Nicalin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Nicalin

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY83_LEIMU

TriTrypDb:

LmxM.26.1040

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

E9AY83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY83

Function

Biological processes
Term	Name	Level	Count
GO:0009966	regulation of signal transduction	4	11
GO:0010646	regulation of cell communication	4	11
GO:0023051	regulation of signaling	3	11
GO:0048583	regulation of response to stimulus	3	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0065007	biological regulation	1	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	240	242	PF00675	0.501
CLV_NRD_NRD_1	389	391	PF00675	0.597
CLV_PCSK_KEX2_1	240	242	PF00082	0.501
CLV_PCSK_KEX2_1	320	322	PF00082	0.623
CLV_PCSK_KEX2_1	389	391	PF00082	0.607
CLV_PCSK_KEX2_1	403	405	PF00082	0.493
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.632
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.573
CLV_PCSK_SKI1_1	154	158	PF00082	0.592
CLV_PCSK_SKI1_1	159	163	PF00082	0.577
CLV_PCSK_SKI1_1	24	28	PF00082	0.551
CLV_PCSK_SKI1_1	240	244	PF00082	0.582
CLV_PCSK_SKI1_1	289	293	PF00082	0.540
CLV_PCSK_SKI1_1	33	37	PF00082	0.563
CLV_PCSK_SKI1_1	366	370	PF00082	0.508
CLV_PCSK_SKI1_1	52	56	PF00082	0.558
CLV_PCSK_SKI1_1	99	103	PF00082	0.609
CLV_Separin_Metazoa	59	63	PF03568	0.375
DEG_Nend_Nbox_1	1	3	PF02207	0.610
DEG_SCF_FBW7_1	493	499	PF00400	0.423
DEG_SPOP_SBC_1	271	275	PF00917	0.392
DOC_CKS1_1	493	498	PF01111	0.425
DOC_MAPK_gen_1	99	108	PF00069	0.354
DOC_MAPK_MEF2A_6	24	31	PF00069	0.283
DOC_MAPK_MEF2A_6	3	11	PF00069	0.491
DOC_MAPK_MEF2A_6	336	344	PF00069	0.329
DOC_MAPK_MEF2A_6	99	108	PF00069	0.395
DOC_MAPK_RevD_3	308	321	PF00069	0.363
DOC_PP1_RVXF_1	31	38	PF00149	0.352
DOC_PP2B_LxvP_1	92	95	PF13499	0.371
DOC_USP7_MATH_1	152	156	PF00917	0.417
DOC_USP7_MATH_1	183	187	PF00917	0.251
DOC_USP7_MATH_1	362	366	PF00917	0.361
DOC_USP7_MATH_1	418	422	PF00917	0.473
DOC_USP7_MATH_1	443	447	PF00917	0.344
DOC_USP7_MATH_1	65	69	PF00917	0.405
DOC_USP7_MATH_1	95	99	PF00917	0.261
DOC_WW_Pin1_4	217	222	PF00397	0.409
DOC_WW_Pin1_4	242	247	PF00397	0.439
DOC_WW_Pin1_4	296	301	PF00397	0.261
DOC_WW_Pin1_4	446	451	PF00397	0.319
DOC_WW_Pin1_4	492	497	PF00397	0.409
LIG_14-3-3_CanoR_1	146	151	PF00244	0.386
LIG_14-3-3_CanoR_1	154	162	PF00244	0.404
LIG_14-3-3_CanoR_1	240	246	PF00244	0.382
LIG_14-3-3_CanoR_1	33	38	PF00244	0.322
LIG_14-3-3_CanoR_1	366	373	PF00244	0.415
LIG_14-3-3_CanoR_1	377	385	PF00244	0.340
LIG_14-3-3_CanoR_1	390	400	PF00244	0.412
LIG_14-3-3_CanoR_1	478	487	PF00244	0.340
LIG_14-3-3_CterR_2	545	549	PF00244	0.638
LIG_APCC_ABBA_1	501	506	PF00400	0.340
