Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY94_LEIMU

TriTrypDb:

LmxM.26.1150

Length:

787

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.617
CLV_C14_Caspase3-7	703	707	PF00656	0.644
CLV_C14_Caspase3-7	715	719	PF00656	0.441
CLV_C14_Caspase3-7	733	737	PF00656	0.491
CLV_NRD_NRD_1	311	313	PF00675	0.733
CLV_NRD_NRD_1	4	6	PF00675	0.697
CLV_NRD_NRD_1	445	447	PF00675	0.606
CLV_NRD_NRD_1	469	471	PF00675	0.432
CLV_NRD_NRD_1	49	51	PF00675	0.610
CLV_NRD_NRD_1	504	506	PF00675	0.606
CLV_NRD_NRD_1	587	589	PF00675	0.737
CLV_NRD_NRD_1	590	592	PF00675	0.673
CLV_NRD_NRD_1	777	779	PF00675	0.721
CLV_PCSK_FUR_1	587	591	PF00082	0.719
CLV_PCSK_KEX2_1	3	5	PF00082	0.696
CLV_PCSK_KEX2_1	311	313	PF00082	0.733
CLV_PCSK_KEX2_1	445	447	PF00082	0.606
CLV_PCSK_KEX2_1	469	471	PF00082	0.557
CLV_PCSK_KEX2_1	49	51	PF00082	0.610
CLV_PCSK_KEX2_1	504	506	PF00082	0.606
CLV_PCSK_KEX2_1	587	589	PF00082	0.737
CLV_PCSK_KEX2_1	590	592	PF00082	0.673
CLV_PCSK_KEX2_1	777	779	PF00082	0.721
CLV_PCSK_PC1ET2_1	589	591	PF00082	0.807
CLV_PCSK_SKI1_1	103	107	PF00082	0.531
CLV_PCSK_SKI1_1	201	205	PF00082	0.599
CLV_PCSK_SKI1_1	311	315	PF00082	0.702
CLV_PCSK_SKI1_1	344	348	PF00082	0.593
CLV_PCSK_SKI1_1	505	509	PF00082	0.609
CLV_PCSK_SKI1_1	546	550	PF00082	0.632
CLV_PCSK_SKI1_1	569	573	PF00082	0.607
CLV_PCSK_SKI1_1	755	759	PF00082	0.370
CLV_PCSK_SKI1_1	778	782	PF00082	0.630
CLV_Separin_Metazoa	332	336	PF03568	0.501
DEG_APCC_DBOX_1	102	110	PF00400	0.520
DEG_APCC_DBOX_1	398	406	PF00400	0.508
DEG_SCF_FBW7_1	631	638	PF00400	0.735
DEG_SPOP_SBC_1	570	574	PF00917	0.612
DOC_CDC14_PxL_1	233	241	PF14671	0.465
DOC_CKS1_1	632	637	PF01111	0.542
DOC_CYCLIN_yCln2_LP_2	766	772	PF00134	0.535
DOC_MAPK_gen_1	445	451	PF00069	0.447
DOC_PP1_RVXF_1	655	661	PF00149	0.567
DOC_PP1_RVXF_1	736	743	PF00149	0.461
DOC_PP4_FxxP_1	226	229	PF00568	0.590
DOC_PP4_MxPP_1	324	327	PF00568	0.726
DOC_SPAK_OSR1_1	225	229	PF12202	0.597
DOC_USP7_MATH_1	105	109	PF00917	0.441
DOC_USP7_MATH_1	132	136	PF00917	0.644
DOC_USP7_MATH_1	15	19	PF00917	0.601
DOC_USP7_MATH_1	288	292	PF00917	0.552
DOC_USP7_MATH_1	300	304	PF00917	0.521
DOC_USP7_MATH_1	354	358	PF00917	0.558
DOC_USP7_MATH_1	439	443	PF00917	0.322
DOC_USP7_MATH_1	452	456	PF00917	0.601
DOC_USP7_MATH_1	464	468	PF00917	0.371
DOC_USP7_MATH_1	53	57	PF00917	0.589
