JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cupin-like domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AYA8_LEIMU

TriTrypDb:

LmxM.26.1290

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYA8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	1
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.418
CLV_NRD_NRD_1	471	473	PF00675	0.262
CLV_NRD_NRD_1	504	506	PF00675	0.475
CLV_NRD_NRD_1	84	86	PF00675	0.748
CLV_PCSK_KEX2_1	155	157	PF00082	0.367
CLV_PCSK_KEX2_1	470	472	PF00082	0.283
CLV_PCSK_KEX2_1	84	86	PF00082	0.786
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.300
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.283
CLV_PCSK_PC7_1	466	472	PF00082	0.262
CLV_PCSK_SKI1_1	113	117	PF00082	0.379
CLV_PCSK_SKI1_1	140	144	PF00082	0.351
CLV_PCSK_SKI1_1	200	204	PF00082	0.344
CLV_PCSK_SKI1_1	379	383	PF00082	0.321
DEG_APCC_DBOX_1	273	281	PF00400	0.344
DEG_APCC_DBOX_1	504	512	PF00400	0.410
DEG_SPOP_SBC_1	473	477	PF00917	0.254
DEG_SPOP_SBC_1	6	10	PF00917	0.748
DOC_ANK_TNKS_1	54	61	PF00023	0.609
DOC_CKS1_1	307	312	PF01111	0.398
DOC_CYCLIN_yCln2_LP_2	386	389	PF00134	0.344
DOC_MAPK_DCC_7	290	298	PF00069	0.398
DOC_MAPK_DCC_7	30	39	PF00069	0.547
DOC_MAPK_DCC_7	505	513	PF00069	0.437
DOC_MAPK_gen_1	198	206	PF00069	0.353
DOC_MAPK_gen_1	379	387	PF00069	0.344
DOC_MAPK_gen_1	505	513	PF00069	0.437
DOC_MAPK_HePTP_8	503	515	PF00069	0.184
DOC_MAPK_MEF2A_6	198	206	PF00069	0.475
DOC_MAPK_MEF2A_6	30	39	PF00069	0.547
DOC_MAPK_MEF2A_6	506	515	PF00069	0.399
DOC_PP2B_LxvP_1	386	389	PF13499	0.338
DOC_PP2B_LxvP_1	521	524	PF13499	0.328
DOC_PP4_FxxP_1	32	35	PF00568	0.544
DOC_PP4_FxxP_1	357	360	PF00568	0.382
DOC_PP4_FxxP_1	576	579	PF00568	0.344
DOC_USP7_MATH_1	21	25	PF00917	0.530
DOC_USP7_MATH_1	361	365	PF00917	0.339
DOC_USP7_MATH_1	473	477	PF00917	0.425
DOC_USP7_MATH_1	552	556	PF00917	0.407
DOC_WW_Pin1_4	11	16	PF00397	0.436
DOC_WW_Pin1_4	204	209	PF00397	0.328
DOC_WW_Pin1_4	244	249	PF00397	0.445
DOC_WW_Pin1_4	284	289	PF00397	0.449
DOC_WW_Pin1_4	306	311	PF00397	0.451
DOC_WW_Pin1_4	475	480	PF00397	0.376
LIG_14-3-3_CanoR_1	217	221	PF00244	0.439
LIG_14-3-3_CanoR_1	274	278	PF00244	0.363
LIG_14-3-3_CanoR_1	471	481	PF00244	0.387
LIG_BIR_III_4	454	458	PF00653	0.449
LIG_BRCT_BRCA1_1	424	428	PF00533	0.449
LIG_deltaCOP1_diTrp_1	128	136	PF00928	0.341
LIG_deltaCOP1_diTrp_1	422	428	PF00928	0.475
LIG_FHA_1	1	7	PF00498	0.763
LIG_FHA_1	201	207	PF00498	0.313
LIG_FHA_1	220	226	PF00498	0.423
LIG_FHA_1	307	313	PF00498	0.492
LIG_FHA_1	518	524	PF00498	0.430
LIG_FHA_1	563	569	PF00498	0.453
LIG_FHA_2	104	110	PF00498	0.339
LIG_FHA_2	15	21	PF00498	0.542
LIG_FHA_2	174	180	PF00498	0.199
