Aldo_ket_red domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY82_LEIMU

TriTrypDb:

LmxM.26.1030

Length:

778

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY82

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.476
CLV_NRD_NRD_1	311	313	PF00675	0.428
CLV_NRD_NRD_1	48	50	PF00675	0.662
CLV_NRD_NRD_1	577	579	PF00675	0.420
CLV_NRD_NRD_1	75	77	PF00675	0.599
CLV_PCSK_FUR_1	575	579	PF00082	0.420
CLV_PCSK_KEX2_1	311	313	PF00082	0.428
CLV_PCSK_KEX2_1	48	50	PF00082	0.641
CLV_PCSK_KEX2_1	577	579	PF00082	0.439
CLV_PCSK_KEX2_1	75	77	PF00082	0.495
CLV_PCSK_PC7_1	307	313	PF00082	0.456
CLV_PCSK_PC7_1	44	50	PF00082	0.660
CLV_PCSK_PC7_1	71	77	PF00082	0.435
CLV_PCSK_SKI1_1	105	109	PF00082	0.626
CLV_PCSK_SKI1_1	125	129	PF00082	0.392
CLV_PCSK_SKI1_1	375	379	PF00082	0.535
CLV_PCSK_SKI1_1	48	52	PF00082	0.634
CLV_PCSK_SKI1_1	520	524	PF00082	0.413
CLV_PCSK_SKI1_1	556	560	PF00082	0.427
CLV_PCSK_SKI1_1	774	778	PF00082	0.766
DEG_APCC_DBOX_1	306	314	PF00400	0.460
DEG_APCC_DBOX_1	47	55	PF00400	0.668
DEG_APCC_DBOX_1	519	527	PF00400	0.428
DEG_Nend_Nbox_1	1	3	PF02207	0.699
DOC_CKS1_1	413	418	PF01111	0.652
DOC_CKS1_1	571	576	PF01111	0.529
DOC_CYCLIN_RxL_1	471	479	PF00134	0.418
DOC_MAPK_MEF2A_6	338	346	PF00069	0.375
DOC_PP1_RVXF_1	642	649	PF00149	0.368
DOC_PP2B_LxvP_1	392	395	PF13499	0.514
DOC_PP2B_LxvP_1	486	489	PF13499	0.465
DOC_PP2B_LxvP_1	680	683	PF13499	0.429
DOC_PP4_FxxP_1	168	171	PF00568	0.553
DOC_PP4_FxxP_1	27	30	PF00568	0.555
DOC_USP7_MATH_1	107	111	PF00917	0.445
DOC_USP7_MATH_1	136	140	PF00917	0.564
DOC_USP7_MATH_1	195	199	PF00917	0.389
DOC_USP7_MATH_1	287	291	PF00917	0.587
DOC_USP7_MATH_1	762	766	PF00917	0.740
DOC_USP7_MATH_1	90	94	PF00917	0.682
DOC_USP7_UBL2_3	592	596	PF12436	0.423
DOC_USP7_UBL2_3	720	724	PF12436	0.631
DOC_USP7_UBL2_3	773	777	PF12436	0.502
DOC_WW_Pin1_4	31	36	PF00397	0.703
DOC_WW_Pin1_4	319	324	PF00397	0.406
DOC_WW_Pin1_4	386	391	PF00397	0.377
DOC_WW_Pin1_4	412	417	PF00397	0.656
DOC_WW_Pin1_4	456	461	PF00397	0.547
DOC_WW_Pin1_4	481	486	PF00397	0.372
DOC_WW_Pin1_4	570	575	PF00397	0.539
DOC_WW_Pin1_4	629	634	PF00397	0.375
DOC_WW_Pin1_4	699	704	PF00397	0.467
LIG_14-3-3_CanoR_1	147	151	PF00244	0.420
LIG_14-3-3_CanoR_1	159	163	PF00244	0.372
LIG_14-3-3_CanoR_1	29	38	PF00244	0.701
LIG_14-3-3_CanoR_1	3	7	PF00244	0.719
