Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY62_LEIMU

TriTrypDb:

LmxM.26.0840

Length:

949

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY62

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.585
CLV_C14_Caspase3-7	154	158	PF00656	0.728
CLV_C14_Caspase3-7	177	181	PF00656	0.552
CLV_C14_Caspase3-7	186	190	PF00656	0.538
CLV_C14_Caspase3-7	303	307	PF00656	0.655
CLV_NRD_NRD_1	110	112	PF00675	0.775
CLV_NRD_NRD_1	278	280	PF00675	0.766
CLV_NRD_NRD_1	593	595	PF00675	0.682
CLV_NRD_NRD_1	63	65	PF00675	0.620
CLV_NRD_NRD_1	734	736	PF00675	0.671
CLV_NRD_NRD_1	859	861	PF00675	0.611
CLV_PCSK_KEX2_1	110	112	PF00082	0.775
CLV_PCSK_KEX2_1	443	445	PF00082	0.569
CLV_PCSK_KEX2_1	593	595	PF00082	0.682
CLV_PCSK_KEX2_1	61	63	PF00082	0.661
CLV_PCSK_KEX2_1	734	736	PF00082	0.622
CLV_PCSK_KEX2_1	859	861	PF00082	0.611
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.671
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.661
CLV_PCSK_PC7_1	58	64	PF00082	0.652
CLV_PCSK_SKI1_1	312	316	PF00082	0.773
CLV_PCSK_SKI1_1	424	428	PF00082	0.499
CLV_PCSK_SKI1_1	457	461	PF00082	0.548
CLV_PCSK_SKI1_1	494	498	PF00082	0.613
CLV_PCSK_SKI1_1	53	57	PF00082	0.640
CLV_PCSK_SKI1_1	749	753	PF00082	0.554
CLV_PCSK_SKI1_1	77	81	PF00082	0.648
CLV_PCSK_SKI1_1	826	830	PF00082	0.557
CLV_PCSK_SKI1_1	831	835	PF00082	0.567
CLV_PCSK_SKI1_1	853	857	PF00082	0.699
CLV_PCSK_SKI1_1	87	91	PF00082	0.647
CLV_PCSK_SKI1_1	871	875	PF00082	0.552
DEG_APCC_DBOX_1	772	780	PF00400	0.570
DEG_SPOP_SBC_1	12	16	PF00917	0.711
DEG_SPOP_SBC_1	184	188	PF00917	0.554
DEG_SPOP_SBC_1	258	262	PF00917	0.825
DEG_SPOP_SBC_1	536	540	PF00917	0.613
DOC_ANK_TNKS_1	800	807	PF00023	0.634
DOC_CKS1_1	210	215	PF01111	0.632
DOC_CKS1_1	489	494	PF01111	0.612
DOC_CKS1_1	705	710	PF01111	0.754
DOC_CYCLIN_RxL_1	50	60	PF00134	0.649
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.833
DOC_MAPK_DCC_7	654	664	PF00069	0.720
DOC_MAPK_gen_1	277	284	PF00069	0.692
DOC_MAPK_gen_1	454	462	PF00069	0.583
DOC_MAPK_gen_1	61	69	PF00069	0.617
DOC_MAPK_gen_1	97	106	PF00069	0.616
DOC_MAPK_HePTP_8	94	106	PF00069	0.610
DOC_MAPK_MEF2A_6	466	474	PF00069	0.637
DOC_MAPK_MEF2A_6	97	106	PF00069	0.616
DOC_PP1_RVXF_1	51	58	PF00149	0.648
DOC_PP1_RVXF_1	541	547	PF00149	0.583
DOC_PP1_RVXF_1	888	894	PF00149	0.597
DOC_PP2B_LxvP_1	335	338	PF13499	0.598
DOC_PP4_FxxP_1	705	708	PF00568	0.541
DOC_USP7_MATH_1	155	159	PF00917	0.727
DOC_USP7_MATH_1	229	233	PF00917	0.766
DOC_USP7_MATH_1	258	262	PF00917	0.825
DOC_USP7_MATH_1	336	340	PF00917	0.751
DOC_USP7_MATH_1	372	376	PF00917	0.775