LIG_FHA_2	300	306	PF00498	0.475
LIG_FHA_2	447	453	PF00498	0.264
LIG_FHA_2	45	51	PF00498	0.553
LIG_FHA_2	84	90	PF00498	0.791
LIG_FXI_DFP_1	441	445	PF00024	0.449
LIG_Integrin_isoDGR_2	209	211	PF01839	0.328
LIG_LIR_Apic_2	573	579	PF02991	0.343
LIG_LIR_Gen_1	324	334	PF02991	0.359
LIG_LIR_Gen_1	372	381	PF02991	0.330
LIG_LIR_Gen_1	383	389	PF02991	0.335
LIG_LIR_Nem_3	128	133	PF02991	0.394
LIG_LIR_Nem_3	324	329	PF02991	0.331
LIG_LIR_Nem_3	372	378	PF02991	0.330
LIG_LIR_Nem_3	383	387	PF02991	0.335
LIG_LIR_Nem_3	425	431	PF02991	0.387
LIG_LIR_Nem_3	586	590	PF02991	0.464
LIG_NRBOX	279	285	PF00104	0.344
LIG_NRBOX	62	68	PF00104	0.598
LIG_PDZ_Class_2	586	591	PF00595	0.489
LIG_Pex14_1	390	394	PF04695	0.344
LIG_Pex14_1	424	428	PF04695	0.449
LIG_Pex14_2	110	114	PF04695	0.344
LIG_SH2_CRK	281	285	PF00017	0.332
LIG_SH2_CRK	314	318	PF00017	0.449
LIG_SH2_CRK	375	379	PF00017	0.328
LIG_SH2_NCK_1	220	224	PF00017	0.449
LIG_SH2_PTP2	514	517	PF00017	0.363
LIG_SH2_SRC	514	517	PF00017	0.363
LIG_SH2_SRC	522	525	PF00017	0.290
LIG_SH2_STAP1	572	576	PF00017	0.333
LIG_SH2_STAT3	51	54	PF00017	0.595
LIG_SH2_STAT5	141	144	PF00017	0.363
LIG_SH2_STAT5	514	517	PF00017	0.341
LIG_SH2_STAT5	522	525	PF00017	0.311
LIG_SH3_3	193	199	PF00018	0.449
LIG_SH3_3	272	278	PF00018	0.359
LIG_SH3_3	289	295	PF00018	0.359
LIG_SH3_3	382	388	PF00018	0.369
LIG_SH3_3	390	396	PF00018	0.317
LIG_SH3_3	504	510	PF00018	0.475
LIG_SH3_3	555	561	PF00018	0.386
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.388
LIG_SUMO_SIM_anti_2	580	586	PF11976	0.506
LIG_SUMO_SIM_par_1	14	20	PF11976	0.652
LIG_SUMO_SIM_par_1	202	207	PF11976	0.327
LIG_SUMO_SIM_par_1	294	299	PF11976	0.358
LIG_SUMO_SIM_par_1	580	586	PF11976	0.452
LIG_TRAF2_1	106	109	PF00917	0.523
LIG_TRAF2_1	159	162	PF00917	0.407
LIG_TRAF2_1	499	502	PF00917	0.475
LIG_TRFH_1	384	388	PF08558	0.344
LIG_TYR_ITIM	312	317	PF00017	0.407
LIG_WW_2	560	563	PF00397	0.385
MOD_CDC14_SPxK_1	287	290	PF00782	0.398
MOD_CDK_SPxK_1	284	290	PF00069	0.398
MOD_CDK_SPxxK_3	204	211	PF00069	0.328
MOD_CK1_1	11	17	PF00069	0.678
MOD_CK1_1	362	368	PF00069	0.322
MOD_CK1_1	4	10	PF00069	0.742
MOD_CK1_1	474	480	PF00069	0.411
MOD_CK1_1	577	583	PF00069	0.570
MOD_CK1_1	83	89	PF00069	0.732
MOD_CK2_1	103	109	PF00069	0.290
MOD_CK2_1	14	20	PF00069	0.560
MOD_CK2_1	154	160	PF00069	0.444
MOD_CK2_1	173	179	PF00069	0.319
MOD_CK2_1	188	194	PF00069	0.465
MOD_CK2_1	266	272	PF00069	0.217
MOD_CK2_1	446	452	PF00069	0.342
MOD_CK2_1	480	486	PF00069	0.440
MOD_CK2_1	488	494	PF00069	0.370
MOD_CK2_1	83	89	PF00069	0.743
MOD_Cter_Amidation	503	506	PF01082	0.439
MOD_GlcNHglycan	10	13	PF01048	0.760
