Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY86_LEIMU

TriTrypDb:

LmxM.26.1070

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY86

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	473	477	PF00656	0.691
CLV_MEL_PAP_1	250	256	PF00089	0.625
CLV_NRD_NRD_1	25	27	PF00675	0.744
CLV_NRD_NRD_1	45	47	PF00675	0.514
CLV_NRD_NRD_1	508	510	PF00675	0.585
CLV_NRD_NRD_1	523	525	PF00675	0.522
CLV_NRD_NRD_1	540	542	PF00675	0.469
CLV_PCSK_KEX2_1	25	27	PF00082	0.747
CLV_PCSK_KEX2_1	309	311	PF00082	0.565
CLV_PCSK_KEX2_1	45	47	PF00082	0.620
CLV_PCSK_KEX2_1	508	510	PF00082	0.585
CLV_PCSK_KEX2_1	540	542	PF00082	0.469
CLV_PCSK_KEX2_1	59	61	PF00082	0.742
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.306
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.782
CLV_PCSK_SKI1_1	120	124	PF00082	0.665
DEG_APCC_DBOX_1	154	162	PF00400	0.785
DOC_CYCLIN_RxL_1	117	127	PF00134	0.688
DOC_MAPK_MEF2A_6	325	332	PF00069	0.317
DOC_MAPK_MEF2A_6	353	361	PF00069	0.552
DOC_MAPK_MEF2A_6	362	369	PF00069	0.548
DOC_MAPK_NFAT4_5	362	370	PF00069	0.409
DOC_PP4_FxxP_1	162	165	PF00568	0.681
DOC_USP7_MATH_1	137	141	PF00917	0.762
DOC_USP7_MATH_1	165	169	PF00917	0.724
DOC_USP7_MATH_1	257	261	PF00917	0.650
DOC_USP7_MATH_1	299	303	PF00917	0.654
DOC_USP7_MATH_1	373	377	PF00917	0.644
DOC_USP7_MATH_1	420	424	PF00917	0.722
DOC_USP7_MATH_1	474	478	PF00917	0.703
DOC_USP7_MATH_1	64	68	PF00917	0.695
DOC_WW_Pin1_4	104	109	PF00397	0.579
DOC_WW_Pin1_4	163	168	PF00397	0.695
DOC_WW_Pin1_4	183	188	PF00397	0.634
DOC_WW_Pin1_4	217	222	PF00397	0.658
DOC_WW_Pin1_4	482	487	PF00397	0.595
DOC_WW_Pin1_4	59	64	PF00397	0.764
DOC_WW_Pin1_4	82	87	PF00397	0.736
DOC_WW_Pin1_4	89	94	PF00397	0.706
LIG_14-3-3_CanoR_1	147	157	PF00244	0.686
LIG_14-3-3_CanoR_1	224	231	PF00244	0.510
LIG_14-3-3_CanoR_1	239	247	PF00244	0.529
LIG_14-3-3_CanoR_1	30	36	PF00244	0.635
LIG_14-3-3_CanoR_1	310	317	PF00244	0.443
LIG_14-3-3_CanoR_1	362	368	PF00244	0.691
LIG_14-3-3_CanoR_1	421	430	PF00244	0.694
LIG_14-3-3_CanoR_1	478	486	PF00244	0.745
LIG_14-3-3_CanoR_1	546	552	PF00244	0.681
LIG_Actin_WH2_2	95	112	PF00022	0.543
LIG_BIR_III_2	425	429	PF00653	0.713
LIG_BRCT_BRCA1_1	139	143	PF00533	0.763
LIG_BRCT_BRCA1_1	227	231	PF00533	0.691
LIG_BRCT_BRCA1_1	250	254	PF00533	0.734
LIG_BRCT_BRCA1_1	259	263	PF00533	0.565
LIG_BRCT_BRCA1_1	311	315	PF00533	0.423
