LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AY89_LEIMU
TriTrypDb:
LmxM.26.1100
Length:
126

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

E9AY89
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY89

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 11 13 PF00675 0.448
CLV_NRD_NRD_1 3 5 PF00675 0.450
CLV_PCSK_KEX2_1 11 13 PF00082 0.448
CLV_PCSK_KEX2_1 3 5 PF00082 0.450
CLV_PCSK_SKI1_1 38 42 PF00082 0.357
DEG_Nend_Nbox_1 1 3 PF02207 0.659
DOC_CDC14_PxL_1 71 79 PF14671 0.447
DOC_MAPK_gen_1 11 17 PF00069 0.654
DOC_PP1_RVXF_1 99 106 PF00149 0.476
DOC_WW_Pin1_4 10 15 PF00397 0.629
LIG_14-3-3_CanoR_1 3 10 PF00244 0.629
LIG_FHA_1 74 80 PF00498 0.349
LIG_LIR_Apic_2 21 26 PF02991 0.617
LIG_LIR_Gen_1 76 84 PF02991 0.355
LIG_LIR_Nem_3 76 81 PF02991 0.355
LIG_Pex14_2 80 84 PF04695 0.357
LIG_SH2_CRK 23 27 PF00017 0.683
LIG_SH2_STAT5 112 115 PF00017 0.431
LIG_SH2_STAT5 71 74 PF00017 0.338
LIG_SH2_STAT5 78 81 PF00017 0.339
LIG_UBA3_1 79 87 PF00899 0.447
LIG_WW_3 98 102 PF00397 0.421
MOD_CDK_SPxK_1 10 16 PF00069 0.642
MOD_CK1_1 34 40 PF00069 0.643
MOD_CK1_1 73 79 PF00069 0.420
MOD_CK2_1 15 21 PF00069 0.642
MOD_GlcNHglycan 17 20 PF01048 0.439
MOD_GlcNHglycan 34 37 PF01048 0.307
MOD_GlcNHglycan 72 75 PF01048 0.436
MOD_NEK2_1 117 122 PF00069 0.458
MOD_NEK2_1 2 7 PF00069 0.638
MOD_PIKK_1 2 8 PF00454 0.677
MOD_PKA_2 15 21 PF00069 0.642
MOD_PKA_2 2 8 PF00069 0.632
MOD_Plk_2-3 104 110 PF00069 0.444
MOD_Plk_4 5 11 PF00069 0.675
MOD_Plk_4 73 79 PF00069 0.355
MOD_ProDKin_1 10 16 PF00069 0.628
MOD_SUMO_for_1 26 29 PF00179 0.638
TRG_DiLeu_BaEn_4 108 114 PF01217 0.435
TRG_ENDOCYTIC_2 78 81 PF00928 0.355
TRG_ER_diArg_1 10 12 PF00400 0.647
TRG_ER_diArg_1 2 4 PF00400 0.654
TRG_NES_CRM1_1 55 69 PF08389 0.543

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0S5 Leptomonas seymouri 83% 100%
A0A0S4JNG0 Bodo saltans 48% 100%
A0A1X0NTS3 Trypanosomatidae 58% 100%
A0A3Q8IP44 Leishmania donovani 97% 100%
A0A422NSR5 Trypanosoma rangeli 59% 100%
A4HEW6 Leishmania braziliensis 93% 100%
A4I239 Leishmania infantum 97% 100%
C9ZRW5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
Q4Q984 Leishmania major 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS