Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYA7_LEIMU

TriTrypDb:

LmxM.26.1280

Length:

1101

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AYA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.692
CLV_C14_Caspase3-7	439	443	PF00656	0.730
CLV_NRD_NRD_1	1063	1065	PF00675	0.682
CLV_NRD_NRD_1	166	168	PF00675	0.743
CLV_NRD_NRD_1	458	460	PF00675	0.586
CLV_NRD_NRD_1	885	887	PF00675	0.772
CLV_NRD_NRD_1	932	934	PF00675	0.636
CLV_NRD_NRD_1	996	998	PF00675	0.791
CLV_PCSK_FUR_1	929	933	PF00082	0.625
CLV_PCSK_KEX2_1	1063	1065	PF00082	0.682
CLV_PCSK_KEX2_1	158	160	PF00082	0.654
CLV_PCSK_KEX2_1	458	460	PF00082	0.586
CLV_PCSK_KEX2_1	885	887	PF00082	0.772
CLV_PCSK_KEX2_1	931	933	PF00082	0.638
CLV_PCSK_KEX2_1	996	998	PF00082	0.680
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.654
CLV_PCSK_SKI1_1	170	174	PF00082	0.665
CLV_PCSK_SKI1_1	361	365	PF00082	0.492
CLV_PCSK_SKI1_1	367	371	PF00082	0.430
CLV_PCSK_SKI1_1	404	408	PF00082	0.683
CLV_PCSK_SKI1_1	66	70	PF00082	0.562
CLV_PCSK_SKI1_1	932	936	PF00082	0.638
CLV_PCSK_SKI1_1	979	983	PF00082	0.672
CLV_PCSK_SKI1_1	986	990	PF00082	0.758
CLV_PCSK_SKI1_1	996	1000	PF00082	0.656
DEG_APCC_DBOX_1	568	576	PF00400	0.748
DEG_APCC_DBOX_1	630	638	PF00400	0.553
DEG_COP1_1	893	902	PF00400	0.644
DEG_SCF_FBW7_1	332	337	PF00400	0.710
DEG_SCF_FBW7_1	89	96	PF00400	0.800
DEG_SCF_FBW7_2	1023	1030	PF00400	0.713
DEG_SIAH_1	971	979	PF03145	0.529
DEG_SPOP_SBC_1	282	286	PF00917	0.785
DEG_SPOP_SBC_1	715	719	PF00917	0.712
DEG_SPOP_SBC_1	891	895	PF00917	0.771
DOC_ANK_TNKS_1	98	105	PF00023	0.625
DOC_CKS1_1	1024	1029	PF01111	0.667
DOC_CKS1_1	335	340	PF01111	0.675
DOC_CKS1_1	90	95	PF01111	0.661
DOC_CYCLIN_RxL_1	983	993	PF00134	0.631
DOC_MAPK_gen_1	1063	1069	PF00069	0.744
DOC_MAPK_gen_1	669	677	PF00069	0.599
DOC_MAPK_MEF2A_6	470	478	PF00069	0.746
DOC_MAPK_MEF2A_6	669	677	PF00069	0.599
DOC_PP1_RVXF_1	365	371	PF00149	0.494
DOC_PP2B_LxvP_1	353	356	PF13499	0.507
DOC_PP2B_LxvP_1	677	680	PF13499	0.758
DOC_PP4_FxxP_1	1005	1008	PF00568	0.631
DOC_USP7_MATH_1	1008	1012	PF00917	0.536
DOC_USP7_MATH_1	201	205	PF00917	0.715
DOC_USP7_MATH_1	225	229	PF00917	0.683
DOC_USP7_MATH_1	258	262	PF00917	0.720
DOC_USP7_MATH_1	27	31	PF00917	0.730
DOC_USP7_MATH_1	282	286	PF00917	0.699
DOC_USP7_MATH_1	289	293	PF00917	0.595
DOC_USP7_MATH_1	298	302	PF00917	0.543
DOC_USP7_MATH_1	34	38	PF00917	0.817
DOC_USP7_MATH_1	396	400	PF00917	0.584
DOC_USP7_MATH_1	426	430	PF00917	0.607
DOC_USP7_MATH_1	449	453	PF00917	0.616
DOC_USP7_MATH_1	472	476	PF00917	0.683
DOC_USP7_MATH_1	521	525	PF00917	0.773
DOC_USP7_MATH_1	601	605	PF00917	0.586
DOC_USP7_MATH_1	623	627	PF00917	0.532
