PseudoU_synth_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase, putative

Species:

Leishmania mexicana

UniProt:

E9AY95_LEIMU

TriTrypDb:

LmxM.26.1160

Length:

969

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY95

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0009982	pseudouridine synthase activity	4	7
GO:0016853	isomerase activity	2	7
GO:0016866	intramolecular transferase activity	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.701
CLV_C14_Caspase3-7	434	438	PF00656	0.712
CLV_NRD_NRD_1	129	131	PF00675	0.598
CLV_NRD_NRD_1	177	179	PF00675	0.660
CLV_NRD_NRD_1	182	184	PF00675	0.623
CLV_NRD_NRD_1	390	392	PF00675	0.471
CLV_NRD_NRD_1	407	409	PF00675	0.491
CLV_NRD_NRD_1	5	7	PF00675	0.673
CLV_NRD_NRD_1	645	647	PF00675	0.434
CLV_NRD_NRD_1	66	68	PF00675	0.410
CLV_NRD_NRD_1	766	768	PF00675	0.843
CLV_NRD_NRD_1	87	89	PF00675	0.395
CLV_PCSK_KEX2_1	129	131	PF00082	0.628
CLV_PCSK_KEX2_1	133	135	PF00082	0.619
CLV_PCSK_KEX2_1	177	179	PF00082	0.658
CLV_PCSK_KEX2_1	182	184	PF00082	0.621
CLV_PCSK_KEX2_1	271	273	PF00082	0.292
CLV_PCSK_KEX2_1	383	385	PF00082	0.292
CLV_PCSK_KEX2_1	406	408	PF00082	0.644
CLV_PCSK_KEX2_1	5	7	PF00082	0.673
CLV_PCSK_KEX2_1	645	647	PF00082	0.434
CLV_PCSK_KEX2_1	66	68	PF00082	0.410
CLV_PCSK_KEX2_1	685	687	PF00082	0.542
CLV_PCSK_KEX2_1	766	768	PF00082	0.779
CLV_PCSK_KEX2_1	788	790	PF00082	0.637
CLV_PCSK_KEX2_1	87	89	PF00082	0.477
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.535
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.376
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.236
CLV_PCSK_PC1ET2_1	685	687	PF00082	0.542
CLV_PCSK_PC1ET2_1	788	790	PF00082	0.637
CLV_PCSK_PC7_1	129	135	PF00082	0.648
CLV_PCSK_PC7_1	178	184	PF00082	0.657
CLV_PCSK_PC7_1	83	89	PF00082	0.485
CLV_PCSK_SKI1_1	119	123	PF00082	0.509
CLV_PCSK_SKI1_1	129	133	PF00082	0.584
CLV_PCSK_SKI1_1	391	395	PF00082	0.594
CLV_PCSK_SKI1_1	51	55	PF00082	0.593
CLV_PCSK_SKI1_1	564	568	PF00082	0.548
CLV_PCSK_SKI1_1	771	775	PF00082	0.716
CLV_PCSK_SKI1_1	785	789	PF00082	0.693
CLV_PCSK_SKI1_1	87	91	PF00082	0.398
CLV_PCSK_SKI1_1	883	887	PF00082	0.576
CLV_Separin_Metazoa	403	407	PF03568	0.608
DEG_APCC_DBOX_1	234	242	PF00400	0.214
DEG_APCC_DBOX_1	563	571	PF00400	0.499
DEG_APCC_DBOX_1	644	652	PF00400	0.507
DEG_ODPH_VHL_1	268	279	PF01847	0.576
DEG_SCF_FBW7_2	423	428	PF00400	0.781
DEG_SIAH_1	673	681	PF03145	0.559
DEG_SPOP_SBC_1	163	167	PF00917	0.646
