PKD_channel domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Polycystin cation channel, putative

Species:

Leishmania mexicana

UniProt:

E9AY77_LEIMU

TriTrypDb:

LmxM.26.0990

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	9
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AY77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY77

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	9
GO:0005216	monoatomic ion channel activity	4	9
GO:0005261	monoatomic cation channel activity	5	9
GO:0008324	monoatomic cation transmembrane transporter activity	4	9
GO:0015075	monoatomic ion transmembrane transporter activity	3	9
GO:0015267	channel activity	4	9
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	9
GO:0022803	passive transmembrane transporter activity	3	9
GO:0022857	transmembrane transporter activity	2	9
GO:0022890	inorganic cation transmembrane transporter activity	4	9
GO:0005217	intracellular ligand-gated monoatomic ion channel activity	6	1
GO:0005262	calcium channel activity	6	1
GO:0015085	calcium ion transmembrane transporter activity	6	1
GO:0015276	ligand-gated monoatomic ion channel activity	5	1
GO:0015278	calcium-release channel activity	7	1
GO:0022834	ligand-gated channel activity	6	1
GO:0022836	gated channel activity	5	1
GO:0046873	metal ion transmembrane transporter activity	5	1
GO:0072345	NAADP-sensitive calcium-release channel activity	8	1
GO:0099094	ligand-gated monoatomic cation channel activity	6	1
GO:0099604	ligand-gated calcium channel activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.319
CLV_MEL_PAP_1	164	170	PF00089	0.649
CLV_NRD_NRD_1	192	194	PF00675	0.601
CLV_NRD_NRD_1	232	234	PF00675	0.627
CLV_NRD_NRD_1	330	332	PF00675	0.457
CLV_NRD_NRD_1	524	526	PF00675	0.526
CLV_NRD_NRD_1	55	57	PF00675	0.559
CLV_NRD_NRD_1	560	562	PF00675	0.537
CLV_PCSK_FUR_1	190	194	PF00082	0.589
CLV_PCSK_KEX2_1	192	194	PF00082	0.601
CLV_PCSK_KEX2_1	232	234	PF00082	0.587
CLV_PCSK_KEX2_1	329	331	PF00082	0.579
CLV_PCSK_KEX2_1	524	526	PF00082	0.582
CLV_PCSK_KEX2_1	55	57	PF00082	0.597
CLV_PCSK_KEX2_1	560	562	PF00082	0.537
CLV_PCSK_KEX2_1	579	581	PF00082	0.307
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.579
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.430
CLV_PCSK_SKI1_1	177	181	PF00082	0.629
CLV_PCSK_SKI1_1	182	186	PF00082	0.481
CLV_PCSK_SKI1_1	198	202	PF00082	0.489
CLV_PCSK_SKI1_1	263	267	PF00082	0.398
CLV_PCSK_SKI1_1	570	574	PF00082	0.477
CLV_PCSK_SKI1_1	579	583	PF00082	0.365
CLV_PCSK_SKI1_1	82	86	PF00082	0.581
CLV_Separin_Metazoa	571	575	PF03568	0.669
DEG_APCC_DBOX_1	176	184	PF00400	0.334
DEG_APCC_DBOX_1	586	594	PF00400	0.536
DOC_ANK_TNKS_1	166	173	PF00023	0.439
DOC_CYCLIN_RxL_1	79	89	PF00134	0.391
DOC_MAPK_MEF2A_6	177	185	PF00069	0.363
DOC_MAPK_MEF2A_6	218	227	PF00069	0.361
DOC_MAPK_MEF2A_6	354	361	PF00069	0.302
DOC_PP1_RVXF_1	180	186	PF00149	0.270
DOC_USP7_MATH_1	477	481	PF00917	0.618
DOC_USP7_MATH_1	500	504	PF00917	0.691
DOC_USP7_MATH_1	544	548	PF00917	0.728
DOC_USP7_MATH_1	553	557	PF00917	0.774
DOC_USP7_MATH_1	78	82	PF00917	0.361
DOC_WW_Pin1_4	129	134	PF00397	0.421
DOC_WW_Pin1_4	149	154	PF00397	0.520
