Leucine rich repeat family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AYA1_LEIMU

TriTrypDb:

LmxM.26.1220

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AYA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYA1

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0036158	outer dynein arm assembly	7	10
GO:0036159	inner dynein arm assembly	7	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0070286	axonemal dynein complex assembly	6	10
GO:0071840	cellular component organization or biogenesis	2	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0044877	protein-containing complex binding	2	10
GO:0070840	dynein complex binding	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.420
CLV_C14_Caspase3-7	203	207	PF00656	0.449
CLV_C14_Caspase3-7	236	240	PF00656	0.711
CLV_C14_Caspase3-7	526	530	PF00656	0.720
CLV_C14_Caspase3-7	553	557	PF00656	0.782
CLV_NRD_NRD_1	339	341	PF00675	0.720
CLV_NRD_NRD_1	431	433	PF00675	0.402
CLV_NRD_NRD_1	455	457	PF00675	0.413
CLV_NRD_NRD_1	492	494	PF00675	0.514
CLV_NRD_NRD_1	546	548	PF00675	0.701
CLV_NRD_NRD_1	549	551	PF00675	0.708
CLV_PCSK_FUR_1	438	442	PF00082	0.566
CLV_PCSK_FUR_1	547	551	PF00082	0.536
CLV_PCSK_KEX2_1	297	299	PF00082	0.568
CLV_PCSK_KEX2_1	339	341	PF00082	0.720
CLV_PCSK_KEX2_1	433	435	PF00082	0.512
CLV_PCSK_KEX2_1	440	442	PF00082	0.475
CLV_PCSK_KEX2_1	455	457	PF00082	0.294
CLV_PCSK_KEX2_1	486	488	PF00082	0.468
CLV_PCSK_KEX2_1	492	494	PF00082	0.503
CLV_PCSK_KEX2_1	546	548	PF00082	0.660
CLV_PCSK_KEX2_1	549	551	PF00082	0.665
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.584
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.512
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.525
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.567
CLV_PCSK_SKI1_1	173	177	PF00082	0.456
CLV_PCSK_SKI1_1	415	419	PF00082	0.293
CLV_PCSK_SKI1_1	433	437	PF00082	0.462
CLV_PCSK_SKI1_1	440	444	PF00082	0.441
CLV_PCSK_SKI1_1	448	452	PF00082	0.412
CLV_PCSK_SKI1_1	456	460	PF00082	0.351
DEG_COP1_1	659	671	PF00400	0.606
DEG_ODPH_VHL_1	72	85	PF01847	0.486
DEG_SPOP_SBC_1	555	559	PF00917	0.658
DOC_CDC14_PxL_1	408	416	PF14671	0.435
DOC_CYCLIN_RxL_1	410	420	PF00134	0.270
DOC_CYCLIN_RxL_1	434	447	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	105	111	PF00134	0.587
DOC_MAPK_gen_1	201	210	PF00069	0.524
DOC_MAPK_gen_1	339	346	PF00069	0.709
DOC_MAPK_gen_1	410	419	PF00069	0.410
DOC_MAPK_gen_1	438	445	PF00069	0.491
DOC_PP1_RVXF_1	82	88	PF00149	0.393
DOC_PP2B_LxvP_1	105	108	PF13499	0.401
