FYR N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ISWI complex protein

Species:

Leishmania mexicana

UniProt:

E9AY65_LEIMU

TriTrypDb:

LmxM.26.0870

Length:

783

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5
GO:0031010	ISWI-type complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0070603	SWI/SNF superfamily-type complex	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1904949	ATPase complex	3	1

Expansion

Sequence features

E9AY65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY65

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	426	430	PF00656	0.783
CLV_C14_Caspase3-7	454	458	PF00656	0.674
CLV_C14_Caspase3-7	627	631	PF00656	0.722
CLV_C14_Caspase3-7	702	706	PF00656	0.703
CLV_C14_Caspase3-7	769	773	PF00656	0.592
CLV_C14_Caspase3-7	97	101	PF00656	0.457
CLV_MEL_PAP_1	392	398	PF00089	0.528
CLV_NRD_NRD_1	108	110	PF00675	0.604
CLV_NRD_NRD_1	241	243	PF00675	0.747
CLV_NRD_NRD_1	247	249	PF00675	0.760
CLV_NRD_NRD_1	287	289	PF00675	0.733
CLV_NRD_NRD_1	290	292	PF00675	0.716
CLV_NRD_NRD_1	324	326	PF00675	0.723
CLV_NRD_NRD_1	389	391	PF00675	0.725
CLV_NRD_NRD_1	394	396	PF00675	0.714
CLV_NRD_NRD_1	441	443	PF00675	0.599
CLV_NRD_NRD_1	474	476	PF00675	0.728
CLV_NRD_NRD_1	586	588	PF00675	0.720
CLV_NRD_NRD_1	709	711	PF00675	0.753
CLV_PCSK_FUR_1	288	292	PF00082	0.745
CLV_PCSK_FUR_1	441	445	PF00082	0.727
CLV_PCSK_FUR_1	472	476	PF00082	0.711
CLV_PCSK_KEX2_1	240	242	PF00082	0.756
CLV_PCSK_KEX2_1	247	249	PF00082	0.725
CLV_PCSK_KEX2_1	285	287	PF00082	0.740
CLV_PCSK_KEX2_1	290	292	PF00082	0.717
CLV_PCSK_KEX2_1	322	324	PF00082	0.665
CLV_PCSK_KEX2_1	393	395	PF00082	0.719
CLV_PCSK_KEX2_1	441	443	PF00082	0.666
CLV_PCSK_KEX2_1	474	476	PF00082	0.728
CLV_PCSK_KEX2_1	576	578	PF00082	0.699
CLV_PCSK_KEX2_1	585	587	PF00082	0.709
CLV_PCSK_KEX2_1	678	680	PF00082	0.590
CLV_PCSK_KEX2_1	714	716	PF00082	0.717
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.756
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.740
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.665
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.730
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.699
CLV_PCSK_PC1ET2_1	678	680	PF00082	0.590
CLV_PCSK_PC1ET2_1	714	716	PF00082	0.759
CLV_PCSK_PC7_1	237	243	PF00082	0.760
CLV_PCSK_PC7_1	286	292	PF00082	0.746
CLV_PCSK_PC7_1	390	396	PF00082	0.719
CLV_PCSK_PC7_1	710	716	PF00082	0.761
CLV_PCSK_SKI1_1	102	106	PF00082	0.553
CLV_PCSK_SKI1_1	109	113	PF00082	0.467
CLV_PCSK_SKI1_1	35	39	PF00082	0.459
CLV_PCSK_SKI1_1	691	695	PF00082	0.600
DEG_Nend_Nbox_1	1	3	PF02207	0.465
DEG_SCF_FBW7_1	220	225	PF00400	0.738
DEG_SPOP_SBC_1	11	15	PF00917	0.656
DEG_SPOP_SBC_1	189	193	PF00917	0.619
DEG_SPOP_SBC_1	222	226	PF00917	0.547
DEG_SPOP_SBC_1	37	41	PF00917	0.563
DEG_SPOP_SBC_1	57	61	PF00917	0.562
