Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY97_LEIMU

TriTrypDb:

LmxM.26.1180

Length:

683

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AY97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY97

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.668
CLV_C14_Caspase3-7	241	245	PF00656	0.516
CLV_C14_Caspase3-7	445	449	PF00656	0.532
CLV_NRD_NRD_1	143	145	PF00675	0.645
CLV_NRD_NRD_1	195	197	PF00675	0.635
CLV_NRD_NRD_1	423	425	PF00675	0.594
CLV_NRD_NRD_1	432	434	PF00675	0.641
CLV_NRD_NRD_1	596	598	PF00675	0.641
CLV_PCSK_KEX2_1	142	144	PF00082	0.581
CLV_PCSK_KEX2_1	423	425	PF00082	0.586
CLV_PCSK_KEX2_1	432	434	PF00082	0.629
CLV_PCSK_KEX2_1	595	597	PF00082	0.671
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.596
CLV_PCSK_SKI1_1	376	380	PF00082	0.460
CLV_PCSK_SKI1_1	597	601	PF00082	0.556
CLV_PCSK_SKI1_1	650	654	PF00082	0.497
DEG_SCF_FBW7_2	40	45	PF00400	0.657
DEG_SPOP_SBC_1	90	94	PF00917	0.737
DOC_ANK_TNKS_1	464	471	PF00023	0.634
DOC_MAPK_FxFP_2	230	233	PF00069	0.506
DOC_MAPK_HePTP_8	522	534	PF00069	0.488
DOC_MAPK_MEF2A_6	296	303	PF00069	0.540
DOC_MAPK_MEF2A_6	525	534	PF00069	0.491
DOC_MAPK_MEF2A_6	77	84	PF00069	0.668
DOC_MAPK_NFAT4_5	77	85	PF00069	0.600
DOC_PP1_RVXF_1	71	77	PF00149	0.649
DOC_PP2B_LxvP_1	652	655	PF13499	0.656
DOC_PP4_FxxP_1	230	233	PF00568	0.506
DOC_PP4_FxxP_1	466	469	PF00568	0.588
DOC_SPAK_OSR1_1	465	469	PF12202	0.605
DOC_USP7_MATH_1	12	16	PF00917	0.737
DOC_USP7_MATH_1	162	166	PF00917	0.611
DOC_USP7_MATH_1	173	177	PF00917	0.497
DOC_USP7_MATH_1	184	188	PF00917	0.564
DOC_USP7_MATH_1	192	196	PF00917	0.505
DOC_USP7_MATH_1	245	249	PF00917	0.725
DOC_USP7_MATH_1	292	296	PF00917	0.569
DOC_USP7_MATH_1	334	338	PF00917	0.702
DOC_USP7_MATH_1	399	403	PF00917	0.636
DOC_USP7_MATH_1	469	473	PF00917	0.584
DOC_USP7_MATH_1	575	579	PF00917	0.615
DOC_USP7_MATH_1	586	590	PF00917	0.557
DOC_USP7_MATH_1	89	93	PF00917	0.728
DOC_WW_Pin1_4	136	141	PF00397	0.720
DOC_WW_Pin1_4	326	331	PF00397	0.584
DOC_WW_Pin1_4	38	43	PF00397	0.672
DOC_WW_Pin1_4	8	13	PF00397	0.609
DOC_WW_Pin1_4	97	102	PF00397	0.640
LIG_14-3-3_CanoR_1	196	202	PF00244	0.653
LIG_14-3-3_CanoR_1	319	327	PF00244	0.505
LIG_14-3-3_CanoR_1	345	353	PF00244	0.511
LIG_14-3-3_CanoR_1	376	382	PF00244	0.323
LIG_14-3-3_CanoR_1	424	434	PF00244	0.605
LIG_14-3-3_CanoR_1	650	655	PF00244	0.546
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_BIR_III_4	69	73	PF00653	0.471
