AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY71_LEIMU

TriTrypDb:

LmxM.26.0930

Length:

689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AY71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY71

Function

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0032200	telomere organization	6	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051276	chromosome organization	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003678	DNA helicase activity	3	1
GO:0003824	catalytic activity	1	1
GO:0004386	helicase activity	2	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0008094	ATP-dependent activity, acting on DNA	2	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017076	purine nucleotide binding	4	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0140657	ATP-dependent activity	1	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	101	107	PF00089	0.571
CLV_NRD_NRD_1	165	167	PF00675	0.423
CLV_NRD_NRD_1	229	231	PF00675	0.514
CLV_NRD_NRD_1	27	29	PF00675	0.548
CLV_NRD_NRD_1	486	488	PF00675	0.567
CLV_NRD_NRD_1	509	511	PF00675	0.521
CLV_PCSK_KEX2_1	165	167	PF00082	0.426
CLV_PCSK_KEX2_1	229	231	PF00082	0.532
CLV_PCSK_KEX2_1	27	29	PF00082	0.548
CLV_PCSK_KEX2_1	384	386	PF00082	0.512
CLV_PCSK_KEX2_1	488	490	PF00082	0.543
CLV_PCSK_KEX2_1	509	511	PF00082	0.521
CLV_PCSK_KEX2_1	667	669	PF00082	0.504
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.512
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.543
CLV_PCSK_PC1ET2_1	667	669	PF00082	0.497
CLV_PCSK_SKI1_1	229	233	PF00082	0.459
CLV_PCSK_SKI1_1	362	366	PF00082	0.707
CLV_PCSK_SKI1_1	381	385	PF00082	0.416
CLV_PCSK_SKI1_1	78	82	PF00082	0.396
DEG_MDM2_SWIB_1	581	589	PF02201	0.337
DEG_Nend_Nbox_1	1	3	PF02207	0.654
DEG_SPOP_SBC_1	397	401	PF00917	0.559
DOC_CKS1_1	171	176	PF01111	0.572
DOC_CYCLIN_RxL_1	654	662	PF00134	0.424
DOC_MAPK_gen_1	226	236	PF00069	0.406
DOC_MAPK_gen_1	487	495	PF00069	0.604
DOC_MAPK_gen_1	611	620	PF00069	0.467
DOC_MAPK_gen_1	74	81	PF00069	0.417
DOC_MAPK_MEF2A_6	611	620	PF00069	0.411
DOC_MAPK_MEF2A_6	655	663	PF00069	0.411
DOC_PP1_RVXF_1	622	629	PF00149	0.428
DOC_PP1_RVXF_1	76	82	PF00149	0.407
DOC_PP2B_LxvP_1	240	243	PF13499	0.532
DOC_USP7_MATH_1	312	316	PF00917	0.713
DOC_USP7_MATH_1	577	581	PF00917	0.464
DOC_USP7_MATH_1	80	84	PF00917	0.368
DOC_USP7_UBL2_3	555	559	PF12436	0.498
DOC_WW_Pin1_4	170	175	PF00397	0.383
DOC_WW_Pin1_4	308	313	PF00397	0.553
LIG_14-3-3_CanoR_1	229	237	PF00244	0.448
LIG_14-3-3_CanoR_1	260	265	PF00244	0.694
LIG_14-3-3_CanoR_1	533	541	PF00244	0.472
LIG_14-3-3_CanoR_1	635	642	PF00244	0.424
LIG_APCC_ABBA_1	607	612	PF00400	0.424
LIG_BRCT_BRCA1_1	171	175	PF00533	0.508
LIG_BRCT_BRCA1_1	258	262	PF00533	0.580
LIG_BRCT_BRCA1_1	354	358	PF00533	0.671
LIG_BRCT_BRCA1_1	447	451	PF00533	0.603
LIG_BRCT_BRCA1_1	6	10	PF00533	0.723
