J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AYA6_LEIMU

TriTrypDb:

LmxM.26.1270

Length:

849

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AYA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.547
CLV_C14_Caspase3-7	307	311	PF00656	0.542
CLV_C14_Caspase3-7	57	61	PF00656	0.563
CLV_NRD_NRD_1	116	118	PF00675	0.676
CLV_NRD_NRD_1	187	189	PF00675	0.558
CLV_NRD_NRD_1	334	336	PF00675	0.556
CLV_NRD_NRD_1	396	398	PF00675	0.432
CLV_NRD_NRD_1	457	459	PF00675	0.358
CLV_NRD_NRD_1	498	500	PF00675	0.642
CLV_NRD_NRD_1	573	575	PF00675	0.752
CLV_NRD_NRD_1	606	608	PF00675	0.729
CLV_NRD_NRD_1	64	66	PF00675	0.589
CLV_NRD_NRD_1	731	733	PF00675	0.656
CLV_NRD_NRD_1	757	759	PF00675	0.565
CLV_NRD_NRD_1	798	800	PF00675	0.475
CLV_PCSK_FUR_1	334	338	PF00082	0.711
CLV_PCSK_FUR_1	798	802	PF00082	0.466
CLV_PCSK_KEX2_1	187	189	PF00082	0.545
CLV_PCSK_KEX2_1	206	208	PF00082	0.437
CLV_PCSK_KEX2_1	322	324	PF00082	0.551
CLV_PCSK_KEX2_1	334	336	PF00082	0.477
CLV_PCSK_KEX2_1	396	398	PF00082	0.311
CLV_PCSK_KEX2_1	457	459	PF00082	0.312
CLV_PCSK_KEX2_1	498	500	PF00082	0.642
CLV_PCSK_KEX2_1	572	574	PF00082	0.750
CLV_PCSK_KEX2_1	606	608	PF00082	0.744
CLV_PCSK_KEX2_1	64	66	PF00082	0.561
CLV_PCSK_KEX2_1	798	800	PF00082	0.470
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.493
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.623
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.578
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.298
CLV_PCSK_PC1ET2_1	800	802	PF00082	0.549
CLV_PCSK_PC7_1	330	336	PF00082	0.532
CLV_PCSK_SKI1_1	162	166	PF00082	0.697
CLV_PCSK_SKI1_1	237	241	PF00082	0.524
CLV_PCSK_SKI1_1	293	297	PF00082	0.583
CLV_PCSK_SKI1_1	322	326	PF00082	0.595
CLV_PCSK_SKI1_1	336	340	PF00082	0.630
CLV_PCSK_SKI1_1	498	502	PF00082	0.609
CLV_PCSK_SKI1_1	557	561	PF00082	0.466
CLV_PCSK_SKI1_1	573	577	PF00082	0.693
CLV_PCSK_SKI1_1	700	704	PF00082	0.551
CLV_PCSK_SKI1_1	732	736	PF00082	0.518
CLV_PCSK_SKI1_1	811	815	PF00082	0.584
CLV_Separin_Metazoa	504	508	PF03568	0.645
DEG_SPOP_SBC_1	580	584	PF00917	0.702
DEG_SPOP_SBC_1	595	599	PF00917	0.497
DEG_SPOP_SBC_1	660	664	PF00917	0.725
DEG_SPOP_SBC_1	836	840	PF00917	0.424
DOC_ANK_TNKS_1	249	256	PF00023	0.433
DOC_CKS1_1	551	556	PF01111	0.687
DOC_CYCLIN_RxL_1	697	705	PF00134	0.574