DOC_USP7_MATH_1	129	133	PF00917	0.551
DOC_USP7_MATH_1	175	179	PF00917	0.506
DOC_USP7_MATH_1	246	250	PF00917	0.774
DOC_USP7_MATH_1	25	29	PF00917	0.735
DOC_USP7_MATH_1	359	363	PF00917	0.466
DOC_USP7_MATH_1	555	559	PF00917	0.720
DOC_USP7_MATH_1	591	595	PF00917	0.752
DOC_USP7_MATH_1	600	604	PF00917	0.702
DOC_USP7_MATH_1	650	654	PF00917	0.791
DOC_WW_Pin1_4	148	153	PF00397	0.742
DOC_WW_Pin1_4	239	244	PF00397	0.690
DOC_WW_Pin1_4	249	254	PF00397	0.698
DOC_WW_Pin1_4	289	294	PF00397	0.501
DOC_WW_Pin1_4	318	323	PF00397	0.587
DOC_WW_Pin1_4	52	57	PF00397	0.387
LIG_14-3-3_CanoR_1	306	316	PF00244	0.479
LIG_14-3-3_CanoR_1	339	344	PF00244	0.804
LIG_14-3-3_CanoR_1	357	366	PF00244	0.284
LIG_14-3-3_CanoR_1	372	377	PF00244	0.390
LIG_14-3-3_CanoR_1	455	463	PF00244	0.575
LIG_14-3-3_CanoR_1	497	507	PF00244	0.582
LIG_14-3-3_CanoR_1	549	555	PF00244	0.774
LIG_14-3-3_CanoR_1	624	629	PF00244	0.836
LIG_14-3-3_CanoR_1	640	648	PF00244	0.642
LIG_Actin_WH2_2	404	420	PF00022	0.408
LIG_AP2alpha_2	112	114	PF02296	0.664
LIG_APCC_ABBA_1	137	142	PF00400	0.459
LIG_APCC_ABBA_1	77	82	PF00400	0.460
LIG_APCC_ABBAyCdc20_2	440	446	PF00400	0.491
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_BRCT_BRCA1_1	210	214	PF00533	0.457
LIG_BRCT_BRCA1_2	210	216	PF00533	0.376
LIG_Clathr_ClatBox_1	405	409	PF01394	0.402
LIG_Clathr_ClatBox_1	442	446	PF01394	0.402
LIG_eIF4E_1	187	193	PF01652	0.546
LIG_FHA_1	308	314	PF00498	0.521
LIG_FHA_1	38	44	PF00498	0.443
LIG_FHA_1	59	65	PF00498	0.257
LIG_FHA_1	7	13	PF00498	0.754
LIG_FHA_2	558	564	PF00498	0.696
LIG_FHA_2	566	572	PF00498	0.691
LIG_FHA_2	73	79	PF00498	0.548
LIG_LIR_Gen_1	174	183	PF02991	0.396
LIG_LIR_Gen_1	200	210	PF02991	0.434
LIG_LIR_Gen_1	312	322	PF02991	0.446
LIG_LIR_Gen_1	78	88	PF02991	0.400
LIG_LIR_Nem_3	174	179	PF02991	0.407
LIG_LIR_Nem_3	200	205	PF02991	0.449
LIG_LIR_Nem_3	312	317	PF02991	0.435
LIG_LIR_Nem_3	489	494	PF02991	0.550
LIG_LIR_Nem_3	75	80	PF02991	0.423
LIG_LYPXL_S_1	179	183	PF13949	0.383
LIG_LYPXL_yS_3	180	183	PF13949	0.381
LIG_PDZ_Class_3	667	672	PF00595	0.488
LIG_PTB_Apo_2	187	194	PF02174	0.521
LIG_PTB_Apo_2	63	70	PF02174	0.496
LIG_PTB_Phospho_1	63	69	PF10480	0.566
LIG_REV1ctd_RIR_1	212	219	PF16727	0.381
LIG_SH2_CRK	102	106	PF00017	0.627
LIG_SH2_CRK	385	389	PF00017	0.408
LIG_SH2_CRK	53	57	PF00017	0.437
LIG_SH2_CRK	69	73	PF00017	0.425
LIG_SH2_GRB2like	511	514	PF00017	0.611
LIG_SH2_NCK_1	69	73	PF00017	0.570
LIG_SH2_SRC	511	514	PF00017	0.689
LIG_SH2_STAP1	140	144	PF00017	0.633