LIG_deltaCOP1_diTrp_1	243	247	PF00928	0.627
LIG_deltaCOP1_diTrp_1	280	289	PF00928	0.597
LIG_FHA_1	133	139	PF00498	0.693
LIG_FHA_1	388	394	PF00498	0.659
LIG_FHA_1	395	401	PF00498	0.530
LIG_FHA_2	285	291	PF00498	0.606
LIG_FHA_2	400	406	PF00498	0.612
LIG_FHA_2	409	415	PF00498	0.481
LIG_GBD_Chelix_1	530	538	PF00786	0.530
LIG_LIR_Apic_2	160	165	PF02991	0.676
LIG_LIR_Apic_2	32	38	PF02991	0.542
LIG_LIR_Gen_1	242	252	PF02991	0.564
LIG_LIR_Gen_1	451	461	PF02991	0.646
LIG_LIR_Nem_3	228	234	PF02991	0.662
LIG_LIR_Nem_3	242	247	PF02991	0.539
LIG_LIR_Nem_3	451	457	PF02991	0.628
LIG_Pex14_2	254	258	PF04695	0.432
LIG_SH2_CRK	133	137	PF00017	0.660
LIG_SH2_CRK	18	22	PF00017	0.720
LIG_SH2_CRK	35	39	PF00017	0.543
LIG_SH2_NCK_1	133	137	PF00017	0.660
LIG_SH2_NCK_1	401	405	PF00017	0.615
LIG_SH2_STAT3	234	237	PF00017	0.745
LIG_SH2_STAT3	347	350	PF00017	0.597
LIG_SH2_STAT5	125	128	PF00017	0.666
LIG_SH2_STAT5	319	322	PF00017	0.508
LIG_SH2_STAT5	401	404	PF00017	0.467
LIG_SH2_STAT5	533	536	PF00017	0.557
LIG_SH3_1	60	66	PF00018	0.630
LIG_SH3_2	2	7	PF14604	0.626
LIG_SH3_3	189	195	PF00018	0.651
LIG_SH3_3	550	556	PF00018	0.746
LIG_SH3_3	60	66	PF00018	0.790
LIG_SH3_3	87	93	PF00018	0.814
LIG_TRAF2_1	114	117	PF00917	0.776
LIG_TRAF2_1	288	291	PF00917	0.522
LIG_WW_3	62	66	PF00397	0.548
MOD_CDC14_SPxK_1	186	189	PF00782	0.527
MOD_CDC14_SPxK_1	62	65	PF00782	0.762
MOD_CDK_SPxK_1	104	110	PF00069	0.538
MOD_CDK_SPxK_1	183	189	PF00069	0.525
MOD_CDK_SPxK_1	59	65	PF00069	0.770
MOD_CDK_SPxxK_3	217	224	PF00069	0.618
MOD_CK1_1	112	118	PF00069	0.781
MOD_CK1_1	203	209	PF00069	0.746
MOD_CK1_1	216	222	PF00069	0.642
MOD_CK1_1	29	35	PF00069	0.713
MOD_CK1_1	468	474	PF00069	0.700
MOD_CK1_1	485	491	PF00069	0.667
MOD_CK1_1	81	87	PF00069	0.783
MOD_CK1_1	89	95	PF00069	0.702
MOD_CK2_1	111	117	PF00069	0.751
MOD_CK2_1	163	169	PF00069	0.725
MOD_CK2_1	229	235	PF00069	0.679
MOD_CK2_1	284	290	PF00069	0.598
MOD_CK2_1	399	405	PF00069	0.566
MOD_CK2_1	520	526	PF00069	0.572
MOD_CK2_1	92	98	PF00069	0.545
MOD_GlcNHglycan	139	142	PF01048	0.762
MOD_GlcNHglycan	174	177	PF01048	0.751
MOD_GlcNHglycan	21	24	PF01048	0.667
MOD_GlcNHglycan	250	253	PF01048	0.734
MOD_GlcNHglycan	255	258	PF01048	0.639
MOD_GlcNHglycan	301	304	PF01048	0.710
MOD_GlcNHglycan	311	314	PF01048	0.323
MOD_GlcNHglycan	472	475	PF01048	0.693
MOD_GlcNHglycan	480	483	PF01048	0.704