DEG_SPOP_SBC_1	447	451	PF00917	0.679
DEG_SPOP_SBC_1	697	701	PF00917	0.518
DEG_SPOP_SBC_1	819	823	PF00917	0.740
DOC_CKS1_1	160	165	PF01111	0.569
DOC_CKS1_1	499	504	PF01111	0.715
DOC_CKS1_1	633	638	PF01111	0.551
DOC_CYCLIN_RxL_1	125	135	PF00134	0.550
DOC_CYCLIN_RxL_1	81	91	PF00134	0.405
DOC_MAPK_gen_1	271	279	PF00069	0.576
DOC_MAPK_gen_1	364	374	PF00069	0.492
DOC_MAPK_gen_1	722	730	PF00069	0.586
DOC_MAPK_gen_1	811	818	PF00069	0.518
DOC_MAPK_MEF2A_6	211	220	PF00069	0.438
DOC_PP4_FxxP_1	516	519	PF00568	0.480
DOC_PP4_FxxP_1	959	962	PF00568	0.450
DOC_USP7_MATH_1	156	160	PF00917	0.732
DOC_USP7_MATH_1	189	193	PF00917	0.583
DOC_USP7_MATH_1	286	290	PF00917	0.405
DOC_USP7_MATH_1	411	415	PF00917	0.703
DOC_USP7_MATH_1	433	437	PF00917	0.630
DOC_USP7_MATH_1	447	451	PF00917	0.586
DOC_USP7_MATH_1	49	53	PF00917	0.525
DOC_USP7_MATH_1	508	512	PF00917	0.586
DOC_USP7_MATH_1	537	541	PF00917	0.557
DOC_USP7_MATH_1	662	666	PF00917	0.560
DOC_USP7_MATH_1	697	701	PF00917	0.640
DOC_USP7_MATH_1	762	766	PF00917	0.817
DOC_USP7_MATH_1	817	821	PF00917	0.679
DOC_USP7_MATH_1	921	925	PF00917	0.676
DOC_USP7_UBL2_3	784	788	PF12436	0.659
DOC_WW_Pin1_4	135	140	PF00397	0.520
DOC_WW_Pin1_4	159	164	PF00397	0.772
DOC_WW_Pin1_4	183	188	PF00397	0.643
DOC_WW_Pin1_4	20	25	PF00397	0.513
DOC_WW_Pin1_4	291	296	PF00397	0.545
DOC_WW_Pin1_4	421	426	PF00397	0.773
DOC_WW_Pin1_4	429	434	PF00397	0.672
DOC_WW_Pin1_4	448	453	PF00397	0.642
DOC_WW_Pin1_4	45	50	PF00397	0.534
DOC_WW_Pin1_4	498	503	PF00397	0.759
DOC_WW_Pin1_4	506	511	PF00397	0.684
DOC_WW_Pin1_4	632	637	PF00397	0.541
DOC_WW_Pin1_4	670	675	PF00397	0.672
DOC_WW_Pin1_4	760	765	PF00397	0.783
DOC_WW_Pin1_4	901	906	PF00397	0.639
DOC_WW_Pin1_4	915	920	PF00397	0.515
DOC_WW_Pin1_4	923	928	PF00397	0.640
DOC_WW_Pin1_4	98	103	PF00397	0.475
LIG_14-3-3_CanoR_1	446	452	PF00244	0.534
LIG_14-3-3_CanoR_1	461	469	PF00244	0.518
LIG_14-3-3_CanoR_1	771	776	PF00244	0.767
LIG_14-3-3_CanoR_1	789	794	PF00244	0.602
LIG_14-3-3_CanoR_1	899	905	PF00244	0.509
LIG_APCC_ABBA_1	90	95	PF00400	0.404
LIG_APCC_ABBAyCdc20_2	725	731	PF00400	0.604
LIG_BIR_III_4	776	780	PF00653	0.697
LIG_FHA_1	164	170	PF00498	0.535
LIG_FHA_1	259	265	PF00498	0.492
LIG_FHA_1	288	294	PF00498	0.492
LIG_FHA_1	30	36	PF00498	0.509
LIG_FHA_1	367	373	PF00498	0.492
LIG_FHA_1	399	405	PF00498	0.520
LIG_FHA_1	464	470	PF00498	0.512
LIG_FHA_1	480	486	PF00498	0.642
LIG_FHA_1	576	582	PF00498	0.589
LIG_FHA_1	60	66	PF00498	0.594