DOC_USP7_MATH_1	520	524	PF00917	0.631
DOC_USP7_MATH_1	536	540	PF00917	0.613
DOC_USP7_MATH_1	603	607	PF00917	0.831
DOC_USP7_MATH_1	701	705	PF00917	0.793
DOC_USP7_MATH_1	907	911	PF00917	0.627
DOC_USP7_MATH_2	133	139	PF00917	0.566
DOC_USP7_UBL2_3	702	706	PF12436	0.760
DOC_USP7_UBL2_3	886	890	PF12436	0.695
DOC_USP7_UBL2_3	93	97	PF12436	0.608
DOC_WW_Pin1_4	15	20	PF00397	0.703
DOC_WW_Pin1_4	209	214	PF00397	0.630
DOC_WW_Pin1_4	221	226	PF00397	0.697
DOC_WW_Pin1_4	318	323	PF00397	0.776
DOC_WW_Pin1_4	330	335	PF00397	0.637
DOC_WW_Pin1_4	434	439	PF00397	0.616
DOC_WW_Pin1_4	488	493	PF00397	0.609
DOC_WW_Pin1_4	617	622	PF00397	0.772
DOC_WW_Pin1_4	704	709	PF00397	0.751
DOC_WW_Pin1_4	874	879	PF00397	0.610
LIG_14-3-3_CanoR_1	277	283	PF00244	0.476
LIG_14-3-3_CanoR_1	444	449	PF00244	0.551
LIG_14-3-3_CanoR_1	457	463	PF00244	0.606
LIG_14-3-3_CanoR_1	504	513	PF00244	0.565
LIG_14-3-3_CanoR_1	718	723	PF00244	0.708
LIG_14-3-3_CanoR_1	77	82	PF00244	0.649
LIG_14-3-3_CanoR_1	906	912	PF00244	0.624
LIG_BRCT_BRCA1_1	531	535	PF00533	0.647
LIG_CaM_IQ_9	69	84	PF13499	0.736
LIG_Clathr_ClatBox_1	459	463	PF01394	0.595
LIG_Clathr_ClatBox_1	570	574	PF01394	0.560
LIG_EH1_1	250	258	PF00400	0.803
LIG_FHA_1	198	204	PF00498	0.552
LIG_FHA_1	21	27	PF00498	0.745
LIG_FHA_1	539	545	PF00498	0.580
LIG_FHA_1	74	80	PF00498	0.640
LIG_FHA_1	797	803	PF00498	0.630
LIG_FHA_1	805	811	PF00498	0.619
LIG_FHA_1	812	818	PF00498	0.563
LIG_FHA_1	886	892	PF00498	0.591
LIG_FHA_1	917	923	PF00498	0.696
LIG_FHA_2	137	143	PF00498	0.765
LIG_FHA_2	161	167	PF00498	0.637
LIG_FHA_2	184	190	PF00498	0.556
LIG_FHA_2	233	239	PF00498	0.800
LIG_FHA_2	360	366	PF00498	0.716
LIG_FHA_2	372	378	PF00498	0.671
LIG_FHA_2	495	501	PF00498	0.597
LIG_FHA_2	683	689	PF00498	0.784
LIG_FHA_2	705	711	PF00498	0.755
LIG_FHA_2	875	881	PF00498	0.693
LIG_FHA_2	929	935	PF00498	0.608
LIG_GBD_Chelix_1	747	755	PF00786	0.578
LIG_HCF-1_HBM_1	759	762	PF13415	0.585
LIG_Integrin_RGD_1	191	193	PF01839	0.553
LIG_LIR_Apic_2	207	213	PF02991	0.659
LIG_LIR_Apic_2	488	492	PF02991	0.618
LIG_LIR_Apic_2	703	708	PF02991	0.756
LIG_LIR_Gen_1	579	587	PF02991	0.644
LIG_LIR_Gen_1	768	779	PF02991	0.577
LIG_LIR_Nem_3	39	44	PF02991	0.685
LIG_LIR_Nem_3	455	459	PF02991	0.570
LIG_LIR_Nem_3	497	501	PF02991	0.585
LIG_LIR_Nem_3	566	571	PF02991	0.619
LIG_LIR_Nem_3	579	585	PF02991	0.551
LIG_LIR_Nem_3	727	733	PF02991	0.675
LIG_LIR_Nem_3	834	838	PF02991	0.576
LIG_PCNA_yPIPBox_3	90	102	PF02747	0.610
LIG_PDZ_Class_3	944	949	PF00595	0.805
LIG_Pex14_2	452	456	PF04695	0.555
LIG_Pex14_2	726	730	PF04695	0.663