LIG_14-3-3_CanoR_1	315	323	PF00244	0.429
LIG_APCC_ABBA_1	369	374	PF00400	0.415
LIG_BRCT_BRCA1_1	159	163	PF00533	0.417
LIG_BRCT_BRCA1_1	662	666	PF00533	0.392
LIG_Clathr_ClatBox_1	729	733	PF01394	0.698
LIG_deltaCOP1_diTrp_1	164	168	PF00928	0.571
LIG_deltaCOP1_diTrp_1	324	330	PF00928	0.414
LIG_eIF4E_1	651	657	PF01652	0.463
LIG_eIF4E_1	707	713	PF01652	0.652
LIG_FHA_1	265	271	PF00498	0.542
LIG_FHA_1	420	426	PF00498	0.529
LIG_FHA_1	53	59	PF00498	0.699
LIG_FHA_1	761	767	PF00498	0.607
LIG_FHA_2	159	165	PF00498	0.431
LIG_FHA_2	258	264	PF00498	0.566
LIG_FHA_2	335	341	PF00498	0.392
LIG_FHA_2	350	356	PF00498	0.364
LIG_FHA_2	514	520	PF00498	0.407
LIG_GBD_Chelix_1	223	231	PF00786	0.529
LIG_LIR_Apic_2	26	30	PF02991	0.428
LIG_LIR_Apic_2	411	416	PF02991	0.663
LIG_LIR_Apic_2	629	633	PF02991	0.539
LIG_LIR_Gen_1	17	28	PF02991	0.633
LIG_LIR_Gen_1	239	249	PF02991	0.375
LIG_LIR_Gen_1	327	335	PF02991	0.403
LIG_LIR_Gen_1	496	505	PF02991	0.489
LIG_LIR_Gen_1	695	706	PF02991	0.550
LIG_LIR_Nem_3	17	23	PF02991	0.634
LIG_LIR_Nem_3	239	244	PF02991	0.365
LIG_LIR_Nem_3	327	333	PF02991	0.396
LIG_LIR_Nem_3	439	445	PF02991	0.519
LIG_LIR_Nem_3	496	501	PF02991	0.501
LIG_LIR_Nem_3	565	570	PF02991	0.425
LIG_LIR_Nem_3	695	701	PF02991	0.523
LIG_LYPXL_yS_3	400	403	PF13949	0.523
LIG_MLH1_MIPbox_1	662	666	PF16413	0.392
LIG_MYND_1	390	394	PF01753	0.440
LIG_MYND_3	539	543	PF01753	0.481
LIG_Pex14_1	325	329	PF04695	0.410
LIG_Pex14_1	567	571	PF04695	0.419
LIG_Pex14_1	594	598	PF04695	0.384
LIG_Pex14_2	27	31	PF04695	0.572
LIG_Pex14_2	558	562	PF04695	0.382
LIG_Pex14_2	563	567	PF04695	0.392
LIG_PTB_Apo_2	329	336	PF02174	0.397
LIG_PTB_Apo_2	557	564	PF02174	0.391
LIG_PTB_Phospho_1	329	335	PF10480	0.397
LIG_Rb_pABgroove_1	348	356	PF01858	0.468
LIG_REV1ctd_RIR_1	25	29	PF16727	0.433
LIG_SH2_CRK	20	24	PF00017	0.430
LIG_SH2_CRK	413	417	PF00017	0.650
LIG_SH2_CRK	571	575	PF00017	0.407
LIG_SH2_CRK	698	702	PF00017	0.567
LIG_SH2_GRB2like	498	501	PF00017	0.402
LIG_SH2_GRB2like	698	701	PF00017	0.491
LIG_SH2_NCK_1	698	702	PF00017	0.567
LIG_SH2_PTP2	630	633	PF00017	0.458
LIG_SH2_SRC	698	701	PF00017	0.530
LIG_SH2_STAP1	20	24	PF00017	0.430
LIG_SH2_STAP1	598	602	PF00017	0.415
LIG_SH2_STAT5	155	158	PF00017	0.406
LIG_SH2_STAT5	372	375	PF00017	0.383
LIG_SH2_STAT5	551	554	PF00017	0.402
LIG_SH2_STAT5	630	633	PF00017	0.511