LIG_Clathr_ClatBox_1	157	161	PF01394	0.449
LIG_Clathr_ClatBox_1	201	205	PF01394	0.427
LIG_deltaCOP1_diTrp_1	205	211	PF00928	0.332
LIG_deltaCOP1_diTrp_1	566	575	PF00928	0.503
LIG_deltaCOP1_diTrp_1	627	631	PF00928	0.388
LIG_EH1_1	390	398	PF00400	0.537
LIG_FHA_1	153	159	PF00498	0.484
LIG_FHA_1	455	461	PF00498	0.500
LIG_FHA_1	512	518	PF00498	0.450
LIG_FHA_1	57	63	PF00498	0.361
LIG_FHA_1	599	605	PF00498	0.491
LIG_FHA_1	654	660	PF00498	0.402
LIG_FHA_2	267	273	PF00498	0.679
LIG_FHA_2	320	326	PF00498	0.630
LIG_FHA_2	561	567	PF00498	0.460
LIG_Integrin_isoDGR_2	507	509	PF01839	0.548
LIG_Integrin_RGD_1	279	281	PF01839	0.516
LIG_LIR_Apic_2	185	190	PF02991	0.391
LIG_LIR_Apic_2	427	432	PF02991	0.545
LIG_LIR_Gen_1	205	213	PF02991	0.351
LIG_LIR_Gen_1	526	532	PF02991	0.424
LIG_LIR_Gen_1	535	545	PF02991	0.452
LIG_LIR_Gen_1	7	17	PF02991	0.522
LIG_LIR_Nem_3	172	178	PF02991	0.350
LIG_LIR_Nem_3	185	189	PF02991	0.381
LIG_LIR_Nem_3	205	210	PF02991	0.339
LIG_LIR_Nem_3	25	29	PF02991	0.505
LIG_LIR_Nem_3	526	530	PF02991	0.437
LIG_LIR_Nem_3	535	541	PF02991	0.426
LIG_LIR_Nem_3	648	654	PF02991	0.453
LIG_LIR_Nem_3	7	13	PF02991	0.603
LIG_LYPXL_S_1	471	475	PF13949	0.488
LIG_LYPXL_yS_3	472	475	PF13949	0.450
LIG_MLH1_MIPbox_1	6	10	PF16413	0.519
LIG_NRBOX	516	522	PF00104	0.522
LIG_PCNA_PIPBox_1	3	12	PF02747	0.572
LIG_PCNA_yPIPBox_3	3	15	PF02747	0.573
LIG_Pex14_1	207	211	PF04695	0.314
LIG_Pex14_2	22	26	PF04695	0.583
LIG_Pex14_2	581	585	PF04695	0.334
LIG_SH2_CRK	237	241	PF00017	0.532
LIG_SH2_CRK	380	384	PF00017	0.595
LIG_SH2_CRK	429	433	PF00017	0.537
LIG_SH2_CRK	553	557	PF00017	0.422
LIG_SH2_NCK_1	181	185	PF00017	0.435
LIG_SH2_STAT3	200	203	PF00017	0.361
LIG_SH2_STAT3	477	480	PF00017	0.488
LIG_SH2_STAT5	200	203	PF00017	0.402
LIG_SH2_STAT5	95	98	PF00017	0.497
LIG_SH3_1	168	174	PF00018	0.521
LIG_SH3_2	483	488	PF14604	0.550
LIG_SH3_3	168	174	PF00018	0.508
LIG_SH3_3	187	193	PF00018	0.321
LIG_SH3_3	326	332	PF00018	0.794
LIG_SH3_3	365	371	PF00018	0.569
LIG_SH3_3	455	461	PF00018	0.553
LIG_SH3_3	467	473	PF00018	0.438
LIG_SH3_3	480	486	PF00018	0.427
LIG_SH3_3	542	548	PF00018	0.476
LIG_SUMO_SIM_anti_2	142	147	PF11976	0.322
LIG_SUMO_SIM_anti_2	340	352	PF11976	0.600
LIG_SUMO_SIM_anti_2	603	608	PF11976	0.410
LIG_SUMO_SIM_par_1	142	147	PF11976	0.345
LIG_SUMO_SIM_par_1	154	159	PF11976	0.373
LIG_SUMO_SIM_par_1	600	605	PF11976	0.503
LIG_TRAF2_1	111	114	PF00917	0.515
LIG_TYR_ITIM	378	383	PF00017	0.608
LIG_TYR_ITIM	551	556	PF00017	0.395
MOD_CK1_1	134	140	PF00069	0.344
MOD_CK1_1	263	269	PF00069	0.668
MOD_CK1_1	338	344	PF00069	0.632
MOD_CK1_1	400	406	PF00069	0.599
MOD_CK2_1	103	109	PF00069	0.617
MOD_CK2_1	249	255	PF00069	0.641
MOD_CK2_1	264	270	PF00069	0.523
MOD_CK2_1	560	566	PF00069	0.398
MOD_CK2_1	577	583	PF00069	0.437
MOD_CMANNOS	628	631	PF00535	0.390
MOD_Cter_Amidation	507	510	PF01082	0.514
MOD_GlcNHglycan	343	346	PF01048	0.587