LIG_APCC_ABBA_1	544	549	PF00400	0.636
LIG_BRCT_BRCA1_1	119	123	PF00533	0.399
LIG_EH1_1	255	263	PF00400	0.325
LIG_eIF4E_1	256	262	PF01652	0.318
LIG_FHA_1	12	18	PF00498	0.574
LIG_FHA_1	155	161	PF00498	0.399
LIG_FHA_1	165	171	PF00498	0.468
LIG_FHA_1	257	263	PF00498	0.339
LIG_FHA_1	272	278	PF00498	0.318
LIG_FHA_1	379	385	PF00498	0.341
LIG_FHA_1	493	499	PF00498	0.369
LIG_FHA_1	505	511	PF00498	0.341
LIG_FHA_1	539	545	PF00498	0.592
LIG_FHA_1	62	68	PF00498	0.307
LIG_FHA_1	73	79	PF00498	0.289
LIG_FHA_2	111	117	PF00498	0.325
LIG_FHA_2	279	285	PF00498	0.421
LIG_FHA_2	301	307	PF00498	0.365
LIG_FHA_2	487	493	PF00498	0.408
LIG_GBD_Chelix_1	234	242	PF00786	0.534
LIG_GBD_Chelix_1	290	298	PF00786	0.458
LIG_LIR_Gen_1	211	222	PF02991	0.295
LIG_LIR_Gen_1	309	319	PF02991	0.318
LIG_LIR_Gen_1	489	498	PF02991	0.422
LIG_LIR_Nem_3	211	217	PF02991	0.290
LIG_LIR_Nem_3	237	242	PF02991	0.289
LIG_LIR_Nem_3	286	291	PF02991	0.301
LIG_LIR_Nem_3	309	314	PF02991	0.300
LIG_LIR_Nem_3	349	354	PF02991	0.355
LIG_LIR_Nem_3	382	388	PF02991	0.373
LIG_LIR_Nem_3	489	493	PF02991	0.413
LIG_LIR_Nem_3	499	504	PF02991	0.350
LIG_LIR_Nem_3	68	74	PF02991	0.408
LIG_MLH1_MIPbox_1	119	123	PF16413	0.399
LIG_NRBOX	143	149	PF00104	0.419
LIG_NRBOX	293	299	PF00104	0.201
LIG_PCNA_PIPBox_1	207	216	PF02747	0.389
LIG_SH2_SRC	311	314	PF00017	0.374
LIG_SH2_STAP1	354	358	PF00017	0.322
LIG_SH2_STAP1	461	465	PF00017	0.303
LIG_SH2_STAP1	504	508	PF00017	0.296
LIG_SH2_STAP1	74	78	PF00017	0.360
LIG_SH2_STAT3	247	250	PF00017	0.456
LIG_SH2_STAT5	133	136	PF00017	0.300
LIG_SH2_STAT5	188	191	PF00017	0.378
LIG_SH2_STAT5	311	314	PF00017	0.349
LIG_SH2_STAT5	435	438	PF00017	0.381
LIG_SH2_STAT5	516	519	PF00017	0.472
LIG_SH2_STAT5	63	66	PF00017	0.358
LIG_SH2_STAT5	74	77	PF00017	0.270
LIG_SH3_3	125	131	PF00018	0.216
LIG_SH3_3	186	192	PF00018	0.400
LIG_SUMO_SIM_par_1	104	114	PF11976	0.391
LIG_SUMO_SIM_par_1	160	165	PF11976	0.230
LIG_SUMO_SIM_par_1	258	266	PF11976	0.314
LIG_SUMO_SIM_par_1	8	14	PF11976	0.534
LIG_TRAF2_1	248	251	PF00917	0.480
LIG_TRAF2_1	489	492	PF00917	0.424
LIG_UBA3_1	337	343	PF00899	0.360
MOD_CDK_SPxxK_3	217	224	PF00069	0.413
MOD_CDK_SPxxK_3	242	249	PF00069	0.443
MOD_CK1_1	220	226	PF00069	0.360
MOD_CK1_1	275	281	PF00069	0.425
MOD_CK1_1	346	352	PF00069	0.399
MOD_CK1_1	446	452	PF00069	0.322
MOD_CK1_1	483	489	PF00069	0.354
MOD_CK2_1	110	116	PF00069	0.328
MOD_CK2_1	278	284	PF00069	0.372
MOD_CK2_1	296	302	PF00069	0.248
MOD_CK2_1	486	492	PF00069	0.400
MOD_GlcNHglycan	154	157	PF01048	0.609
MOD_GlcNHglycan	180	183	PF01048	0.569
MOD_GlcNHglycan	200	203	PF01048	0.477
MOD_GlcNHglycan	225	228	PF01048	0.535
MOD_GlcNHglycan	229	232	PF01048	0.504
MOD_GlcNHglycan	345	348	PF01048	0.598
