RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY93_LEIMU

TriTrypDb:

LmxM.26.1140

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY93

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016553	base conversion or substitution editing	6	1
GO:0016554	cytidine to uridine editing	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	189	191	PF00675	0.339
CLV_NRD_NRD_1	222	224	PF00675	0.331
CLV_NRD_NRD_1	283	285	PF00675	0.483
CLV_NRD_NRD_1	294	296	PF00675	0.413
CLV_NRD_NRD_1	303	305	PF00675	0.376
CLV_NRD_NRD_1	360	362	PF00675	0.364
CLV_NRD_NRD_1	61	63	PF00675	0.641
CLV_NRD_NRD_1	7	9	PF00675	0.553
CLV_PCSK_KEX2_1	189	191	PF00082	0.339
CLV_PCSK_KEX2_1	222	224	PF00082	0.331
CLV_PCSK_KEX2_1	283	285	PF00082	0.484
CLV_PCSK_KEX2_1	294	296	PF00082	0.371
CLV_PCSK_KEX2_1	303	305	PF00082	0.360
CLV_PCSK_KEX2_1	489	491	PF00082	0.463
CLV_PCSK_KEX2_1	61	63	PF00082	0.616
CLV_PCSK_KEX2_1	7	9	PF00082	0.553
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.463
CLV_PCSK_SKI1_1	160	164	PF00082	0.518
CLV_PCSK_SKI1_1	214	218	PF00082	0.349
CLV_PCSK_SKI1_1	257	261	PF00082	0.366
CLV_PCSK_SKI1_1	278	282	PF00082	0.372
CLV_PCSK_SKI1_1	295	299	PF00082	0.289
CLV_PCSK_SKI1_1	408	412	PF00082	0.614
CLV_PCSK_SKI1_1	492	496	PF00082	0.394
CLV_Separin_Metazoa	219	223	PF03568	0.344
DEG_APCC_DBOX_1	294	302	PF00400	0.327
DEG_APCC_DBOX_1	416	424	PF00400	0.382
DEG_Nend_Nbox_1	1	3	PF02207	0.580
DEG_SCF_FBW7_1	22	27	PF00400	0.596
DEG_SCF_FBW7_1	30	37	PF00400	0.552
DEG_SPOP_SBC_1	39	43	PF00917	0.689
DOC_CKS1_1	31	36	PF01111	0.539
DOC_CYCLIN_RxL_1	254	265	PF00134	0.481
DOC_MAPK_gen_1	361	368	PF00069	0.369
DOC_MAPK_HePTP_8	464	476	PF00069	0.411
DOC_MAPK_MEF2A_6	361	370	PF00069	0.348
DOC_MAPK_MEF2A_6	467	476	PF00069	0.506
DOC_PP2B_LxvP_1	106	109	PF13499	0.533
DOC_PP4_FxxP_1	312	315	PF00568	0.342
DOC_PP4_MxPP_1	329	332	PF00568	0.440
DOC_USP7_MATH_1	24	28	PF00917	0.676
DOC_USP7_MATH_1	333	337	PF00917	0.470
DOC_USP7_MATH_1	34	38	PF00917	0.755
DOC_USP7_MATH_1	457	461	PF00917	0.374
DOC_USP7_MATH_1	50	54	PF00917	0.690
DOC_USP7_UBL2_3	522	526	PF12436	0.504
DOC_WW_Pin1_4	173	178	PF00397	0.434
DOC_WW_Pin1_4	20	25	PF00397	0.720
DOC_WW_Pin1_4	30	35	PF00397	0.736
DOC_WW_Pin1_4	327	332	PF00397	0.391
DOC_WW_Pin1_4	346	351	PF00397	0.344
DOC_WW_Pin1_4	65	70	PF00397	0.697
DOC_WW_Pin1_4	93	98	PF00397	0.572
LIG_14-3-3_CanoR_1	17	23	PF00244	0.716
LIG_14-3-3_CanoR_1	189	193	PF00244	0.339
LIG_14-3-3_CanoR_1	214	219	PF00244	0.343