LIG_BRCT_BRCA1_1	209	213	PF00533	0.659
LIG_BRCT_BRCA1_1	53	57	PF00533	0.719
LIG_CaM_NSCaTE_8	148	155	PF13499	0.632
LIG_FHA_1	248	254	PF00498	0.640
LIG_FHA_1	321	327	PF00498	0.516
LIG_FHA_1	352	358	PF00498	0.475
LIG_FHA_1	402	408	PF00498	0.477
LIG_FHA_1	426	432	PF00498	0.623
LIG_FHA_1	495	501	PF00498	0.532
LIG_FHA_1	513	519	PF00498	0.428
LIG_FHA_2	333	339	PF00498	0.707
LIG_GBD_Chelix_1	549	557	PF00786	0.436
LIG_LIR_Apic_2	134	140	PF02991	0.731
LIG_LIR_Gen_1	35	43	PF02991	0.662
LIG_LIR_Gen_1	542	553	PF02991	0.494
LIG_LIR_Nem_3	176	182	PF02991	0.529
LIG_LIR_Nem_3	35	40	PF02991	0.647
LIG_LIR_Nem_3	367	372	PF02991	0.399
LIG_LIR_Nem_3	542	548	PF02991	0.479
LIG_LYPXL_S_1	226	230	PF13949	0.570
LIG_MYND_1	224	228	PF01753	0.558
LIG_NRBOX	552	558	PF00104	0.430
LIG_PALB2_WD40_1	144	152	PF16756	0.655
LIG_Pex14_2	57	61	PF04695	0.688
LIG_PTB_Apo_2	626	633	PF02174	0.560
LIG_SH2_CRK	137	141	PF00017	0.720
LIG_SH2_CRK	179	183	PF00017	0.585
LIG_SH2_CRK	372	376	PF00017	0.375
LIG_SH2_CRK	545	549	PF00017	0.486
LIG_SH2_GRB2like	238	241	PF00017	0.376
LIG_SH2_NCK_1	396	400	PF00017	0.672
LIG_SH2_NCK_1	88	92	PF00017	0.682
LIG_SH2_SRC	372	375	PF00017	0.471
LIG_SH2_SRC	533	536	PF00017	0.473
LIG_SH2_STAP1	115	119	PF00017	0.674
LIG_SH2_STAP1	545	549	PF00017	0.422
LIG_SH2_STAT3	256	259	PF00017	0.718
LIG_SH2_STAT5	151	154	PF00017	0.657
LIG_SH2_STAT5	238	241	PF00017	0.568
LIG_SH2_STAT5	256	259	PF00017	0.623
LIG_SH2_STAT5	533	536	PF00017	0.473
LIG_SH2_STAT5	664	667	PF00017	0.694
LIG_SH3_3	129	135	PF00018	0.516
LIG_SH3_3	209	215	PF00018	0.631
LIG_SH3_3	383	389	PF00018	0.485
LIG_SH3_3	555	561	PF00018	0.416
LIG_SH3_3	571	577	PF00018	0.505
LIG_SH3_3	628	634	PF00018	0.570
LIG_SUMO_SIM_anti_2	484	491	PF11976	0.423
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.566
LIG_SUMO_SIM_par_1	95	106	PF11976	0.713
LIG_TRAF2_1	16	19	PF00917	0.696
LIG_TRAF2_1	283	286	PF00917	0.795
LIG_TRAF2_1	295	298	PF00917	0.539
LIG_TRAF2_1	577	580	PF00917	0.682
LIG_TYR_ITIM	543	548	PF00017	0.479
MOD_CDC14_SPxK_1	139	142	PF00782	0.704
MOD_CDK_SPxK_1	136	142	PF00069	0.719
MOD_CDK_SPxxK_3	136	143	PF00069	0.716
MOD_CK1_1	166	172	PF00069	0.581
MOD_CK1_1	200	206	PF00069	0.708
MOD_CK1_1	208	214	PF00069	0.655
MOD_CK1_1	337	343	PF00069	0.775
MOD_CK1_1	523	529	PF00069	0.427
MOD_CK1_1	92	98	PF00069	0.768
MOD_CK2_1	12	18	PF00069	0.699
MOD_CK2_1	287	293	PF00069	0.684
MOD_CK2_1	332	338	PF00069	0.723
