Putative RNA-editing complex protein MP100

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-editing complex protein MP100, putative

Species:

Leishmania mexicana

UniProt:

E9AY64_LEIMU

TriTrypDb:

LmxM.26.0860

Length:

986

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016604	nuclear body	2	1
GO:0016605	PML body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AY64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY64

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003697	single-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0008081	phosphoric diester hydrolase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0070259	tyrosyl-DNA phosphodiesterase activity	4	1
GO:0070260	5'-tyrosyl-DNA phosphodiesterase activity	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	664	668	PF00656	0.444
CLV_NRD_NRD_1	111	113	PF00675	0.433
CLV_NRD_NRD_1	160	162	PF00675	0.464
CLV_NRD_NRD_1	281	283	PF00675	0.507
CLV_NRD_NRD_1	62	64	PF00675	0.431
CLV_NRD_NRD_1	765	767	PF00675	0.297
CLV_NRD_NRD_1	80	82	PF00675	0.378
CLV_NRD_NRD_1	820	822	PF00675	0.365
CLV_PCSK_KEX2_1	111	113	PF00082	0.524
CLV_PCSK_KEX2_1	280	282	PF00082	0.492
CLV_PCSK_KEX2_1	62	64	PF00082	0.459
CLV_PCSK_KEX2_1	704	706	PF00082	0.291
CLV_PCSK_KEX2_1	765	767	PF00082	0.294
CLV_PCSK_KEX2_1	80	82	PF00082	0.279
CLV_PCSK_PC1ET2_1	704	706	PF00082	0.291
CLV_PCSK_SKI1_1	132	136	PF00082	0.437
CLV_PCSK_SKI1_1	161	165	PF00082	0.441
CLV_PCSK_SKI1_1	2	6	PF00082	0.622
CLV_PCSK_SKI1_1	238	242	PF00082	0.458
CLV_PCSK_SKI1_1	436	440	PF00082	0.554
CLV_PCSK_SKI1_1	447	451	PF00082	0.523
CLV_PCSK_SKI1_1	536	540	PF00082	0.485
CLV_PCSK_SKI1_1	605	609	PF00082	0.574
CLV_PCSK_SKI1_1	675	679	PF00082	0.335
CLV_PCSK_SKI1_1	69	73	PF00082	0.524
CLV_PCSK_SKI1_1	857	861	PF00082	0.407
CLV_PCSK_SKI1_1	927	931	PF00082	0.291
CLV_PCSK_SKI1_1	942	946	PF00082	0.291
CLV_Separin_Metazoa	533	537	PF03568	0.518
DEG_APCC_DBOX_1	435	443	PF00400	0.558
DEG_APCC_DBOX_1	604	612	PF00400	0.579
DEG_APCC_DBOX_1	68	76	PF00400	0.458
DEG_APCC_DBOX_1	768	776	PF00400	0.367
DEG_APCC_DBOX_1	941	949	PF00400	0.367
DEG_COP1_1	664	674	PF00400	0.440
DEG_Nend_UBRbox_1	1	4	PF02207	0.624
DEG_SPOP_SBC_1	355	359	PF00917	0.613
DEG_SPOP_SBC_1	477	481	PF00917	0.475
DOC_CKS1_1	615	620	PF01111	0.402
DOC_CKS1_1	689	694	PF01111	0.385
DOC_CYCLIN_yCln2_LP_2	778	784	PF00134	0.222
DOC_CYCLIN_yCln2_LP_2	883	886	PF00134	0.367
DOC_MAPK_DCC_7	685	695	PF00069	0.291
DOC_MAPK_gen_1	111	117	PF00069	0.310
DOC_MAPK_gen_1	914	922	PF00069	0.291