LIG_14-3-3_CanoR_1	295	305	PF00244	0.460
LIG_14-3-3_CanoR_1	361	366	PF00244	0.381
LIG_14-3-3_CanoR_1	377	384	PF00244	0.342
LIG_14-3-3_CanoR_1	492	497	PF00244	0.546
LIG_14-3-3_CanoR_1	61	71	PF00244	0.643
LIG_Actin_RPEL_3	216	235	PF02755	0.344
LIG_Clathr_ClatBox_1	365	369	PF01394	0.429
LIG_DLG_GKlike_1	361	368	PF00625	0.351
LIG_FHA_1	108	114	PF00498	0.455
LIG_FHA_1	162	168	PF00498	0.401
LIG_FHA_1	17	23	PF00498	0.560
LIG_FHA_1	215	221	PF00498	0.373
LIG_FHA_1	237	243	PF00498	0.345
LIG_FHA_1	288	294	PF00498	0.412
LIG_FHA_1	34	40	PF00498	0.652
LIG_FHA_1	340	346	PF00498	0.386
LIG_FHA_1	436	442	PF00498	0.411
LIG_FHA_1	464	470	PF00498	0.473
LIG_FHA_2	140	146	PF00498	0.631
LIG_FHA_2	161	167	PF00498	0.514
LIG_FHA_2	323	329	PF00498	0.340
LIG_FHA_2	347	353	PF00498	0.354
LIG_FHA_2	378	384	PF00498	0.484
LIG_LIR_Apic_2	202	206	PF02991	0.441
LIG_LIR_Apic_2	311	315	PF02991	0.349
LIG_LIR_Gen_1	398	405	PF02991	0.431
LIG_LIR_Nem_3	398	403	PF02991	0.411
LIG_NRBOX	501	507	PF00104	0.346
LIG_NRBOX	516	522	PF00104	0.338
LIG_SH2_CRK	209	213	PF00017	0.464
LIG_SH2_CRK	400	404	PF00017	0.390
LIG_SH2_CRK	57	61	PF00017	0.705
LIG_SH2_NCK_1	25	29	PF00017	0.471
LIG_SH2_NCK_1	264	268	PF00017	0.388
LIG_SH2_NCK_1	400	404	PF00017	0.410
LIG_SH2_STAP1	194	198	PF00017	0.321
LIG_SH2_STAP1	209	213	PF00017	0.322
LIG_SH2_STAT5	209	212	PF00017	0.391
LIG_SH2_STAT5	236	239	PF00017	0.329
LIG_SH2_STAT5	324	327	PF00017	0.333
LIG_SH2_STAT5	455	458	PF00017	0.348
LIG_SH3_3	225	231	PF00018	0.466
LIG_SH3_3	28	34	PF00018	0.508
LIG_SUMO_SIM_anti_2	163	171	PF11976	0.506
LIG_SUMO_SIM_anti_2	217	222	PF11976	0.366
LIG_SUMO_SIM_par_1	214	219	PF11976	0.359
LIG_SUMO_SIM_par_1	391	398	PF11976	0.411
LIG_TRAF2_1	349	352	PF00917	0.499
LIG_TYR_ITSM	396	403	PF00017	0.438
MOD_CK1_1	20	26	PF00069	0.727
MOD_CK1_1	346	352	PF00069	0.510
MOD_CK1_1	37	43	PF00069	0.671
MOD_CK1_1	395	401	PF00069	0.489
MOD_CK1_1	460	466	PF00069	0.384
MOD_CK1_1	65	71	PF00069	0.658
MOD_CK1_1	96	102	PF00069	0.610
MOD_CK2_1	160	166	PF00069	0.507
MOD_CK2_1	346	352	PF00069	0.367
MOD_CK2_1	377	383	PF00069	0.490
MOD_Cter_Amidation	487	490	PF01082	0.476
MOD_GlcNHglycan	26	29	PF01048	0.658
MOD_GlcNHglycan	298	301	PF01048	0.446
MOD_GlcNHglycan	390	393	PF01048	0.461
MOD_GlcNHglycan	405	408	PF01048	0.631
MOD_GlcNHglycan	65	68	PF01048	0.677
MOD_GlcNHglycan	98	101	PF01048	0.584
MOD_GSK3_1	104	111	PF00069	0.511
MOD_GSK3_1	118	125	PF00069	0.374
MOD_GSK3_1	16	23	PF00069	0.669
MOD_GSK3_1	236	243	PF00069	0.353