DOC_USP7_MATH_1	535	539	PF00917	0.812
DOC_USP7_MATH_1	624	628	PF00917	0.788
DOC_USP7_MATH_1	635	639	PF00917	0.683
DOC_USP7_MATH_1	647	651	PF00917	0.664
DOC_USP7_MATH_1	656	660	PF00917	0.390
DOC_USP7_MATH_1	771	775	PF00917	0.539
DOC_WW_Pin1_4	23	28	PF00397	0.563
DOC_WW_Pin1_4	239	244	PF00397	0.654
DOC_WW_Pin1_4	405	410	PF00397	0.560
DOC_WW_Pin1_4	460	465	PF00397	0.639
DOC_WW_Pin1_4	626	631	PF00397	0.728
LIG_14-3-3_CanoR_1	201	206	PF00244	0.368
LIG_14-3-3_CanoR_1	399	409	PF00244	0.628
LIG_14-3-3_CanoR_1	445	450	PF00244	0.410
LIG_14-3-3_CanoR_1	487	492	PF00244	0.494
LIG_14-3-3_CanoR_1	49	58	PF00244	0.704
LIG_14-3-3_CanoR_1	505	511	PF00244	0.343
LIG_14-3-3_CanoR_1	588	594	PF00244	0.760
LIG_14-3-3_CanoR_1	649	658	PF00244	0.635
LIG_14-3-3_CanoR_1	731	735	PF00244	0.570
LIG_14-3-3_CanoR_1	746	756	PF00244	0.345
LIG_14-3-3_CanoR_1	777	781	PF00244	0.731
LIG_14-3-3_CanoR_1	84	89	PF00244	0.486
LIG_Actin_WH2_2	471	489	PF00022	0.718
LIG_BIR_III_4	718	722	PF00653	0.637
LIG_deltaCOP1_diTrp_1	683	693	PF00928	0.499
LIG_FHA_1	245	251	PF00498	0.786
LIG_FHA_1	756	762	PF00498	0.375
LIG_FHA_2	202	208	PF00498	0.371
LIG_FHA_2	343	349	PF00498	0.429
LIG_FHA_2	406	412	PF00498	0.477
LIG_FHA_2	507	513	PF00498	0.584
LIG_FHA_2	590	596	PF00498	0.700
LIG_FHA_2	632	638	PF00498	0.737
LIG_FHA_2	678	684	PF00498	0.690
LIG_FHA_2	731	737	PF00498	0.508
LIG_FHA_2	777	783	PF00498	0.441
LIG_Integrin_RGD_1	676	678	PF01839	0.677
LIG_LIR_Gen_1	207	217	PF02991	0.387
LIG_LIR_Gen_1	42	51	PF02991	0.599
LIG_LIR_Gen_1	430	440	PF02991	0.422
LIG_LIR_Gen_1	65	75	PF02991	0.485
LIG_LIR_Gen_1	659	666	PF02991	0.510
LIG_LIR_Gen_1	750	761	PF02991	0.470
LIG_LIR_Nem_3	207	212	PF02991	0.393
LIG_LIR_Nem_3	362	367	PF02991	0.478
LIG_LIR_Nem_3	42	47	PF02991	0.594
LIG_LIR_Nem_3	430	435	PF02991	0.584
LIG_LIR_Nem_3	65	71	PF02991	0.487
LIG_LIR_Nem_3	659	663	PF02991	0.517
LIG_LIR_Nem_3	750	756	PF02991	0.471
LIG_NRBOX	211	217	PF00104	0.551
LIG_PALB2_WD40_1	204	212	PF16756	0.358
LIG_PDZ_Class_1	782	787	PF00595	0.654
LIG_Pex14_1	113	117	PF04695	0.494
LIG_SH2_CRK	364	368	PF00017	0.477
LIG_SH2_CRK	44	48	PF00017	0.600
LIG_SH2_CRK	753	757	PF00017	0.440
LIG_SH2_NCK_1	44	48	PF00017	0.600
LIG_SH2_STAP1	753	757	PF00017	0.462
LIG_SH2_STAT5	749	752	PF00017	0.579
LIG_SH3_3	231	237	PF00018	0.469
LIG_SH3_3	323	329	PF00018	0.607
