NUC153 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYA4_LEIMU

TriTrypDb:

LmxM.26.1250

Length:

695

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	3
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AYA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYA4

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.382
CLV_C14_Caspase3-7	317	321	PF00656	0.399
CLV_C14_Caspase3-7	631	635	PF00656	0.667
CLV_NRD_NRD_1	105	107	PF00675	0.342
CLV_NRD_NRD_1	521	523	PF00675	0.533
CLV_NRD_NRD_1	536	538	PF00675	0.362
CLV_NRD_NRD_1	543	545	PF00675	0.444
CLV_NRD_NRD_1	616	618	PF00675	0.607
CLV_NRD_NRD_1	673	675	PF00675	0.497
CLV_PCSK_FUR_1	613	617	PF00082	0.676
CLV_PCSK_KEX2_1	31	33	PF00082	0.444
CLV_PCSK_KEX2_1	458	460	PF00082	0.485
CLV_PCSK_KEX2_1	488	490	PF00082	0.475
CLV_PCSK_KEX2_1	521	523	PF00082	0.540
CLV_PCSK_KEX2_1	536	538	PF00082	0.396
CLV_PCSK_KEX2_1	543	545	PF00082	0.485
CLV_PCSK_KEX2_1	615	617	PF00082	0.623
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.473
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.469
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.393
CLV_PCSK_PC1ET2_1	615	617	PF00082	0.698
CLV_PCSK_PC7_1	27	33	PF00082	0.495
CLV_PCSK_SKI1_1	107	111	PF00082	0.330
CLV_PCSK_SKI1_1	115	119	PF00082	0.380
CLV_PCSK_SKI1_1	265	269	PF00082	0.471
CLV_PCSK_SKI1_1	303	307	PF00082	0.330
CLV_PCSK_SKI1_1	536	540	PF00082	0.490
CLV_PCSK_SKI1_1	54	58	PF00082	0.291
CLV_PCSK_SKI1_1	573	577	PF00082	0.538
CLV_PCSK_SKI1_1	637	641	PF00082	0.668
CLV_PCSK_SKI1_1	648	652	PF00082	0.533
DEG_APCC_DBOX_1	572	580	PF00400	0.539
DEG_APCC_DBOX_1	601	609	PF00400	0.647
DEG_Nend_UBRbox_3	1	3	PF02207	0.370
DOC_CYCLIN_RxL_1	262	271	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	263	269	PF00134	0.366
DOC_MAPK_gen_1	674	684	PF00069	0.509
DOC_USP7_MATH_1	16	20	PF00917	0.433
DOC_USP7_MATH_1	205	209	PF00917	0.335
DOC_USP7_MATH_1	340	344	PF00917	0.537
DOC_USP7_MATH_1	513	517	PF00917	0.613
DOC_USP7_MATH_1	538	542	PF00917	0.468
DOC_USP7_MATH_1	624	628	PF00917	0.658
DOC_USP7_MATH_1	642	646	PF00917	0.689
DOC_USP7_UBL2_3	306	310	PF12436	0.332
DOC_WW_Pin1_4	150	155	PF00397	0.442
DOC_WW_Pin1_4	99	104	PF00397	0.326
LIG_14-3-3_CanoR_1	235	245	PF00244	0.480
LIG_14-3-3_CanoR_1	371	376	PF00244	0.383
LIG_14-3-3_CanoR_1	459	467	PF00244	0.480
LIG_14-3-3_CanoR_1	537	547	PF00244	0.569
LIG_BRCT_BRCA1_1	634	638	PF00533	0.453
LIG_BRCT_BRCA1_1	83	87	PF00533	0.415
LIG_BRCT_BRCA1_2	634	640	PF00533	0.452
LIG_FHA_1	246	252	PF00498	0.400
LIG_FHA_1	300	306	PF00498	0.352
LIG_FHA_1	378	384	PF00498	0.387
LIG_FHA_1	386	392	PF00498	0.487
LIG_FHA_1	403	409	PF00498	0.451
LIG_FHA_1	9	15	PF00498	0.340
LIG_FHA_2	315	321	PF00498	0.332
LIG_FHA_2	388	394	PF00498	0.466
LIG_FHA_2	469	475	PF00498	0.484
LIG_FHA_2	530	536	PF00498	0.565
LIG_FHA_2	649	655	PF00498	0.577
LIG_FHA_2	681	687	PF00498	0.574
LIG_LIR_Gen_1	137	148	PF02991	0.438