DOC_WW_Pin1_4	199	204	PF00397	0.381
DOC_WW_Pin1_4	289	294	PF00397	0.684
DOC_WW_Pin1_4	435	440	PF00397	0.318
DOC_WW_Pin1_4	549	554	PF00397	0.717
DOC_WW_Pin1_4	565	570	PF00397	0.702
LIG_14-3-3_CanoR_1	167	175	PF00244	0.410
LIG_14-3-3_CanoR_1	182	188	PF00244	0.344
LIG_14-3-3_CanoR_1	198	203	PF00244	0.300
LIG_14-3-3_CanoR_1	226	231	PF00244	0.439
LIG_14-3-3_CanoR_1	35	39	PF00244	0.328
LIG_14-3-3_CanoR_1	531	537	PF00244	0.794
LIG_14-3-3_CanoR_1	587	591	PF00244	0.530
LIG_Actin_WH2_2	168	184	PF00022	0.398
LIG_BRCT_BRCA1_1	39	43	PF00533	0.333
LIG_deltaCOP1_diTrp_1	302	307	PF00928	0.538
LIG_EH1_1	352	360	PF00400	0.386
LIG_EVH1_2	101	105	PF00568	0.371
LIG_FHA_1	101	107	PF00498	0.351
LIG_FHA_1	123	129	PF00498	0.363
LIG_FHA_1	139	145	PF00498	0.422
LIG_FHA_1	203	209	PF00498	0.350
LIG_FHA_1	220	226	PF00498	0.377
LIG_FHA_1	319	325	PF00498	0.336
LIG_FHA_1	339	345	PF00498	0.312
LIG_FHA_2	57	63	PF00498	0.340
LIG_LIR_Gen_1	117	126	PF02991	0.438
LIG_LIR_Gen_1	318	326	PF02991	0.376
LIG_LIR_Gen_1	418	428	PF02991	0.237
LIG_LIR_Gen_1	430	439	PF02991	0.246
LIG_LIR_Gen_1	453	462	PF02991	0.269
LIG_LIR_Nem_3	103	108	PF02991	0.384
LIG_LIR_Nem_3	117	121	PF02991	0.403
LIG_LIR_Nem_3	318	322	PF02991	0.375
LIG_LIR_Nem_3	351	356	PF02991	0.362
LIG_LIR_Nem_3	453	457	PF02991	0.269
LIG_NRBOX	12	18	PF00104	0.328
LIG_Pex14_1	506	510	PF04695	0.689
LIG_Pex14_2	420	424	PF04695	0.320
LIG_Pex14_2	446	450	PF04695	0.269
LIG_Pex14_2	454	458	PF04695	0.269
LIG_SH2_CRK	118	122	PF00017	0.412
LIG_SH2_CRK	23	27	PF00017	0.296
LIG_SH2_CRK	275	279	PF00017	0.724
LIG_SH2_CRK	75	79	PF00017	0.281
LIG_SH2_GRB2like	88	91	PF00017	0.393
LIG_SH2_NCK_1	36	40	PF00017	0.326
LIG_SH2_NCK_1	75	79	PF00017	0.322
LIG_SH2_PTP2	366	369	PF00017	0.452
LIG_SH2_STAP1	126	130	PF00017	0.423
LIG_SH2_STAP1	474	478	PF00017	0.515
LIG_SH2_STAP1	481	485	PF00017	0.574
LIG_SH2_STAT5	310	313	PF00017	0.391
LIG_SH2_STAT5	36	39	PF00017	0.378
LIG_SH2_STAT5	366	369	PF00017	0.471
LIG_SH2_STAT5	408	411	PF00017	0.235
LIG_SH2_STAT5	41	44	PF00017	0.363
LIG_SH2_STAT5	52	55	PF00017	0.357
LIG_SH2_STAT5	88	91	PF00017	0.359
LIG_SH3_3	130	136	PF00018	0.333
LIG_SH3_3	563	569	PF00018	0.753
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.343
LIG_SUMO_SIM_anti_2	312	318	PF11976	0.367
LIG_SUMO_SIM_anti_2	321	326	PF11976	0.392
LIG_SUMO_SIM_anti_2	337	344	PF11976	0.291
LIG_SUMO_SIM_par_1	247	253	PF11976	0.323
LIG_TRAF2_1	279	282	PF00917	0.664
LIG_TRAF2_1	335	338	PF00917	0.337
LIG_WRC_WIRS_1	316	321	PF05994	0.328
LIG_WRC_WIRS_1	350	355	PF05994	0.386
LIG_WRC_WIRS_1	429	434	PF05994	0.269
LIG_WRC_WIRS_1	451	456	PF05994	0.269
MOD_CDK_SPK_2	149	154	PF00069	0.403
MOD_CDK_SPK_2	565	570	PF00069	0.643
MOD_CK1_1	147	153	PF00069	0.636
MOD_CK1_1	228	234	PF00069	0.461
MOD_CK1_1	318	324	PF00069	0.337
MOD_CK1_1	480	486	PF00069	0.563
MOD_CK1_1	535	541	PF00069	0.628
MOD_CK1_1	93	99	PF00069	0.530
MOD_CK2_1	332	338	PF00069	0.455
MOD_CK2_1	511	517	PF00069	0.748
MOD_CK2_1	544	550	PF00069	0.649
MOD_CK2_1	56	62	PF00069	0.477
MOD_CK2_1	565	571	PF00069	0.643
MOD_CK2_1	586	592	PF00069	0.487
MOD_GlcNHglycan	168	171	PF01048	0.538
MOD_GlcNHglycan	302	305	PF01048	0.372
MOD_GlcNHglycan	404	407	PF01048	0.432