DOC_CYCLIN_yCln2_LP_2	126	132	PF00134	0.375
DOC_CYCLIN_yCln2_LP_2	531	537	PF00134	0.730
DOC_MAPK_gen_1	375	385	PF00069	0.724
DOC_MAPK_RevD_3	563	577	PF00069	0.668
DOC_PP1_RVXF_1	48	54	PF00149	0.357
DOC_PP2B_LxvP_1	126	129	PF13499	0.522
DOC_PP2B_LxvP_1	156	159	PF13499	0.558
DOC_PP2B_LxvP_1	531	534	PF13499	0.649
DOC_PP4_FxxP_1	21	24	PF00568	0.644
DOC_SPAK_OSR1_1	682	686	PF12202	0.604
DOC_USP7_MATH_1	168	172	PF00917	0.526
DOC_USP7_MATH_1	232	236	PF00917	0.700
DOC_USP7_MATH_1	257	261	PF00917	0.672
DOC_USP7_MATH_1	262	266	PF00917	0.595
DOC_USP7_MATH_1	459	463	PF00917	0.782
DOC_USP7_MATH_1	486	490	PF00917	0.782
DOC_USP7_MATH_1	704	708	PF00917	0.654
DOC_USP7_MATH_1	774	778	PF00917	0.630
DOC_USP7_MATH_1	779	783	PF00917	0.652
DOC_USP7_MATH_2	229	235	PF00917	0.833
DOC_USP7_UBL2_3	223	227	PF12436	0.762
DOC_USP7_UBL2_3	635	639	PF12436	0.528
DOC_WW_Pin1_4	216	221	PF00397	0.681
DOC_WW_Pin1_4	253	258	PF00397	0.704
DOC_WW_Pin1_4	298	303	PF00397	0.826
DOC_WW_Pin1_4	356	361	PF00397	0.536
DOC_WW_Pin1_4	505	510	PF00397	0.667
DOC_WW_Pin1_4	645	650	PF00397	0.710
DOC_WW_Pin1_4	709	714	PF00397	0.726
DOC_WW_Pin1_4	752	757	PF00397	0.757
DOC_WW_Pin1_4	89	94	PF00397	0.354
LIG_14-3-3_CanoR_1	175	181	PF00244	0.396
LIG_14-3-3_CanoR_1	190	195	PF00244	0.643
LIG_14-3-3_CanoR_1	205	214	PF00244	0.683
LIG_14-3-3_CanoR_1	215	220	PF00244	0.513
LIG_14-3-3_CanoR_1	241	245	PF00244	0.813
LIG_14-3-3_CanoR_1	247	252	PF00244	0.761
LIG_14-3-3_CanoR_1	323	332	PF00244	0.647
LIG_14-3-3_CanoR_1	35	44	PF00244	0.530
LIG_14-3-3_CanoR_1	532	538	PF00244	0.623
LIG_Actin_WH2_2	134	151	PF00022	0.506
LIG_APCC_ABBAyCdc20_2	23	29	PF00400	0.482
LIG_BIR_III_2	254	258	PF00653	0.711
LIG_DCNL_PONY_1	1	4	PF03556	0.559
LIG_FHA_1	175	181	PF00498	0.626
LIG_FHA_1	190	196	PF00498	0.669
LIG_FHA_1	259	265	PF00498	0.727
LIG_FHA_1	310	316	PF00498	0.516
LIG_FHA_1	495	501	PF00498	0.714
LIG_FHA_1	502	508	PF00498	0.705
LIG_FHA_1	59	65	PF00498	0.636
LIG_FHA_1	71	77	PF00498	0.380
LIG_FHA_1	82	88	PF00498	0.597
LIG_FHA_2	417	423	PF00498	0.658
LIG_FHA_2	452	458	PF00498	0.569
LIG_FHA_2	534	540	PF00498	0.710
LIG_FHA_2	690	696	PF00498	0.705
LIG_FHA_2	86	92	PF00498	0.462
LIG_FHA_2	95	101	PF00498	0.437
LIG_Integrin_RGD_1	501	503	PF01839	0.611
LIG_LIR_Apic_2	52	58	PF02991	0.627
LIG_LIR_Apic_2	523	529	PF02991	0.650
LIG_LIR_Nem_3	527	531	PF02991	0.768
LIG_LIR_Nem_3	690	696	PF02991	0.571
LIG_LRP6_Inhibitor_1	136	142	PF00058	0.506
LIG_LYPXL_yS_3	528	531	PF13949	0.664
LIG_MYND_1	529	533	PF01753	0.655
LIG_Pex14_1	551	555	PF04695	0.600
LIG_SH2_CRK	526	530	PF00017	0.683
LIG_SH2_CRK	55	59	PF00017	0.653
LIG_SH2_STAT5	31	34	PF00017	0.394
LIG_SH2_STAT5	526	529	PF00017	0.608
LIG_SH2_STAT5	687	690	PF00017	0.676
LIG_SH2_STAT5	71	74	PF00017	0.561
LIG_SH2_STAT5	98	101	PF00017	0.528
LIG_SH3_1	710	716	PF00018	0.740
LIG_SH3_3	126	132	PF00018	0.375