LIG_SH2_STAP1	225	229	PF00017	0.576
LIG_SH2_STAP1	69	73	PF00017	0.570
LIG_SH2_STAT5	102	105	PF00017	0.581
LIG_SH2_STAT5	140	143	PF00017	0.633
LIG_SH2_STAT5	187	190	PF00017	0.473
LIG_SH2_STAT5	511	514	PF00017	0.656
LIG_SH2_STAT5	63	66	PF00017	0.417
LIG_SH2_STAT5	80	83	PF00017	0.388
LIG_SH3_3	287	293	PF00018	0.649
LIG_SH3_3	346	352	PF00018	0.746
LIG_SH3_5	507	511	PF00018	0.691
LIG_SUMO_SIM_anti_2	284	292	PF11976	0.676
LIG_SUMO_SIM_anti_2	377	384	PF11976	0.365
LIG_SUMO_SIM_anti_2	387	392	PF11976	0.475
LIG_SUMO_SIM_anti_2	402	409	PF11976	0.242
LIG_SUMO_SIM_par_1	389	394	PF11976	0.335
LIG_SUMO_SIM_par_1	402	409	PF11976	0.384
LIG_TRAF2_1	475	478	PF00917	0.610
LIG_TYR_ITIM	383	388	PF00017	0.435
LIG_UBA3_1	407	415	PF00899	0.343
LIG_WRC_WIRS_1	373	378	PF05994	0.436
LIG_WW_3	618	622	PF00397	0.706
MOD_CK1_1	151	157	PF00069	0.745
MOD_CK1_1	23	29	PF00069	0.683
MOD_CK1_1	242	248	PF00069	0.707
MOD_CK1_1	249	255	PF00069	0.777
MOD_CK1_1	362	368	PF00069	0.377
MOD_CK1_1	540	546	PF00069	0.766
MOD_CK1_1	557	563	PF00069	0.738
MOD_CK2_1	197	203	PF00069	0.552
MOD_CK2_1	396	402	PF00069	0.262
MOD_CK2_1	499	505	PF00069	0.507
MOD_CK2_1	557	563	PF00069	0.721
MOD_CK2_1	610	616	PF00069	0.805
MOD_CK2_1	72	78	PF00069	0.461
MOD_Cter_Amidation	547	550	PF01082	0.562
MOD_GlcNHglycan	210	213	PF01048	0.468
MOD_GlcNHglycan	226	229	PF01048	0.390
MOD_GlcNHglycan	244	247	PF01048	0.700
MOD_GlcNHglycan	248	251	PF01048	0.760
MOD_GlcNHglycan	27	30	PF01048	0.681
MOD_GlcNHglycan	419	422	PF01048	0.392
MOD_GlcNHglycan	521	524	PF01048	0.553
MOD_GlcNHglycan	580	584	PF01048	0.787
MOD_GlcNHglycan	601	605	PF01048	0.774
MOD_GSK3_1	1	8	PF00069	0.708
MOD_GSK3_1	11	18	PF00069	0.696
MOD_GSK3_1	175	182	PF00069	0.453
MOD_GSK3_1	20	27	PF00069	0.626
MOD_GSK3_1	238	245	PF00069	0.775
MOD_GSK3_1	249	256	PF00069	0.704
MOD_GSK3_1	274	281	PF00069	0.719
MOD_GSK3_1	285	292	PF00069	0.554
MOD_GSK3_1	358	365	PF00069	0.416
MOD_GSK3_1	550	557	PF00069	0.706
MOD_GSK3_1	561	568	PF00069	0.622
MOD_GSK3_1	575	582	PF00069	0.699
MOD_GSK3_1	589	596	PF00069	0.730
MOD_LATS_1	337	343	PF00433	0.613
MOD_LATS_1	498	504	PF00433	0.429
MOD_N-GLC_1	20	25	PF02516	0.779
MOD_N-GLC_1	208	213	PF02516	0.393
MOD_N-GLC_1	31	36	PF02516	0.633
MOD_N-GLC_1	58	63	PF02516	0.266
MOD_NEK2_1	1	6	PF00069	0.679
MOD_NEK2_1	192	197	PF00069	0.544
MOD_NEK2_1	24	29	PF00069	0.693
MOD_NEK2_1	255	260	PF00069	0.644
MOD_NEK2_1	391	396	PF00069	0.319
MOD_NEK2_1	417	422	PF00069	0.389
MOD_NEK2_1	424	429	PF00069	0.411
MOD_NEK2_1	610	615	PF00069	0.809
