J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AY99_LEIMU

TriTrypDb:

LmxM.26.1200

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 7
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AY99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.408
CLV_C14_Caspase3-7	435	439	PF00656	0.394
CLV_C14_Caspase3-7	561	565	PF00656	0.387
CLV_NRD_NRD_1	192	194	PF00675	0.726
CLV_NRD_NRD_1	254	256	PF00675	0.626
CLV_NRD_NRD_1	338	340	PF00675	0.437
CLV_NRD_NRD_1	491	493	PF00675	0.644
CLV_NRD_NRD_1	547	549	PF00675	0.548
CLV_NRD_NRD_1	605	607	PF00675	0.533
CLV_NRD_NRD_1	7	9	PF00675	0.612
CLV_NRD_NRD_1	86	88	PF00675	0.604
CLV_NRD_NRD_1	89	91	PF00675	0.606
CLV_PCSK_FUR_1	87	91	PF00082	0.644
CLV_PCSK_KEX2_1	192	194	PF00082	0.726
CLV_PCSK_KEX2_1	250	252	PF00082	0.610
CLV_PCSK_KEX2_1	254	256	PF00082	0.607
CLV_PCSK_KEX2_1	338	340	PF00082	0.437
CLV_PCSK_KEX2_1	357	359	PF00082	0.592
CLV_PCSK_KEX2_1	441	443	PF00082	0.721
CLV_PCSK_KEX2_1	480	482	PF00082	0.626
CLV_PCSK_KEX2_1	490	492	PF00082	0.710
CLV_PCSK_KEX2_1	537	539	PF00082	0.585
CLV_PCSK_KEX2_1	547	549	PF00082	0.551
CLV_PCSK_KEX2_1	604	606	PF00082	0.538
CLV_PCSK_KEX2_1	7	9	PF00082	0.612
CLV_PCSK_KEX2_1	86	88	PF00082	0.617
CLV_PCSK_KEX2_1	89	91	PF00082	0.616
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.629
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.447
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.530
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.721
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.626
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.680
CLV_PCSK_PC7_1	3	9	PF00082	0.645
CLV_PCSK_PC7_1	543	549	PF00082	0.640
CLV_PCSK_SKI1_1	106	110	PF00082	0.548
CLV_PCSK_SKI1_1	247	251	PF00082	0.651
CLV_PCSK_SKI1_1	262	266	PF00082	0.619
CLV_PCSK_SKI1_1	296	300	PF00082	0.448
CLV_PCSK_SKI1_1	362	366	PF00082	0.610
CLV_PCSK_SKI1_1	460	464	PF00082	0.575
CLV_PCSK_SKI1_1	469	473	PF00082	0.515
CLV_PCSK_SKI1_1	560	564	PF00082	0.621
CLV_PCSK_SKI1_1	606	610	PF00082	0.542
CLV_PCSK_SKI1_1	8	12	PF00082	0.579
CLV_PCSK_SKI1_1	97	101	PF00082	0.615
DEG_APCC_DBOX_1	105	113	PF00400	0.440
DEG_APCC_DBOX_1	230	238	PF00400	0.437
DEG_APCC_DBOX_1	547	555	PF00400	0.332
DEG_APCC_DBOX_1	605	613	PF00400	0.328
DEG_APCC_DBOX_1	7	15	PF00400	0.494
DEG_SPOP_SBC_1	45	49	PF00917	0.569
DEG_SPOP_SBC_1	64	68	PF00917	0.478
DOC_CKS1_1	182	187	PF01111	0.464
DOC_CKS1_1	225	230	PF01111	0.454
DOC_CYCLIN_RxL_1	356	369	PF00134	0.424
DOC_MAPK_DCC_7	520	529	PF00069	0.397