MOD_GlcNHglycan	400	403	PF01048	0.604
MOD_GlcNHglycan	556	559	PF01048	0.486
MOD_GlcNHglycan	82	85	PF01048	0.380
MOD_GSK3_1	126	133	PF00069	0.502
MOD_GSK3_1	152	159	PF00069	0.335
MOD_GSK3_1	256	263	PF00069	0.596
MOD_GSK3_1	308	315	PF00069	0.566
MOD_GSK3_1	335	342	PF00069	0.654
MOD_GSK3_1	354	361	PF00069	0.539
MOD_GSK3_1	396	403	PF00069	0.612
MOD_GSK3_1	528	535	PF00069	0.483
MOD_GSK3_1	584	591	PF00069	0.339
MOD_GSK3_1	672	679	PF00069	0.582
MOD_N-GLC_1	533	538	PF02516	0.549
MOD_N-GLC_1	598	603	PF02516	0.429
MOD_NEK2_1	126	131	PF00069	0.417
MOD_NEK2_1	2	7	PF00069	0.569
MOD_NEK2_1	217	222	PF00069	0.539
MOD_NEK2_1	262	267	PF00069	0.691
MOD_NEK2_1	339	344	PF00069	0.696
MOD_NEK2_1	358	363	PF00069	0.584
MOD_NEK2_1	396	401	PF00069	0.468
MOD_NEK2_1	407	412	PF00069	0.479
MOD_NEK2_2	528	533	PF00069	0.372
MOD_NEK2_2	577	582	PF00069	0.462
MOD_NEK2_2	588	593	PF00069	0.399
MOD_PIKK_1	109	115	PF00454	0.493
MOD_PIKK_1	34	40	PF00454	0.393
MOD_PK_1	643	649	PF00069	0.346
MOD_PKA_1	229	235	PF00069	0.518
MOD_PKA_2	103	109	PF00069	0.586
MOD_PKA_2	229	235	PF00069	0.438
MOD_PKA_2	532	538	PF00069	0.515
MOD_PKA_2	634	640	PF00069	0.416
MOD_Plk_1	127	133	PF00069	0.423
MOD_Plk_1	249	255	PF00069	0.543
MOD_Plk_1	528	534	PF00069	0.412
MOD_Plk_1	598	604	PF00069	0.511
MOD_Plk_1	643	649	PF00069	0.346
MOD_Plk_2-3	249	255	PF00069	0.625
MOD_Plk_2-3	409	415	PF00069	0.607
MOD_Plk_2-3	454	460	PF00069	0.647
MOD_Plk_4	152	158	PF00069	0.353
MOD_Plk_4	212	218	PF00069	0.458
MOD_Plk_4	354	360	PF00069	0.644
MOD_Plk_4	577	583	PF00069	0.388
MOD_ProDKin_1	170	176	PF00069	0.375
MOD_ProDKin_1	308	314	PF00069	0.553
TRG_DiLeu_BaEn_2	386	392	PF01217	0.571
TRG_ENDOCYTIC_2	237	240	PF00928	0.452
TRG_ENDOCYTIC_2	380	383	PF00928	0.601
TRG_ENDOCYTIC_2	468	471	PF00928	0.440
TRG_ENDOCYTIC_2	472	475	PF00928	0.444
TRG_ENDOCYTIC_2	553	556	PF00928	0.404
TRG_ER_diArg_1	165	168	PF00400	0.381
TRG_ER_diArg_1	228	230	PF00400	0.542
TRG_ER_diArg_1	26	28	PF00400	0.578
TRG_ER_diArg_1	461	464	PF00400	0.474
TRG_ER_diArg_1	486	489	PF00400	0.624
TRG_ER_diArg_1	509	511	PF00400	0.546
TRG_ER_diArg_1	654	657	PF00400	0.411
TRG_NES_CRM1_1	114	128	PF08389	0.532
TRG_NES_CRM1_1	244	255	PF08389	0.450
TRG_NES_CRM1_1	409	424	PF08389	0.486
TRG_NLS_MonoExtN_4	486	491	PF00514	0.547
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	657	662	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7F1	Leptomonas seymouri	68%	99%
A0A0S4IRV6	Bodo saltans	42%	99%
A0A1X0NSL8	Trypanosomatidae	53%	94%
A0A3S7WZQ1	Leishmania donovani	96%	100%
A0A422MXA7	Trypanosoma rangeli	52%	95%
A4HEU8	Leishmania braziliensis	89%	100%
A4I222	Leishmania infantum	97%	100%
C9ZRY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	99%
Q4Q9A1	Leishmania major	95%	100%
Q57VU6	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	52%	99%
V5DR06	Trypanosoma cruzi	52%	95%