LIG_SH3_3	22	28	PF00018	0.605
LIG_SH3_3	346	352	PF00018	0.684
LIG_SH3_3	380	386	PF00018	0.726
LIG_SH3_3	503	509	PF00018	0.763
LIG_SH3_3	511	517	PF00018	0.672
LIG_SH3_3	527	533	PF00018	0.635
LIG_SH3_3	556	562	PF00018	0.572
LIG_SH3_3	643	649	PF00018	0.718
LIG_SH3_3	654	660	PF00018	0.674
LIG_SH3_3	710	716	PF00018	0.740
LIG_SUMO_SIM_anti_2	508	515	PF11976	0.501
LIG_SUMO_SIM_par_1	265	272	PF11976	0.613
LIG_SUMO_SIM_par_1	343	348	PF11976	0.667
LIG_SUMO_SIM_par_1	533	539	PF11976	0.715
LIG_SUMO_SIM_par_1	664	669	PF11976	0.662
LIG_SUMO_SIM_par_1	747	752	PF11976	0.532
LIG_TRAF2_1	520	523	PF00917	0.690
MOD_CDK_SPK_2	218	223	PF00069	0.749
MOD_CDK_SPK_2	709	714	PF00069	0.635
MOD_CDK_SPxK_1	709	715	PF00069	0.555
MOD_CDK_SPxxK_3	216	223	PF00069	0.834
MOD_CDK_SPxxK_3	89	96	PF00069	0.356
MOD_CK1_1	103	109	PF00069	0.495
MOD_CK1_1	178	184	PF00069	0.517
MOD_CK1_1	193	199	PF00069	0.782
MOD_CK1_1	235	241	PF00069	0.825
MOD_CK1_1	328	334	PF00069	0.731
MOD_CK1_1	356	362	PF00069	0.552
MOD_CK1_1	489	495	PF00069	0.774
MOD_CK1_1	59	65	PF00069	0.636
MOD_CK1_1	640	646	PF00069	0.695
MOD_CK1_1	648	654	PF00069	0.658
MOD_CK1_1	689	695	PF00069	0.596
MOD_CK1_1	752	758	PF00069	0.818
MOD_CK1_1	777	783	PF00069	0.514
MOD_CK2_1	416	422	PF00069	0.658
MOD_CK2_1	489	495	PF00069	0.725
MOD_CK2_1	533	539	PF00069	0.715
MOD_Cter_Amidation	676	679	PF01082	0.573
MOD_Cter_Amidation	708	711	PF01082	0.840
MOD_DYRK1A_RPxSP_1	89	93	PF00069	0.344
MOD_GlcNHglycan	102	105	PF01048	0.524
MOD_GlcNHglycan	170	173	PF01048	0.586
MOD_GlcNHglycan	234	237	PF01048	0.682
MOD_GlcNHglycan	264	267	PF01048	0.744
MOD_GlcNHglycan	355	358	PF01048	0.599
MOD_GlcNHglycan	422	428	PF01048	0.763
MOD_GlcNHglycan	454	457	PF01048	0.752
MOD_GlcNHglycan	461	464	PF01048	0.744
MOD_GlcNHglycan	61	64	PF01048	0.608
MOD_GlcNHglycan	639	642	PF01048	0.751
MOD_GlcNHglycan	643	646	PF01048	0.762
MOD_GlcNHglycan	701	704	PF01048	0.653
MOD_GlcNHglycan	705	709	PF01048	0.662
MOD_GlcNHglycan	720	723	PF01048	0.653
MOD_GlcNHglycan	750	754	PF01048	0.831
MOD_GlcNHglycan	776	779	PF01048	0.506
MOD_GlcNHglycan	79	82	PF01048	0.349
MOD_GSK3_1	174	181	PF00069	0.506
MOD_GSK3_1	189	196	PF00069	0.660
MOD_GSK3_1	197	204	PF00069	0.658
MOD_GSK3_1	2	9	PF00069	0.486
MOD_GSK3_1	205	212	PF00069	0.621
MOD_GSK3_1	214	221	PF00069	0.669
MOD_GSK3_1	231	238	PF00069	0.759
MOD_GSK3_1	243	250	PF00069	0.714
MOD_GSK3_1	253	260	PF00069	0.648
MOD_GSK3_1	269	276	PF00069	0.539
MOD_GSK3_1	324	331	PF00069	0.733
MOD_GSK3_1	459	466	PF00069	0.570
MOD_GSK3_1	501	508	PF00069	0.625
MOD_GSK3_1	637	644	PF00069	0.721
MOD_GSK3_1	645	652	PF00069	0.667
MOD_GSK3_1	666	673	PF00069	0.600
MOD_GSK3_1	685	692	PF00069	0.464
MOD_GSK3_1	77	84	PF00069	0.499
MOD_GSK3_1	773	780	PF00069	0.654
MOD_GSK3_1	85	92	PF00069	0.539
MOD_GSK3_1	94	101	PF00069	0.535
MOD_N-GLC_1	2	7	PF02516	0.561