MOD_CK2_1	523	529	PF00069	0.418
MOD_CK2_1	97	103	PF00069	0.780
MOD_Cter_Amidation	593	596	PF01082	0.478
MOD_GlcNHglycan	1	4	PF01048	0.697
MOD_GlcNHglycan	166	169	PF01048	0.672
MOD_GlcNHglycan	207	210	PF01048	0.657
MOD_GlcNHglycan	241	244	PF01048	0.675
MOD_GlcNHglycan	288	293	PF01048	0.674
MOD_GlcNHglycan	338	342	PF01048	0.525
MOD_GlcNHglycan	366	369	PF01048	0.478
MOD_GlcNHglycan	401	404	PF01048	0.653
MOD_GlcNHglycan	407	410	PF01048	0.720
MOD_GlcNHglycan	415	418	PF01048	0.627
MOD_GlcNHglycan	448	451	PF01048	0.710
MOD_GlcNHglycan	471	474	PF01048	0.603
MOD_GlcNHglycan	561	564	PF01048	0.505
MOD_GlcNHglycan	622	625	PF01048	0.633
MOD_GSK3_1	122	129	PF00069	0.670
MOD_GSK3_1	162	169	PF00069	0.600
MOD_GSK3_1	199	206	PF00069	0.750
MOD_GSK3_1	232	239	PF00069	0.560
MOD_GSK3_1	243	250	PF00069	0.710
MOD_GSK3_1	288	295	PF00069	0.579
MOD_GSK3_1	313	320	PF00069	0.457
MOD_GSK3_1	333	340	PF00069	0.658
MOD_GSK3_1	401	408	PF00069	0.641
MOD_GSK3_1	8	15	PF00069	0.612
MOD_GSK3_1	89	96	PF00069	0.687
MOD_N-GLC_1	13	18	PF02516	0.748
MOD_N-GLC_1	239	244	PF02516	0.415
MOD_NEK2_1	204	209	PF00069	0.725
MOD_NEK2_1	317	322	PF00069	0.432
MOD_NEK2_2	377	382	PF00069	0.317
MOD_OFUCOSY	377	384	PF10250	0.491
MOD_PIKK_1	425	431	PF00454	0.667
MOD_PK_1	520	526	PF00069	0.492
MOD_PKA_2	575	581	PF00069	0.689
MOD_Plk_1	337	343	PF00069	0.678
MOD_Plk_1	358	364	PF00069	0.272
MOD_Plk_2-3	260	266	PF00069	0.597
MOD_Plk_4	208	214	PF00069	0.659
MOD_Plk_4	358	364	PF00069	0.272
MOD_Plk_4	514	520	PF00069	0.506
MOD_Plk_4	544	550	PF00069	0.424
MOD_ProDKin_1	136	142	PF00069	0.716
MOD_ProDKin_1	326	332	PF00069	0.597
MOD_ProDKin_1	38	44	PF00069	0.667
MOD_ProDKin_1	8	14	PF00069	0.612
MOD_ProDKin_1	97	103	PF00069	0.692
TRG_DiLeu_BaEn_1	78	83	PF01217	0.608
TRG_ENDOCYTIC_2	179	182	PF00928	0.586
TRG_ENDOCYTIC_2	227	230	PF00928	0.559
TRG_ENDOCYTIC_2	545	548	PF00928	0.488
TRG_ER_diArg_1	143	145	PF00400	0.617
TRG_ER_diArg_1	431	433	PF00400	0.635
TRG_ER_diArg_1	595	597	PF00400	0.693
TRG_NLS_MonoExtN_4	140	146	PF00514	0.700
TRG_Pf-PMV_PEXEL_1	525	529	PF00026	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I055	Leptomonas seymouri	50%	98%
A0A1X0NTQ8	Trypanosomatidae	24%	100%
A0A3Q8IH11	Leishmania donovani	89%	100%
A4HEX3	Leishmania braziliensis	75%	100%
A4I247	Leishmania infantum	89%	100%
C9ZRV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4Q976	Leishmania major	92%	100%