LIG_FHA_1	636	642	PF00498	0.630
LIG_FHA_1	688	694	PF00498	0.553
LIG_FHA_1	75	81	PF00498	0.339
LIG_FHA_1	819	825	PF00498	0.682
LIG_FHA_1	868	874	PF00498	0.669
LIG_FHA_1	902	908	PF00498	0.528
LIG_FHA_2	40	46	PF00498	0.598
LIG_FHA_2	488	494	PF00498	0.665
LIG_FHA_2	7	13	PF00498	0.647
LIG_FHA_2	747	753	PF00498	0.460
LIG_FHA_2	802	808	PF00498	0.622
LIG_LIR_Apic_2	157	163	PF02991	0.707
LIG_LIR_Apic_2	18	24	PF02991	0.512
LIG_LIR_Gen_1	203	214	PF02991	0.419
LIG_LIR_Gen_1	726	735	PF02991	0.608
LIG_LIR_Gen_1	73	80	PF02991	0.395
LIG_LIR_Gen_1	953	964	PF02991	0.395
LIG_LIR_Nem_3	203	209	PF02991	0.402
LIG_LIR_Nem_3	300	305	PF02991	0.491
LIG_LIR_Nem_3	726	730	PF02991	0.628
LIG_LIR_Nem_3	73	79	PF02991	0.399
LIG_LIR_Nem_3	953	959	PF02991	0.392
LIG_NRBOX	259	265	PF00104	0.576
LIG_NRBOX	596	602	PF00104	0.664
LIG_NRP_CendR_1	968	969	PF00754	0.662
LIG_SH2_CRK	160	164	PF00017	0.710
LIG_SH2_CRK	206	210	PF00017	0.416
LIG_SH2_CRK	236	240	PF00017	0.335
LIG_SH2_CRK	257	261	PF00017	0.492
LIG_SH2_CRK	305	309	PF00017	0.476
LIG_SH2_GRB2like	256	259	PF00017	0.576
LIG_SH2_NCK_1	160	164	PF00017	0.710
LIG_SH2_NCK_1	305	309	PF00017	0.530
LIG_SH2_NCK_1	852	856	PF00017	0.570
LIG_SH2_SRC	305	308	PF00017	0.576
LIG_SH2_STAP1	105	109	PF00017	0.403
LIG_SH2_STAP1	302	306	PF00017	0.576
LIG_SH2_STAP1	72	76	PF00017	0.488
LIG_SH2_STAP1	93	97	PF00017	0.430
LIG_SH2_STAT3	115	118	PF00017	0.502
LIG_SH2_STAT3	41	44	PF00017	0.481
LIG_SH2_STAT3	467	470	PF00017	0.542
LIG_SH2_STAT5	115	118	PF00017	0.502
LIG_SH2_STAT5	160	163	PF00017	0.712
LIG_SH2_STAT5	266	269	PF00017	0.541
LIG_SH2_STAT5	335	338	PF00017	0.530
LIG_SH2_STAT5	41	44	PF00017	0.481
LIG_SH2_STAT5	473	476	PF00017	0.539
LIG_SH2_STAT5	538	541	PF00017	0.638
LIG_SH2_STAT5	637	640	PF00017	0.586
LIG_SH2_STAT5	742	745	PF00017	0.664
LIG_SH3_1	305	311	PF00018	0.530
LIG_SH3_1	33	39	PF00018	0.580
LIG_SH3_2	308	313	PF14604	0.530
LIG_SH3_2	680	685	PF14604	0.558
LIG_SH3_3	238	244	PF00018	0.576
LIG_SH3_3	264	270	PF00018	0.492
LIG_SH3_3	276	282	PF00018	0.492
LIG_SH3_3	305	311	PF00018	0.553
LIG_SH3_3	315	321	PF00018	0.502
LIG_SH3_3	33	39	PF00018	0.502
LIG_SH3_3	355	361	PF00018	0.576
LIG_SH3_3	43	49	PF00018	0.542
LIG_SH3_3	449	455	PF00018	0.585
LIG_SH3_3	499	505	PF00018	0.777
LIG_SH3_3	507	513	PF00018	0.750
LIG_SH3_3	576	582	PF00018	0.710
LIG_SH3_3	677	683	PF00018	0.655
LIG_Sin3_3	223	230	PF02671	0.442
LIG_SUMO_SIM_anti_2	369	376	PF11976	0.492
LIG_TRAF2_1	42	45	PF00917	0.559