LIG_LIR_Gen_1	314	323	PF02991	0.341
LIG_LIR_Gen_1	374	383	PF02991	0.386
LIG_LIR_Gen_1	389	398	PF02991	0.430
LIG_LIR_Gen_1	525	533	PF02991	0.417
LIG_LIR_Gen_1	549	558	PF02991	0.552
LIG_LIR_Nem_3	102	108	PF02991	0.325
LIG_LIR_Nem_3	137	143	PF02991	0.359
LIG_LIR_Nem_3	314	319	PF02991	0.332
LIG_LIR_Nem_3	326	331	PF02991	0.307
LIG_LIR_Nem_3	374	378	PF02991	0.374
LIG_LIR_Nem_3	389	395	PF02991	0.400
LIG_LIR_Nem_3	442	447	PF02991	0.492
LIG_LIR_Nem_3	525	529	PF02991	0.415
LIG_LIR_Nem_3	549	555	PF02991	0.498
LIG_Pex14_2	502	506	PF04695	0.467
LIG_PTB_Apo_2	426	433	PF02174	0.415
LIG_PTB_Apo_2	520	527	PF02174	0.511
LIG_PTB_Phospho_1	426	432	PF10480	0.369
LIG_PTB_Phospho_1	520	526	PF10480	0.567
LIG_REV1ctd_RIR_1	281	291	PF16727	0.428
LIG_RPA_C_Fungi	204	216	PF08784	0.363
LIG_RPA_C_Fungi	532	544	PF08784	0.473
LIG_SH2_CRK	526	530	PF00017	0.431
LIG_SH2_GRB2like	567	570	PF00017	0.456
LIG_SH2_SRC	567	570	PF00017	0.504
LIG_SH2_STAP1	259	263	PF00017	0.333
LIG_SH2_STAP1	526	530	PF00017	0.431
LIG_SH2_STAP1	547	551	PF00017	0.467
LIG_SH2_STAT5	282	285	PF00017	0.309
LIG_SH2_STAT5	447	450	PF00017	0.430
LIG_SH3_3	126	132	PF00018	0.344
LIG_SH3_3	435	441	PF00018	0.385
LIG_SUMO_SIM_anti_2	374	382	PF11976	0.420
LIG_SUMO_SIM_par_1	265	271	PF11976	0.354
LIG_TRAF2_1	238	241	PF00917	0.455
LIG_TRAF2_1	35	38	PF00917	0.611
LIG_TRAF2_1	399	402	PF00917	0.276
MOD_CDK_SPxxK_3	99	106	PF00069	0.333
MOD_CK1_1	169	175	PF00069	0.365
MOD_CK1_1	222	228	PF00069	0.513
MOD_CK1_1	288	294	PF00069	0.401
MOD_CK1_1	299	305	PF00069	0.356
MOD_CK1_1	314	320	PF00069	0.356
MOD_CK1_1	343	349	PF00069	0.428
MOD_CK1_1	583	589	PF00069	0.666
MOD_CK1_1	627	633	PF00069	0.516
MOD_CK2_1	16	22	PF00069	0.448
MOD_CK2_1	371	377	PF00069	0.384
MOD_CK2_1	396	402	PF00069	0.412
MOD_CK2_1	529	535	PF00069	0.498
MOD_CK2_1	648	654	PF00069	0.582
MOD_CK2_1	674	680	PF00069	0.552
MOD_GlcNHglycan	122	125	PF01048	0.375
MOD_GlcNHglycan	148	151	PF01048	0.288
MOD_GlcNHglycan	173	176	PF01048	0.469
MOD_GlcNHglycan	190	193	PF01048	0.436
MOD_GlcNHglycan	221	224	PF01048	0.403
MOD_GlcNHglycan	225	228	PF01048	0.359
MOD_GlcNHglycan	240	244	PF01048	0.283
MOD_GlcNHglycan	252	255	PF01048	0.381
MOD_GlcNHglycan	298	301	PF01048	0.308
MOD_GlcNHglycan	33	36	PF01048	0.675
MOD_GlcNHglycan	344	348	PF01048	0.316
MOD_GlcNHglycan	490	493	PF01048	0.555
MOD_GlcNHglycan	540	543	PF01048	0.526
MOD_GlcNHglycan	582	585	PF01048	0.783
MOD_GlcNHglycan	610	613	PF01048	0.627
MOD_GlcNHglycan	626	629	PF01048	0.579
MOD_GlcNHglycan	634	637	PF01048	0.644
MOD_GlcNHglycan	644	647	PF01048	0.514
MOD_GlcNHglycan	654	658	PF01048	0.393
MOD_GlcNHglycan	692	695	PF01048	0.685
MOD_GlcNHglycan	96	99	PF01048	0.429
MOD_GSK3_1	1	8	PF00069	0.484
MOD_GSK3_1	115	122	PF00069	0.328
MOD_GSK3_1	12	19	PF00069	0.379
MOD_GSK3_1	146	153	PF00069	0.291
MOD_GSK3_1	166	173	PF00069	0.220
MOD_GSK3_1	219	226	PF00069	0.440
MOD_GSK3_1	288	295	PF00069	0.392