DOC_USP7_MATH_1	688	692	PF00917	0.677
DOC_USP7_MATH_1	70	74	PF00917	0.772
DOC_USP7_MATH_1	715	719	PF00917	0.643
DOC_USP7_MATH_1	725	729	PF00917	0.610
DOC_USP7_MATH_1	743	747	PF00917	0.751
DOC_USP7_MATH_1	75	79	PF00917	0.724
DOC_USP7_MATH_1	775	779	PF00917	0.674
DOC_USP7_MATH_1	849	853	PF00917	0.619
DOC_USP7_MATH_1	861	865	PF00917	0.590
DOC_USP7_MATH_1	892	896	PF00917	0.739
DOC_USP7_MATH_1	953	957	PF00917	0.783
DOC_USP7_MATH_1	97	101	PF00917	0.709
DOC_USP7_MATH_1	984	988	PF00917	0.630
DOC_USP7_MATH_1	992	996	PF00917	0.487
DOC_WW_Pin1_4	1023	1028	PF00397	0.752
DOC_WW_Pin1_4	1058	1063	PF00397	0.776
DOC_WW_Pin1_4	14	19	PF00397	0.704
DOC_WW_Pin1_4	174	179	PF00397	0.629
DOC_WW_Pin1_4	330	335	PF00397	0.610
DOC_WW_Pin1_4	428	433	PF00397	0.798
DOC_WW_Pin1_4	643	648	PF00397	0.767
DOC_WW_Pin1_4	651	656	PF00397	0.698
DOC_WW_Pin1_4	738	743	PF00397	0.736
DOC_WW_Pin1_4	751	756	PF00397	0.587
DOC_WW_Pin1_4	89	94	PF00397	0.798
DOC_WW_Pin1_4	979	984	PF00397	0.629
DOC_WW_Pin1_4	997	1002	PF00397	0.782
LIG_14-3-3_CanoR_1	159	165	PF00244	0.754
LIG_14-3-3_CanoR_1	167	175	PF00244	0.721
LIG_14-3-3_CanoR_1	392	396	PF00244	0.580
LIG_14-3-3_CanoR_1	513	517	PF00244	0.683
LIG_14-3-3_CanoR_1	553	558	PF00244	0.675
LIG_14-3-3_CanoR_1	569	573	PF00244	0.660
LIG_14-3-3_CanoR_1	631	635	PF00244	0.548
LIG_14-3-3_CanoR_1	859	869	PF00244	0.654
LIG_14-3-3_CanoR_1	937	942	PF00244	0.760
LIG_14-3-3_CanoR_1	991	998	PF00244	0.796
LIG_APCC_ABBA_1	1081	1086	PF00400	0.593
LIG_APCC_ABBA_1	360	365	PF00400	0.500
LIG_BIR_II_1	1	5	PF00653	0.663
LIG_BRCT_BRCA1_1	745	749	PF00533	0.716
LIG_FHA_1	1	7	PF00498	0.489
LIG_FHA_1	1090	1096	PF00498	0.619
LIG_FHA_1	110	116	PF00498	0.720
LIG_FHA_1	372	378	PF00498	0.478
LIG_FHA_1	379	385	PF00498	0.524
LIG_FHA_1	513	519	PF00498	0.804
LIG_FHA_1	553	559	PF00498	0.751
LIG_FHA_1	892	898	PF00498	0.787
LIG_FHA_1	937	943	PF00498	0.702
LIG_FHA_1	959	965	PF00498	0.832
LIG_FHA_2	371	377	PF00498	0.471
LIG_FHA_2	437	443	PF00498	0.736
LIG_FHA_2	815	821	PF00498	0.735
LIG_FHA_2	965	971	PF00498	0.824
LIG_LIR_Apic_2	511	517	PF02991	0.792
LIG_LIR_Gen_1	1075	1084	PF02991	0.603
LIG_LIR_Gen_1	321	332	PF02991	0.562
LIG_LIR_Gen_1	385	396	PF02991	0.490
LIG_LIR_Gen_1	403	412	PF02991	0.549
LIG_LIR_Gen_1	51	59	PF02991	0.564
LIG_LIR_Nem_3	1075	1081	PF02991	0.609
LIG_LIR_Nem_3	302	308	PF02991	0.633
LIG_LIR_Nem_3	321	327	PF02991	0.548
LIG_LIR_Nem_3	385	391	PF02991	0.486
LIG_LIR_Nem_3	403	408	PF02991	0.520
LIG_LIR_Nem_3	51	55	PF02991	0.631
LIG_Pex14_2	876	880	PF04695	0.617
LIG_PTB_Apo_2	791	798	PF02174	0.545
LIG_PTB_Phospho_1	791	797	PF10480	0.555
LIG_REV1ctd_RIR_1	932	941	PF16727	0.704
LIG_RPA_C_Fungi	848	860	PF08784	0.581