LIG_TRFH_1	266	270	PF08558	0.335
LIG_TYR_ITIM	204	209	PF00017	0.403
MOD_CDC14_SPxK_1	48	51	PF00782	0.594
MOD_CDC14_SPxK_1	763	766	PF00782	0.714
MOD_CDK_SPxK_1	45	51	PF00069	0.582
MOD_CDK_SPxK_1	760	766	PF00069	0.719
MOD_CDK_SPxxK_3	20	27	PF00069	0.515
MOD_CDK_SPxxK_3	291	298	PF00069	0.389
MOD_CDK_SPxxK_3	760	767	PF00069	0.783
MOD_CK1_1	135	141	PF00069	0.544
MOD_CK1_1	158	164	PF00069	0.734
MOD_CK1_1	259	265	PF00069	0.389
MOD_CK1_1	328	334	PF00069	0.343
MOD_CK1_1	665	671	PF00069	0.524
MOD_CK1_1	672	678	PF00069	0.544
MOD_CK1_1	765	771	PF00069	0.605
MOD_CK1_1	820	826	PF00069	0.588
MOD_CK2_1	189	195	PF00069	0.591
MOD_CK2_1	259	265	PF00069	0.389
MOD_CK2_1	291	297	PF00069	0.335
MOD_CK2_1	39	45	PF00069	0.583
MOD_CK2_1	462	468	PF00069	0.653
MOD_CK2_1	487	493	PF00069	0.675
MOD_CK2_1	6	12	PF00069	0.656
MOD_CK2_1	622	628	PF00069	0.665
MOD_CK2_1	746	752	PF00069	0.528
MOD_CK2_1	900	906	PF00069	0.502
MOD_Cter_Amidation	85	88	PF01082	0.411
MOD_DYRK1A_RPxSP_1	183	187	PF00069	0.649
MOD_GlcNHglycan	134	137	PF01048	0.521
MOD_GlcNHglycan	150	153	PF01048	0.594
MOD_GlcNHglycan	169	172	PF01048	0.556
MOD_GlcNHglycan	327	331	PF01048	0.473
MOD_GlcNHglycan	341	345	PF01048	0.276
MOD_GlcNHglycan	369	372	PF01048	0.335
MOD_GlcNHglycan	50	54	PF01048	0.564
MOD_GlcNHglycan	544	547	PF01048	0.578
MOD_GlcNHglycan	564	567	PF01048	0.745
MOD_GlcNHglycan	589	592	PF01048	0.674
MOD_GlcNHglycan	601	604	PF01048	0.639
MOD_GlcNHglycan	664	667	PF01048	0.742
MOD_GlcNHglycan	674	677	PF01048	0.665
MOD_GlcNHglycan	711	715	PF01048	0.592
MOD_GlcNHglycan	870	873	PF01048	0.546
MOD_GlcNHglycan	931	934	PF01048	0.721
MOD_GSK3_1	138	145	PF00069	0.592
MOD_GSK3_1	154	161	PF00069	0.643
MOD_GSK3_1	163	170	PF00069	0.552
MOD_GSK3_1	242	249	PF00069	0.335
MOD_GSK3_1	287	294	PF00069	0.338
MOD_GSK3_1	325	332	PF00069	0.418
MOD_GSK3_1	336	343	PF00069	0.245
MOD_GSK3_1	429	436	PF00069	0.714
MOD_GSK3_1	447	454	PF00069	0.655
MOD_GSK3_1	45	52	PF00069	0.480
MOD_GSK3_1	537	544	PF00069	0.580
MOD_GSK3_1	583	590	PF00069	0.558
MOD_GSK3_1	599	606	PF00069	0.642
MOD_GSK3_1	618	625	PF00069	0.756
MOD_GSK3_1	661	668	PF00069	0.525
MOD_GSK3_1	687	694	PF00069	0.789
MOD_GSK3_1	698	705	PF00069	0.698
MOD_GSK3_1	789	796	PF00069	0.651
MOD_GSK3_1	910	917	PF00069	0.527
MOD_N-GLC_1	914	919	PF02516	0.594
MOD_NEK2_1	132	137	PF00069	0.529
MOD_NEK2_1	148	153	PF00069	0.614
MOD_NEK2_1	155	160	PF00069	0.587
MOD_NEK2_1	29	34	PF00069	0.518