LIG_SH2_STAT5	665	668	PF00017	0.389
LIG_SH2_STAT5	728	731	PF00017	0.654
LIG_SH3_1	398	404	PF00018	0.498
LIG_SH3_1	414	420	PF00018	0.501
LIG_SH3_1	731	737	PF00018	0.595
LIG_SH3_3	32	38	PF00018	0.690
LIG_SH3_3	384	390	PF00018	0.458
LIG_SH3_3	391	397	PF00018	0.423
LIG_SH3_3	398	404	PF00018	0.410
LIG_SH3_3	414	420	PF00018	0.501
LIG_SH3_3	442	448	PF00018	0.381
LIG_SH3_3	63	69	PF00018	0.563
LIG_SH3_3	698	704	PF00018	0.447
LIG_SH3_3	731	737	PF00018	0.575
LIG_SUMO_SIM_anti_2	340	346	PF11976	0.348
LIG_SUMO_SIM_par_1	343	348	PF11976	0.363
LIG_TRAF2_1	77	80	PF00917	0.661
LIG_TYR_ITIM	382	387	PF00017	0.380
LIG_TYR_ITIM	481	486	PF00017	0.416
LIG_TYR_ITIM	696	701	PF00017	0.550
LIG_TYR_ITSM	16	23	PF00017	0.432
LIG_UBA3_1	274	282	PF00899	0.667
LIG_UBA3_1	369	378	PF00899	0.410
LIG_UBA3_1	708	717	PF00899	0.605
LIG_WRC_WIRS_1	24	29	PF05994	0.433
LIG_WRPW_2	28	31	PF00400	0.437
MOD_CDK_SPK_2	570	575	PF00069	0.539
MOD_CDK_SPxK_1	412	418	PF00069	0.656
MOD_CDK_SPxxK_3	570	577	PF00069	0.542
MOD_CK1_1	15	21	PF00069	0.580
MOD_CK1_1	285	291	PF00069	0.488
MOD_CK1_1	36	42	PF00069	0.696
MOD_CK1_1	57	63	PF00069	0.713
MOD_CK1_1	74	80	PF00069	0.622
MOD_CK2_1	158	164	PF00069	0.414
MOD_CK2_1	257	263	PF00069	0.558
MOD_CK2_1	334	340	PF00069	0.400
MOD_CK2_1	481	487	PF00069	0.378
MOD_CK2_1	513	519	PF00069	0.388
MOD_CK2_1	74	80	PF00069	0.673
MOD_CK2_1	748	754	PF00069	0.706
MOD_GlcNHglycan	109	112	PF01048	0.439
MOD_GlcNHglycan	121	124	PF01048	0.491
MOD_GlcNHglycan	14	17	PF01048	0.714
MOD_GlcNHglycan	237	241	PF01048	0.459
MOD_GlcNHglycan	292	295	PF01048	0.543
MOD_GlcNHglycan	587	590	PF01048	0.464
MOD_GlcNHglycan	757	760	PF01048	0.714
MOD_GlcNHglycan	92	95	PF01048	0.708
MOD_GSK3_1	14	21	PF00069	0.511
MOD_GSK3_1	146	153	PF00069	0.407
MOD_GSK3_1	176	183	PF00069	0.421
MOD_GSK3_1	281	288	PF00069	0.533
MOD_GSK3_1	29	36	PF00069	0.709
MOD_GSK3_1	50	57	PF00069	0.560
MOD_GSK3_1	58	65	PF00069	0.687
MOD_GSK3_1	716	723	PF00069	0.621
MOD_N-GLC_1	449	454	PF02516	0.365
MOD_N-GLC_1	465	470	PF02516	0.394
MOD_N-GLC_1	699	704	PF02516	0.452
MOD_N-GLC_1	90	95	PF02516	0.711
MOD_NEK2_1	1	6	PF00069	0.545
MOD_NEK2_1	157	162	PF00069	0.465
MOD_NEK2_1	181	186	PF00069	0.518
MOD_NEK2_1	236	241	PF00069	0.460
MOD_NEK2_1	300	305	PF00069	0.487
MOD_NEK2_1	449	454	PF00069	0.384
MOD_NEK2_1	476	481	PF00069	0.376