DOC_MAPK_gen_1	356	365	PF00069	0.326
DOC_MAPK_MEF2A_6	356	365	PF00069	0.326
DOC_MAPK_MEF2A_6	451	459	PF00069	0.445
DOC_MAPK_MEF2A_6	520	529	PF00069	0.447
DOC_MAPK_RevD_3	522	538	PF00069	0.282
DOC_PP1_RVXF_1	360	366	PF00149	0.329
DOC_PP1_RVXF_1	531	537	PF00149	0.401
DOC_PP1_SILK_1	106	111	PF00149	0.263
DOC_PP2B_LxvP_1	287	290	PF13499	0.291
DOC_PP4_FxxP_1	221	224	PF00568	0.502
DOC_SPAK_OSR1_1	3	7	PF12202	0.449
DOC_USP7_MATH_1	104	108	PF00917	0.380
DOC_USP7_MATH_1	174	178	PF00917	0.327
DOC_USP7_MATH_1	200	204	PF00917	0.536
DOC_USP7_MATH_1	270	274	PF00917	0.419
DOC_USP7_MATH_1	41	45	PF00917	0.542
DOC_USP7_MATH_1	424	428	PF00917	0.477
DOC_USP7_MATH_1	430	434	PF00917	0.488
DOC_USP7_MATH_1	46	50	PF00917	0.511
DOC_USP7_MATH_1	493	497	PF00917	0.539
DOC_USP7_MATH_1	626	630	PF00917	0.451
DOC_USP7_MATH_1	69	73	PF00917	0.489
DOC_USP7_MATH_1	93	97	PF00917	0.490
DOC_USP7_UBL2_3	257	261	PF12436	0.453
DOC_USP7_UBL2_3	265	269	PF12436	0.489
DOC_USP7_UBL2_3	533	537	PF12436	0.496
DOC_USP7_UBL2_3	624	628	PF12436	0.375
DOC_WW_Pin1_4	123	128	PF00397	0.289
DOC_WW_Pin1_4	181	186	PF00397	0.456
DOC_WW_Pin1_4	224	229	PF00397	0.454
DOC_WW_Pin1_4	291	296	PF00397	0.211
DOC_WW_Pin1_4	313	318	PF00397	0.339
DOC_WW_Pin1_4	506	511	PF00397	0.495
LIG_14-3-3_CanoR_1	442	450	PF00244	0.333
LIG_14-3-3_CanoR_1	558	563	PF00244	0.375
LIG_APCC_ABBA_1	235	240	PF00400	0.523
LIG_APCC_ABBA_1	307	312	PF00400	0.237
LIG_BIR_II_1	1	5	PF00653	0.515
LIG_BIR_III_2	292	296	PF00653	0.211
LIG_BRCT_BRCA1_1	70	74	PF00533	0.483
LIG_EH1_1	3	11	PF00400	0.379
LIG_FHA_1	345	351	PF00498	0.394
LIG_FHA_1	584	590	PF00498	0.376
LIG_FHA_1	613	619	PF00498	0.377
LIG_FHA_2	391	397	PF00498	0.401
LIG_FHA_2	433	439	PF00498	0.467
LIG_FHA_2	559	565	PF00498	0.391
LIG_FHA_2	76	82	PF00498	0.394
LIG_GBD_Chelix_1	455	463	PF00786	0.631
LIG_HP1_1	127	131	PF01393	0.352
LIG_LIR_Apic_2	145	151	PF02991	0.400
LIG_LIR_Gen_1	176	187	PF02991	0.484
LIG_LIR_Gen_1	71	82	PF02991	0.506
LIG_LIR_Nem_3	176	182	PF02991	0.411
LIG_LIR_Nem_3	184	190	PF02991	0.417
LIG_LIR_Nem_3	280	286	PF02991	0.267
LIG_LIR_Nem_3	327	333	PF02991	0.277
LIG_LIR_Nem_3	478	482	PF02991	0.297
LIG_LIR_Nem_3	614	619	PF02991	0.325
LIG_LIR_Nem_3	71	77	PF02991	0.510
LIG_NRBOX	116	122	PF00104	0.217
LIG_PCNA_PIPBox_1	172	181	PF02747	0.369
LIG_Pex14_1	157	161	PF04695	0.274
LIG_Pex14_2	378	382	PF04695	0.485
LIG_Rb_pABgroove_1	587	595	PF01858	0.450
LIG_SH2_CRK	167	171	PF00017	0.328
LIG_SH2_CRK	179	183	PF00017	0.370
LIG_SH2_CRK	284	288	PF00017	0.248
