Putative aldo/keto reductase (Aldo/keto reductase family-like protein)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldo/keto reductase, putative

Species:

Leishmania mexicana

UniProt:

E9AYA0_LEIMU

TriTrypDb:

LmxM.26.1210

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AYA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AYA0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0016491	oxidoreductase activity	2	14
GO:0004032	alditol:NADP+ 1-oxidoreductase activity	7	1
GO:0004033	aldo-keto reductase (NADP) activity	5	1
GO:0008106	alcohol dehydrogenase (NADP+) activity	6	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	3
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	3
GO:0036131	prostaglandin D2 11-ketoreductase activity	5	2
GO:0047017	prostaglandin-F synthase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.254
CLV_PCSK_KEX2_1	195	197	PF00082	0.459
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.459
CLV_PCSK_SKI1_1	161	165	PF00082	0.326
CLV_PCSK_SKI1_1	378	382	PF00082	0.507
CLV_PCSK_SKI1_1	40	44	PF00082	0.321
DEG_APCC_DBOX_1	72	80	PF00400	0.448
DOC_CYCLIN_RxL_1	375	384	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	230	233	PF00134	0.489
DOC_MAPK_gen_1	254	261	PF00069	0.519
DOC_MAPK_gen_1	390	398	PF00069	0.373
DOC_MAPK_MEF2A_6	73	82	PF00069	0.435
DOC_PP2B_LxvP_1	229	232	PF13499	0.569
DOC_PP4_FxxP_1	18	21	PF00568	0.449
DOC_USP7_MATH_1	188	192	PF00917	0.730
DOC_USP7_MATH_1	215	219	PF00917	0.720
DOC_USP7_MATH_1	223	227	PF00917	0.603
DOC_USP7_MATH_1	308	312	PF00917	0.516
DOC_USP7_MATH_1	34	38	PF00917	0.427
DOC_USP7_MATH_1	8	12	PF00917	0.636
DOC_USP7_MATH_1	83	87	PF00917	0.533
DOC_USP7_UBL2_3	81	85	PF12436	0.433
DOC_WW_Pin1_4	211	216	PF00397	0.763
DOC_WW_Pin1_4	262	267	PF00397	0.369
DOC_WW_Pin1_4	302	307	PF00397	0.741
LIG_14-3-3_CanoR_1	210	215	PF00244	0.455
LIG_14-3-3_CanoR_1	378	388	PF00244	0.458
LIG_BIR_III_4	126	130	PF00653	0.526
LIG_BRCT_BRCA1_1	14	18	PF00533	0.385
LIG_CSL_BTD_1	220	223	PF09270	0.428
LIG_eIF4E_1	56	62	PF01652	0.487
LIG_FHA_1	25	31	PF00498	0.450
LIG_FHA_1	375	381	PF00498	0.393
LIG_Integrin_isoDGR_2	362	364	PF01839	0.406
LIG_Integrin_RGD_1	31	33	PF01839	0.291
LIG_LIR_Apic_2	15	21	PF02991	0.368
LIG_LIR_Gen_1	348	357	PF02991	0.490
LIG_LIR_Gen_1	75	84	PF02991	0.451
LIG_LIR_Nem_3	348	353	PF02991	0.371
LIG_LIR_Nem_3	75	80	PF02991	0.451
LIG_PCNA_PIPBox_1	385	394	PF02747	0.385
LIG_SH2_CRK	152	156	PF00017	0.457
LIG_SH2_CRK	264	268	PF00017	0.351
LIG_SH2_CRK	327	331	PF00017	0.428
LIG_SH2_STAP1	409	413	PF00017	0.514
LIG_SH2_STAT3	409	412	PF00017	0.478
LIG_SH2_STAT5	152	155	PF00017	0.457
LIG_SH2_STAT5	252	255	PF00017	0.392
LIG_SH2_STAT5	287	290	PF00017	0.504
LIG_SH2_STAT5	327	330	PF00017	0.400
LIG_SH2_STAT5	349	352	PF00017	0.366
LIG_SH3_3	294	300	PF00018	0.562
LIG_SUMO_SIM_anti_2	384	390	PF11976	0.286
LIG_TYR_ITIM	150	155	PF00017	0.457
LIG_UBA3_1	140	149	PF00899	0.457
LIG_UBA3_1	97	103	PF00899	0.514
MOD_CDK_SPxxK_3	262	269	PF00069	0.431
MOD_CK1_1	211	217	PF00069	0.722
MOD_CK1_1	224	230	PF00069	0.465
MOD_CK1_1	289	295	PF00069	0.607
MOD_CK1_1	370	376	PF00069	0.647
MOD_CK2_1	174	180	PF00069	0.548
MOD_CK2_1	213	219	PF00069	0.586
MOD_Cter_Amidation	193	196	PF01082	0.456
MOD_GlcNHglycan	107	110	PF01048	0.146
MOD_GlcNHglycan	126	130	PF01048	0.227
MOD_GlcNHglycan	210	213	PF01048	0.603
MOD_GlcNHglycan	223	226	PF01048	0.443
MOD_GlcNHglycan	297	300	PF01048	0.671
MOD_GlcNHglycan	36	39	PF01048	0.296
