C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY79_LEIMU

TriTrypDb:

LmxM.26.1010

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AY79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY79

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.632
CLV_NRD_NRD_1	282	284	PF00675	0.639
CLV_PCSK_KEX2_1	217	219	PF00082	0.599
CLV_PCSK_KEX2_1	282	284	PF00082	0.639
CLV_PCSK_KEX2_1	5	7	PF00082	0.679
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.599
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.757
CLV_PCSK_SKI1_1	129	133	PF00082	0.481
CLV_PCSK_SKI1_1	161	165	PF00082	0.587
CLV_PCSK_SKI1_1	217	221	PF00082	0.612
DEG_APCC_DBOX_1	26	34	PF00400	0.559
DEG_SCF_FBW7_1	374	381	PF00400	0.676
DEG_SPOP_SBC_1	378	382	PF00917	0.785
DOC_CYCLIN_RxL_1	129	140	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	329	335	PF00134	0.752
DOC_MAPK_gen_1	217	225	PF00069	0.513
DOC_MAPK_gen_1	5	11	PF00069	0.616
DOC_MAPK_MEF2A_6	5	13	PF00069	0.650
DOC_PP1_RVXF_1	132	139	PF00149	0.551
DOC_PP1_RVXF_1	192	198	PF00149	0.610
DOC_PP2B_LxvP_1	11	14	PF13499	0.632
DOC_USP7_MATH_1	325	329	PF00917	0.615
DOC_USP7_MATH_1	361	365	PF00917	0.610
DOC_USP7_MATH_1	396	400	PF00917	0.684
DOC_WW_Pin1_4	122	127	PF00397	0.593
DOC_WW_Pin1_4	328	333	PF00397	0.638
DOC_WW_Pin1_4	334	339	PF00397	0.585
DOC_WW_Pin1_4	374	379	PF00397	0.656
DOC_WW_Pin1_4	383	388	PF00397	0.641
LIG_14-3-3_CanoR_1	129	138	PF00244	0.572
LIG_14-3-3_CanoR_1	344	348	PF00244	0.579
LIG_14-3-3_CanoR_1	6	12	PF00244	0.684
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_BRCT_BRCA1_1	221	225	PF00533	0.498
LIG_FHA_1	130	136	PF00498	0.505
LIG_FHA_1	14	20	PF00498	0.482
LIG_FHA_1	286	292	PF00498	0.760
LIG_FHA_1	337	343	PF00498	0.708
LIG_FHA_1	384	390	PF00498	0.645
LIG_FHA_1	57	63	PF00498	0.469
LIG_FHA_1	78	84	PF00498	0.527
LIG_FHA_2	29	35	PF00498	0.588
LIG_FHA_2	344	350	PF00498	0.572
LIG_FHA_2	366	372	PF00498	0.636
LIG_LIR_Gen_1	85	94	PF02991	0.470
LIG_LIR_Nem_3	222	228	PF02991	0.514
LIG_LIR_Nem_3	25	29	PF02991	0.521
LIG_LIR_Nem_3	85	89	PF02991	0.455
LIG_MLH1_MIPbox_1	221	225	PF16413	0.498
LIG_PAM2_1	334	346	PF00658	0.711
LIG_Pex14_1	240	244	PF04695	0.543
LIG_Pex14_1	82	86	PF04695	0.405
LIG_PTB_Apo_2	391	398	PF02174	0.699
LIG_REV1ctd_RIR_1	222	231	PF16727	0.504
LIG_REV1ctd_RIR_1	241	249	PF16727	0.529
LIG_SH2_CRK	86	90	PF00017	0.483
LIG_SH2_NCK_1	108	112	PF00017	0.546
LIG_SH2_NCK_1	86	90	PF00017	0.405
LIG_SH2_STAP1	108	112	PF00017	0.475
LIG_SH2_STAT3	350	353	PF00017	0.602
LIG_SH2_STAT3	93	96	PF00017	0.599
LIG_SH2_STAT5	248	251	PF00017	0.566
LIG_SH2_STAT5	29	32	PF00017	0.552
LIG_SH2_STAT5	350	353	PF00017	0.602
