MRH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glucosidase II beta subunit-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9AY78_LEIMU

TriTrypDb:

LmxM.26.1000

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0017177	glucosidase II complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AY78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY78

Function

Biological processes
Term	Name	Level	Count
GO:0006491	N-glycan processing	5	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	10
GO:0009100	glycoprotein metabolic process	4	8
GO:0009987	cellular process	1	10
GO:0019538	protein metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:1901135	carbohydrate derivative metabolic process	3	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0016310	phosphorylation	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	143	149	PF00089	0.435
CLV_NRD_NRD_1	192	194	PF00675	0.601
CLV_NRD_NRD_1	35	37	PF00675	0.663
CLV_NRD_NRD_1	8	10	PF00675	0.550
CLV_PCSK_KEX2_1	102	104	PF00082	0.371
CLV_PCSK_KEX2_1	202	204	PF00082	0.507
CLV_PCSK_KEX2_1	7	9	PF00082	0.627
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.358
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.507
CLV_PCSK_SKI1_1	209	213	PF00082	0.580
CLV_PCSK_SKI1_1	326	330	PF00082	0.568
DOC_AGCK_PIF_1	235	240	PF00069	0.368
DOC_CKS1_1	329	334	PF01111	0.300
DOC_CYCLIN_RxL_1	203	216	PF00134	0.301
DOC_CYCLIN_yClb5_NLxxxL_5	217	226	PF00134	0.220
DOC_PP4_FxxP_1	329	332	PF00568	0.287
DOC_USP7_MATH_1	12	16	PF00917	0.460
DOC_USP7_MATH_1	187	191	PF00917	0.443
DOC_USP7_MATH_1	88	92	PF00917	0.520
DOC_USP7_UBL2_3	170	174	PF12436	0.687
DOC_WW_Pin1_4	169	174	PF00397	0.456
DOC_WW_Pin1_4	328	333	PF00397	0.300
LIG_14-3-3_CanoR_1	140	146	PF00244	0.606
LIG_AP_GAE_1	64	70	PF02883	0.516
LIG_Clathr_ClatBox_1	16	20	PF01394	0.334
LIG_Clathr_ClatBox_1	314	318	PF01394	0.343
LIG_deltaCOP1_diTrp_1	289	295	PF00928	0.282
LIG_FHA_1	170	176	PF00498	0.471
LIG_FHA_1	217	223	PF00498	0.306
LIG_FHA_1	237	243	PF00498	0.212
LIG_FHA_1	270	276	PF00498	0.290
LIG_FHA_1	70	76	PF00498	0.669
LIG_FHA_2	111	117	PF00498	0.626
LIG_FHA_2	177	183	PF00498	0.631
LIG_FHA_2	223	229	PF00498	0.358
LIG_LIR_Gen_1	20	31	PF02991	0.447
LIG_LIR_Gen_1	237	248	PF02991	0.304
LIG_LIR_Gen_1	45	53	PF02991	0.610
LIG_LIR_Nem_3	20	26	PF02991	0.450
LIG_LIR_Nem_3	232	238	PF02991	0.351
LIG_LIR_Nem_3	239	243	PF02991	0.334
LIG_LIR_Nem_3	264	268	PF02991	0.303
LIG_LIR_Nem_3	45	51	PF02991	0.637
LIG_MYND_3	30	34	PF01753	0.489
LIG_Pex14_2	231	235	PF04695	0.368
LIG_SH2_CRK	23	27	PF00017	0.443
LIG_SH2_CRK	240	244	PF00017	0.335
LIG_SH2_CRK	325	329	PF00017	0.273
LIG_SH2_GRB2like	288	291	PF00017	0.368