MOD_NEK2_2	175	180	PF00069	0.514
MOD_NEK2_2	359	364	PF00069	0.482
MOD_NEK2_2	58	63	PF00069	0.266
MOD_PIKK_1	100	106	PF00454	0.572
MOD_PIKK_1	610	616	PF00454	0.809
MOD_PIKK_1	626	632	PF00454	0.833
MOD_PK_1	339	345	PF00069	0.504
MOD_PKA_1	339	345	PF00069	0.718
MOD_PKA_1	549	555	PF00069	0.626
MOD_PKA_2	307	313	PF00069	0.484
MOD_PKA_2	339	345	PF00069	0.796
MOD_PKA_2	499	505	PF00069	0.507
MOD_PKA_2	540	546	PF00069	0.753
MOD_PKA_2	549	555	PF00069	0.701
MOD_PKA_2	575	581	PF00069	0.749
MOD_PKA_2	6	12	PF00069	0.679
MOD_PKA_2	623	629	PF00069	0.540
MOD_PKB_1	432	440	PF00069	0.519
MOD_PKB_1	547	555	PF00069	0.529
MOD_PKB_1	638	646	PF00069	0.619
MOD_Plk_1	158	164	PF00069	0.698
MOD_Plk_1	197	203	PF00069	0.497
MOD_Plk_1	20	26	PF00069	0.752
MOD_Plk_1	285	291	PF00069	0.647
MOD_Plk_1	58	64	PF00069	0.261
MOD_Plk_2-3	565	571	PF00069	0.604
MOD_Plk_4	129	135	PF00069	0.586
MOD_Plk_4	175	181	PF00069	0.414
MOD_Plk_4	285	291	PF00069	0.647
MOD_Plk_4	339	345	PF00069	0.504
MOD_Plk_4	58	64	PF00069	0.362
MOD_Plk_4	91	97	PF00069	0.483
MOD_ProDKin_1	148	154	PF00069	0.741
MOD_ProDKin_1	239	245	PF00069	0.694
MOD_ProDKin_1	249	255	PF00069	0.698
MOD_ProDKin_1	289	295	PF00069	0.492
MOD_ProDKin_1	318	324	PF00069	0.598
MOD_ProDKin_1	52	58	PF00069	0.389
MOD_SUMO_rev_2	112	121	PF00179	0.504
MOD_SUMO_rev_2	478	488	PF00179	0.554
MOD_SUMO_rev_2	613	620	PF00179	0.732
MOD_SUMO_rev_2	78	86	PF00179	0.410
TRG_DiLeu_BaEn_1	402	407	PF01217	0.400
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.583
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.552
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.596
TRG_ENDOCYTIC_2	102	105	PF00928	0.614
TRG_ENDOCYTIC_2	180	183	PF00928	0.381
TRG_ENDOCYTIC_2	385	388	PF00928	0.408
TRG_ENDOCYTIC_2	69	72	PF00928	0.492
TRG_ENDOCYTIC_2	80	83	PF00928	0.331
TRG_ER_diArg_1	339	341	PF00400	0.711
TRG_ER_diArg_1	431	434	PF00400	0.512
TRG_ER_diArg_1	455	457	PF00400	0.413
TRG_ER_diArg_1	491	493	PF00400	0.513
TRG_ER_diArg_1	546	549	PF00400	0.720
TRG_ER_diArg_1	638	641	PF00400	0.517
TRG_NLS_MonoExtN_4	429	436	PF00514	0.523
TRG_Pf-PMV_PEXEL_1	441	446	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C5	Leptomonas seymouri	52%	100%
A0A0S4JQS0	Bodo saltans	37%	100%
A0A3Q8IFU8	Leishmania donovani	87%	100%
A0A422N6Q2	Trypanosoma rangeli	40%	100%
A4HEX7	Leishmania braziliensis	72%	98%
A4I251	Leishmania infantum	87%	100%
C9ZRV3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q972	Leishmania major	89%	100%
V5DQX0	Trypanosoma cruzi	38%	91%