DOC_MAPK_MEF2A_6	244	252	PF00069	0.335
DOC_MAPK_MEF2A_6	563	570	PF00069	0.498
DOC_MAPK_MEF2A_6	85	92	PF00069	0.340
DOC_MAPK_NFAT4_5	85	93	PF00069	0.432
DOC_MAPK_RevD_3	753	766	PF00069	0.303
DOC_PP1_RVXF_1	673	680	PF00149	0.326
DOC_PP2B_LxvP_1	335	338	PF13499	0.759
DOC_PP2B_LxvP_1	693	696	PF13499	0.291
DOC_PP2B_LxvP_1	778	781	PF13499	0.291
DOC_PP2B_LxvP_1	837	840	PF13499	0.291
DOC_PP2B_LxvP_1	883	886	PF13499	0.367
DOC_PP4_FxxP_1	352	355	PF00568	0.669
DOC_PP4_FxxP_1	882	885	PF00568	0.291
DOC_PP4_FxxP_1	92	95	PF00568	0.368
DOC_USP7_MATH_1	449	453	PF00917	0.641
DOC_USP7_MATH_1	473	477	PF00917	0.690
DOC_USP7_MATH_1	478	482	PF00917	0.598
DOC_USP7_MATH_1	529	533	PF00917	0.554
DOC_USP7_MATH_1	537	541	PF00917	0.387
DOC_USP7_MATH_1	564	568	PF00917	0.448
DOC_USP7_MATH_1	653	657	PF00917	0.681
DOC_USP7_MATH_1	801	805	PF00917	0.423
DOC_USP7_MATH_1	815	819	PF00917	0.257
DOC_WW_Pin1_4	196	201	PF00397	0.383
DOC_WW_Pin1_4	260	265	PF00397	0.524
DOC_WW_Pin1_4	340	345	PF00397	0.717
DOC_WW_Pin1_4	55	60	PF00397	0.536
DOC_WW_Pin1_4	614	619	PF00397	0.430
DOC_WW_Pin1_4	688	693	PF00397	0.291
DOC_WW_Pin1_4	699	704	PF00397	0.291
DOC_WW_Pin1_4	746	751	PF00397	0.378
LIG_14-3-3_CanoR_1	105	109	PF00244	0.287
LIG_14-3-3_CanoR_1	11	16	PF00244	0.556
LIG_14-3-3_CanoR_1	132	138	PF00244	0.402
LIG_14-3-3_CanoR_1	161	170	PF00244	0.440
LIG_14-3-3_CanoR_1	215	220	PF00244	0.448
LIG_14-3-3_CanoR_1	350	355	PF00244	0.672
LIG_14-3-3_CanoR_1	425	429	PF00244	0.597
LIG_14-3-3_CanoR_1	536	542	PF00244	0.517
LIG_14-3-3_CanoR_1	549	553	PF00244	0.323
LIG_14-3-3_CanoR_1	602	608	PF00244	0.572
LIG_14-3-3_CanoR_1	652	658	PF00244	0.472
LIG_14-3-3_CanoR_1	675	680	PF00244	0.367
LIG_14-3-3_CanoR_1	743	753	PF00244	0.316
LIG_14-3-3_CanoR_1	85	89	PF00244	0.351
LIG_Actin_WH2_2	534	551	PF00022	0.444
LIG_AP2alpha_2	756	758	PF02296	0.363
LIG_BIR_III_4	453	457	PF00653	0.466
LIG_BRCT_BRCA1_1	653	657	PF00533	0.472
LIG_BRCT_BRCA1_1	878	882	PF00533	0.385
LIG_BRCT_BRCA1_1	908	912	PF00533	0.385
LIG_BRCT_BRCA1_1	979	983	PF00533	0.314
LIG_BRCT_BRCA1_2	908	914	PF00533	0.385
LIG_CaM_IQ_9	12	28	PF13499	0.439
LIG_Clathr_ClatBox_1	89	93	PF01394	0.420
LIG_deltaCOP1_diTrp_1	433	437	PF00928	0.506
LIG_deltaCOP1_diTrp_1	876	882	PF00928	0.291
LIG_DLG_GKlike_1	11	19	PF00625	0.502
LIG_FHA_1	108	114	PF00498	0.431
LIG_FHA_1	134	140	PF00498	0.310
LIG_FHA_1	203	209	PF00498	0.447
LIG_FHA_1	243	249	PF00498	0.334
LIG_FHA_1	257	263	PF00498	0.415
LIG_FHA_1	344	350	PF00498	0.478
LIG_FHA_1	433	439	PF00498	0.565
