RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9AY85_LEIMU

TriTrypDb:

LmxM.26.1060

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY85

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.589
CLV_C14_Caspase3-7	310	314	PF00656	0.703
CLV_NRD_NRD_1	221	223	PF00675	0.693
CLV_PCSK_KEX2_1	221	223	PF00082	0.693
CLV_PCSK_SKI1_1	133	137	PF00082	0.727
CLV_PCSK_SKI1_1	63	67	PF00082	0.317
DEG_SCF_FBW7_2	284	291	PF00400	0.804
DEG_SPOP_SBC_1	266	270	PF00917	0.503
DOC_CKS1_1	285	290	PF01111	0.732
DOC_USP7_MATH_1	173	177	PF00917	0.726
DOC_USP7_MATH_1	267	271	PF00917	0.609
DOC_USP7_MATH_1	273	277	PF00917	0.735
DOC_USP7_MATH_1	294	298	PF00917	0.751
DOC_USP7_MATH_1	309	313	PF00917	0.626
DOC_USP7_MATH_1	48	52	PF00917	0.423
DOC_USP7_MATH_1	58	62	PF00917	0.485
DOC_USP7_MATH_1	84	88	PF00917	0.517
DOC_WW_Pin1_4	160	165	PF00397	0.514
DOC_WW_Pin1_4	189	194	PF00397	0.721
DOC_WW_Pin1_4	284	289	PF00397	0.731
DOC_WW_Pin1_4	3	8	PF00397	0.591
LIG_14-3-3_CanoR_1	30	38	PF00244	0.453
LIG_BRCT_BRCA1_1	131	135	PF00533	0.719
LIG_FHA_1	100	106	PF00498	0.545
LIG_FHA_1	186	192	PF00498	0.614
LIG_FHA_1	19	25	PF00498	0.512
LIG_FHA_2	299	305	PF00498	0.725
LIG_FHA_2	4	10	PF00498	0.702
LIG_LIR_Apic_2	79	83	PF02991	0.517
LIG_LIR_Gen_1	203	209	PF02991	0.567
LIG_LIR_Nem_3	246	252	PF02991	0.581
LIG_LIR_Nem_3	4	8	PF02991	0.594
LIG_LIR_Nem_3	51	56	PF02991	0.520
LIG_LIR_Nem_3	60	65	PF02991	0.513
LIG_PDZ_Class_3	323	328	PF00595	0.776
LIG_SH2_CRK	80	84	PF00017	0.517
LIG_SH2_STAP1	205	209	PF00017	0.601
LIG_SH2_STAT3	32	35	PF00017	0.458
LIG_SH2_STAT5	252	255	PF00017	0.572
LIG_SH2_STAT5	32	35	PF00017	0.422
LIG_SH2_STAT5	91	94	PF00017	0.555
LIG_SH3_1	261	267	PF00018	0.725
LIG_SH3_3	261	267	PF00018	0.767
LIG_SH3_3	313	319	PF00018	0.485
LIG_SH3_3	52	58	PF00018	0.555
LIG_SUMO_SIM_par_1	112	118	PF11976	0.627
LIG_TRAF2_1	293	296	PF00917	0.531
LIG_WRC_WIRS_1	2	7	PF05994	0.647
MOD_CDK_SPxxK_3	160	167	PF00069	0.519
MOD_CK1_1	118	124	PF00069	0.646
MOD_CK1_1	160	166	PF00069	0.746
MOD_CK1_1	171	177	PF00069	0.690
MOD_CK1_1	268	274	PF00069	0.728
MOD_CK1_1	276	282	PF00069	0.720
MOD_CK2_1	298	304	PF00069	0.735
MOD_CK2_1	48	54	PF00069	0.439
MOD_GlcNHglycan	117	120	PF01048	0.669
MOD_GlcNHglycan	159	162	PF01048	0.805
MOD_GlcNHglycan	193	196	PF01048	0.745
MOD_GlcNHglycan	270	273	PF01048	0.682
MOD_GlcNHglycan	295	299	PF01048	0.538
MOD_GlcNHglycan	46	49	PF01048	0.563
MOD_GlcNHglycan	74	77	PF01048	0.321
MOD_GSK3_1	114	121	PF00069	0.616
MOD_GSK3_1	185	192	PF00069	0.632
MOD_GSK3_1	294	301	PF00069	0.730
MOD_GSK3_1	44	51	PF00069	0.568
MOD_GSK3_1	72	79	PF00069	0.517
MOD_N-GLC_1	171	176	PF02516	0.738
MOD_NEK2_1	1	6	PF00069	0.658
MOD_NEK2_1	136	141	PF00069	0.726
MOD_NEK2_1	72	77	PF00069	0.517
MOD_PIKK_1	136	142	PF00454	0.785
MOD_PIKK_1	31	37	PF00454	0.449
MOD_PKA_2	136	142	PF00069	0.699
MOD_PKA_2	157	163	PF00069	0.738
MOD_Plk_1	84	90	PF00069	0.542
MOD_ProDKin_1	160	166	PF00069	0.516
MOD_ProDKin_1	189	195	PF00069	0.720
MOD_ProDKin_1	284	290	PF00069	0.732
MOD_ProDKin_1	3	9	PF00069	0.592
MOD_SUMO_for_1	49	52	PF00179	0.555
MOD_SUMO_rev_2	206	214	PF00179	0.667
TRG_ENDOCYTIC_2	205	208	PF00928	0.558
TRG_ENDOCYTIC_2	56	59	PF00928	0.527
TRG_ENDOCYTIC_2	62	65	PF00928	0.505
TRG_ER_diArg_1	220	222	PF00400	0.671
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I9	Leptomonas seymouri	58%	98%
A0A3Q8ICS1	Leishmania donovani	91%	100%
A0A422NSU1	Trypanosoma rangeli	41%	100%
A4HEW2	Leishmania braziliensis	83%	100%
A4I235	Leishmania infantum	91%	100%
Q4Q988	Leishmania major	92%	100%