LIG_SH2_STAT5	93	96	PF00017	0.488
LIG_SH3_1	154	160	PF00018	0.620
LIG_SH3_1	318	324	PF00018	0.735
LIG_SH3_3	120	126	PF00018	0.533
LIG_SH3_3	145	151	PF00018	0.637
LIG_SH3_3	154	160	PF00018	0.556
LIG_SH3_3	318	324	PF00018	0.688
LIG_SH3_3	332	338	PF00018	0.698
LIG_SUMO_SIM_anti_2	331	337	PF11976	0.697
LIG_SUMO_SIM_par_1	331	337	PF11976	0.701
LIG_UBA3_1	365	373	PF00899	0.696
MOD_CDK_SPxxK_3	122	129	PF00069	0.582
MOD_CK1_1	28	34	PF00069	0.559
MOD_CK1_1	328	334	PF00069	0.694
MOD_CK1_1	399	405	PF00069	0.740
MOD_CK1_1	75	81	PF00069	0.467
MOD_CK2_1	309	315	PF00069	0.651
MOD_CK2_1	316	322	PF00069	0.778
MOD_CK2_1	377	383	PF00069	0.783
MOD_GlcNHglycan	142	145	PF01048	0.528
MOD_GlcNHglycan	311	314	PF01048	0.603
MOD_GlcNHglycan	318	321	PF01048	0.663
MOD_GlcNHglycan	34	38	PF01048	0.640
MOD_GlcNHglycan	353	356	PF01048	0.733
MOD_GlcNHglycan	72	75	PF01048	0.478
MOD_GlcNHglycan	77	80	PF01048	0.422
MOD_GSK3_1	256	263	PF00069	0.621
MOD_GSK3_1	361	368	PF00069	0.617
MOD_GSK3_1	374	381	PF00069	0.646
MOD_GSK3_1	396	403	PF00069	0.662
MOD_GSK3_1	68	75	PF00069	0.506
MOD_N-GLC_1	397	402	PF02516	0.694
MOD_N-GLC_2	260	262	PF02516	0.474
MOD_NEK2_1	115	120	PF00069	0.548
MOD_NEK2_1	243	248	PF00069	0.542
MOD_NEK2_1	365	370	PF00069	0.617
MOD_NEK2_1	397	402	PF00069	0.659
MOD_NEK2_1	62	67	PF00069	0.442
MOD_NEK2_1	70	75	PF00069	0.454
MOD_NEK2_2	343	348	PF00069	0.570
MOD_OFUCOSY	174	180	PF10250	0.678
MOD_PIKK_1	115	121	PF00454	0.517
MOD_PIKK_1	149	155	PF00454	0.625
MOD_PIKK_1	397	403	PF00454	0.746
MOD_PIKK_1	68	74	PF00454	0.538
MOD_PKA_2	343	349	PF00069	0.580
MOD_PKA_2	351	357	PF00069	0.622
MOD_Plk_1	361	367	PF00069	0.614
MOD_Plk_4	219	225	PF00069	0.480
MOD_Plk_4	243	249	PF00069	0.576
MOD_Plk_4	331	337	PF00069	0.736
MOD_Plk_4	361	367	PF00069	0.614
MOD_Plk_4	62	68	PF00069	0.469
MOD_Plk_4	77	83	PF00069	0.354
MOD_ProDKin_1	122	128	PF00069	0.585
MOD_ProDKin_1	328	334	PF00069	0.637
MOD_ProDKin_1	374	380	PF00069	0.654
MOD_ProDKin_1	383	389	PF00069	0.640
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.547
TRG_DiLeu_BaLyEn_6	384	389	PF01217	0.637
TRG_ENDOCYTIC_2	175	178	PF00928	0.585
TRG_ENDOCYTIC_2	86	89	PF00928	0.407
TRG_ER_diArg_1	191	194	PF00400	0.566
TRG_ER_diArg_1	282	284	PF00400	0.664
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL9	Leptomonas seymouri	83%	100%
A0A0S4II62	Bodo saltans	51%	100%
A0A1X0NSZ7	Trypanosomatidae	62%	100%
A0A3Q8IDL6	Leishmania donovani	98%	100%
A0A3R7NVU2	Trypanosoma rangeli	61%	100%
A4HEV6	Leishmania braziliensis	96%	100%
A4I230	Leishmania infantum	98%	100%
C9ZRX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	93%
Q4Q993	Leishmania major	98%	100%