LIG_SH3_3	346	352	PF00018	0.509
LIG_SH3_3	406	412	PF00018	0.555
LIG_SH3_3	629	635	PF00018	0.589
LIG_SH3_3	88	94	PF00018	0.450
LIG_SUMO_SIM_par_1	199	207	PF11976	0.359
LIG_SUMO_SIM_par_1	335	341	PF11976	0.481
LIG_TRAF2_1	172	175	PF00917	0.308
LIG_TRAF2_1	329	332	PF00917	0.604
LIG_TRAF2_1	408	411	PF00917	0.584
LIG_TRAF2_1	681	684	PF00917	0.584
LIG_UBA3_1	560	567	PF00899	0.665
LIG_WRC_WIRS_1	440	445	PF05994	0.336
LIG_WW_2	326	329	PF00397	0.578
MOD_CDK_SPK_2	23	28	PF00069	0.471
MOD_CDK_SPxxK_3	462	469	PF00069	0.504
MOD_CK1_1	291	297	PF00069	0.547
MOD_CK1_1	303	309	PF00069	0.484
MOD_CK1_1	378	384	PF00069	0.474
MOD_CK1_1	455	461	PF00069	0.624
MOD_CK1_1	52	58	PF00069	0.727
MOD_CK1_1	538	544	PF00069	0.686
MOD_CK1_1	575	581	PF00069	0.671
MOD_CK1_1	650	656	PF00069	0.595
MOD_CK2_1	105	111	PF00069	0.450
MOD_CK2_1	173	179	PF00069	0.536
MOD_CK2_1	201	207	PF00069	0.425
MOD_CK2_1	405	411	PF00069	0.468
MOD_CK2_1	462	468	PF00069	0.595
MOD_CK2_1	571	577	PF00069	0.761
MOD_CK2_1	589	595	PF00069	0.721
MOD_CK2_1	677	683	PF00069	0.610
MOD_Cter_Amidation	47	50	PF01082	0.662
MOD_GlcNHglycan	114	117	PF01048	0.489
MOD_GlcNHglycan	13	16	PF01048	0.673
MOD_GlcNHglycan	134	137	PF01048	0.447
MOD_GlcNHglycan	139	142	PF01048	0.450
MOD_GlcNHglycan	188	191	PF01048	0.486
MOD_GlcNHglycan	259	262	PF01048	0.660
MOD_GlcNHglycan	293	296	PF01048	0.720
MOD_GlcNHglycan	302	305	PF01048	0.647
MOD_GlcNHglycan	356	359	PF01048	0.622
MOD_GlcNHglycan	418	422	PF01048	0.610
MOD_GlcNHglycan	454	457	PF01048	0.643
MOD_GlcNHglycan	51	54	PF01048	0.703
MOD_GlcNHglycan	610	613	PF01048	0.747
MOD_GlcNHglycan	626	629	PF01048	0.729
MOD_GlcNHglycan	648	652	PF01048	0.726
MOD_GlcNHglycan	667	670	PF01048	0.426
MOD_GlcNHglycan	773	776	PF01048	0.559
MOD_GlcNHglycan	79	82	PF01048	0.497
MOD_GSK3_1	11	18	PF00069	0.647
MOD_GSK3_1	137	144	PF00069	0.455
MOD_GSK3_1	197	204	PF00069	0.557
MOD_GSK3_1	235	242	PF00069	0.667
MOD_GSK3_1	366	373	PF00069	0.500
MOD_GSK3_1	377	384	PF00069	0.438
MOD_GSK3_1	401	408	PF00069	0.469
MOD_GSK3_1	452	459	PF00069	0.640
MOD_GSK3_1	460	467	PF00069	0.574
MOD_GSK3_1	49	56	PF00069	0.665
MOD_GSK3_1	535	542	PF00069	0.713
MOD_GSK3_1	569	576	PF00069	0.787
MOD_GSK3_1	626	633	PF00069	0.735
MOD_GSK3_1	73	80	PF00069	0.544
MOD_GSK3_1	82	89	PF00069	0.526
MOD_GSK3_1	97	104	PF00069	0.576
MOD_N-GLC_1	608	613	PF02516	0.793
MOD_N-GLC_1	97	102	PF02516	0.359
MOD_NEK2_1	11	16	PF00069	0.748
MOD_NEK2_1	112	117	PF00069	0.532
MOD_NEK2_1	173	178	PF00069	0.439
MOD_NEK2_1	377	382	PF00069	0.425
MOD_NEK2_1	506	511	PF00069	0.543
MOD_NEK2_1	571	576	PF00069	0.642
MOD_NEK2_1	86	91	PF00069	0.719
MOD_NEK2_2	535	540	PF00069	0.514
MOD_NEK2_2	776	781	PF00069	0.531
MOD_PIKK_1	141	147	PF00454	0.442
MOD_PIKK_1	17	23	PF00454	0.649
MOD_PIKK_1	575	581	PF00454	0.660
MOD_PK_1	487	493	PF00069	0.580
MOD_PKA_1	445	451	PF00069	0.661
MOD_PKA_1	49	55	PF00069	0.648
MOD_PKA_1	589	595	PF00069	0.785
MOD_PKA_2	445	451	PF00069	0.661
MOD_PKA_2	49	55	PF00069	0.648
MOD_PKA_2	539	545	PF00069	0.504
MOD_PKA_2	589	595	PF00069	0.756
MOD_PKA_2	656	662	PF00069	0.598
MOD_PKA_2	730	736	PF00069	0.516
MOD_PKA_2	776	782	PF00069	0.728
MOD_PKB_1	485	493	PF00069	0.554
MOD_Plk_1	535	541	PF00069	0.513
MOD_Plk_2-3	246	252	PF00069	0.631
MOD_Plk_4	173	179	PF00069	0.322
MOD_Plk_4	228	234	PF00069	0.488
MOD_Plk_4	366	372	PF00069	0.501
MOD_Plk_4	439	445	PF00069	0.334
MOD_Plk_4	506	512	PF00069	0.508
MOD_Plk_4	578	584	PF00069	0.551
MOD_Plk_4	730	736	PF00069	0.516
MOD_Plk_4	756	762	PF00069	0.492
MOD_ProDKin_1	23	29	PF00069	0.564
MOD_ProDKin_1	239	245	PF00069	0.654
MOD_ProDKin_1	405	411	PF00069	0.565
MOD_ProDKin_1	460	466	PF00069	0.646
MOD_ProDKin_1	626	632	PF00069	0.725
TRG_DiLeu_BaEn_1	211	216	PF01217	0.448
TRG_DiLeu_BaEn_3	157	163	PF01217	0.497
TRG_DiLeu_BaEn_4	154	160	PF01217	0.544
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.602
TRG_DiLeu_BaLyEn_6	198	203	PF01217	0.474
TRG_ENDOCYTIC_2	364	367	PF00928	0.473
TRG_ENDOCYTIC_2	44	47	PF00928	0.600
TRG_ENDOCYTIC_2	753	756	PF00928	0.467
TRG_ER_diArg_1	2	5	PF00400	0.687
TRG_ER_diArg_1	310	312	PF00400	0.732
TRG_ER_diArg_1	444	446	PF00400	0.647
TRG_ER_diArg_1	485	488	PF00400	0.599
TRG_ER_diArg_1	49	51	PF00400	0.613
TRG_ER_diArg_1	504	506	PF00400	0.504
TRG_ER_diArg_1	586	588	PF00400	0.738
TRG_ER_diArg_1	655	658	PF00400	0.379
TRG_NLS_MonoCore_2	587	592	PF00514	0.807
TRG_NLS_MonoExtN_4	586	593	PF00514	0.804
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC42	Leptomonas seymouri	38%	96%
A0A3Q8IDS0	Leishmania donovani	83%	100%
A4HEX0	Leishmania braziliensis	67%	100%
A4I244	Leishmania infantum	83%	100%
Q4Q979	Leishmania major	80%	98%