LIG_SH2_CRK	330	334	PF00017	0.237
LIG_SH2_CRK	479	483	PF00017	0.340
LIG_SH2_CRK	574	578	PF00017	0.420
LIG_SH2_CRK	619	623	PF00017	0.386
LIG_SH2_NCK_1	167	171	PF00017	0.346
LIG_SH2_NCK_1	179	183	PF00017	0.388
LIG_SH2_NCK_1	238	242	PF00017	0.508
LIG_SH2_NCK_1	420	424	PF00017	0.417
LIG_SH2_NCK_1	574	578	PF00017	0.354
LIG_SH2_SRC	238	241	PF00017	0.502
LIG_SH2_SRC	420	423	PF00017	0.360
LIG_SH2_STAP1	179	183	PF00017	0.426
LIG_SH2_STAP1	420	424	PF00017	0.480
LIG_SH2_STAT3	593	596	PF00017	0.396
LIG_SH2_STAT3	641	644	PF00017	0.424
LIG_SH2_STAT5	188	191	PF00017	0.450
LIG_SH2_STAT5	392	395	PF00017	0.457
LIG_SH2_STAT5	416	419	PF00017	0.356
LIG_SH2_STAT5	535	538	PF00017	0.454
LIG_SH2_STAT5	553	556	PF00017	0.439
LIG_SH2_STAT5	574	577	PF00017	0.327
LIG_SH3_3	121	127	PF00018	0.417
LIG_SH3_3	179	185	PF00018	0.421
LIG_SH3_3	519	525	PF00018	0.516
LIG_SH3_3	592	598	PF00018	0.429
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.350
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.497
LIG_SUMO_SIM_par_1	129	134	PF11976	0.233
LIG_TRAF2_1	393	396	PF00917	0.426
LIG_TRAF2_1	576	579	PF00917	0.346
LIG_WRC_WIRS_1	379	384	PF05994	0.488
MOD_CDC14_SPxK_1	509	512	PF00782	0.457
MOD_CDK_SPK_2	291	296	PF00069	0.226
MOD_CDK_SPxK_1	506	512	PF00069	0.458
MOD_CDK_SPxxK_3	224	231	PF00069	0.411
MOD_CK1_1	142	148	PF00069	0.491
MOD_CK1_1	177	183	PF00069	0.493
MOD_CK1_1	2	8	PF00069	0.504
MOD_CK1_1	201	207	PF00069	0.516
MOD_CK1_1	380	386	PF00069	0.437
MOD_CK1_1	44	50	PF00069	0.512
MOD_CK1_1	627	633	PF00069	0.373
MOD_CK1_1	68	74	PF00069	0.523
MOD_CK2_1	390	396	PF00069	0.404
MOD_CK2_1	492	498	PF00069	0.455
MOD_CK2_1	573	579	PF00069	0.331
MOD_CK2_1	634	640	PF00069	0.427
MOD_CK2_1	646	652	PF00069	0.452
MOD_CK2_1	75	81	PF00069	0.400
MOD_GlcNHglycan	141	144	PF01048	0.405
MOD_GlcNHglycan	200	203	PF01048	0.721
MOD_GlcNHglycan	204	207	PF01048	0.714
MOD_GlcNHglycan	266	269	PF01048	0.700
MOD_GlcNHglycan	27	30	PF01048	0.709
MOD_GlcNHglycan	272	275	PF01048	0.657
MOD_GlcNHglycan	41	44	PF01048	0.606
MOD_GlcNHglycan	495	498	PF01048	0.741
MOD_GlcNHglycan	67	70	PF01048	0.774
MOD_GSK3_1	142	149	PF00069	0.566
MOD_GSK3_1	173	180	PF00069	0.438
MOD_GSK3_1	198	205	PF00069	0.541
MOD_GSK3_1	21	28	PF00069	0.560
MOD_GSK3_1	41	48	PF00069	0.515
MOD_GSK3_1	558	565	PF00069	0.375
MOD_GSK3_1	59	66	PF00069	0.491
MOD_N-GLC_1	302	307	PF02516	0.513
MOD_NEK2_1	344	349	PF00069	0.415
MOD_NEK2_1	378	383	PF00069	0.481
MOD_NEK2_1	562	567	PF00069	0.293
MOD_NEK2_1	580	585	PF00069	0.380