LIG_FHA_1	671	677	PF00498	0.360
LIG_FHA_1	792	798	PF00498	0.342
LIG_FHA_1	859	865	PF00498	0.297
LIG_FHA_1	939	945	PF00498	0.393
LIG_FHA_1	953	959	PF00498	0.231
LIG_FHA_2	469	475	PF00498	0.580
LIG_FHA_2	498	504	PF00498	0.354
LIG_FHA_2	615	621	PF00498	0.469
LIG_FHA_2	641	647	PF00498	0.716
LIG_FHA_2	662	668	PF00498	0.586
LIG_FHA_2	848	854	PF00498	0.291
LIG_FHA_2	903	909	PF00498	0.291
LIG_LIR_Apic_2	351	355	PF02991	0.622
LIG_LIR_Apic_2	699	703	PF02991	0.325
LIG_LIR_Apic_2	879	885	PF02991	0.291
LIG_LIR_Gen_1	190	200	PF02991	0.348
LIG_LIR_Gen_1	224	233	PF02991	0.374
LIG_LIR_Gen_1	23	33	PF02991	0.402
LIG_LIR_Gen_1	268	277	PF02991	0.458
LIG_LIR_Gen_1	35	46	PF02991	0.333
LIG_LIR_Gen_1	433	442	PF02991	0.503
LIG_LIR_Gen_1	586	596	PF02991	0.585
LIG_LIR_Gen_1	678	686	PF02991	0.291
LIG_LIR_Gen_1	909	920	PF02991	0.291
LIG_LIR_Gen_1	980	986	PF02991	0.427
LIG_LIR_Nem_3	190	195	PF02991	0.364
LIG_LIR_Nem_3	224	228	PF02991	0.346
LIG_LIR_Nem_3	23	28	PF02991	0.381
LIG_LIR_Nem_3	268	273	PF02991	0.464
LIG_LIR_Nem_3	35	41	PF02991	0.332
LIG_LIR_Nem_3	433	437	PF02991	0.550
LIG_LIR_Nem_3	486	492	PF02991	0.617
LIG_LIR_Nem_3	503	507	PF02991	0.251
LIG_LIR_Nem_3	586	592	PF02991	0.571
LIG_LIR_Nem_3	727	733	PF02991	0.291
LIG_LIR_Nem_3	756	761	PF02991	0.355
LIG_LIR_Nem_3	892	897	PF02991	0.291
LIG_LIR_Nem_3	909	915	PF02991	0.291
LIG_LIR_Nem_3	980	986	PF02991	0.427
LIG_LYPXL_yS_3	706	709	PF13949	0.291
LIG_MYND_1	753	757	PF01753	0.319
LIG_NRBOX	248	254	PF00104	0.441
LIG_NRBOX	381	387	PF00104	0.502
LIG_PDZ_Class_3	981	986	PF00595	0.233
LIG_Pex14_1	585	589	PF04695	0.416
LIG_Pex14_1	679	683	PF04695	0.291
LIG_REV1ctd_RIR_1	553	562	PF16727	0.332
LIG_REV1ctd_RIR_1	919	928	PF16727	0.291
LIG_SH2_CRK	25	29	PF00017	0.481
LIG_SH2_CRK	36	40	PF00017	0.410
LIG_SH2_CRK	504	508	PF00017	0.340
LIG_SH2_GRB2like	686	689	PF00017	0.385
LIG_SH2_PTP2	38	41	PF00017	0.311
LIG_SH2_PTP2	589	592	PF00017	0.422
LIG_SH2_SRC	36	39	PF00017	0.412
LIG_SH2_STAP1	36	40	PF00017	0.410
LIG_SH2_STAT3	686	689	PF00017	0.385
LIG_SH2_STAT5	201	204	PF00017	0.351
LIG_SH2_STAT5	251	254	PF00017	0.434
LIG_SH2_STAT5	316	319	PF00017	0.465
LIG_SH2_STAT5	38	41	PF00017	0.311
LIG_SH2_STAT5	381	384	PF00017	0.441
LIG_SH2_STAT5	504	507	PF00017	0.397
LIG_SH2_STAT5	589	592	PF00017	0.548
LIG_SH2_STAT5	733	736	PF00017	0.335
LIG_SH2_STAT5	744	747	PF00017	0.250
LIG_SH2_STAT5	890	893	PF00017	0.270
LIG_SH2_STAT5	970	973	PF00017	0.291
LIG_SH3_3	152	158	PF00018	0.449
LIG_SH3_3	647	653	PF00018	0.479
LIG_SH3_3	723	729	PF00018	0.367