MOD_GlcNHglycan	500	503	PF01048	0.553
MOD_GlcNHglycan	512	516	PF01048	0.543
MOD_GlcNHglycan	534	537	PF01048	0.789
MOD_GlcNHglycan	557	560	PF01048	0.760
MOD_GSK3_1	122	129	PF00069	0.547
MOD_GSK3_1	145	152	PF00069	0.576
MOD_GSK3_1	188	195	PF00069	0.401
MOD_GSK3_1	198	205	PF00069	0.553
MOD_GSK3_1	221	228	PF00069	0.445
MOD_GSK3_1	415	422	PF00069	0.307
MOD_GSK3_1	42	49	PF00069	0.541
MOD_GSK3_1	461	468	PF00069	0.440
MOD_GSK3_1	477	484	PF00069	0.519
MOD_GSK3_1	532	539	PF00069	0.719
MOD_GSK3_1	549	556	PF00069	0.733
MOD_GSK3_1	86	93	PF00069	0.525
MOD_LATS_1	54	60	PF00433	0.483
MOD_N-GLC_1	138	143	PF02516	0.560
MOD_N-GLC_1	144	149	PF02516	0.570
MOD_N-GLC_1	332	337	PF02516	0.326
MOD_N-GLC_1	554	559	PF02516	0.589
MOD_N-GLC_1	89	94	PF02516	0.534
MOD_NEK2_1	183	188	PF00069	0.335
MOD_NEK2_1	3	8	PF00069	0.368
MOD_NEK2_1	349	354	PF00069	0.310
MOD_NEK2_1	372	377	PF00069	0.483
MOD_NEK2_1	419	424	PF00069	0.290
MOD_NEK2_1	428	433	PF00069	0.244
MOD_NEK2_1	450	455	PF00069	0.328
MOD_NEK2_1	86	91	PF00069	0.442
MOD_NEK2_2	126	131	PF00069	0.391
MOD_NEK2_2	415	420	PF00069	0.178
MOD_PIKK_1	472	478	PF00454	0.386
MOD_PK_1	226	232	PF00069	0.534
MOD_PKA_1	192	198	PF00069	0.376
MOD_PKA_1	329	335	PF00069	0.443
MOD_PKA_2	166	172	PF00069	0.497
MOD_PKA_2	192	198	PF00069	0.392
MOD_PKA_2	225	231	PF00069	0.523
MOD_PKA_2	329	335	PF00069	0.524
MOD_PKA_2	34	40	PF00069	0.472
MOD_PKA_2	498	504	PF00069	0.497
MOD_PKA_2	530	536	PF00069	0.749
MOD_PKA_2	586	592	PF00069	0.402
MOD_PKA_2	93	99	PF00069	0.504
MOD_PKB_1	190	198	PF00069	0.359
MOD_Plk_1	138	144	PF00069	0.620
MOD_Plk_1	263	269	PF00069	0.384
MOD_Plk_1	332	338	PF00069	0.433
MOD_Plk_2-3	586	592	PF00069	0.402
MOD_Plk_4	100	106	PF00069	0.490
MOD_Plk_4	263	269	PF00069	0.400
MOD_Plk_4	3	9	PF00069	0.330
MOD_Plk_4	338	344	PF00069	0.333
MOD_Plk_4	37	43	PF00069	0.464
MOD_Plk_4	377	383	PF00069	0.365
MOD_Plk_4	415	421	PF00069	0.327
MOD_Plk_4	428	434	PF00069	0.384
MOD_Plk_4	450	456	PF00069	0.329
MOD_Plk_4	465	471	PF00069	0.260
MOD_Plk_4	48	54	PF00069	0.521
MOD_Plk_4	66	72	PF00069	0.489
MOD_ProDKin_1	129	135	PF00069	0.529
MOD_ProDKin_1	149	155	PF00069	0.669
MOD_ProDKin_1	199	205	PF00069	0.468
MOD_ProDKin_1	289	295	PF00069	0.616
MOD_ProDKin_1	435	441	PF00069	0.386
MOD_ProDKin_1	549	555	PF00069	0.666
MOD_ProDKin_1	565	571	PF00069	0.643
MOD_SUMO_rev_2	571	581	PF00179	0.563
TRG_DiLeu_BaEn_1	338	343	PF01217	0.386
TRG_DiLeu_LyEn_5	236	241	PF01217	0.485
TRG_ENDOCYTIC_2	118	121	PF00928	0.527
TRG_ENDOCYTIC_2	23	26	PF00928	0.355
TRG_ENDOCYTIC_2	275	278	PF00928	0.634
TRG_ENDOCYTIC_2	366	369	PF00928	0.299
TRG_ENDOCYTIC_2	510	513	PF00928	0.707
TRG_ENDOCYTIC_2	74	77	PF00928	0.336
TRG_ER_diArg_1	190	193	PF00400	0.467
TRG_ER_diArg_1	257	260	PF00400	0.388
TRG_ER_diArg_1	524	527	PF00400	0.651
TRG_ER_diArg_1	55	57	PF00400	0.439
TRG_NLS_MonoExtC_3	328	334	PF00514	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKU9	Leptomonas seymouri	57%	98%
A0A1X0NSA4	Trypanosomatidae	40%	100%
A0A3R7KKX3	Trypanosoma rangeli	37%	100%
A0A3S7WZS8	Leishmania donovani	91%	100%
A4I228	Leishmania infantum	91%	100%
C9ZRX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q995	Leishmania major	92%	100%