LIG_SH2_SRC	288	291	PF00017	0.382
LIG_SH2_STAP1	23	27	PF00017	0.443
LIG_SH2_STAP1	238	242	PF00017	0.285
LIG_SH2_STAP1	273	277	PF00017	0.340
LIG_SH2_STAP1	63	67	PF00017	0.558
LIG_SH2_STAT5	108	111	PF00017	0.486
LIG_SH2_STAT5	158	161	PF00017	0.630
LIG_SH2_STAT5	238	241	PF00017	0.302
LIG_SH3_3	304	310	PF00018	0.309
LIG_SH3_3	314	320	PF00018	0.263
LIG_SUMO_SIM_par_1	15	22	PF11976	0.424
LIG_SUMO_SIM_par_1	313	319	PF11976	0.327
LIG_TRAF2_1	225	228	PF00917	0.241
LIG_TRAF2_1	316	319	PF00917	0.368
LIG_TYR_ITSM	19	26	PF00017	0.413
MOD_CDK_SPK_2	169	174	PF00069	0.456
MOD_CK1_1	213	219	PF00069	0.365
MOD_CK1_1	264	270	PF00069	0.349
MOD_CK1_1	65	71	PF00069	0.629
MOD_CK2_1	110	116	PF00069	0.564
MOD_CK2_1	12	18	PF00069	0.543
MOD_CK2_1	222	228	PF00069	0.439
MOD_CK2_1	264	270	PF00069	0.393
MOD_CMANNOS	292	295	PF00535	0.420
MOD_GlcNHglycan	104	108	PF01048	0.528
MOD_GlcNHglycan	161	165	PF01048	0.463
MOD_GlcNHglycan	2	5	PF01048	0.592
MOD_GSK3_1	141	148	PF00069	0.591
MOD_GSK3_1	211	218	PF00069	0.380
MOD_GSK3_1	253	260	PF00069	0.410
MOD_GSK3_1	65	72	PF00069	0.593
MOD_N-GLC_1	152	157	PF02516	0.520
MOD_N-GLC_1	176	181	PF02516	0.574
MOD_NEK2_1	211	216	PF00069	0.302
MOD_NEK2_1	261	266	PF00069	0.390
MOD_NEK2_1	93	98	PF00069	0.352
MOD_OFUCOSY	149	156	PF10250	0.432
MOD_PIKK_1	281	287	PF00454	0.304
MOD_PKA_1	102	108	PF00069	0.318
MOD_PKA_2	102	108	PF00069	0.346
MOD_PKA_2	139	145	PF00069	0.627
MOD_PKA_2	187	193	PF00069	0.543
MOD_PKA_2	77	83	PF00069	0.417
MOD_PKA_2	88	94	PF00069	0.560
MOD_Plk_1	152	158	PF00069	0.403
MOD_Plk_1	176	182	PF00069	0.431
MOD_Plk_1	229	235	PF00069	0.380
MOD_Plk_1	236	242	PF00069	0.366
MOD_Plk_1	269	275	PF00069	0.287
MOD_Plk_1	281	287	PF00069	0.287
MOD_Plk_2-3	229	235	PF00069	0.302
MOD_Plk_4	12	18	PF00069	0.399
MOD_Plk_4	257	263	PF00069	0.336
MOD_Plk_4	271	277	PF00069	0.294
MOD_ProDKin_1	169	175	PF00069	0.448
MOD_ProDKin_1	328	334	PF00069	0.300
MOD_SUMO_rev_2	104	113	PF00179	0.479
MOD_SUMO_rev_2	199	204	PF00179	0.285
TRG_DiLeu_BaEn_4	228	234	PF01217	0.220
TRG_ENDOCYTIC_2	23	26	PF00928	0.441
TRG_ENDOCYTIC_2	240	243	PF00928	0.335
TRG_ENDOCYTIC_2	325	328	PF00928	0.287
TRG_ER_diArg_1	6	9	PF00400	0.631
TRG_NLS_MonoExtC_3	193	199	PF00514	0.304
TRG_NLS_MonoExtN_4	193	198	PF00514	0.315
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4ILH9	Bodo saltans	32%	70%
A0A1X0NSB3	Trypanosomatidae	39%	70%
A0A3Q8IDT4	Leishmania donovani	87%	100%
A0A3R7L6D4	Trypanosoma rangeli	38%	70%
A4HEV5	Leishmania braziliensis	54%	100%
A4I229	Leishmania infantum	88%	100%
C9ZRX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	70%
Q4Q994	Leishmania major	82%	100%
V5DQZ5	Trypanosoma cruzi	36%	70%