LIG_SH3_3	747	753	PF00018	0.319
LIG_SH3_3	778	784	PF00018	0.318
LIG_SH3_3	941	947	PF00018	0.367
LIG_SUMO_SIM_par_1	194	199	PF11976	0.437
LIG_SUMO_SIM_par_1	427	433	PF11976	0.520
LIG_SUMO_SIM_par_1	793	798	PF11976	0.385
LIG_TRAF2_1	363	366	PF00917	0.537
LIG_TYR_ITIM	34	39	PF00017	0.427
LIG_WRC_WIRS_1	349	354	PF05994	0.627
MOD_CDC14_SPxK_1	702	705	PF00782	0.325
MOD_CDK_SPK_2	614	619	PF00069	0.413
MOD_CDK_SPK_2	699	704	PF00069	0.325
MOD_CDK_SPxK_1	699	705	PF00069	0.325
MOD_CDK_SPxxK_3	55	62	PF00069	0.542
MOD_CK1_1	263	269	PF00069	0.518
MOD_CK1_1	343	349	PF00069	0.586
MOD_CK1_1	359	365	PF00069	0.678
MOD_CK1_1	380	386	PF00069	0.502
MOD_CK1_1	459	465	PF00069	0.674
MOD_CK1_1	468	474	PF00069	0.563
MOD_CK1_1	476	482	PF00069	0.566
MOD_CK1_1	749	755	PF00069	0.482
MOD_CK1_1	804	810	PF00069	0.367
MOD_CK2_1	359	365	PF00069	0.536
MOD_CK2_1	390	396	PF00069	0.419
MOD_CK2_1	497	503	PF00069	0.370
MOD_CK2_1	614	620	PF00069	0.409
MOD_CK2_1	640	646	PF00069	0.632
MOD_CK2_1	902	908	PF00069	0.291
MOD_GlcNHglycan	150	153	PF01048	0.369
MOD_GlcNHglycan	265	268	PF01048	0.476
MOD_GlcNHglycan	358	361	PF01048	0.743
MOD_GlcNHglycan	418	421	PF01048	0.559
MOD_GlcNHglycan	467	470	PF01048	0.586
MOD_GlcNHglycan	474	478	PF01048	0.576
MOD_GlcNHglycan	48	51	PF01048	0.251
MOD_GlcNHglycan	494	497	PF01048	0.485
MOD_GlcNHglycan	511	514	PF01048	0.532
MOD_GlcNHglycan	664	667	PF01048	0.508
MOD_GlcNHglycan	796	800	PF01048	0.364
MOD_GlcNHglycan	805	809	PF01048	0.346
MOD_GlcNHglycan	813	816	PF01048	0.304
MOD_GlcNHglycan	817	820	PF01048	0.380
MOD_GSK3_1	103	110	PF00069	0.434
MOD_GSK3_1	238	245	PF00069	0.428
MOD_GSK3_1	256	263	PF00069	0.295
MOD_GSK3_1	350	357	PF00069	0.670
MOD_GSK3_1	376	383	PF00069	0.565
MOD_GSK3_1	412	419	PF00069	0.580
MOD_GSK3_1	456	463	PF00069	0.627
MOD_GSK3_1	473	480	PF00069	0.719
MOD_GSK3_1	502	509	PF00069	0.403
MOD_GSK3_1	51	58	PF00069	0.502
MOD_GSK3_1	626	633	PF00069	0.621
MOD_GSK3_1	658	665	PF00069	0.617
MOD_GSK3_1	684	691	PF00069	0.291
MOD_GSK3_1	791	798	PF00069	0.277
MOD_GSK3_1	811	818	PF00069	0.162
MOD_GSK3_1	902	909	PF00069	0.300
MOD_GSK3_1	929	936	PF00069	0.416
MOD_N-GLC_1	268	273	PF02516	0.589
MOD_N-GLC_1	460	465	PF02516	0.670
MOD_N-GLC_1	55	60	PF02516	0.439
MOD_N-GLC_2	220	222	PF02516	0.249
MOD_N-GLC_2	831	833	PF02516	0.385
MOD_NEK2_1	104	109	PF00069	0.376
MOD_NEK2_1	191	196	PF00069	0.336
MOD_NEK2_1	202	207	PF00069	0.465
MOD_NEK2_1	265	270	PF00069	0.554
MOD_NEK2_1	27	32	PF00069	0.478
MOD_NEK2_1	356	361	PF00069	0.691
MOD_NEK2_1	376	381	PF00069	0.430