LIG_SH2_CRK	380	384	PF00017	0.473
LIG_SH2_CRK	405	409	PF00017	0.598
LIG_SH2_CRK	836	840	PF00017	0.576
LIG_SH2_GRB2like	380	383	PF00017	0.505
LIG_SH2_STAP1	320	324	PF00017	0.675
LIG_SH2_STAP1	405	409	PF00017	0.699
LIG_SH2_STAP1	485	489	PF00017	0.566
LIG_SH2_STAP1	628	632	PF00017	0.585
LIG_SH2_STAP1	857	861	PF00017	0.602
LIG_SH2_STAT3	845	848	PF00017	0.642
LIG_SH2_STAT3	857	860	PF00017	0.550
LIG_SH2_STAT5	105	108	PF00017	0.526
LIG_SH2_STAT5	1052	1055	PF00017	0.723
LIG_SH2_STAT5	305	308	PF00017	0.683
LIG_SH2_STAT5	380	383	PF00017	0.529
LIG_SH2_STAT5	506	509	PF00017	0.710
LIG_SH2_STAT5	514	517	PF00017	0.668
LIG_SH2_STAT5	578	581	PF00017	0.688
LIG_SH2_STAT5	693	696	PF00017	0.786
LIG_SH2_STAT5	797	800	PF00017	0.498
LIG_SH2_STAT5	845	848	PF00017	0.531
LIG_SH2_STAT5	857	860	PF00017	0.543
LIG_SH3_3	1059	1065	PF00018	0.771
LIG_SH3_3	471	477	PF00018	0.727
LIG_SH3_3	487	493	PF00018	0.552
LIG_SH3_3	504	510	PF00018	0.433
LIG_SH3_3	576	582	PF00018	0.689
LIG_SH3_3	649	655	PF00018	0.803
LIG_SH3_3	894	900	PF00018	0.564
LIG_SH3_3	972	978	PF00018	0.524
LIG_SUMO_SIM_anti_2	488	493	PF11976	0.531
LIG_SUMO_SIM_anti_2	837	844	PF11976	0.679
LIG_SUMO_SIM_par_1	479	484	PF11976	0.544
LIG_SUMO_SIM_par_1	805	813	PF11976	0.676
LIG_SUMO_SIM_par_1	893	901	PF11976	0.528
LIG_TRAF2_1	238	241	PF00917	0.607
LIG_TRAF2_1	249	252	PF00917	0.525
LIG_TRAF2_1	494	497	PF00917	0.623
LIG_TRAF2_1	562	565	PF00917	0.473
LIG_TRAF2_1	817	820	PF00917	0.629
LIG_WRC_WIRS_1	143	148	PF05994	0.644
LIG_WRC_WIRS_1	450	455	PF05994	0.801
LIG_WRC_WIRS_1	49	54	PF05994	0.645
LIG_WW_3	976	980	PF00397	0.521
MOD_CDC14_SPxK_1	1061	1064	PF00782	0.770
MOD_CDK_SPK_2	1058	1063	PF00069	0.776
MOD_CDK_SPxK_1	1058	1064	PF00069	0.775
MOD_CDK_SPxxK_3	979	986	PF00069	0.519
MOD_CK1_1	1057	1063	PF00069	0.779
MOD_CK1_1	109	115	PF00069	0.725
MOD_CK1_1	126	132	PF00069	0.817
MOD_CK1_1	145	151	PF00069	0.633
MOD_CK1_1	163	169	PF00069	0.698
MOD_CK1_1	2	8	PF00069	0.696
MOD_CK1_1	277	283	PF00069	0.719
MOD_CK1_1	284	290	PF00069	0.817
MOD_CK1_1	292	298	PF00069	0.527
MOD_CK1_1	431	437	PF00069	0.731
MOD_CK1_1	452	458	PF00069	0.714
MOD_CK1_1	525	531	PF00069	0.719
MOD_CK1_1	590	596	PF00069	0.787
MOD_CK1_1	604	610	PF00069	0.577
MOD_CK1_1	653	659	PF00069	0.671
MOD_CK1_1	709	715	PF00069	0.701
MOD_CK1_1	73	79	PF00069	0.801
MOD_CK1_1	736	742	PF00069	0.783
MOD_CK1_1	754	760	PF00069	0.721
MOD_CK1_1	767	773	PF00069	0.621
MOD_CK1_1	778	784	PF00069	0.642
MOD_CK1_1	808	814	PF00069	0.580
MOD_CK1_1	837	843	PF00069	0.572
MOD_CK1_1	863	869	PF00069	0.672
MOD_CK1_1	895	901	PF00069	0.677
MOD_CK1_1	958	964	PF00069	0.756
MOD_CK2_1	246	252	PF00069	0.707
