J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain/Domain of unknown function (DUF3395), putative

Species:

Leishmania mexicana

UniProt:

E9AY72_LEIMU

TriTrypDb:

LmxM.26.0940

Length:

839

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AY72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY72

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007005	mitochondrion organization	5	1
GO:0007006	mitochondrial membrane organization	5	1
GO:0007007	inner mitochondrial membrane organization	6	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0042407	cristae formation	7	1
GO:0061024	membrane organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.503
CLV_C14_Caspase3-7	17	21	PF00656	0.620
CLV_C14_Caspase3-7	22	26	PF00656	0.449
CLV_C14_Caspase3-7	85	89	PF00656	0.335
CLV_NRD_NRD_1	122	124	PF00675	0.483
CLV_NRD_NRD_1	340	342	PF00675	0.690
CLV_NRD_NRD_1	452	454	PF00675	0.441
CLV_NRD_NRD_1	53	55	PF00675	0.314
CLV_NRD_NRD_1	648	650	PF00675	0.265
CLV_NRD_NRD_1	682	684	PF00675	0.404
CLV_NRD_NRD_1	813	815	PF00675	0.308
CLV_PCSK_FUR_1	338	342	PF00082	0.481
CLV_PCSK_KEX2_1	122	124	PF00082	0.479
CLV_PCSK_KEX2_1	340	342	PF00082	0.467
CLV_PCSK_KEX2_1	53	55	PF00082	0.314
CLV_PCSK_KEX2_1	815	817	PF00082	0.272
CLV_PCSK_PC1ET2_1	815	817	PF00082	0.351
CLV_PCSK_SKI1_1	112	116	PF00082	0.477
CLV_PCSK_SKI1_1	217	221	PF00082	0.565
CLV_PCSK_SKI1_1	355	359	PF00082	0.410
CLV_PCSK_SKI1_1	508	512	PF00082	0.528
CLV_PCSK_SKI1_1	53	57	PF00082	0.291
CLV_PCSK_SKI1_1	8	12	PF00082	0.592
DEG_Nend_UBRbox_2	1	3	PF02207	0.619
DOC_CKS1_1	799	804	PF01111	0.404
DOC_CYCLIN_yCln2_LP_2	619	625	PF00134	0.500
DOC_MAPK_DCC_7	597	607	PF00069	0.516
DOC_MAPK_gen_1	507	513	PF00069	0.471
DOC_MAPK_gen_1	53	59	PF00069	0.292
DOC_MAPK_gen_1	552	560	PF00069	0.468
DOC_MAPK_gen_1	595	604	PF00069	0.511
DOC_MAPK_gen_1	662	670	PF00069	0.404
DOC_MAPK_gen_1	680	690	PF00069	0.404
DOC_MAPK_gen_1	814	821	PF00069	0.283
DOC_MAPK_HePTP_8	592	604	PF00069	0.382
DOC_MAPK_MEF2A_6	595	604	PF00069	0.436
DOC_MAPK_MEF2A_6	758	766	PF00069	0.335
DOC_PP1_RVXF_1	806	813	PF00149	0.337
DOC_PP2B_LxvP_1	366	369	PF13499	0.430
DOC_PP2B_LxvP_1	619	622	PF13499	0.433
DOC_PP2B_LxvP_1	781	784	PF13499	0.271
DOC_PP4_FxxP_1	164	167	PF00568	0.573
DOC_PP4_FxxP_1	607	610	PF00568	0.429
