRD_1	36	38	PF00675	0.695
CLV_PCSK_FUR_1	207	211	PF00082	0.426
CLV_PCSK_KEX2_1	193	195	PF00082	0.440
CLV_PCSK_KEX2_1	204	206	PF00082	0.420
CLV_PCSK_KEX2_1	209	211	PF00082	0.421
CLV_PCSK_KEX2_1	268	270	PF00082	0.570
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.420
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.606
CLV_PCSK_PC7_1	189	195	PF00082	0.445
CLV_PCSK_PC7_1	205	211	PF00082	0.423
CLV_PCSK_SKI1_1	121	125	PF00082	0.620
CLV_PCSK_SKI1_1	201	205	PF00082	0.435
CLV_PCSK_SKI1_1	37	41	PF00082	0.696
DEG_APCC_DBOX_1	120	128	PF00400	0.650
DEG_APCC_DBOX_1	209	217	PF00400	0.407
DEG_Nend_UBRbox_1	1	4	PF02207	0.584
DOC_CYCLIN_yClb3_PxF_3	71	77	PF00134	0.530
DOC_MAPK_JIP1_4	121	127	PF00069	0.648
DOC_PP4_FxxP_1	87	90	PF00568	0.666
DOC_USP7_MATH_1	138	142	PF00917	0.703
DOC_USP7_MATH_1	184	188	PF00917	0.446
DOC_USP7_MATH_1	255	259	PF00917	0.516
DOC_USP7_MATH_1	47	51	PF00917	0.707
DOC_USP7_MATH_1	80	84	PF00917	0.717
DOC_USP7_MATH_1	90	94	PF00917	0.591
DOC_USP7_UBL2_3	171	175	PF12436	0.531
DOC_USP7_UBL2_3	264	268	PF12436	0.613
DOC_WW_Pin1_4	141	146	PF00397	0.494
DOC_WW_Pin1_4	22	27	PF00397	0.647
DOC_WW_Pin1_4	40	45	PF00397	0.679
LIG_14-3-3_CanoR_1	111	120	PF00244	0.572
LIG_14-3-3_CanoR_1	9	18	PF00244	0.677
LIG_Actin_WH2_2	218	236	PF00022	0.430
LIG_Clathr_ClatBox_1	124	128	PF01394	0.641
LIG_FHA_1	2	8	PF00498	0.461
LIG_FHA_1	41	47	PF00498	0.731
LIG_FHA_2	112	118	PF00498	0.621
LIG_FHA_2	26	32	PF00498	0.729
LIG_FHA_2	84	90	PF00498	0.653
LIG_LIR_Apic_2	85	90	PF02991	0.672
LIG_LIR_Nem_3	155	160	PF02991	0.626
LIG_PDZ_Class_2	273	278	PF00595	0.504
LIG_Pex14_1	168	172	PF04695	0.432
LIG_PTB_Apo_2	21	28	PF02174	0.568
LIG_PTB_Apo_2	215	222	PF02174	0.428
LIG_PTB_Phospho_1	21	27	PF10480	0.565
LIG_SH2_CRK	173	177	PF00017	0.418
LIG_SH2_GRB2like	22	25	PF00017	0.566
LIG_SH2_STAT5	27	30	PF00017	0.593
LIG_SH2_STAT5	56	59	PF00017	0.544
LIG_SH3_3	66	72	PF00018	0.587
LIG_SUMO_SIM_par_1	122	130	PF11976	0.650
LIG_UBA3_1	229	237	PF00899	0.446
LIG_WRC_WIRS_1	105	110	PF05994	0.577
MOD_CDK_SPK_2	40	45	PF00069	0.684
MOD_CDK_SPxxK_3	22	29	PF00069	0.683
MOD_CK1_1	141	147	PF00069	0.707
MOD_CK1_1	152	158	PF00069	0.474
MOD_CK1_1	235	241	PF00069	0.466
MOD_CK1_1	50	56	PF00069	0.704
MOD_CK1_1	83	89	PF00069	0.582
MOD_CK1_1	98	104	PF00069	0.440
MOD_Cter_Amidation	266	269	PF01082	0.582
MOD_GlcNHglycan	11	14	PF01048	0.708
MOD_GlcNHglycan	151	154	PF01048	0.630
MOD_GlcNHglycan	258	261	PF01048	0.523
MOD_GlcNHglycan	30	36	PF01048	0.442
MOD_GlcNHglycan	52	55	PF01048	0.654
MOD_GlcNHglycan	82	85	PF01048	0.686
MOD_GlcNHglycan	92	95	PF01048	0.720
MOD_GSK3_1	256	263	PF00069	0.537
MOD_GSK3_1	267	274	PF00069	0.487
MOD_GSK3_1	90	97	PF00069	0.717
MOD_N-GLC_1	138	143	PF02516	0.687
MOD_N-GLC_1	20	25	PF02516	0.692
MOD_N-GLC_1	40	45	PF02516	0.563
MOD_N-GLC_1	50	55	PF02516	0.720
MOD_NEK2_1	1	6	PF00069	0.631
MOD_NEK2_1	127	132	PF00069	0.634
MOD_NEK2_1	233	238	PF00069	0.463
MOD_NEK2_1	246	251	PF00069	0.456
MOD_NEK2_2	146	151	PF00069	0.691
MOD_PIKK_1	247	253	PF00454	0.545
MOD_PKA_1	37	43	PF00069	0.574
MOD_PKA_2	256	262	PF00069	0.538
MOD_PKB_1	109	117	PF00069	0.591
MOD_PKB_1	269	277	PF00069	0.513
MOD_Plk_1	116	122	PF00069	0.605
MOD_Plk_1	138	144	PF00069	0.626
MOD_Plk_4	138	144	PF00069	0.509
MOD_Plk_4	83	89	PF00069	0.549
MOD_ProDKin_1	141	147	PF00069	0.493
MOD_ProDKin_1	22	28	PF00069	0.649
MOD_ProDKin_1	40	46	PF00069	0.677
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.642
TRG_ENDOCYTIC_2	157	160	PF00928	0.603
TRG_ENDOCYTIC_2	173	176	PF00928	0.303
TRG_ER_diArg_1	108	111	PF00400	0.561
TRG_ER_diArg_1	193	195	PF00400	0.440
TRG_ER_diArg_1	208	210	PF00400	0.425
TRG_ER_diArg_1	269	272	PF00400	0.530
TRG_ER_diLys_1	273	278	PF00400	0.504
TRG_NLS_Bipartite_1	193	208	PF00514	0.428
TRG_NLS_MonoExtC_3	267	272	PF00514	0.641
TRG_NLS_MonoExtN_4	201	208	PF00514	0.435
TRG_NLS_MonoExtN_4	266	272	PF00514	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC03	Leptomonas seymouri	66%	100%
A0A1X0NS69	Trypanosomatidae	62%	100%
A0A3R7ND13	Trypanosoma rangeli	62%	100%
A0A3S7WZU2	Leishmania donovani	90%	100%
A4HEY7	Leishmania braziliensis	78%	100%
A4I261	Leishmania infantum	90%	100%
C9ZRT8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
Q4Q962	Leishmania major	92%	100%
V5BIT0	Trypanosoma cruzi	63%	91%