MOD_GlcNHglycan	24	27	PF01048	0.514
MOD_GlcNHglycan	268	271	PF01048	0.243
MOD_GlcNHglycan	546	549	PF01048	0.396
MOD_GlcNHglycan	554	557	PF01048	0.372
MOD_GSK3_1	1	8	PF00069	0.805
MOD_GSK3_1	200	207	PF00069	0.368
MOD_GSK3_1	284	291	PF00069	0.398
MOD_GSK3_1	40	47	PF00069	0.546
MOD_GSK3_1	471	478	PF00069	0.490
MOD_GSK3_1	481	488	PF00069	0.310
MOD_GSK3_1	89	96	PF00069	0.549
MOD_LATS_1	76	82	PF00433	0.653
MOD_N-GLC_1	200	205	PF02516	0.474
MOD_N-GLC_2	319	321	PF02516	0.328
MOD_NEK2_1	145	150	PF00069	0.475
MOD_NEK2_1	22	27	PF00069	0.495
MOD_NEK2_1	273	278	PF00069	0.409
MOD_NEK2_1	574	579	PF00069	0.356
MOD_NEK2_1	67	72	PF00069	0.552
MOD_NEK2_1	93	98	PF00069	0.690
MOD_NEK2_2	517	522	PF00069	0.449
MOD_PIKK_1	44	50	PF00454	0.538
MOD_PIKK_1	83	89	PF00454	0.758
MOD_PK_1	211	217	PF00069	0.425
MOD_PKA_1	471	477	PF00069	0.294
MOD_PKA_2	216	222	PF00069	0.434
MOD_PKA_2	273	279	PF00069	0.363
MOD_PKA_2	471	477	PF00069	0.475
MOD_PKA_2	488	494	PF00069	0.394
MOD_PKA_2	544	550	PF00069	0.403
MOD_PKA_2	83	89	PF00069	0.757
MOD_Plk_1	145	151	PF00069	0.459
MOD_Plk_1	200	206	PF00069	0.451
MOD_Plk_1	572	578	PF00069	0.333
MOD_Plk_1	68	74	PF00069	0.631
MOD_Plk_1	88	94	PF00069	0.452
MOD_Plk_2-3	154	160	PF00069	0.389
MOD_Plk_2-3	175	181	PF00069	0.307
MOD_Plk_2-3	299	305	PF00069	0.449
MOD_Plk_2-3	409	415	PF00069	0.437
MOD_Plk_2-3	89	95	PF00069	0.775
MOD_Plk_4	14	20	PF00069	0.652
MOD_Plk_4	373	379	PF00069	0.449
MOD_Plk_4	409	415	PF00069	0.449
MOD_Plk_4	434	440	PF00069	0.484
MOD_Plk_4	477	483	PF00069	0.398
MOD_Plk_4	517	523	PF00069	0.422
MOD_Plk_4	577	583	PF00069	0.541
MOD_Plk_4	62	68	PF00069	0.555
MOD_ProDKin_1	11	17	PF00069	0.424
MOD_ProDKin_1	204	210	PF00069	0.328
MOD_ProDKin_1	244	250	PF00069	0.445
MOD_ProDKin_1	284	290	PF00069	0.449
MOD_ProDKin_1	306	312	PF00069	0.451
MOD_ProDKin_1	475	481	PF00069	0.376
MOD_SUMO_for_1	396	399	PF00179	0.329
TRG_DiLeu_BaEn_1	409	414	PF01217	0.398
TRG_DiLeu_BaEn_1	586	591	PF01217	0.489
TRG_DiLeu_BaLyEn_6	463	468	PF01217	0.475
TRG_ENDOCYTIC_2	281	284	PF00928	0.344
TRG_ENDOCYTIC_2	314	317	PF00928	0.344
TRG_ENDOCYTIC_2	326	329	PF00928	0.344
TRG_ENDOCYTIC_2	375	378	PF00928	0.331
TRG_ER_diArg_1	35	38	PF00400	0.429
TRG_ER_diArg_1	55	58	PF00400	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9S7	Leptomonas seymouri	65%	100%
A0A0S4JXF9	Bodo saltans	30%	100%
A0A1X0NS77	Trypanosomatidae	42%	100%
A0A3Q8IP66	Leishmania donovani	93%	100%
A0A3R7K325	Trypanosoma rangeli	42%	100%
A4HEY4	Leishmania braziliensis	80%	100%
A4I258	Leishmania infantum	92%	100%
C9ZRU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q965	Leishmania major	89%	100%
V5BED3	Trypanosoma cruzi	42%	100%