DOC_PP4_FxxP_1	794	797	PF00568	0.271
DOC_USP7_MATH_1	167	171	PF00917	0.680
DOC_USP7_MATH_1	185	189	PF00917	0.687
DOC_USP7_MATH_1	208	212	PF00917	0.713
DOC_USP7_MATH_1	227	231	PF00917	0.744
DOC_USP7_MATH_1	239	243	PF00917	0.692
DOC_USP7_MATH_1	250	254	PF00917	0.680
DOC_USP7_MATH_1	257	261	PF00917	0.669
DOC_USP7_MATH_1	32	36	PF00917	0.523
DOC_USP7_MATH_1	320	324	PF00917	0.574
DOC_USP7_MATH_1	537	541	PF00917	0.549
DOC_USP7_MATH_1	610	614	PF00917	0.514
DOC_USP7_MATH_1	669	673	PF00917	0.378
DOC_USP7_MATH_1	740	744	PF00917	0.333
DOC_USP7_MATH_1	752	756	PF00917	0.250
DOC_USP7_UBL2_3	680	684	PF12436	0.292
DOC_WW_Pin1_4	174	179	PF00397	0.546
DOC_WW_Pin1_4	240	245	PF00397	0.749
DOC_WW_Pin1_4	252	257	PF00397	0.806
DOC_WW_Pin1_4	41	46	PF00397	0.404
DOC_WW_Pin1_4	531	536	PF00397	0.486
DOC_WW_Pin1_4	566	571	PF00397	0.494
DOC_WW_Pin1_4	606	611	PF00397	0.418
DOC_WW_Pin1_4	709	714	PF00397	0.405
DOC_WW_Pin1_4	798	803	PF00397	0.404
LIG_14-3-3_CanoR_1	341	350	PF00244	0.606
LIG_14-3-3_CanoR_1	360	364	PF00244	0.459
LIG_14-3-3_CanoR_1	370	376	PF00244	0.456
LIG_14-3-3_CanoR_1	382	390	PF00244	0.465
LIG_14-3-3_CanoR_1	453	461	PF00244	0.435
LIG_14-3-3_CanoR_1	476	480	PF00244	0.533
LIG_14-3-3_CanoR_1	597	603	PF00244	0.460
LIG_14-3-3_CanoR_1	643	651	PF00244	0.386
LIG_Actin_WH2_2	126	143	PF00022	0.443
LIG_APCC_ABBA_1	819	824	PF00400	0.404
LIG_BIR_III_2	760	764	PF00653	0.378
LIG_BIR_III_4	103	107	PF00653	0.438
LIG_BRCT_BRCA1_1	355	359	PF00533	0.489
LIG_BRCT_BRCA1_1	371	375	PF00533	0.475
LIG_BRCT_BRCA1_1	579	583	PF00533	0.582
LIG_EH1_1	625	633	PF00400	0.520
LIG_EH1_1	723	731	PF00400	0.171
LIG_FHA_1	156	162	PF00498	0.592
LIG_FHA_1	385	391	PF00498	0.659
LIG_FHA_1	456	462	PF00498	0.496
LIG_FHA_1	481	487	PF00498	0.573
LIG_FHA_1	539	545	PF00498	0.442
LIG_FHA_1	559	565	PF00498	0.308
LIG_FHA_1	767	773	PF00498	0.209
LIG_FHA_1	799	805	PF00498	0.483
LIG_FHA_2	281	287	PF00498	0.606
LIG_FHA_2	390	396	PF00498	0.503
LIG_FHA_2	46	52	PF00498	0.404
LIG_FHA_2	652	658	PF00498	0.197
LIG_HCF-1_HBM_1	471	474	PF13415	0.398
LIG_LIR_Apic_2	163	167	PF02991	0.574
LIG_LIR_Apic_2	545	550	PF02991	0.460
LIG_LIR_Gen_1	35	45	PF02991	0.326
LIG_LIR_Gen_1	361	371	PF02991	0.442
LIG_LIR_Gen_1	477	486	PF02991	0.459
LIG_LIR_Gen_1	491	501	PF02991	0.452