DOC_MAPK_gen_1	206	213	PF00069	0.523
DOC_MAPK_gen_1	312	320	PF00069	0.602
DOC_MAPK_gen_1	405	415	PF00069	0.433
DOC_MAPK_gen_1	532	540	PF00069	0.514
DOC_MAPK_gen_1	88	98	PF00069	0.703
DOC_MAPK_MEF2A_6	138	147	PF00069	0.395
DOC_MAPK_MEF2A_6	206	213	PF00069	0.449
DOC_MAPK_MEF2A_6	513	522	PF00069	0.557
DOC_MAPK_MEF2A_6	532	540	PF00069	0.486
DOC_MAPK_RevD_3	718	733	PF00069	0.642
DOC_MAPK_RevD_3	786	801	PF00069	0.567
DOC_PP1_RVXF_1	149	155	PF00149	0.649
DOC_PP1_RVXF_1	256	263	PF00149	0.466
DOC_PP4_FxxP_1	577	580	PF00568	0.558
DOC_PP4_FxxP_1	698	701	PF00568	0.509
DOC_PP4_FxxP_1	723	726	PF00568	0.519
DOC_USP7_MATH_1	286	290	PF00917	0.658
DOC_USP7_MATH_1	4	8	PF00917	0.784
DOC_USP7_MATH_1	516	520	PF00917	0.570
DOC_USP7_MATH_1	568	572	PF00917	0.595
DOC_USP7_MATH_1	580	584	PF00917	0.506
DOC_USP7_MATH_1	612	616	PF00917	0.655
DOC_USP7_MATH_1	652	656	PF00917	0.736
DOC_USP7_MATH_1	660	664	PF00917	0.720
DOC_USP7_MATH_1	836	840	PF00917	0.561
DOC_USP7_MATH_1	841	845	PF00917	0.709
DOC_USP7_UBL2_3	114	118	PF12436	0.683
DOC_USP7_UBL2_3	361	365	PF12436	0.685
DOC_USP7_UBL2_3	405	409	PF12436	0.297
DOC_USP7_UBL2_3	640	644	PF12436	0.497
DOC_WW_Pin1_4	112	117	PF00397	0.722
DOC_WW_Pin1_4	129	134	PF00397	0.703
DOC_WW_Pin1_4	201	206	PF00397	0.520
DOC_WW_Pin1_4	267	272	PF00397	0.388
DOC_WW_Pin1_4	360	365	PF00397	0.494
DOC_WW_Pin1_4	428	433	PF00397	0.450
DOC_WW_Pin1_4	480	485	PF00397	0.518
DOC_WW_Pin1_4	550	555	PF00397	0.641
DOC_WW_Pin1_4	661	666	PF00397	0.612
LIG_14-3-3_CanoR_1	138	143	PF00244	0.569
LIG_14-3-3_CanoR_1	146	151	PF00244	0.682
LIG_14-3-3_CanoR_1	305	309	PF00244	0.626
LIG_14-3-3_CanoR_1	347	352	PF00244	0.451
LIG_14-3-3_CanoR_1	396	404	PF00244	0.279
LIG_14-3-3_CanoR_1	572	578	PF00244	0.721
LIG_14-3-3_CanoR_1	750	756	PF00244	0.641
LIG_Actin_WH2_2	172	189	PF00022	0.637
LIG_Actin_WH2_2	224	239	PF00022	0.507
LIG_Actin_WH2_2	311	328	PF00022	0.640
LIG_AP_GAE_1	31	37	PF02883	0.699
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_BIR_III_4	226	230	PF00653	0.482
LIG_BIR_III_4	39	43	PF00653	0.672
LIG_BRCT_BRCA1_1	310	314	PF00533	0.531
LIG_BRCT_BRCA1_1	349	353	PF00533	0.552
LIG_BRCT_BRCA1_1	662	666	PF00533	0.678
LIG_BRCT_BRCA1_1	678	682	PF00533	0.396
LIG_DLG_GKlike_1	146	153	PF00625	0.642
LIG_DLG_GKlike_1	347	355	PF00625	0.627
LIG_eIF4E_1	724	730	PF01652	0.610