MOD_NEK2_1	546	551	PF00069	0.381
MOD_NEK2_1	58	63	PF00069	0.618
MOD_NEK2_1	660	665	PF00069	0.389
MOD_NEK2_2	182	187	PF00069	0.405
MOD_NEK2_2	287	292	PF00069	0.599
MOD_NEK2_2	349	354	PF00069	0.397
MOD_NEK2_2	762	767	PF00069	0.503
MOD_PIKK_1	18	24	PF00454	0.678
MOD_PIKK_1	300	306	PF00454	0.503
MOD_PIKK_1	449	455	PF00454	0.391
MOD_PKA_2	12	18	PF00069	0.690
MOD_PKA_2	136	142	PF00069	0.519
MOD_PKA_2	146	152	PF00069	0.397
MOD_PKA_2	158	164	PF00069	0.381
MOD_PKA_2	2	8	PF00069	0.734
MOD_PKA_2	295	301	PF00069	0.456
MOD_PKA_2	314	320	PF00069	0.441
MOD_PKA_2	74	80	PF00069	0.574
MOD_Plk_1	157	163	PF00069	0.461
MOD_Plk_1	257	263	PF00069	0.582
MOD_Plk_1	300	306	PF00069	0.480
MOD_Plk_1	465	471	PF00069	0.481
MOD_Plk_2-3	158	164	PF00069	0.445
MOD_Plk_4	15	21	PF00069	0.600
MOD_Plk_4	158	164	PF00069	0.445
MOD_Plk_4	349	355	PF00069	0.407
MOD_Plk_4	54	60	PF00069	0.554
MOD_Plk_4	546	552	PF00069	0.376
MOD_ProDKin_1	31	37	PF00069	0.704
MOD_ProDKin_1	319	325	PF00069	0.406
MOD_ProDKin_1	386	392	PF00069	0.376
MOD_ProDKin_1	412	418	PF00069	0.656
MOD_ProDKin_1	456	462	PF00069	0.557
MOD_ProDKin_1	481	487	PF00069	0.378
MOD_ProDKin_1	570	576	PF00069	0.536
MOD_ProDKin_1	629	635	PF00069	0.369
MOD_ProDKin_1	699	705	PF00069	0.472
MOD_SUMO_rev_2	504	510	PF00179	0.407
MOD_SUMO_rev_2	525	531	PF00179	0.446
MOD_SUMO_rev_2	710	719	PF00179	0.571
TRG_DiLeu_BaEn_1	487	492	PF01217	0.427
TRG_ENDOCYTIC_2	20	23	PF00928	0.430
TRG_ENDOCYTIC_2	228	231	PF00928	0.404
TRG_ENDOCYTIC_2	384	387	PF00928	0.372
TRG_ENDOCYTIC_2	400	403	PF00928	0.419
TRG_ENDOCYTIC_2	426	429	PF00928	0.391
TRG_ENDOCYTIC_2	483	486	PF00928	0.416
TRG_ENDOCYTIC_2	498	501	PF00928	0.335
TRG_ENDOCYTIC_2	598	601	PF00928	0.378
TRG_ENDOCYTIC_2	698	701	PF00928	0.562
TRG_ER_diArg_1	270	273	PF00400	0.550
TRG_ER_diArg_1	310	312	PF00400	0.414
TRG_ER_diArg_1	47	49	PF00400	0.634
TRG_ER_diArg_1	576	578	PF00400	0.418
TRG_ER_diArg_1	606	609	PF00400	0.385
TRG_NES_CRM1_1	360	374	PF08389	0.235
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK7	Leptomonas seymouri	76%	100%
A0A0S4JUK7	Bodo saltans	63%	100%
A0A1X0NTZ9	Trypanosomatidae	76%	100%
A0A3Q8IH01	Leishmania donovani	95%	100%
A4HEV9	Leishmania braziliensis	88%	100%
C9ZRX3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
Q4Q991	Leishmania major	95%	100%
V5BUF5	Trypanosoma cruzi	70%	100%