Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY63_LEIMU

TriTrypDb:

LmxM.26.0850

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.346
CLV_C14_Caspase3-7	77	81	PF00656	0.577
CLV_NRD_NRD_1	108	110	PF00675	0.358
CLV_NRD_NRD_1	195	197	PF00675	0.430
CLV_NRD_NRD_1	225	227	PF00675	0.354
CLV_NRD_NRD_1	286	288	PF00675	0.452
CLV_NRD_NRD_1	318	320	PF00675	0.390
CLV_PCSK_FUR_1	106	110	PF00082	0.354
CLV_PCSK_KEX2_1	108	110	PF00082	0.342
CLV_PCSK_KEX2_1	318	320	PF00082	0.480
CLV_PCSK_SKI1_1	265	269	PF00082	0.451
CLV_PCSK_SKI1_1	79	83	PF00082	0.527
DEG_APCC_DBOX_1	69	77	PF00400	0.558
DOC_MAPK_gen_1	196	203	PF00069	0.340
DOC_MAPK_MEF2A_6	196	205	PF00069	0.336
DOC_PP2B_LxvP_1	24	27	PF13499	0.537
DOC_PP2B_LxvP_1	252	255	PF13499	0.409
DOC_PP4_FxxP_1	208	211	PF00568	0.361
DOC_USP7_MATH_1	13	17	PF00917	0.505
DOC_USP7_MATH_1	257	261	PF00917	0.550
DOC_USP7_MATH_1	27	31	PF00917	0.519
DOC_USP7_MATH_1	289	293	PF00917	0.457
DOC_USP7_UBL2_3	79	83	PF12436	0.388
DOC_WW_Pin1_4	128	133	PF00397	0.679
DOC_WW_Pin1_4	250	255	PF00397	0.420
DOC_WW_Pin1_4	71	76	PF00397	0.411
LIG_BIR_II_1	1	5	PF00653	0.468
LIG_deltaCOP1_diTrp_1	110	115	PF00928	0.411
LIG_EH1_1	43	51	PF00400	0.363
LIG_FHA_1	165	171	PF00498	0.531
LIG_FHA_1	237	243	PF00498	0.429
LIG_FHA_1	274	280	PF00498	0.500
LIG_FHA_1	29	35	PF00498	0.364
LIG_FHA_1	308	314	PF00498	0.557
LIG_FHA_1	46	52	PF00498	0.494
LIG_FHA_2	202	208	PF00498	0.378
LIG_FHA_2	56	62	PF00498	0.360
LIG_FHA_2	63	69	PF00498	0.439
LIG_Integrin_RGD_1	98	100	PF01839	0.456
LIG_LIR_Apic_2	207	211	PF02991	0.369
LIG_LIR_Gen_1	101	112	PF02991	0.369
LIG_LIR_Nem_3	101	107	PF02991	0.359
LIG_PCNA_yPIPBox_3	36	50	PF02747	0.394
LIG_SH2_CRK	104	108	PF00017	0.336
LIG_SH2_STAT3	40	43	PF00017	0.379
LIG_SH2_STAT5	104	107	PF00017	0.340
LIG_SH2_STAT5	163	166	PF00017	0.563
LIG_SH2_STAT5	295	298	PF00017	0.497
LIG_SH2_STAT5	40	43	PF00017	0.376
LIG_SH3_3	264	270	PF00018	0.491
LIG_SUMO_SIM_par_1	47	54	PF11976	0.385
LIG_TYR_ITIM	102	107	PF00017	0.361
MOD_CK1_1	16	22	PF00069	0.544
MOD_CK1_1	253	259	PF00069	0.460
MOD_CK2_1	16	22	PF00069	0.561
MOD_CK2_1	268	274	PF00069	0.533
MOD_CK2_1	55	61	PF00069	0.351
MOD_CK2_1	62	68	PF00069	0.434
MOD_Cter_Amidation	316	319	PF01082	0.376
MOD_GlcNHglycan	151	154	PF01048	0.713
MOD_GlcNHglycan	259	262	PF01048	0.551
MOD_GlcNHglycan	291	294	PF01048	0.427
MOD_GSK3_1	246	253	PF00069	0.399
MOD_GSK3_1	257	264	PF00069	0.347
MOD_GSK3_1	291	298	PF00069	0.442
MOD_GSK3_1	9	16	PF00069	0.517
MOD_N-GLC_1	257	262	PF02516	0.628
MOD_N-GLC_1	27	32	PF02516	0.635
MOD_NEK2_2	275	280	PF00069	0.408
MOD_Plk_1	246	252	PF00069	0.407
MOD_Plk_4	16	22	PF00069	0.553
MOD_Plk_4	237	243	PF00069	0.407
MOD_Plk_4	291	297	PF00069	0.445
MOD_Plk_4	45	51	PF00069	0.416
MOD_ProDKin_1	128	134	PF00069	0.679
MOD_ProDKin_1	250	256	PF00069	0.431
MOD_ProDKin_1	71	77	PF00069	0.405
MOD_SUMO_rev_2	74	81	PF00179	0.398
TRG_DiLeu_BaEn_4	68	74	PF01217	0.477
TRG_ENDOCYTIC_2	104	107	PF00928	0.340
TRG_ER_diArg_1	106	109	PF00400	0.344
TRG_ER_diArg_1	318	320	PF00400	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0T3	Leptomonas seymouri	67%	76%
A0A0S4JP39	Bodo saltans	38%	87%
A0A1X0NTU5	Trypanosomatidae	44%	80%
A0A3R7RM36	Trypanosoma rangeli	50%	86%
A0A3S7WZT0	Leishmania donovani	95%	100%
A4HEU0	Leishmania braziliensis	87%	100%
A4I215	Leishmania infantum	95%	100%
C9ZRZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	89%
Q4Q9A9	Leishmania major	96%	100%
V5B9C8	Trypanosoma cruzi	53%	85%