MOD_GlcNHglycan	373	376	PF01048	0.500
MOD_GlcNHglycan	420	423	PF01048	0.688
MOD_GlcNHglycan	482	485	PF01048	0.623
MOD_GSK3_1	117	124	PF00069	0.372
MOD_GSK3_1	138	145	PF00069	0.367
MOD_GSK3_1	160	167	PF00069	0.398
MOD_GSK3_1	174	181	PF00069	0.406
MOD_GSK3_1	194	201	PF00069	0.293
MOD_GSK3_1	213	220	PF00069	0.362
MOD_GSK3_1	223	230	PF00069	0.305
MOD_GSK3_1	271	278	PF00069	0.393
MOD_GSK3_1	296	303	PF00069	0.271
MOD_GSK3_1	362	369	PF00069	0.335
MOD_GSK3_1	479	486	PF00069	0.314
MOD_GSK3_1	492	499	PF00069	0.333
MOD_GSK3_1	61	68	PF00069	0.360
MOD_GSK3_1	78	85	PF00069	0.360
MOD_N-GLC_1	175	180	PF02516	0.545
MOD_NEK2_1	1	6	PF00069	0.563
MOD_NEK2_1	10	15	PF00069	0.440
MOD_NEK2_1	121	126	PF00069	0.378
MOD_NEK2_1	162	167	PF00069	0.375
MOD_NEK2_1	261	266	PF00069	0.305
MOD_NEK2_1	338	343	PF00069	0.411
MOD_NEK2_1	371	376	PF00069	0.371
MOD_NEK2_1	48	53	PF00069	0.349
MOD_NEK2_1	61	66	PF00069	0.315
MOD_NEK2_2	496	501	PF00069	0.391
MOD_PIKK_1	164	170	PF00454	0.387
MOD_PIKK_1	275	281	PF00454	0.383
MOD_PIKK_1	443	449	PF00454	0.348
MOD_PK_1	146	152	PF00069	0.431
MOD_PK_1	249	255	PF00069	0.415
MOD_PKA_1	240	246	PF00069	0.381
MOD_PKA_2	168	174	PF00069	0.454
MOD_PKA_2	223	229	PF00069	0.404
MOD_PKA_2	240	246	PF00069	0.271
MOD_PKA_2	477	483	PF00069	0.361
MOD_PKA_2	61	67	PF00069	0.304
MOD_Plk_1	142	148	PF00069	0.349
MOD_Plk_1	174	180	PF00069	0.347
MOD_Plk_1	504	510	PF00069	0.385
MOD_Plk_4	117	123	PF00069	0.404
MOD_Plk_4	256	262	PF00069	0.318
MOD_Plk_4	272	278	PF00069	0.346
MOD_Plk_4	424	430	PF00069	0.437
MOD_Plk_4	431	437	PF00069	0.344
MOD_Plk_4	512	518	PF00069	0.355
MOD_Plk_4	72	78	PF00069	0.284
MOD_ProDKin_1	217	223	PF00069	0.410
MOD_ProDKin_1	242	248	PF00069	0.440
MOD_ProDKin_1	296	302	PF00069	0.274
MOD_ProDKin_1	446	452	PF00069	0.320
MOD_ProDKin_1	492	498	PF00069	0.404
MOD_SUMO_for_1	136	139	PF00179	0.226
TRG_DiLeu_BaEn_1	143	148	PF01217	0.415
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.205
TRG_DiLeu_LyEn_5	143	148	PF01217	0.415
TRG_ENDOCYTIC_2	311	314	PF00928	0.315
TRG_ENDOCYTIC_2	490	493	PF00928	0.386
TRG_ER_diArg_1	239	241	PF00400	0.296
TRG_ER_diArg_1	388	390	PF00400	0.405
TRG_NES_CRM1_1	284	296	PF08389	0.336
TRG_NES_CRM1_1	309	322	PF08389	0.366
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	413	417	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P650	Leptomonas seymouri	60%	100%
A0A1X0NSR2	Trypanosomatidae	34%	86%
A0A3R7MV36	Trypanosoma rangeli	36%	91%
A0A3S7WZU9	Leishmania donovani	91%	100%
A4HEW0	Leishmania braziliensis	77%	100%
A4I233	Leishmania infantum	91%	100%
C9ZRX2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	92%
Q4Q990	Leishmania major	90%	100%
Q969V3	Homo sapiens	24%	98%
V5BPU6	Trypanosoma cruzi	34%	91%