LIG_FHA_1	399	405	PF00498	0.433
LIG_FHA_1	729	735	PF00498	0.628
LIG_FHA_1	818	824	PF00498	0.681
LIG_FHA_2	18	24	PF00498	0.629
LIG_FHA_2	305	311	PF00498	0.514
LIG_FHA_2	341	347	PF00498	0.379
LIG_FHA_2	361	367	PF00498	0.423
LIG_FHA_2	481	487	PF00498	0.500
LIG_FHA_2	734	740	PF00498	0.568
LIG_FHA_2	812	818	PF00498	0.496
LIG_FHA_2	88	94	PF00498	0.705
LIG_GBD_Chelix_1	772	780	PF00786	0.587
LIG_IBAR_NPY_1	388	390	PF08397	0.433
LIG_LIR_Apic_2	576	580	PF02991	0.580
LIG_LIR_Apic_2	695	701	PF02991	0.521
LIG_LIR_Gen_1	212	222	PF02991	0.468
LIG_LIR_Gen_1	31	40	PF02991	0.641
LIG_LIR_Gen_1	446	455	PF02991	0.303
LIG_LIR_Gen_1	672	682	PF02991	0.541
LIG_LIR_Gen_1	739	747	PF02991	0.540
LIG_LIR_Gen_1	768	776	PF02991	0.476
LIG_LIR_Nem_3	212	217	PF02991	0.462
LIG_LIR_Nem_3	261	265	PF02991	0.439
LIG_LIR_Nem_3	31	37	PF02991	0.686
LIG_LIR_Nem_3	446	452	PF02991	0.303
LIG_LIR_Nem_3	473	479	PF02991	0.618
LIG_LIR_Nem_3	495	500	PF02991	0.683
LIG_LIR_Nem_3	672	678	PF02991	0.561
LIG_LIR_Nem_3	687	692	PF02991	0.476
LIG_LIR_Nem_3	739	745	PF02991	0.547
LIG_LIR_Nem_3	768	772	PF02991	0.469
LIG_PCNA_yPIPBox_3	225	237	PF02747	0.416
LIG_PCNA_yPIPBox_3	781	792	PF02747	0.570
LIG_Pex14_1	210	214	PF04695	0.456
LIG_Pex14_2	678	682	PF04695	0.490
LIG_PTB_Apo_2	278	285	PF02174	0.476
LIG_PTB_Apo_2	763	770	PF02174	0.623
LIG_PTB_Phospho_1	278	284	PF10480	0.477
LIG_PTB_Phospho_1	763	769	PF10480	0.626
LIG_SH2_CRK	198	202	PF00017	0.648
LIG_SH2_CRK	408	412	PF00017	0.297
LIG_SH2_CRK	449	453	PF00017	0.297
LIG_SH2_CRK	769	773	PF00017	0.530
LIG_SH2_GRB2like	764	767	PF00017	0.610
LIG_SH2_STAP1	769	773	PF00017	0.566
LIG_SH2_STAP1	782	786	PF00017	0.422
LIG_SH2_STAP1	803	807	PF00017	0.453
LIG_SH2_STAT3	782	785	PF00017	0.479
LIG_SH2_STAT3	832	835	PF00017	0.551
LIG_SH2_STAT5	185	188	PF00017	0.489
LIG_SH2_STAT5	589	592	PF00017	0.725
LIG_SH2_STAT5	68	71	PF00017	0.553
LIG_SH2_STAT5	710	713	PF00017	0.442
LIG_SH2_STAT5	764	767	PF00017	0.523
LIG_SH2_STAT5	807	810	PF00017	0.459
LIG_SH2_STAT5	832	835	PF00017	0.551
LIG_SH3_3	149	155	PF00018	0.597
LIG_SH3_3	265	271	PF00018	0.435
LIG_SH3_3	411	417	PF00018	0.297
LIG_SH3_3	426	432	PF00018	0.320
LIG_SH3_3	548	554	PF00018	0.678
LIG_SH3_3	664	670	PF00018	0.661
LIG_SH3_3	812	818	PF00018	0.341
LIG_Sin3_3	74	81	PF02671	0.440
LIG_TRAF2_1	431	434	PF00917	0.333