MOD_NEK2_1	59	64	PF00069	0.430
MOD_NEK2_1	612	617	PF00069	0.346
MOD_NEK2_1	634	639	PF00069	0.405
MOD_PIKK_1	562	568	PF00454	0.425
MOD_PKA_1	440	446	PF00069	0.439
MOD_PKA_1	491	497	PF00069	0.456
MOD_PKA_2	2	8	PF00069	0.642
MOD_PKA_2	324	330	PF00069	0.339
MOD_PKA_2	441	447	PF00069	0.383
MOD_PKA_2	491	497	PF00069	0.558
MOD_PKA_2	646	652	PF00069	0.534
MOD_PKB_1	137	145	PF00069	0.631
MOD_PKB_1	490	498	PF00069	0.393
MOD_Plk_1	302	308	PF00069	0.205
MOD_Plk_1	93	99	PF00069	0.528
MOD_Plk_4	174	180	PF00069	0.475
MOD_Plk_4	239	245	PF00069	0.514
MOD_Plk_4	302	308	PF00069	0.192
MOD_Plk_4	50	56	PF00069	0.462
MOD_Plk_4	612	618	PF00069	0.330
MOD_ProDKin_1	123	129	PF00069	0.289
MOD_ProDKin_1	181	187	PF00069	0.460
MOD_ProDKin_1	224	230	PF00069	0.453
MOD_ProDKin_1	291	297	PF00069	0.211
MOD_ProDKin_1	313	319	PF00069	0.339
MOD_ProDKin_1	506	512	PF00069	0.497
TRG_DiLeu_BaEn_4	395	401	PF01217	0.450
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.472
TRG_ENDOCYTIC_2	153	156	PF00928	0.372
TRG_ENDOCYTIC_2	167	170	PF00928	0.270
TRG_ENDOCYTIC_2	179	182	PF00928	0.366
TRG_ENDOCYTIC_2	187	190	PF00928	0.503
TRG_ENDOCYTIC_2	283	286	PF00928	0.238
TRG_ENDOCYTIC_2	330	333	PF00928	0.248
TRG_ENDOCYTIC_2	479	482	PF00928	0.311
TRG_ENDOCYTIC_2	485	488	PF00928	0.351
TRG_ENDOCYTIC_2	574	577	PF00928	0.327
TRG_ER_diArg_1	137	140	PF00400	0.610
TRG_ER_diArg_1	192	194	PF00400	0.519
TRG_ER_diArg_1	207	210	PF00400	0.527
TRG_ER_diArg_1	400	403	PF00400	0.384
TRG_ER_diArg_1	457	460	PF00400	0.419
TRG_ER_diArg_1	490	492	PF00400	0.462
TRG_ER_diArg_1	546	548	PF00400	0.356
TRG_ER_diArg_1	557	560	PF00400	0.415
TRG_ER_diArg_1	6	8	PF00400	0.524
TRG_ER_diArg_1	604	606	PF00400	0.351
TRG_ER_diArg_1	85	87	PF00400	0.419
TRG_ER_FFAT_2	176	184	PF00635	0.307
TRG_NES_CRM1_1	607	621	PF08389	0.354
TRG_NLS_Bipartite_1	250	266	PF00514	0.436
TRG_NLS_MonoCore_2	337	342	PF00514	0.300
TRG_NLS_MonoExtC_3	260	265	PF00514	0.531
TRG_NLS_MonoExtC_3	337	343	PF00514	0.304
TRG_NLS_MonoExtN_4	259	266	PF00514	0.528
TRG_NLS_MonoExtN_4	336	342	PF00514	0.288
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUL2	Leptomonas seymouri	64%	100%
A0A0S4JWY5	Bodo saltans	35%	100%
A0A1X0NS91	Trypanosomatidae	43%	100%
A0A3Q8ICT2	Leishmania donovani	90%	100%
A0A422N6M1	Trypanosoma rangeli	44%	100%
A4HEX5	Leishmania braziliensis	80%	100%
A4I249	Leishmania infantum	90%	100%
C9ZRV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4Q974	Leishmania major	90%	99%
V5BUD6	Trypanosoma cruzi	44%	100%