Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY88_LEIMU

TriTrypDb:

LmxM.26.1090

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.374
CLV_NRD_NRD_1	262	264	PF00675	0.425
CLV_NRD_NRD_1	27	29	PF00675	0.718
CLV_NRD_NRD_1	297	299	PF00675	0.312
CLV_NRD_NRD_1	39	41	PF00675	0.646
CLV_NRD_NRD_1	62	64	PF00675	0.533
CLV_NRD_NRD_1	88	90	PF00675	0.806
CLV_PCSK_KEX2_1	27	29	PF00082	0.692
CLV_PCSK_KEX2_1	297	299	PF00082	0.312
CLV_PCSK_KEX2_1	39	41	PF00082	0.602
CLV_PCSK_KEX2_1	87	89	PF00082	0.806
CLV_PCSK_SKI1_1	16	20	PF00082	0.609
CLV_PCSK_SKI1_1	269	273	PF00082	0.369
CLV_PCSK_SKI1_1	28	32	PF00082	0.671
CLV_PCSK_SKI1_1	297	301	PF00082	0.284
CLV_PCSK_SKI1_1	383	387	PF00082	0.494
CLV_PCSK_SKI1_1	406	410	PF00082	0.458
DEG_SPOP_SBC_1	178	182	PF00917	0.397
DEG_SPOP_SBC_1	195	199	PF00917	0.473
DOC_CKS1_1	220	225	PF01111	0.608
DOC_CKS1_1	45	50	PF01111	0.655
DOC_CYCLIN_RxL_1	13	21	PF00134	0.614
DOC_CYCLIN_RxL_1	207	218	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	158	164	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	313	319	PF00134	0.262
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.579
DOC_MAPK_DCC_7	366	375	PF00069	0.354
DOC_MAPK_MEF2A_6	366	375	PF00069	0.303
DOC_PP1_RVXF_1	208	215	PF00149	0.502
DOC_PP2B_LxvP_1	183	186	PF13499	0.573
DOC_PP2B_LxvP_1	313	316	PF13499	0.502
DOC_PP4_FxxP_1	31	34	PF00568	0.667
DOC_USP7_MATH_1	133	137	PF00917	0.516
DOC_USP7_MATH_1	178	182	PF00917	0.692
DOC_USP7_MATH_1	193	197	PF00917	0.662
DOC_USP7_MATH_1	342	346	PF00917	0.465
DOC_USP7_MATH_1	420	424	PF00917	0.508
DOC_WW_Pin1_4	111	116	PF00397	0.585
DOC_WW_Pin1_4	196	201	PF00397	0.557
DOC_WW_Pin1_4	219	224	PF00397	0.622
DOC_WW_Pin1_4	280	285	PF00397	0.494
DOC_WW_Pin1_4	290	295	PF00397	0.258
DOC_WW_Pin1_4	361	366	PF00397	0.430
DOC_WW_Pin1_4	44	49	PF00397	0.707
LIG_14-3-3_CanoR_1	138	147	PF00244	0.459
LIG_14-3-3_CanoR_1	210	215	PF00244	0.451
LIG_14-3-3_CanoR_1	238	245	PF00244	0.470
LIG_14-3-3_CanoR_1	263	267	PF00244	0.422
LIG_14-3-3_CanoR_1	27	31	PF00244	0.558
LIG_14-3-3_CanoR_1	297	307	PF00244	0.405
LIG_14-3-3_CanoR_1	366	370	PF00244	0.282
LIG_14-3-3_CanoR_1	61	71	PF00244	0.700
LIG_14-3-3_CanoR_1	72	82	PF00244	0.713
LIG_Actin_WH2_2	283	299	PF00022	0.359
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_eIF4E_1	356	362	PF01652	0.388
LIG_FHA_1	152	158	PF00498	0.369
LIG_FHA_1	308	314	PF00498	0.468
LIG_FHA_1	334	340	PF00498	0.400
LIG_FHA_1	374	380	PF00498	0.461
LIG_FHA_1	77	83	PF00498	0.691
LIG_FHA_2	122	128	PF00498	0.414
LIG_FHA_2	220	226	PF00498	0.598
LIG_FHA_2	342	348	PF00498	0.433
LIG_FHA_2	95	101	PF00498	0.501
LIG_FXI_DFP_1	300	304	PF00024	0.372
LIG_GBD_Chelix_1	413	421	PF00786	0.415
LIG_HP1_1	371	375	PF01393	0.391
LIG_LIR_Apic_2	199	205	PF02991	0.525
LIG_LIR_Apic_2	29	34	PF02991	0.592
LIG_LIR_Gen_1	141	149	PF02991	0.316
LIG_LIR_Gen_1	416	422	PF02991	0.421
LIG_LIR_Nem_3	141	146	PF02991	0.305
LIG_LIR_Nem_3	312	317	PF02991	0.403
LIG_LIR_Nem_3	416	421	PF02991	0.412
LIG_LIR_Nem_3	69	74	PF02991	0.549
LIG_NRBOX	14	20	PF00104	0.649
LIG_NRBOX	287	293	PF00104	0.393
LIG_NRBOX	356	362	PF00104	0.388
LIG_Pex14_1	139	143	PF04695	0.455
LIG_PTAP_UEV_1	152	157	PF05743	0.461
LIG_SH2_CRK	112	116	PF00017	0.665
LIG_SH2_CRK	118	122	PF00017	0.492
LIG_SH2_CRK	71	75	PF00017	0.559
LIG_SH2_GRB2like	356	359	PF00017	0.434