MOD_GlcNHglycan	542	545	PF01048	0.470
MOD_GlcNHglycan	66	69	PF01048	0.825
MOD_GlcNHglycan	94	97	PF01048	0.659
MOD_GSK3_1	104	111	PF00069	0.734
MOD_GSK3_1	170	177	PF00069	0.766
MOD_GSK3_1	213	220	PF00069	0.776
MOD_GSK3_1	225	232	PF00069	0.565
MOD_GSK3_1	248	255	PF00069	0.698
MOD_GSK3_1	299	306	PF00069	0.607
MOD_GSK3_1	369	376	PF00069	0.607
MOD_GSK3_1	37	44	PF00069	0.750
MOD_GSK3_1	399	406	PF00069	0.434
MOD_GSK3_1	466	473	PF00069	0.704
MOD_GSK3_1	474	481	PF00069	0.625
MOD_GSK3_1	78	85	PF00069	0.735
MOD_LATS_1	24	30	PF00433	0.556
MOD_NEK2_1	109	114	PF00069	0.521
MOD_NEK2_1	132	137	PF00069	0.763
MOD_NEK2_1	174	179	PF00069	0.797
MOD_NEK2_1	28	33	PF00069	0.673
MOD_NEK2_1	369	374	PF00069	0.664
MOD_NEK2_1	450	455	PF00069	0.459
MOD_NEK2_1	470	475	PF00069	0.460
MOD_NEK2_2	157	162	PF00069	0.691
MOD_PIKK_1	148	154	PF00454	0.636
MOD_PIKK_1	319	325	PF00454	0.475
MOD_PIKK_1	78	84	PF00454	0.811
MOD_PKA_1	309	315	PF00069	0.529
MOD_PKA_1	540	546	PF00069	0.577
MOD_PKA_2	109	115	PF00069	0.728
MOD_PKA_2	146	152	PF00069	0.761
MOD_PKA_2	170	176	PF00069	0.522
MOD_PKA_2	252	258	PF00069	0.729
MOD_PKA_2	29	35	PF00069	0.631
MOD_PKA_2	309	315	PF00069	0.529
MOD_PKA_2	420	426	PF00069	0.742
MOD_PKA_2	520	526	PF00069	0.580
MOD_PKA_2	540	546	PF00069	0.577
MOD_PKA_2	64	70	PF00069	0.561
MOD_Plk_1	465	471	PF00069	0.757
MOD_Plk_4	157	163	PF00069	0.695
MOD_Plk_4	389	395	PF00069	0.356
MOD_Plk_4	450	456	PF00069	0.516
MOD_ProDKin_1	104	110	PF00069	0.580
MOD_ProDKin_1	163	169	PF00069	0.694
MOD_ProDKin_1	183	189	PF00069	0.635
MOD_ProDKin_1	217	223	PF00069	0.655
MOD_ProDKin_1	482	488	PF00069	0.594
MOD_ProDKin_1	59	65	PF00069	0.763
MOD_ProDKin_1	82	88	PF00069	0.738
MOD_ProDKin_1	89	95	PF00069	0.709
TRG_DiLeu_BaEn_2	443	449	PF01217	0.550
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.735
TRG_ENDOCYTIC_2	133	136	PF00928	0.660
TRG_ENDOCYTIC_2	18	21	PF00928	0.720
TRG_ER_diArg_1	25	27	PF00400	0.741
TRG_ER_diArg_1	540	542	PF00400	0.507
TRG_NLS_Bipartite_1	45	62	PF00514	0.607
TRG_NLS_MonoExtN_4	55	62	PF00514	0.794
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.763

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P648	Leptomonas seymouri	34%	100%
A0A3S7WZS1	Leishmania donovani	82%	100%
A4HEW3	Leishmania braziliensis	66%	100%
A4I236	Leishmania infantum	82%	100%
Q4Q987	Leishmania major	82%	100%