LIG_TRFH_1	666	670	PF08558	0.607
LIG_TYR_ITIM	263	268	PF00017	0.376
MOD_CDC14_SPxK_1	115	118	PF00782	0.504
MOD_CDK_SPK_2	112	117	PF00069	0.573
MOD_CDK_SPK_2	201	206	PF00069	0.520
MOD_CDK_SPK_2	360	365	PF00069	0.440
MOD_CDK_SPxK_1	112	118	PF00069	0.509
MOD_CDK_SPxK_1	201	207	PF00069	0.518
MOD_CDK_SPxxK_3	428	435	PF00069	0.415
MOD_CDK_SPxxK_3	550	557	PF00069	0.708
MOD_CK1_1	121	127	PF00069	0.729
MOD_CK1_1	171	177	PF00069	0.679
MOD_CK1_1	422	428	PF00069	0.427
MOD_CK1_1	582	588	PF00069	0.632
MOD_CK1_1	656	662	PF00069	0.723
MOD_CK1_1	7	13	PF00069	0.710
MOD_CK1_1	746	752	PF00069	0.684
MOD_CK1_1	839	845	PF00069	0.565
MOD_CK2_1	360	366	PF00069	0.446
MOD_CK2_1	428	434	PF00069	0.357
MOD_CK2_1	450	456	PF00069	0.304
MOD_CK2_1	480	486	PF00069	0.510
MOD_CK2_1	518	524	PF00069	0.570
MOD_CK2_1	624	630	PF00069	0.719
MOD_CK2_1	811	817	PF00069	0.571
MOD_DYRK1A_RPxSP_1	550	554	PF00069	0.689
MOD_GlcNHglycan	1	4	PF01048	0.718
MOD_GlcNHglycan	120	123	PF01048	0.774
MOD_GlcNHglycan	222	225	PF01048	0.422
MOD_GlcNHglycan	299	302	PF01048	0.529
MOD_GlcNHglycan	373	376	PF01048	0.704
MOD_GlcNHglycan	424	427	PF01048	0.413
MOD_GlcNHglycan	446	449	PF01048	0.439
MOD_GlcNHglycan	591	594	PF01048	0.641
MOD_GlcNHglycan	598	601	PF01048	0.591
MOD_GlcNHglycan	655	658	PF01048	0.727
MOD_GlcNHglycan	85	88	PF01048	0.672
MOD_GSK3_1	117	124	PF00069	0.645
MOD_GSK3_1	167	174	PF00069	0.687
MOD_GSK3_1	304	311	PF00069	0.565
MOD_GSK3_1	347	354	PF00069	0.512
MOD_GSK3_1	360	367	PF00069	0.603
MOD_GSK3_1	478	485	PF00069	0.671
MOD_GSK3_1	575	582	PF00069	0.726
MOD_GSK3_1	652	659	PF00069	0.719
MOD_GSK3_1	746	753	PF00069	0.685
MOD_GSK3_1	77	84	PF00069	0.628
MOD_GSK3_1	835	842	PF00069	0.570
MOD_N-GLC_1	201	206	PF02516	0.520
MOD_NEK2_1	273	278	PF00069	0.540
MOD_NEK2_1	279	284	PF00069	0.488
MOD_NEK2_1	304	309	PF00069	0.568
MOD_NEK2_1	380	385	PF00069	0.670
MOD_NEK2_1	471	476	PF00069	0.483
MOD_NEK2_1	505	510	PF00069	0.510
MOD_NEK2_1	728	733	PF00069	0.674
MOD_NEK2_1	77	82	PF00069	0.743
MOD_PIKK_1	398	404	PF00454	0.336
MOD_PKA_1	117	123	PF00069	0.668
MOD_PKA_1	573	579	PF00069	0.745
MOD_PKA_1	606	612	PF00069	0.705
MOD_PKA_2	137	143	PF00069	0.524
MOD_PKA_2	304	310	PF00069	0.628
MOD_PKA_2	395	401	PF00069	0.418
MOD_PKA_2	549	555	PF00069	0.690
MOD_PKA_2	573	579	PF00069	0.745
MOD_PKA_2	595	601	PF00069	0.666