MOD_NEK2_1	314	319	PF00069	0.214
MOD_NEK2_1	326	331	PF00069	0.227
MOD_NEK2_1	542	547	PF00069	0.575
MOD_NEK2_1	587	592	PF00069	0.532
MOD_NEK2_1	60	65	PF00069	0.590
MOD_NEK2_1	74	79	PF00069	0.412
MOD_NEK2_1	746	751	PF00069	0.527
MOD_NEK2_1	818	823	PF00069	0.682
MOD_NEK2_1	910	915	PF00069	0.656
MOD_PIKK_1	124	130	PF00454	0.569
MOD_PIKK_1	493	499	PF00454	0.615
MOD_PK_1	384	390	PF00069	0.389
MOD_PKA_2	718	724	PF00069	0.672
MOD_PKA_2	765	771	PF00069	0.595
MOD_PKB_1	476	484	PF00069	0.704
MOD_Plk_1	479	485	PF00069	0.570
MOD_Plk_1	72	78	PF00069	0.391
MOD_Plk_4	259	265	PF00069	0.389
MOD_Plk_4	384	390	PF00069	0.320
MOD_Plk_4	551	557	PF00069	0.474
MOD_ProDKin_1	135	141	PF00069	0.527
MOD_ProDKin_1	159	165	PF00069	0.774
MOD_ProDKin_1	183	189	PF00069	0.642
MOD_ProDKin_1	20	26	PF00069	0.513
MOD_ProDKin_1	291	297	PF00069	0.410
MOD_ProDKin_1	421	427	PF00069	0.772
MOD_ProDKin_1	429	435	PF00069	0.670
MOD_ProDKin_1	448	454	PF00069	0.636
MOD_ProDKin_1	45	51	PF00069	0.537
MOD_ProDKin_1	498	504	PF00069	0.755
MOD_ProDKin_1	506	512	PF00069	0.684
MOD_ProDKin_1	632	638	PF00069	0.548
MOD_ProDKin_1	670	676	PF00069	0.673
MOD_ProDKin_1	760	766	PF00069	0.783
MOD_ProDKin_1	901	907	PF00069	0.628
MOD_ProDKin_1	915	921	PF00069	0.519
MOD_ProDKin_1	923	929	PF00069	0.641
MOD_ProDKin_1	98	104	PF00069	0.468
MOD_SUMO_rev_2	806	816	PF00179	0.625
TRG_AP2beta_CARGO_1	73	83	PF09066	0.404
TRG_DiLeu_BaEn_4	628	634	PF01217	0.655
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.552
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.335
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.551
TRG_ENDOCYTIC_2	206	209	PF00928	0.410
TRG_ENDOCYTIC_2	236	239	PF00928	0.360
TRG_ENDOCYTIC_2	257	260	PF00928	0.335
TRG_ER_diArg_1	129	131	PF00400	0.567
TRG_ER_diArg_1	405	408	PF00400	0.636
TRG_ER_diArg_1	476	479	PF00400	0.670
TRG_ER_diArg_1	5	8	PF00400	0.673
TRG_ER_diArg_1	644	646	PF00400	0.407
TRG_ER_diArg_1	65	67	PF00400	0.440
TRG_ER_diArg_1	87	89	PF00400	0.477
TRG_ER_diArg_1	967	969	PF00400	0.618
TRG_ER_FFAT_2	157	166	PF00635	0.517
TRG_NLS_MonoExtN_4	558	565	PF00514	0.490
TRG_NLS_MonoExtN_4	683	688	PF00514	0.546
TRG_NLS_MonoExtN_4	785	792	PF00514	0.693
TRG_Pf-PMV_PEXEL_1	483	487	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN9	Leptomonas seymouri	42%	100%
A0A3Q8IC63	Leishmania donovani	86%	99%
A4HEX1	Leishmania braziliensis	69%	98%
A4I245	Leishmania infantum	85%	100%
Q4Q978	Leishmania major	85%	100%