Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY69_LEIMU

TriTrypDb:

LmxM.26.0910

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AY69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY69

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0001653	peptide receptor activity	3	11
GO:0038023	signaling receptor activity	2	11
GO:0060089	molecular transducer activity	1	11
GO:0140625	opioid growth factor receptor activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.399
CLV_C14_Caspase3-7	168	172	PF00656	0.516
CLV_C14_Caspase3-7	293	297	PF00656	0.771
CLV_C14_Caspase3-7	398	402	PF00656	0.555
CLV_C14_Caspase3-7	62	66	PF00656	0.526
CLV_NRD_NRD_1	211	213	PF00675	0.567
CLV_NRD_NRD_1	29	31	PF00675	0.663
CLV_NRD_NRD_1	309	311	PF00675	0.606
CLV_PCSK_KEX2_1	211	213	PF00082	0.567
CLV_PCSK_KEX2_1	29	31	PF00082	0.784
CLV_PCSK_KEX2_1	309	311	PF00082	0.606
CLV_PCSK_KEX2_1	392	394	PF00082	0.433
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.383
CLV_PCSK_SKI1_1	212	216	PF00082	0.445
CLV_PCSK_SKI1_1	251	255	PF00082	0.527
CLV_PCSK_SKI1_1	263	267	PF00082	0.376
CLV_PCSK_SKI1_1	309	313	PF00082	0.650
CLV_PCSK_SKI1_1	334	338	PF00082	0.307
CLV_PCSK_SKI1_1	360	364	PF00082	0.314
DEG_APCC_DBOX_1	262	270	PF00400	0.392
DEG_Nend_UBRbox_2	1	3	PF02207	0.557
DEG_SPOP_SBC_1	76	80	PF00917	0.696
DOC_CYCLIN_RxL_1	209	218	PF00134	0.339
DOC_CYCLIN_RxL_1	331	338	PF00134	0.302
DOC_CYCLIN_yCln2_LP_2	107	110	PF00134	0.400
DOC_MAPK_gen_1	331	341	PF00069	0.343
DOC_MAPK_MEF2A_6	138	147	PF00069	0.346
DOC_MAPK_MEF2A_6	334	341	PF00069	0.367
DOC_PP1_RVXF_1	136	142	PF00149	0.344
DOC_PP1_RVXF_1	345	352	PF00149	0.352
DOC_PP1_RVXF_1	358	364	PF00149	0.293
DOC_PP2B_LxvP_1	107	110	PF13499	0.400
DOC_PP2B_LxvP_1	312	315	PF13499	0.547
DOC_PP4_FxxP_1	363	366	PF00568	0.431
DOC_USP7_MATH_1	120	124	PF00917	0.396
DOC_USP7_MATH_1	163	167	PF00917	0.504
DOC_USP7_MATH_1	195	199	PF00917	0.540
DOC_USP7_MATH_1	60	64	PF00917	0.549
DOC_USP7_MATH_1	76	80	PF00917	0.467
DOC_USP7_MATH_1	85	89	PF00917	0.511
DOC_USP7_UBL2_3	387	391	PF12436	0.458
DOC_WW_Pin1_4	191	196	PF00397	0.500
DOC_WW_Pin1_4	72	77	PF00397	0.748
DOC_WW_Pin1_4	87	92	PF00397	0.599
DOC_WW_Pin1_4	93	98	PF00397	0.492
LIG_14-3-3_CanoR_1	182	186	PF00244	0.610
LIG_14-3-3_CanoR_1	230	236	PF00244	0.310
LIG_14-3-3_CanoR_1	331	337	PF00244	0.265
LIG_14-3-3_CanoR_1	44	50	PF00244	0.434
LIG_Actin_WH2_2	329	345	PF00022	0.406
LIG_BRCT_BRCA1_1	320	324	PF00533	0.400
LIG_BRCT_BRCA1_1	38	42	PF00533	0.352
LIG_eIF4E_1	233	239	PF01652	0.428
LIG_EVH1_1	312	316	PF00568	0.472
LIG_FHA_1	277	283	PF00498	0.647
LIG_FHA_1	51	57	PF00498	0.634
LIG_FHA_2	396	402	PF00498	0.617
LIG_FHA_2	78	84	PF00498	0.680
LIG_GBD_Chelix_1	344	352	PF00786	0.317
LIG_LIR_Gen_1	135	144	PF02991	0.399
LIG_LIR_Gen_1	203	214	PF02991	0.511
LIG_LIR_Gen_1	234	242	PF02991	0.298
LIG_LIR_Gen_1	262	270	PF02991	0.496
LIG_LIR_Gen_1	318	325	PF02991	0.405
LIG_LIR_Gen_1	338	349	PF02991	0.414
LIG_LIR_Nem_3	135	139	PF02991	0.409
LIG_LIR_Nem_3	203	209	PF02991	0.435
LIG_LIR_Nem_3	229	235	PF02991	0.398
LIG_LIR_Nem_3	262	267	PF02991	0.371
LIG_LIR_Nem_3	318	322	PF02991	0.520
LIG_LIR_Nem_3	338	344	PF02991	0.330
LIG_LIR_Nem_3	355	361	PF02991	0.338
LIG_MYND_1	146	150	PF01753	0.411
LIG_NRBOX	204	210	PF00104	0.495
LIG_NRBOX	332	338	PF00104	0.264
LIG_Pex14_1	260	264	PF04695	0.352