MOD_N-GLC_1	698	703	PF02516	0.664
MOD_NEK2_1	194	199	PF00069	0.696
MOD_NEK2_1	2	7	PF00069	0.468
MOD_NEK2_1	361	366	PF00069	0.685
MOD_NEK2_1	38	43	PF00069	0.598
MOD_NEK2_1	547	552	PF00069	0.592
MOD_NEK2_1	666	671	PF00069	0.615
MOD_NEK2_1	697	702	PF00069	0.556
MOD_NEK2_1	72	77	PF00069	0.364
MOD_NEK2_1	85	90	PF00069	0.416
MOD_PIKK_1	199	205	PF00454	0.787
MOD_PIKK_1	209	215	PF00454	0.545
MOD_PIKK_1	269	275	PF00454	0.648
MOD_PIKK_1	38	44	PF00454	0.601
MOD_PIKK_1	666	672	PF00454	0.657
MOD_PK_1	247	253	PF00069	0.730
MOD_PKA_1	240	246	PF00069	0.737
MOD_PKA_1	247	253	PF00069	0.732
MOD_PKA_1	286	292	PF00069	0.746
MOD_PKA_1	323	329	PF00069	0.696
MOD_PKA_1	394	400	PF00069	0.808
MOD_PKA_1	678	684	PF00069	0.588
MOD_PKA_2	174	180	PF00069	0.392
MOD_PKA_2	189	195	PF00069	0.637
MOD_PKA_2	214	220	PF00069	0.662
MOD_PKA_2	236	242	PF00069	0.762
MOD_PKA_2	247	253	PF00069	0.706
MOD_PKA_2	286	292	PF00069	0.746
MOD_PKA_2	323	329	PF00069	0.696
MOD_PKA_2	394	400	PF00069	0.808
MOD_PKA_2	476	482	PF00069	0.715
MOD_PKA_2	678	684	PF00069	0.588
MOD_PKB_1	323	331	PF00069	0.818
MOD_Plk_1	2	8	PF00069	0.562
MOD_Plk_1	666	672	PF00069	0.657
MOD_Plk_1	689	695	PF00069	0.596
MOD_Plk_1	94	100	PF00069	0.562
MOD_Plk_2-3	29	35	PF00069	0.575
MOD_Plk_4	190	196	PF00069	0.733
MOD_Plk_4	264	270	PF00069	0.635
MOD_Plk_4	345	351	PF00069	0.629
MOD_Plk_4	495	501	PF00069	0.555
MOD_Plk_4	6	12	PF00069	0.556
MOD_Plk_4	658	664	PF00069	0.655
MOD_Plk_4	760	766	PF00069	0.690
MOD_ProDKin_1	216	222	PF00069	0.676
MOD_ProDKin_1	253	259	PF00069	0.703
MOD_ProDKin_1	298	304	PF00069	0.824
MOD_ProDKin_1	356	362	PF00069	0.528
MOD_ProDKin_1	505	511	PF00069	0.668
MOD_ProDKin_1	645	651	PF00069	0.710
MOD_ProDKin_1	709	715	PF00069	0.727
MOD_ProDKin_1	752	758	PF00069	0.756
MOD_ProDKin_1	89	95	PF00069	0.360
MOD_SUMO_for_1	66	69	PF00179	0.441
MOD_SUMO_rev_2	448	454	PF00179	0.751
MOD_SUMO_rev_2	601	606	PF00179	0.819
MOD_SUMO_rev_2	731	736	PF00179	0.738
MOD_SUMO_rev_2	742	748	PF00179	0.617
MOD_SUMO_rev_2	95	104	PF00179	0.567
TRG_ENDOCYTIC_2	528	531	PF00928	0.664
TRG_ER_diArg_1	286	288	PF00400	0.749
TRG_ER_diArg_1	290	292	PF00400	0.696
TRG_ER_diArg_1	323	325	PF00400	0.665
TRG_ER_diArg_1	392	395	PF00400	0.717
TRG_ER_diArg_1	440	442	PF00400	0.758
TRG_ER_diArg_1	472	475	PF00400	0.715
TRG_ER_diArg_1	585	587	PF00400	0.709
TRG_NLS_MonoCore_2	321	326	PF00514	0.724
TRG_NLS_MonoExtC_3	389	394	PF00514	0.697
TRG_NLS_MonoExtC_3	441	446	PF00514	0.811
TRG_NLS_MonoExtN_4	320	326	PF00514	0.646
TRG_NLS_MonoExtN_4	440	447	PF00514	0.721
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.754
TRG_Pf-PMV_PEXEL_1	682	686	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAK0	Leptomonas seymouri	39%	98%
A0A3Q8IC42	Leishmania donovani	83%	100%
A4HEU2	Leishmania braziliensis	65%	97%
A4I217	Leishmania infantum	84%	97%
Q4Q9A7	Leishmania major	83%	100%