MOD_NEK2_1	385	390	PF00069	0.456
MOD_NEK2_1	398	403	PF00069	0.512
MOD_NEK2_1	416	421	PF00069	0.543
MOD_NEK2_1	46	51	PF00069	0.344
MOD_NEK2_1	492	497	PF00069	0.571
MOD_NEK2_1	5	10	PF00069	0.507
MOD_NEK2_1	507	512	PF00069	0.282
MOD_NEK2_1	548	553	PF00069	0.478
MOD_NEK2_1	658	663	PF00069	0.605
MOD_NEK2_1	795	800	PF00069	0.385
MOD_NEK2_1	906	911	PF00069	0.291
MOD_NEK2_1	929	934	PF00069	0.291
MOD_NEK2_1	952	957	PF00069	0.291
MOD_PIKK_1	626	632	PF00454	0.509
MOD_PKA_1	161	167	PF00069	0.435
MOD_PKA_2	10	16	PF00069	0.453
MOD_PKA_2	104	110	PF00069	0.282
MOD_PKA_2	424	430	PF00069	0.598
MOD_PKA_2	51	57	PF00069	0.494
MOD_PKA_2	548	554	PF00069	0.460
MOD_PKA_2	651	657	PF00069	0.514
MOD_PKA_2	684	690	PF00069	0.291
MOD_PKA_2	84	90	PF00069	0.431
MOD_Plk_1	268	274	PF00069	0.519
MOD_Plk_1	432	438	PF00069	0.582
MOD_Plk_1	456	462	PF00069	0.773
MOD_Plk_1	502	508	PF00069	0.322
MOD_Plk_4	191	197	PF00069	0.325
MOD_Plk_4	221	227	PF00069	0.299
MOD_Plk_4	377	383	PF00069	0.545
MOD_Plk_4	424	430	PF00069	0.598
MOD_Plk_4	502	508	PF00069	0.358
MOD_Plk_4	653	659	PF00069	0.472
MOD_Plk_4	785	791	PF00069	0.291
MOD_Plk_4	84	90	PF00069	0.278
MOD_Plk_4	865	871	PF00069	0.363
MOD_ProDKin_1	196	202	PF00069	0.386
MOD_ProDKin_1	260	266	PF00069	0.532
MOD_ProDKin_1	340	346	PF00069	0.721
MOD_ProDKin_1	55	61	PF00069	0.541
MOD_ProDKin_1	614	620	PF00069	0.426
MOD_ProDKin_1	688	694	PF00069	0.291
MOD_ProDKin_1	699	705	PF00069	0.291
MOD_ProDKin_1	746	752	PF00069	0.378
MOD_SUMO_for_1	339	342	PF00179	0.511
MOD_SUMO_for_1	915	918	PF00179	0.291
MOD_SUMO_rev_2	156	164	PF00179	0.468
TRG_DiLeu_BaLyEn_6	514	519	PF01217	0.450
TRG_ENDOCYTIC_2	25	28	PF00928	0.423
TRG_ENDOCYTIC_2	316	319	PF00928	0.465
TRG_ENDOCYTIC_2	36	39	PF00928	0.280
TRG_ENDOCYTIC_2	489	492	PF00928	0.592
TRG_ENDOCYTIC_2	504	507	PF00928	0.269
TRG_ENDOCYTIC_2	589	592	PF00928	0.493
TRG_ENDOCYTIC_2	706	709	PF00928	0.291
TRG_ER_diArg_1	111	113	PF00400	0.524
TRG_ER_diArg_1	280	282	PF00400	0.492
TRG_ER_diArg_1	400	403	PF00400	0.543
TRG_ER_diArg_1	764	766	PF00400	0.297
TRG_ER_diArg_1	79	81	PF00400	0.460
TRG_NES_CRM1_1	298	311	PF08389	0.420
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	862	867	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU57	Leptomonas seymouri	54%	96%
A0A3Q8IDQ4	Leishmania donovani	91%	99%
A0A3R7NI16	Trypanosoma rangeli	39%	100%
A4HEU1	Leishmania braziliensis	78%	100%
A4I216	Leishmania infantum	91%	99%
C9ZRZ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q6T443	Leishmania major	89%	100%