LIG_REV1ctd_RIR_1	239	249	PF16727	0.548
LIG_SH2_CRK	233	237	PF00017	0.300
LIG_SH2_CRK	358	362	PF00017	0.317
LIG_SH2_PTP2	235	238	PF00017	0.419
LIG_SH2_STAP1	124	128	PF00017	0.486
LIG_SH2_STAP1	206	210	PF00017	0.375
LIG_SH2_STAP1	233	237	PF00017	0.300
LIG_SH2_STAT3	124	127	PF00017	0.493
LIG_SH2_STAT5	235	238	PF00017	0.290
LIG_SH3_1	310	316	PF00018	0.477
LIG_SH3_3	140	146	PF00018	0.295
LIG_SH3_3	219	225	PF00018	0.334
LIG_SH3_3	310	316	PF00018	0.624
LIG_SH3_3	374	380	PF00018	0.486
LIG_SUMO_SIM_anti_2	216	224	PF11976	0.349
LIG_SUMO_SIM_anti_2	234	240	PF11976	0.463
LIG_SUMO_SIM_anti_2	96	102	PF11976	0.554
LIG_TRAF2_1	18	21	PF00917	0.465
LIG_TRAF2_1	188	191	PF00917	0.504
LIG_TRAF2_1	259	262	PF00917	0.399
LIG_TYR_ITIM	231	236	PF00017	0.303
LIG_WRC_WIRS_1	319	324	PF05994	0.613
LIG_WW_1	316	319	PF00397	0.575
MOD_CDK_SPxxK_3	87	94	PF00069	0.446
MOD_CK1_1	198	204	PF00069	0.428
MOD_CK1_1	385	391	PF00069	0.374
MOD_CK1_1	75	81	PF00069	0.595
MOD_CK1_1	90	96	PF00069	0.487
MOD_CK2_1	191	197	PF00069	0.491
MOD_CK2_1	198	204	PF00069	0.402
MOD_CK2_1	71	77	PF00069	0.744
MOD_GlcNHglycan	167	170	PF01048	0.640
MOD_GlcNHglycan	173	176	PF01048	0.468
MOD_GlcNHglycan	185	188	PF01048	0.727
MOD_GlcNHglycan	200	203	PF01048	0.391
MOD_GlcNHglycan	303	306	PF01048	0.456
MOD_GlcNHglycan	326	329	PF01048	0.522
MOD_GSK3_1	171	178	PF00069	0.705
MOD_GSK3_1	191	198	PF00069	0.490
MOD_GSK3_1	277	284	PF00069	0.652
MOD_GSK3_1	381	388	PF00069	0.398
MOD_GSK3_1	395	402	PF00069	0.495
MOD_GSK3_1	60	67	PF00069	0.584
MOD_GSK3_1	71	78	PF00069	0.579
MOD_GSK3_1	86	93	PF00069	0.470
MOD_N-GLC_1	171	176	PF02516	0.508
MOD_NEK2_1	103	108	PF00069	0.330
MOD_NEK2_1	128	133	PF00069	0.491
MOD_NEK2_1	269	274	PF00069	0.580
MOD_NEK2_1	324	329	PF00069	0.558
MOD_NEK2_1	86	91	PF00069	0.450
MOD_PIKK_1	47	53	PF00454	0.602
MOD_PKA_2	181	187	PF00069	0.439
MOD_PKA_2	270	276	PF00069	0.393
MOD_PKA_2	395	401	PF00069	0.472
MOD_Plk_1	120	126	PF00069	0.464
MOD_Plk_1	368	374	PF00069	0.307
MOD_Plk_4	103	109	PF00069	0.483
MOD_Plk_4	231	237	PF00069	0.379
MOD_Plk_4	368	374	PF00069	0.360
MOD_Plk_4	96	102	PF00069	0.529
MOD_ProDKin_1	191	197	PF00069	0.491
MOD_ProDKin_1	72	78	PF00069	0.748
MOD_ProDKin_1	87	93	PF00069	0.596
TRG_DiLeu_BaEn_1	204	209	PF01217	0.374
TRG_DiLeu_BaEn_1	249	254	PF01217	0.544
TRG_DiLeu_BaEn_1	262	267	PF01217	0.551
TRG_DiLeu_BaEn_4	249	255	PF01217	0.420
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.330
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.349
TRG_DiLeu_BaLyEn_6	357	362	PF01217	0.320
TRG_ENDOCYTIC_2	206	209	PF00928	0.443
TRG_ENDOCYTIC_2	233	236	PF00928	0.301
TRG_ENDOCYTIC_2	264	267	PF00928	0.353
TRG_ENDOCYTIC_2	319	322	PF00928	0.486
TRG_ENDOCYTIC_2	358	361	PF00928	0.312
TRG_ENDOCYTIC_2	43	46	PF00928	0.446
TRG_ER_diArg_1	210	212	PF00400	0.595
TRG_ER_diArg_1	29	31	PF00400	0.467
TRG_NES_CRM1_1	338	350	PF08389	0.307
TRG_NLS_MonoExtN_4	389	395	PF00514	0.358
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ78	Leptomonas seymouri	52%	100%
A0A1X0NT07	Trypanosomatidae	34%	100%
A0A3Q8IFS6	Leishmania donovani	87%	100%
A0A422MXD1	Trypanosoma rangeli	37%	100%
A4HEU6	Leishmania braziliensis	73%	96%
A4I220	Leishmania infantum	87%	100%
C9ZRY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q9A3	Leishmania major	88%	99%
V5BUN4	Trypanosoma cruzi	34%	100%