LIG_SH2_NCK_1	55	59	PF00017	0.473
LIG_SH2_STAT3	229	232	PF00017	0.490
LIG_SH2_STAT5	130	133	PF00017	0.466
LIG_SH2_STAT5	148	151	PF00017	0.537
LIG_SH2_STAT5	356	359	PF00017	0.561
LIG_SH3_1	150	156	PF00018	0.480
LIG_SH3_3	150	156	PF00018	0.443
LIG_SH3_3	45	51	PF00018	0.700
LIG_SH3_CIN85_PxpxPR_1	34	39	PF14604	0.551
LIG_SUMO_SIM_par_1	269	275	PF11976	0.337
LIG_SUMO_SIM_par_1	370	376	PF11976	0.335
LIG_UBA3_1	287	295	PF00899	0.438
MOD_CDK_SPK_2	290	295	PF00069	0.389
MOD_CDK_SPK_2	361	366	PF00069	0.380
MOD_CDK_SPxxK_3	290	297	PF00069	0.246
MOD_CK1_1	181	187	PF00069	0.551
MOD_CK1_1	194	200	PF00069	0.505
MOD_CK1_1	345	351	PF00069	0.514
MOD_CK1_1	53	59	PF00069	0.633
MOD_CK1_1	76	82	PF00069	0.666
MOD_CK2_1	201	207	PF00069	0.382
MOD_CK2_1	219	225	PF00069	0.613
MOD_CK2_1	280	286	PF00069	0.580
MOD_CK2_1	341	347	PF00069	0.429
MOD_CK2_1	94	100	PF00069	0.537
MOD_GlcNHglycan	183	186	PF01048	0.698
MOD_GlcNHglycan	193	196	PF01048	0.603
MOD_GlcNHglycan	254	257	PF01048	0.491
MOD_GlcNHglycan	347	350	PF01048	0.370
MOD_GlcNHglycan	56	59	PF01048	0.654
MOD_GlcNHglycan	64	67	PF01048	0.613
MOD_GlcNHglycan	75	78	PF01048	0.591
MOD_GSK3_1	129	136	PF00069	0.536
MOD_GSK3_1	177	184	PF00069	0.708
MOD_GSK3_1	191	198	PF00069	0.632
MOD_GSK3_1	341	348	PF00069	0.392
MOD_GSK3_1	361	368	PF00069	0.274
MOD_GSK3_1	50	57	PF00069	0.626
MOD_GSK3_1	72	79	PF00069	0.532
MOD_N-GLC_1	10	15	PF02516	0.625
MOD_N-GLC_1	342	347	PF02516	0.524
MOD_NEK2_1	18	23	PF00069	0.609
MOD_NEK2_1	237	242	PF00069	0.460
MOD_NEK2_1	341	346	PF00069	0.560
MOD_NEK2_1	351	356	PF00069	0.442
MOD_NEK2_1	408	413	PF00069	0.389
MOD_NEK2_1	421	426	PF00069	0.549
MOD_NEK2_1	73	78	PF00069	0.671
MOD_NEK2_2	333	338	PF00069	0.447
MOD_PIKK_1	262	268	PF00454	0.478
MOD_PIKK_1	408	414	PF00454	0.298
MOD_PIKK_1	421	427	PF00454	0.502
MOD_PIKK_1	50	56	PF00454	0.471
MOD_PKA_2	237	243	PF00069	0.369
MOD_PKA_2	26	32	PF00069	0.665
MOD_PKA_2	262	268	PF00069	0.416
MOD_PKA_2	365	371	PF00069	0.278
MOD_PKA_2	62	68	PF00069	0.569
MOD_PKA_2	94	100	PF00069	0.500
MOD_Plk_1	10	16	PF00069	0.624
MOD_Plk_1	178	184	PF00069	0.405
MOD_Plk_1	342	348	PF00069	0.519
MOD_Plk_4	121	127	PF00069	0.475
MOD_Plk_4	210	216	PF00069	0.486
MOD_Plk_4	321	327	PF00069	0.445
MOD_Plk_4	352	358	PF00069	0.450
MOD_ProDKin_1	111	117	PF00069	0.572
MOD_ProDKin_1	196	202	PF00069	0.541
MOD_ProDKin_1	219	225	PF00069	0.616
MOD_ProDKin_1	280	286	PF00069	0.492
MOD_ProDKin_1	290	296	PF00069	0.251
MOD_ProDKin_1	361	367	PF00069	0.425
MOD_ProDKin_1	44	50	PF00069	0.703
MOD_SUMO_rev_2	219	228	PF00179	0.567
TRG_DiLeu_BaEn_1	347	352	PF01217	0.397
TRG_DiLeu_BaEn_2	68	74	PF01217	0.462
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.455
TRG_ENDOCYTIC_2	418	421	PF00928	0.419
TRG_ENDOCYTIC_2	71	74	PF00928	0.559
TRG_ER_diArg_1	296	298	PF00400	0.313
TRG_ER_diArg_1	38	40	PF00400	0.675
TRG_ER_diArg_1	87	89	PF00400	0.776
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	383	387	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7E4	Leptomonas seymouri	40%	91%
A0A1X0NTZ3	Trypanosomatidae	30%	100%
A0A3Q8ICX1	Leishmania donovani	88%	100%
A0A3R7L6E6	Trypanosoma rangeli	30%	100%
A4HEW5	Leishmania braziliensis	74%	100%
A4I238	Leishmania infantum	87%	100%
C9ZRW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4Q985	Leishmania major	86%	100%