MOD_GSK3_1	30	37	PF00069	0.627
MOD_GSK3_1	339	346	PF00069	0.517
MOD_GSK3_1	38	45	PF00069	0.610
MOD_GSK3_1	388	395	PF00069	0.470
MOD_GSK3_1	87	94	PF00069	0.710
MOD_LATS_1	15	21	PF00433	0.736
MOD_NEK2_1	1	6	PF00069	0.656
MOD_NEK2_1	18	23	PF00069	0.478
MOD_NEK2_1	188	193	PF00069	0.336
MOD_NEK2_1	235	240	PF00069	0.310
MOD_NEK2_1	255	260	PF00069	0.275
MOD_NEK2_1	279	284	PF00069	0.403
MOD_NEK2_1	38	43	PF00069	0.698
MOD_NEK2_1	388	393	PF00069	0.454
MOD_NEK2_2	194	199	PF00069	0.342
MOD_NEK2_2	392	397	PF00069	0.314
MOD_PIKK_1	354	360	PF00454	0.384
MOD_PKA_1	222	228	PF00069	0.490
MOD_PKA_1	361	367	PF00069	0.401
MOD_PKA_2	16	22	PF00069	0.627
MOD_PKA_2	188	194	PF00069	0.334
MOD_PKA_2	222	228	PF00069	0.490
MOD_PKA_2	339	345	PF00069	0.386
MOD_PKA_2	401	407	PF00069	0.559
MOD_PKB_1	490	498	PF00069	0.399
MOD_Plk_1	255	261	PF00069	0.414
MOD_Plk_1	432	438	PF00069	0.494
MOD_Plk_4	208	214	PF00069	0.453
MOD_Plk_4	255	261	PF00069	0.414
MOD_Plk_4	313	319	PF00069	0.332
MOD_Plk_4	34	40	PF00069	0.658
MOD_Plk_4	460	466	PF00069	0.390
MOD_Plk_4	516	522	PF00069	0.481
MOD_Plk_4	87	93	PF00069	0.690
MOD_ProDKin_1	173	179	PF00069	0.430
MOD_ProDKin_1	20	26	PF00069	0.724
MOD_ProDKin_1	30	36	PF00069	0.738
MOD_ProDKin_1	327	333	PF00069	0.392
MOD_ProDKin_1	346	352	PF00069	0.340
MOD_ProDKin_1	65	71	PF00069	0.697
MOD_ProDKin_1	93	99	PF00069	0.571
MOD_SUMO_rev_2	153	162	PF00179	0.368
TRG_DiLeu_BaEn_1	166	171	PF01217	0.378
TRG_DiLeu_BaEn_1	256	261	PF01217	0.505
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.492
TRG_ENDOCYTIC_2	209	212	PF00928	0.419
TRG_ENDOCYTIC_2	264	267	PF00928	0.385
TRG_ENDOCYTIC_2	400	403	PF00928	0.381
TRG_ER_diArg_1	188	190	PF00400	0.340
TRG_ER_diArg_1	221	223	PF00400	0.337
TRG_ER_diArg_1	293	295	PF00400	0.386
TRG_ER_diArg_1	303	305	PF00400	0.375
TRG_ER_diArg_1	490	493	PF00400	0.440
TRG_ER_diArg_1	6	8	PF00400	0.582
TRG_ER_diArg_1	60	62	PF00400	0.637
TRG_NES_CRM1_1	358	372	PF08389	0.403
TRG_NLS_MonoExtC_3	488	493	PF00514	0.464
TRG_Pf-PMV_PEXEL_1	214	219	PF00026	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGU4	Leptomonas seymouri	78%	94%
A0A0S4JSB1	Bodo saltans	58%	100%
A0A1X0NS86	Trypanosomatidae	67%	99%
A0A3Q8IDM7	Leishmania donovani	96%	99%
A0A422N6M4	Trypanosoma rangeli	64%	100%
A4HEW9	Leishmania braziliensis	89%	100%
A4I243	Leishmania infantum	95%	99%
C9ZRW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	99%
Q4Q980	Leishmania major	93%	100%
V5B995	Trypanosoma cruzi	65%	100%