MOD_CK2_1	370	376	PF00069	0.469
MOD_CK2_1	505	511	PF00069	0.624
MOD_CK2_1	76	82	PF00069	0.765
MOD_CK2_1	810	816	PF00069	0.604
MOD_CK2_1	849	855	PF00069	0.663
MOD_Cter_Amidation	929	932	PF01082	0.640
MOD_GlcNHglycan	1039	1042	PF01048	0.755
MOD_GlcNHglycan	108	111	PF01048	0.711
MOD_GlcNHglycan	14	17	PF01048	0.726
MOD_GlcNHglycan	170	173	PF01048	0.638
MOD_GlcNHglycan	203	206	PF01048	0.775
MOD_GlcNHglycan	275	279	PF01048	0.682
MOD_GlcNHglycan	280	283	PF01048	0.725
MOD_GlcNHglycan	398	401	PF01048	0.530
MOD_GlcNHglycan	433	436	PF01048	0.759
MOD_GlcNHglycan	455	458	PF01048	0.539
MOD_GlcNHglycan	466	469	PF01048	0.550
MOD_GlcNHglycan	507	510	PF01048	0.742
MOD_GlcNHglycan	525	528	PF01048	0.764
MOD_GlcNHglycan	606	609	PF01048	0.705
MOD_GlcNHglycan	655	658	PF01048	0.737
MOD_GlcNHglycan	704	707	PF01048	0.806
MOD_GlcNHglycan	709	712	PF01048	0.723
MOD_GlcNHglycan	727	730	PF01048	0.672
MOD_GlcNHglycan	743	746	PF01048	0.765
MOD_GlcNHglycan	757	760	PF01048	0.673
MOD_GlcNHglycan	778	781	PF01048	0.657
MOD_GlcNHglycan	78	81	PF01048	0.644
MOD_GlcNHglycan	812	815	PF01048	0.609
MOD_GlcNHglycan	865	868	PF01048	0.679
MOD_GlcNHglycan	870	873	PF01048	0.648
MOD_GlcNHglycan	907	910	PF01048	0.759
MOD_GlcNHglycan	950	953	PF01048	0.798
MOD_GlcNHglycan	957	960	PF01048	0.732
MOD_GlcNHglycan	969	975	PF01048	0.572
MOD_GSK3_1	1003	1010	PF00069	0.807
MOD_GSK3_1	1046	1053	PF00069	0.710
MOD_GSK3_1	1054	1061	PF00069	0.668
MOD_GSK3_1	119	126	PF00069	0.653
MOD_GSK3_1	142	149	PF00069	0.747
MOD_GSK3_1	170	177	PF00069	0.669
MOD_GSK3_1	273	280	PF00069	0.660
MOD_GSK3_1	330	337	PF00069	0.609
MOD_GSK3_1	391	398	PF00069	0.641
MOD_GSK3_1	426	433	PF00069	0.719
MOD_GSK3_1	448	455	PF00069	0.707
MOD_GSK3_1	521	528	PF00069	0.720
MOD_GSK3_1	543	550	PF00069	0.801
MOD_GSK3_1	623	630	PF00069	0.570
MOD_GSK3_1	702	709	PF00069	0.695
MOD_GSK3_1	750	757	PF00069	0.724
MOD_GSK3_1	759	766	PF00069	0.776
MOD_GSK3_1	767	774	PF00069	0.609
MOD_GSK3_1	78	85	PF00069	0.706
MOD_GSK3_1	805	812	PF00069	0.589
MOD_GSK3_1	868	875	PF00069	0.762
MOD_GSK3_1	89	96	PF00069	0.677
MOD_GSK3_1	891	898	PF00069	0.716
MOD_GSK3_1	903	910	PF00069	0.588
MOD_GSK3_1	919	926	PF00069	0.692
MOD_GSK3_1	937	944	PF00069	0.803
MOD_N-GLC_1	168	173	PF02516	0.544
MOD_N-GLC_1	725	730	PF02516	0.713
MOD_N-GLC_2	823	825	PF02516	0.757
MOD_NEK2_1	1090	1095	PF00069	0.700
MOD_NEK2_1	146	151	PF00069	0.654
MOD_NEK2_1	274	279	PF00069	0.682
MOD_NEK2_1	370	375	PF00069	0.468
MOD_NEK2_1	391	396	PF00069	0.573
MOD_NEK2_1	453	458	PF00069	0.733
MOD_NEK2_1	50	55	PF00069	0.636
MOD_NEK2_1	523	528	PF00069	0.822
MOD_NEK2_1	543	548	PF00069	0.467
MOD_NEK2_1	701	706	PF00069	0.798