MOD_PKA_2	605	611	PF00069	0.677
MOD_PKA_2	749	755	PF00069	0.549
MOD_PKA_2	87	93	PF00069	0.657
MOD_Plk_1	746	752	PF00069	0.564
MOD_Plk_4	279	285	PF00069	0.477
MOD_Plk_4	487	493	PF00069	0.481
MOD_Plk_4	624	630	PF00069	0.702
MOD_Plk_4	768	774	PF00069	0.432
MOD_ProDKin_1	112	118	PF00069	0.722
MOD_ProDKin_1	129	135	PF00069	0.700
MOD_ProDKin_1	201	207	PF00069	0.518
MOD_ProDKin_1	267	273	PF00069	0.392
MOD_ProDKin_1	360	366	PF00069	0.500
MOD_ProDKin_1	428	434	PF00069	0.450
MOD_ProDKin_1	480	486	PF00069	0.516
MOD_ProDKin_1	550	556	PF00069	0.645
MOD_ProDKin_1	661	667	PF00069	0.611
MOD_SUMO_rev_2	431	436	PF00179	0.433
TRG_DiLeu_BaEn_4	24	30	PF01217	0.676
TRG_DiLeu_BaEn_4	32	38	PF01217	0.643
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.451
TRG_DiLeu_BaLyEn_6	698	703	PF01217	0.545
TRG_ENDOCYTIC_2	198	201	PF00928	0.521
TRG_ENDOCYTIC_2	214	217	PF00928	0.468
TRG_ENDOCYTIC_2	265	268	PF00928	0.398
TRG_ENDOCYTIC_2	284	287	PF00928	0.615
TRG_ENDOCYTIC_2	390	393	PF00928	0.297
TRG_ENDOCYTIC_2	408	411	PF00928	0.297
TRG_ENDOCYTIC_2	449	452	PF00928	0.297
TRG_ENDOCYTIC_2	675	678	PF00928	0.588
TRG_ENDOCYTIC_2	742	745	PF00928	0.623
TRG_ENDOCYTIC_2	764	767	PF00928	0.520
TRG_ENDOCYTIC_2	769	772	PF00928	0.447
TRG_ER_diArg_1	186	188	PF00400	0.562
TRG_ER_diArg_1	333	335	PF00400	0.536
TRG_ER_diArg_1	395	397	PF00400	0.432
TRG_ER_diArg_1	497	499	PF00400	0.627
TRG_ER_diArg_1	531	534	PF00400	0.530
TRG_ER_diArg_1	572	574	PF00400	0.753
TRG_ER_diArg_1	63	65	PF00400	0.608
TRG_ER_diArg_1	797	799	PF00400	0.463
TRG_NES_CRM1_1	775	790	PF08389	0.583
TRG_NLS_Bipartite_1	322	340	PF00514	0.654
TRG_NLS_MonoExtC_3	334	339	PF00514	0.634
TRG_NLS_MonoExtN_4	334	340	PF00514	0.676
TRG_NLS_MonoExtN_4	798	803	PF00514	0.571
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	499	504	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	758	763	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P0	Leptomonas seymouri	66%	93%
A0A0S4JSE4	Bodo saltans	34%	100%
A0A1X0NTP4	Trypanosomatidae	44%	95%
A0A3Q8ICY0	Leishmania donovani	91%	87%
A0A3S5IQK9	Trypanosoma rangeli	48%	100%
A4HEY2	Leishmania braziliensis	82%	100%
A4I256	Leishmania infantum	91%	100%
C9ZRU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q967	Leishmania major	92%	100%
V5DAC5	Trypanosoma cruzi	49%	100%