LIG_LIR_Gen_1	580	591	PF02991	0.452
LIG_LIR_Gen_1	698	709	PF02991	0.404
LIG_LIR_Gen_1	81	91	PF02991	0.270
LIG_LIR_Nem_3	35	41	PF02991	0.291
LIG_LIR_Nem_3	361	366	PF02991	0.516
LIG_LIR_Nem_3	477	482	PF02991	0.504
LIG_LIR_Nem_3	491	496	PF02991	0.438
LIG_LIR_Nem_3	580	586	PF02991	0.459
LIG_LIR_Nem_3	630	636	PF02991	0.490
LIG_LIR_Nem_3	698	704	PF02991	0.404
LIG_LIR_Nem_3	81	86	PF02991	0.274
LIG_LIR_Nem_3	88	93	PF02991	0.275
LIG_PCNA_yPIPBox_3	340	353	PF02747	0.505
LIG_PCNA_yPIPBox_3	660	674	PF02747	0.404
LIG_PCNA_yPIPBox_3	727	741	PF02747	0.171
LIG_Pex14_2	359	363	PF04695	0.398
LIG_Pex14_2	475	479	PF04695	0.353
LIG_PTB_Apo_2	688	695	PF02174	0.271
LIG_PTB_Apo_2	77	84	PF02174	0.267
LIG_PTB_Phospho_1	688	694	PF10480	0.271
LIG_REV1ctd_RIR_1	573	583	PF16727	0.508
LIG_SH2_CRK	38	42	PF00017	0.289
LIG_SH2_PTP2	90	93	PF00017	0.384
LIG_SH2_SRC	548	551	PF00017	0.383
LIG_SH2_STAP1	404	408	PF00017	0.420
LIG_SH2_STAT3	645	648	PF00017	0.406
LIG_SH2_STAT5	129	132	PF00017	0.441
LIG_SH2_STAT5	474	477	PF00017	0.492
LIG_SH2_STAT5	500	503	PF00017	0.451
LIG_SH2_STAT5	548	551	PF00017	0.491
LIG_SH2_STAT5	645	648	PF00017	0.335
LIG_SH2_STAT5	800	803	PF00017	0.349
LIG_SH2_STAT5	90	93	PF00017	0.314
LIG_SH3_3	238	244	PF00018	0.763
LIG_SH3_3	24	30	PF00018	0.510
LIG_SH3_3	293	299	PF00018	0.525
LIG_SH3_3	515	521	PF00018	0.608
LIG_SH3_3	567	573	PF00018	0.510
LIG_SH3_3	693	699	PF00018	0.271
LIG_SH3_3	796	802	PF00018	0.365
LIG_SH3_3	825	831	PF00018	0.271
LIG_SH3_CIN85_PxpxPR_1	333	338	PF14604	0.591
LIG_Sin3_3	560	567	PF02671	0.403
LIG_SUMO_SIM_anti_2	433	439	PF11976	0.423
LIG_SUMO_SIM_anti_2	671	677	PF11976	0.404
LIG_SUMO_SIM_par_1	129	134	PF11976	0.503
LIG_SUMO_SIM_par_1	762	767	PF11976	0.295
LIG_TRAF2_1	299	302	PF00917	0.545
LIG_TRAF2_1	679	682	PF00917	0.404
LIG_UBA3_1	604	611	PF00899	0.442
LIG_WRC_WIRS_1	161	166	PF05994	0.497
LIG_WRPW_2	633	636	PF00400	0.441
LIG_WW_1	521	524	PF00397	0.560
MOD_CDK_SPK_2	41	46	PF00069	0.335
MOD_CDK_SPK_2	606	611	PF00069	0.434
MOD_CK1_1	147	153	PF00069	0.453
MOD_CK1_1	155	161	PF00069	0.447
MOD_CK1_1	165	171	PF00069	0.747
MOD_CK1_1	173	179	PF00069	0.766
MOD_CK1_1	226	232	PF00069	0.631
MOD_CK1_1	325	331	PF00069	0.695
MOD_CK1_1	389	395	PF00069	0.513
MOD_CK1_1	756	762	PF00069	0.396
MOD_CK1_1	779	785	PF00069	0.349