MOD_GlcNHglycan	372	375	PF01048	0.714
MOD_GlcNHglycan	68	71	PF01048	0.274
MOD_GSK3_1	210	217	PF00069	0.711
MOD_GSK3_1	326	333	PF00069	0.466
MOD_GSK3_1	366	373	PF00069	0.662
MOD_GSK3_1	8	15	PF00069	0.511
MOD_N-GLC_1	289	294	PF02516	0.578
MOD_NEK2_1	1	6	PF00069	0.624
MOD_NEK2_1	330	335	PF00069	0.428
MOD_NEK2_1	49	54	PF00069	0.442
MOD_NEK2_2	188	193	PF00069	0.714
MOD_NEK2_2	89	94	PF00069	0.376
MOD_PIKK_1	224	230	PF00454	0.481
MOD_PIKK_1	408	414	PF00454	0.535
MOD_Plk_1	367	373	PF00069	0.468
MOD_Plk_1	89	95	PF00069	0.524
MOD_Plk_4	326	332	PF00069	0.432
MOD_Plk_4	8	14	PF00069	0.362
MOD_ProDKin_1	211	217	PF00069	0.763
MOD_ProDKin_1	262	268	PF00069	0.369
MOD_ProDKin_1	302	308	PF00069	0.733
TRG_DiLeu_BaEn_1	315	320	PF01217	0.291
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.530
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.526
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.448
TRG_ENDOCYTIC_2	152	155	PF00928	0.540
TRG_ENDOCYTIC_2	264	267	PF00928	0.350
TRG_ENDOCYTIC_2	327	330	PF00928	0.415
TRG_ENDOCYTIC_2	47	50	PF00928	0.524
TRG_NES_CRM1_1	95	110	PF08389	0.427
TRG_NLS_MonoExtC_3	101	107	PF00514	0.427
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4R8	Leptomonas seymouri	57%	100%
A0A0N0P8F4	Leptomonas seymouri	27%	100%
A0A0N1I9Z1	Leptomonas seymouri	27%	100%
A0A1D5XGW0	Triticum aestivum	26%	100%
A0A1X0NIH1	Trypanosomatidae	38%	100%
A0A1X0NNX8	Trypanosomatidae	26%	100%
A0A1X0P7C2	Trypanosomatidae	25%	100%
A0A1X9QHJ0	Triticum aestivum	26%	100%
A0A3Q8IFG1	Leishmania donovani	27%	100%
A0A3S7WZZ0	Leishmania donovani	93%	73%
A0A3S7X124	Leishmania donovani	26%	100%
A0A422N1G0	Trypanosoma rangeli	26%	100%
A0A422N9R4	Trypanosoma rangeli	40%	100%
A0A422NBS6	Trypanosoma rangeli	28%	100%
A4HEX6	Leishmania braziliensis	78%	100%
A4HG21	Leishmania braziliensis	25%	100%
A4HJJ7	Leishmania braziliensis	29%	100%
A4I250	Leishmania infantum	93%	73%
A4I342	Leishmania infantum	26%	100%
A4I6Z4	Leishmania infantum	27%	100%
A4TE41	Mycolicibacterium gilvum (strain PYR-GCK)	27%	100%
B4F9A4	Zea mays	24%	100%
B9VRJ2	Papaver somniferum	23%	100%
D0A735	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ACW1	Leishmania major	25%	100%
E9AZF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B215	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
O49133	Fragaria ananassa	25%	100%
O60218	Homo sapiens	26%	100%
O80944	Arabidopsis thaliana	25%	100%
P14065	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P14550	Homo sapiens	25%	100%
P22045	Leishmania major	27%	85%
P23901	Hordeum vulgare	22%	100%
P38115	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P50578	Sus scrofa	26%	100%
P51635	Rattus norvegicus	25%	100%
Q0GYU4	Hypocrea jecorina	25%	100%
Q0PCF4	Hordeum vulgare	26%	100%
Q10PE7	Oryza sativa subsp. japonica	24%	100%
Q12458	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q3ZCJ2	Bos taurus	25%	100%
Q3ZFI7	Hypocrea jecorina	25%	100%
Q4Q973	Leishmania major	90%	100%
Q54NZ7	Dictyostelium discoideum	23%	100%
Q568L5	Danio rerio	23%	100%
Q5R5D5	Pongo abelii	25%	100%
Q7G764	Oryza sativa subsp. japonica	24%	100%
Q7G765	Oryza sativa subsp. japonica	24%	100%
Q8SSK6	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
Q9C1X5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q9JII6	Mus musculus	25%	100%
Q9SQ67	Papaver somniferum	25%	100%
Q9SQ68	Papaver somniferum	25%	100%
Q9SQ70	Papaver somniferum	25%	100%
V5BR74	Trypanosoma cruzi	39%	100%
W5DYE3	Triticum aestivum	26%	100%