MOD_GSK3_1	311	318	PF00069	0.358
MOD_GSK3_1	326	333	PF00069	0.473
MOD_GSK3_1	454	461	PF00069	0.442
MOD_GSK3_1	488	495	PF00069	0.578
MOD_GSK3_1	580	587	PF00069	0.464
MOD_GSK3_1	624	631	PF00069	0.697
MOD_GSK3_1	648	655	PF00069	0.635
MOD_GSK3_1	81	88	PF00069	0.330
MOD_N-GLC_1	12	17	PF02516	0.377
MOD_N-GLC_1	314	319	PF02516	0.357
MOD_N-GLC_1	60	65	PF02516	0.289
MOD_NEK2_1	1	6	PF00069	0.411
MOD_NEK2_1	134	139	PF00069	0.370
MOD_NEK2_1	166	171	PF00069	0.537
MOD_NEK2_1	245	250	PF00069	0.315
MOD_NEK2_1	330	335	PF00069	0.446
MOD_NEK2_1	652	657	PF00069	0.645
MOD_NEK2_1	690	695	PF00069	0.515
MOD_NEK2_1	85	90	PF00069	0.339
MOD_PIKK_1	330	336	PF00454	0.363
MOD_PKA_1	31	37	PF00069	0.541
MOD_PKA_1	458	464	PF00069	0.455
MOD_PKA_1	488	494	PF00069	0.448
MOD_PKA_1	674	680	PF00069	0.601
MOD_PKA_2	31	37	PF00069	0.541
MOD_PKA_2	454	460	PF00069	0.441
MOD_PKA_2	462	468	PF00069	0.480
MOD_PKA_2	488	494	PF00069	0.582
MOD_PKA_2	580	586	PF00069	0.552
MOD_PKA_2	632	638	PF00069	0.754
MOD_Plk_1	292	298	PF00069	0.386
MOD_Plk_1	314	320	PF00069	0.363
MOD_Plk_1	326	332	PF00069	0.437
MOD_Plk_1	386	392	PF00069	0.445
MOD_Plk_1	393	399	PF00069	0.379
MOD_Plk_1	81	87	PF00069	0.444
MOD_Plk_2-3	377	383	PF00069	0.376
MOD_Plk_2-3	387	393	PF00069	0.448
MOD_Plk_2-3	563	569	PF00069	0.530
MOD_Plk_2-3	680	686	PF00069	0.535
MOD_Plk_4	278	284	PF00069	0.302
MOD_Plk_4	292	298	PF00069	0.354
MOD_Plk_4	371	377	PF00069	0.346
MOD_Plk_4	387	393	PF00069	0.483
MOD_Plk_4	648	654	PF00069	0.592
MOD_ProDKin_1	150	156	PF00069	0.438
MOD_ProDKin_1	99	105	PF00069	0.328
TRG_DiLeu_BaEn_1	241	246	PF01217	0.505
TRG_DiLeu_BaEn_1	525	530	PF01217	0.443
TRG_DiLeu_BaEn_2	161	167	PF01217	0.377
TRG_DiLeu_BaEn_4	401	407	PF01217	0.286
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.366
TRG_ENDOCYTIC_2	105	108	PF00928	0.459
TRG_ENDOCYTIC_2	140	143	PF00928	0.465
TRG_ENDOCYTIC_2	392	395	PF00928	0.439
TRG_ENDOCYTIC_2	432	435	PF00928	0.388
TRG_ENDOCYTIC_2	526	529	PF00928	0.430
TRG_ER_diArg_1	128	131	PF00400	0.330
TRG_NES_CRM1_1	92	104	PF08389	0.306
TRG_NLS_MonoExtC_3	614	619	PF00514	0.709
TRG_NLS_MonoExtC_3	673	678	PF00514	0.520
TRG_NLS_MonoExtN_4	613	619	PF00514	0.713
TRG_NLS_MonoExtN_4	674	679	PF00514	0.519
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D9	Leptomonas seymouri	79%	100%
A0A0S4JNM6	Bodo saltans	53%	100%
A0A1X0NSW1	Trypanosomatidae	63%	100%
A0A3R7KNJ7	Trypanosoma rangeli	70%	100%
A0A3S7WZS4	Leishmania donovani	92%	99%
A4HEY0	Leishmania braziliensis	87%	100%
A4I254	Leishmania infantum	93%	100%
C9ZRU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
G0S902	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	25%	100%
O74879	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q4Q969	Leishmania major	92%	99%
Q5RJG1	Mus musculus	34%	100%
Q66H99	Rattus norvegicus	34%	100%
Q7T0Q5	Xenopus laevis	34%	100%
Q802W4	Danio rerio	34%	96%
Q9BSC4	Homo sapiens	31%	100%