RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AY96_LEIMU

TriTrypDb:

LmxM.26.1170

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY96

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.677
CLV_C14_Caspase3-7	413	417	PF00656	0.524
CLV_NRD_NRD_1	229	231	PF00675	0.639
CLV_NRD_NRD_1	401	403	PF00675	0.502
CLV_NRD_NRD_1	428	430	PF00675	0.470
CLV_NRD_NRD_1	456	458	PF00675	0.459
CLV_NRD_NRD_1	463	465	PF00675	0.517
CLV_NRD_NRD_1	504	506	PF00675	0.849
CLV_PCSK_FUR_1	399	403	PF00082	0.499
CLV_PCSK_KEX2_1	224	226	PF00082	0.630
CLV_PCSK_KEX2_1	231	233	PF00082	0.639
CLV_PCSK_KEX2_1	399	401	PF00082	0.493
CLV_PCSK_KEX2_1	428	430	PF00082	0.470
CLV_PCSK_KEX2_1	456	458	PF00082	0.448
CLV_PCSK_KEX2_1	504	506	PF00082	0.854
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.630
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.639
CLV_PCSK_SKI1_1	393	397	PF00082	0.514
CLV_PCSK_SKI1_1	402	406	PF00082	0.457
DEG_APCC_DBOX_1	401	409	PF00400	0.495
DEG_Nend_Nbox_1	1	3	PF02207	0.568
DEG_SPOP_SBC_1	141	145	PF00917	0.740
DEG_SPOP_SBC_1	437	441	PF00917	0.520
DOC_ANK_TNKS_1	271	278	PF00023	0.689
DOC_MAPK_gen_1	221	229	PF00069	0.485
DOC_MAPK_gen_1	399	408	PF00069	0.507
DOC_MAPK_gen_1	423	432	PF00069	0.598
DOC_MAPK_MEF2A_6	399	408	PF00069	0.484
DOC_PP2B_LxvP_1	23	26	PF13499	0.647
DOC_PP2B_LxvP_1	292	295	PF13499	0.687
DOC_PP2B_LxvP_1	406	409	PF13499	0.518
DOC_PP2B_LxvP_1	498	501	PF13499	0.697
DOC_USP7_MATH_1	141	145	PF00917	0.784
DOC_USP7_MATH_1	206	210	PF00917	0.627
DOC_USP7_MATH_1	267	271	PF00917	0.595
DOC_USP7_MATH_1	281	285	PF00917	0.617
DOC_USP7_MATH_1	31	35	PF00917	0.611
DOC_USP7_MATH_1	318	322	PF00917	0.766
DOC_USP7_MATH_1	417	421	PF00917	0.498
DOC_USP7_MATH_1	437	441	PF00917	0.527
DOC_USP7_MATH_1	487	491	PF00917	0.698
DOC_USP7_MATH_2	106	112	PF00917	0.574
DOC_USP7_UBL2_3	461	465	PF12436	0.480
DOC_WW_Pin1_4	262	267	PF00397	0.771
DOC_WW_Pin1_4	29	34	PF00397	0.661
DOC_WW_Pin1_4	314	319	PF00397	0.735
DOC_WW_Pin1_4	55	60	PF00397	0.656
DOC_WW_Pin1_4	99	104	PF00397	0.740
LIG_14-3-3_CanoR_1	199	203	PF00244	0.712
LIG_14-3-3_CanoR_1	225	230	PF00244	0.488
LIG_14-3-3_CanoR_1	358	364	PF00244	0.460
LIG_14-3-3_CanoR_1	393	398	PF00244	0.582
LIG_14-3-3_CanoR_1	435	445	PF00244	0.571
LIG_14-3-3_CanoR_1	456	463	PF00244	0.586
LIG_AP2alpha_2	92	94	PF02296	0.584
LIG_BIR_III_2	416	420	PF00653	0.493
LIG_CSL_BTD_1	93	96	PF09270	0.518
LIG_EVH1_1	498	502	PF00568	0.621
LIG_FHA_1	294	300	PF00498	0.631
LIG_FHA_1	36	42	PF00498	0.716
LIG_FHA_1	392	398	PF00498	0.583
LIG_FHA_1	440	446	PF00498	0.470
LIG_LIR_Gen_1	349	357	PF02991	0.589
LIG_LIR_Nem_3	349	355	PF02991	0.591
LIG_Pex14_2	77	81	PF04695	0.581
LIG_SH2_SRC	172	175	PF00017	0.514
LIG_SH2_STAP1	352	356	PF00017	0.461
LIG_SH2_STAT3	21	24	PF00017	0.473
LIG_SH2_STAT5	163	166	PF00017	0.517
LIG_SH2_STAT5	247	250	PF00017	0.533
LIG_SH3_1	56	62	PF00018	0.533
LIG_SH3_2	499	504	PF14604	0.604
LIG_SH3_3	120	126	PF00018	0.597
LIG_SH3_3	150	156	PF00018	0.452
LIG_SH3_3	173	179	PF00018	0.427
LIG_SH3_3	24	30	PF00018	0.650
LIG_SH3_3	260	266	PF00018	0.651
LIG_SH3_3	272	278	PF00018	0.642
LIG_SH3_3	38	44	PF00018	0.590
LIG_SH3_3	496	502	PF00018	0.654
LIG_SH3_3	56	62	PF00018	0.654
LIG_SH3_3	90	96	PF00018	0.592
LIG_SH3_3	97	103	PF00018	0.647
LIG_SUMO_SIM_anti_2	335	342	PF11976	0.606
LIG_SUMO_SIM_anti_2	97	102	PF11976	0.680
LIG_SUMO_SIM_par_1	295	302	PF11976	0.632