MOD_NEK2_1	810	815	PF00069	0.601
MOD_NEK2_1	941	946	PF00069	0.776
MOD_NEK2_1	990	995	PF00069	0.565
MOD_NEK2_2	984	989	PF00069	0.690
MOD_PIKK_1	1090	1096	PF00454	0.706
MOD_PIKK_1	230	236	PF00454	0.821
MOD_PIKK_1	34	40	PF00454	0.814
MOD_PIKK_1	459	465	PF00454	0.505
MOD_PIKK_1	560	566	PF00454	0.661
MOD_PKA_2	160	166	PF00069	0.779
MOD_PKA_2	236	242	PF00069	0.817
MOD_PKA_2	292	298	PF00069	0.738
MOD_PKA_2	391	397	PF00069	0.583
MOD_PKA_2	512	518	PF00069	0.798
MOD_PKA_2	552	558	PF00069	0.674
MOD_PKA_2	568	574	PF00069	0.655
MOD_PKA_2	590	596	PF00069	0.773
MOD_PKA_2	630	636	PF00069	0.555
MOD_PKA_2	706	712	PF00069	0.631
MOD_PKA_2	814	820	PF00069	0.736
MOD_PKA_2	834	840	PF00069	0.350
MOD_PKA_2	936	942	PF00069	0.692
MOD_PKA_2	990	996	PF00069	0.728
MOD_Plk_1	264	270	PF00069	0.608
MOD_Plk_1	320	326	PF00069	0.659
MOD_Plk_1	386	392	PF00069	0.651
MOD_Plk_2-3	119	125	PF00069	0.817
MOD_Plk_4	142	148	PF00069	0.619
MOD_Plk_4	2	8	PF00069	0.532
MOD_Plk_4	320	326	PF00069	0.518
MOD_Plk_4	553	559	PF00069	0.779
MOD_Plk_4	568	574	PF00069	0.509
MOD_Plk_4	617	623	PF00069	0.577
MOD_Plk_4	837	843	PF00069	0.674
MOD_Plk_4	872	878	PF00069	0.751
MOD_Plk_4	937	943	PF00069	0.803
MOD_ProDKin_1	1023	1029	PF00069	0.749
MOD_ProDKin_1	1058	1064	PF00069	0.775
MOD_ProDKin_1	14	20	PF00069	0.710
MOD_ProDKin_1	174	180	PF00069	0.621
MOD_ProDKin_1	330	336	PF00069	0.603
MOD_ProDKin_1	428	434	PF00069	0.801
MOD_ProDKin_1	643	649	PF00069	0.769
MOD_ProDKin_1	651	657	PF00069	0.693
MOD_ProDKin_1	738	744	PF00069	0.736
MOD_ProDKin_1	751	757	PF00069	0.585
MOD_ProDKin_1	89	95	PF00069	0.799
MOD_ProDKin_1	979	985	PF00069	0.626
MOD_ProDKin_1	997	1003	PF00069	0.784
MOD_SUMO_rev_2	171	178	PF00179	0.659
MOD_SUMO_rev_2	496	501	PF00179	0.702
MOD_SUMO_rev_2	816	824	PF00179	0.633
TRG_DiLeu_BaEn_1	1086	1091	PF01217	0.702
TRG_DiLeu_BaEn_4	1086	1092	PF01217	0.621
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.721
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.509
TRG_DiLeu_BaLyEn_6	584	589	PF01217	0.636
TRG_ENDOCYTIC_2	305	308	PF00928	0.624
TRG_ENDOCYTIC_2	405	408	PF00928	0.575
TRG_ENDOCYTIC_2	836	839	PF00928	0.535
TRG_ER_diArg_1	1062	1064	PF00400	0.689
TRG_ER_diArg_1	458	460	PF00400	0.586
TRG_ER_diArg_1	929	932	PF00400	0.688
TRG_ER_diArg_1	996	998	PF00400	0.680
TRG_Pf-PMV_PEXEL_1	133	138	PF00026	0.801
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.814
TRG_Pf-PMV_PEXEL_1	587	592	PF00026	0.767

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIE5	Leptomonas seymouri	42%	89%
A0A3S7WZV6	Leishmania donovani	89%	100%
A4HEY3	Leishmania braziliensis	74%	99%
A4I257	Leishmania infantum	89%	100%
Q4Q966	Leishmania major	88%	99%