MOD_CK2_1	174	180	PF00069	0.645
MOD_CK2_1	193	199	PF00069	0.792
MOD_CK2_1	209	215	PF00069	0.586
MOD_CK2_1	261	267	PF00069	0.710
MOD_CK2_1	280	286	PF00069	0.518
MOD_CK2_1	389	395	PF00069	0.476
MOD_CK2_1	465	471	PF00069	0.415
MOD_CK2_1	741	747	PF00069	0.226
MOD_Cter_Amidation	505	508	PF01082	0.413
MOD_GlcNHglycan	146	149	PF01048	0.539
MOD_GlcNHglycan	164	167	PF01048	0.605
MOD_GlcNHglycan	20	24	PF01048	0.719
MOD_GlcNHglycan	225	228	PF01048	0.702
MOD_GlcNHglycan	252	255	PF01048	0.798
MOD_GlcNHglycan	273	276	PF01048	0.682
MOD_GlcNHglycan	324	327	PF01048	0.701
MOD_GlcNHglycan	33	37	PF01048	0.469
MOD_GlcNHglycan	440	443	PF01048	0.620
MOD_GlcNHglycan	455	458	PF01048	0.374
MOD_GlcNHglycan	579	582	PF01048	0.649
MOD_GlcNHglycan	619	622	PF01048	0.454
MOD_GlcNHglycan	713	716	PF01048	0.430
MOD_GlcNHglycan	778	781	PF01048	0.404
MOD_GSK3_1	146	153	PF00069	0.506
MOD_GSK3_1	167	174	PF00069	0.652
MOD_GSK3_1	19	26	PF00069	0.692
MOD_GSK3_1	217	224	PF00069	0.723
MOD_GSK3_1	235	242	PF00069	0.664
MOD_GSK3_1	257	264	PF00069	0.703
MOD_GSK3_1	355	362	PF00069	0.464
MOD_GSK3_1	374	381	PF00069	0.333
MOD_GSK3_1	384	391	PF00069	0.463
MOD_GSK3_1	400	407	PF00069	0.330
MOD_GSK3_1	41	48	PF00069	0.247
MOD_GSK3_1	449	456	PF00069	0.385
MOD_GSK3_1	527	534	PF00069	0.394
MOD_GSK3_1	606	613	PF00069	0.499
MOD_GSK3_1	617	624	PF00069	0.484
MOD_GSK3_1	62	69	PF00069	0.413
MOD_GSK3_1	736	743	PF00069	0.454
MOD_GSK3_1	752	759	PF00069	0.150
MOD_GSK3_1	762	769	PF00069	0.418
MOD_N-GLC_1	170	175	PF02516	0.568
MOD_N-GLC_1	258	263	PF02516	0.750
MOD_N-GLC_1	531	536	PF02516	0.475
MOD_N-GLC_1	709	714	PF02516	0.292
MOD_NEK2_1	139	144	PF00069	0.502
MOD_NEK2_1	146	151	PF00069	0.516
MOD_NEK2_1	162	167	PF00069	0.580
MOD_NEK2_1	223	228	PF00069	0.626
MOD_NEK2_1	359	364	PF00069	0.363
MOD_NEK2_1	371	376	PF00069	0.378
MOD_NEK2_1	383	388	PF00069	0.487
MOD_NEK2_1	438	443	PF00069	0.480
MOD_NEK2_1	447	452	PF00069	0.360
MOD_NEK2_1	465	470	PF00069	0.291
MOD_NEK2_1	475	480	PF00069	0.359
MOD_NEK2_1	499	504	PF00069	0.407
MOD_NEK2_1	527	532	PF00069	0.406
MOD_NEK2_1	558	563	PF00069	0.386
MOD_NEK2_1	57	62	PF00069	0.336
MOD_NEK2_1	617	622	PF00069	0.430
MOD_NEK2_2	23	28	PF00069	0.522
MOD_NEK2_2	404	409	PF00069	0.466
MOD_NEK2_2	427	432	PF00069	0.587
MOD_PIKK_1	147	153	PF00454	0.572