LIG_TRFH_1	21	25	PF08558	0.619
LIG_UBA3_1	405	412	PF00899	0.605
MOD_CK1_1	102	108	PF00069	0.600
MOD_CK1_1	137	143	PF00069	0.670
MOD_CK1_1	210	216	PF00069	0.707
MOD_CK1_1	265	271	PF00069	0.734
MOD_CK1_1	293	299	PF00069	0.602
MOD_CK1_1	317	323	PF00069	0.626
MOD_CK1_1	32	38	PF00069	0.649
MOD_CK1_1	386	392	PF00069	0.577
MOD_CK1_1	439	445	PF00069	0.568
MOD_CK1_1	46	52	PF00069	0.739
MOD_CK1_1	55	61	PF00069	0.673
MOD_CK1_1	68	74	PF00069	0.565
MOD_CK1_1	88	94	PF00069	0.670
MOD_CK2_1	102	108	PF00069	0.744
MOD_CK2_1	141	147	PF00069	0.747
MOD_CK2_1	285	291	PF00069	0.764
MOD_CK2_1	386	392	PF00069	0.523
MOD_CK2_1	408	414	PF00069	0.635
MOD_CK2_1	464	470	PF00069	0.599
MOD_DYRK1A_RPxSP_1	29	33	PF00069	0.659
MOD_GlcNHglycan	112	115	PF01048	0.636
MOD_GlcNHglycan	127	130	PF01048	0.730
MOD_GlcNHglycan	136	139	PF01048	0.668
MOD_GlcNHglycan	186	189	PF01048	0.549
MOD_GlcNHglycan	209	212	PF01048	0.717
MOD_GlcNHglycan	287	290	PF01048	0.761
MOD_GlcNHglycan	291	295	PF01048	0.694
MOD_GlcNHglycan	324	327	PF01048	0.732
MOD_GlcNHglycan	35	38	PF01048	0.625
MOD_GlcNHglycan	419	422	PF01048	0.678
MOD_GlcNHglycan	45	48	PF01048	0.683
MOD_GlcNHglycan	470	473	PF01048	0.604
MOD_GlcNHglycan	489	492	PF01048	0.596
MOD_GlcNHglycan	52	55	PF01048	0.754
MOD_GlcNHglycan	65	68	PF01048	0.703
MOD_GlcNHglycan	70	73	PF01048	0.507
MOD_GSK3_1	110	117	PF00069	0.677
MOD_GSK3_1	137	144	PF00069	0.778
MOD_GSK3_1	206	213	PF00069	0.600
MOD_GSK3_1	25	32	PF00069	0.656
MOD_GSK3_1	281	288	PF00069	0.689
MOD_GSK3_1	314	321	PF00069	0.715
MOD_GSK3_1	43	50	PF00069	0.706
MOD_GSK3_1	433	440	PF00069	0.587
MOD_GSK3_1	464	471	PF00069	0.609
MOD_GSK3_1	481	488	PF00069	0.769
MOD_N-GLC_1	132	137	PF02516	0.671
MOD_N-GLC_1	68	73	PF02516	0.623
MOD_NEK2_1	134	139	PF00069	0.765
MOD_NEK2_1	198	203	PF00069	0.668
MOD_NEK2_1	285	290	PF00069	0.559
MOD_NEK2_1	356	361	PF00069	0.461
MOD_NEK2_1	377	382	PF00069	0.479
MOD_NEK2_1	391	396	PF00069	0.470
MOD_NEK2_1	438	443	PF00069	0.510
MOD_NEK2_1	63	68	PF00069	0.767
MOD_NEK2_1	77	82	PF00069	0.580
MOD_PIKK_1	267	273	PF00454	0.727
MOD_PIKK_1	283	289	PF00454	0.699
MOD_PIKK_1	311	317	PF00454	0.754
MOD_PIKK_1	346	352	PF00454	0.548
MOD_PIKK_1	377	383	PF00454	0.465
MOD_PK_1	225	231	PF00069	0.491
MOD_PKA_1	456	462	PF00069	0.567
MOD_PKA_1	464	470	PF00069	0.523
MOD_PKA_2	198	204	PF00069	0.586
MOD_PKA_2	357	363	PF00069	0.456
MOD_PKA_2	456	462	PF00069	0.586
MOD_Plk_1	336	342	PF00069	0.643
MOD_Plk_1	391	397	PF00069	0.584
MOD_Plk_2-3	142	148	PF00069	0.642
MOD_Plk_4	198	204	PF00069	0.660
MOD_Plk_4	293	299	PF00069	0.515
MOD_ProDKin_1	262	268	PF00069	0.768
MOD_ProDKin_1	29	35	PF00069	0.662
MOD_ProDKin_1	314	320	PF00069	0.736
MOD_ProDKin_1	55	61	PF00069	0.656
MOD_ProDKin_1	99	105	PF00069	0.739
MOD_SUMO_rev_2	220	226	PF00179	0.512
TRG_ENDOCYTIC_2	352	355	PF00928	0.468
TRG_ER_diArg_1	229	232	PF00400	0.667
TRG_ER_diArg_1	399	402	PF00400	0.499
TRG_ER_diArg_1	427	429	PF00400	0.480
TRG_ER_diArg_1	455	457	PF00400	0.458
TRG_NES_CRM1_1	422	433	PF08389	0.599
TRG_NLS_MonoExtC_3	229	234	PF00514	0.631
TRG_NLS_MonoExtN_4	230	235	PF00514	0.626
TRG_Pf-PMV_PEXEL_1	428	433	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J9	Leptomonas seymouri	48%	97%
A0A3S7WZT2	Leishmania donovani	88%	100%
A4HEX2	Leishmania braziliensis	68%	98%
A4I246	Leishmania infantum	88%	100%
Q4Q977	Leishmania major	86%	99%