MOD_PIKK_1	342	348	PF00454	0.505
MOD_PIKK_1	45	51	PF00454	0.362
MOD_PIKK_1	550	556	PF00454	0.438
MOD_PIKK_1	57	63	PF00454	0.275
MOD_PIKK_1	67	73	PF00454	0.314
MOD_PIKK_1	716	722	PF00454	0.404
MOD_PK_1	753	759	PF00069	0.171
MOD_PKA_1	453	459	PF00069	0.421
MOD_PKA_2	359	365	PF00069	0.460
MOD_PKA_2	369	375	PF00069	0.462
MOD_PKA_2	475	481	PF00069	0.441
MOD_PKA_2	598	604	PF00069	0.499
MOD_PKA_2	752	758	PF00069	0.236
MOD_PKA_2	776	782	PF00069	0.289
MOD_Plk_1	3	9	PF00069	0.564
MOD_Plk_1	404	410	PF00069	0.533
MOD_Plk_1	447	453	PF00069	0.364
MOD_Plk_1	71	77	PF00069	0.228
MOD_Plk_1	766	772	PF00069	0.271
MOD_Plk_2-3	400	406	PF00069	0.466
MOD_Plk_4	433	439	PF00069	0.459
MOD_Plk_4	489	495	PF00069	0.455
MOD_Plk_4	587	593	PF00069	0.378
MOD_Plk_4	621	627	PF00069	0.497
MOD_Plk_4	669	675	PF00069	0.281
MOD_Plk_4	787	793	PF00069	0.404
MOD_ProDKin_1	174	180	PF00069	0.547
MOD_ProDKin_1	240	246	PF00069	0.748
MOD_ProDKin_1	252	258	PF00069	0.807
MOD_ProDKin_1	41	47	PF00069	0.404
MOD_ProDKin_1	531	537	PF00069	0.491
MOD_ProDKin_1	566	572	PF00069	0.494
MOD_ProDKin_1	606	612	PF00069	0.419
MOD_ProDKin_1	709	715	PF00069	0.230
MOD_ProDKin_1	798	804	PF00069	0.404
MOD_SUMO_for_1	679	682	PF00179	0.292
MOD_SUMO_rev_2	194	202	PF00179	0.765
MOD_SUMO_rev_2	514	521	PF00179	0.545
TRG_DiLeu_BaEn_1	671	676	PF01217	0.404
TRG_ENDOCYTIC_2	38	41	PF00928	0.291
TRG_ENDOCYTIC_2	493	496	PF00928	0.414
TRG_ENDOCYTIC_2	524	527	PF00928	0.522
TRG_ENDOCYTIC_2	694	697	PF00928	0.271
TRG_ENDOCYTIC_2	90	93	PF00928	0.271
TRG_ER_diArg_1	121	123	PF00400	0.524
TRG_ER_diArg_1	307	310	PF00400	0.592
TRG_ER_diArg_1	337	340	PF00400	0.500
TRG_ER_diArg_1	52	54	PF00400	0.314
TRG_ER_diArg_1	597	600	PF00400	0.603
TRG_ER_diArg_1	662	665	PF00400	0.420
TRG_ER_diArg_1	813	816	PF00400	0.295
TRG_NES_CRM1_1	460	471	PF08389	0.431
TRG_NLS_MonoCore_2	813	818	PF00514	0.404
TRG_NLS_MonoExtN_4	814	819	PF00514	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P653	Leptomonas seymouri	61%	91%
A0A1X0NU14	Trypanosomatidae	32%	100%
A0A3S7WZV8	Leishmania donovani	92%	100%
A0A422MXE6	Trypanosoma rangeli	34%	100%
A4HEU9	Leishmania braziliensis	79%	100%
A4I223	Leishmania infantum	92%	100%
C9ZRY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q9A0	Leishmania major	91%	100%
V5B9C2	Trypanosoma cruzi	35%	100%