LIG_Pex14_2	818	822	PF04695	0.569
LIG_PTAP_UEV_1	365	370	PF05743	0.549
LIG_REV1ctd_RIR_1	891	901	PF16727	0.608
LIG_SH2_CRK	210	214	PF00017	0.699
LIG_SH2_CRK	223	227	PF00017	0.760
LIG_SH2_CRK	480	484	PF00017	0.559
LIG_SH2_CRK	489	493	PF00017	0.612
LIG_SH2_CRK	65	69	PF00017	0.596
LIG_SH2_CRK	835	839	PF00017	0.582
LIG_SH2_NCK_1	210	214	PF00017	0.658
LIG_SH2_NCK_1	223	227	PF00017	0.643
LIG_SH2_SRC	762	765	PF00017	0.729
LIG_SH2_STAP1	430	434	PF00017	0.688
LIG_SH2_STAT5	223	226	PF00017	0.752
LIG_SH2_STAT5	407	410	PF00017	0.721
LIG_SH2_STAT5	451	454	PF00017	0.552
LIG_SH2_STAT5	480	483	PF00017	0.552
LIG_SH2_STAT5	513	516	PF00017	0.591
LIG_SH2_STAT5	65	68	PF00017	0.590
LIG_SH2_STAT5	762	765	PF00017	0.627
LIG_SH3_3	295	301	PF00018	0.707
LIG_SH3_3	363	369	PF00018	0.844
LIG_SH3_3	615	621	PF00018	0.643
LIG_SH3_3	641	647	PF00018	0.701
LIG_SH3_3	665	671	PF00018	0.698
LIG_SH3_3	719	725	PF00018	0.696
LIG_SH3_3	740	746	PF00018	0.631
LIG_SH3_3	881	887	PF00018	0.565
LIG_SH3_4	886	893	PF00018	0.697
LIG_SUMO_SIM_par_1	333	340	PF11976	0.754
LIG_SUMO_SIM_par_1	458	464	PF11976	0.625
LIG_SUMO_SIM_par_1	569	574	PF11976	0.564
LIG_TRAF2_1	272	275	PF00917	0.596
LIG_TRAF2_1	697	700	PF00917	0.828
LIG_TRAF2_1	910	913	PF00917	0.621
LIG_WW_2	644	647	PF00397	0.513
MOD_CDK_SPxK_1	488	494	PF00069	0.611
MOD_CK1_1	138	144	PF00069	0.565
MOD_CK1_1	18	24	PF00069	0.664
MOD_CK1_1	232	238	PF00069	0.808
MOD_CK1_1	260	266	PF00069	0.831
MOD_CK1_1	488	494	PF00069	0.611
MOD_CK1_1	538	544	PF00069	0.587
MOD_CK1_1	583	589	PF00069	0.650
MOD_CK1_1	690	696	PF00069	0.746
MOD_CK1_1	704	710	PF00069	0.745
MOD_CK1_1	889	895	PF00069	0.600
MOD_CK1_1	896	902	PF00069	0.613
MOD_CK2_1	138	144	PF00069	0.755
MOD_CK2_1	232	238	PF00069	0.808
MOD_CK2_1	260	266	PF00069	0.823
MOD_CK2_1	371	377	PF00069	0.764
MOD_CK2_1	494	500	PF00069	0.607
MOD_CK2_1	583	589	PF00069	0.625
MOD_CK2_1	682	688	PF00069	0.667
MOD_CK2_1	753	759	PF00069	0.571
MOD_CK2_1	874	880	PF00069	0.602
MOD_CK2_1	906	912	PF00069	0.628
MOD_CK2_1	928	934	PF00069	0.708
MOD_GlcNHglycan	153	156	PF01048	0.702
MOD_GlcNHglycan	374	377	PF01048	0.757
MOD_GlcNHglycan	529	532	PF01048	0.658
MOD_GlcNHglycan	604	608	PF01048	0.726
MOD_GlcNHglycan	621	624	PF01048	0.571
MOD_GlcNHglycan	634	637	PF01048	0.680
MOD_GlcNHglycan	675	678	PF01048	0.700
MOD_GlcNHglycan	687	692	PF01048	0.720
MOD_GlcNHglycan	938	941	PF01048	0.674
MOD_GSK3_1	11	18	PF00069	0.695
MOD_GSK3_1	151	158	PF00069	0.829
MOD_GSK3_1	257	264	PF00069	0.745
MOD_GSK3_1	341	348	PF00069	0.847
MOD_GSK3_1	430	437	PF00069	0.659
MOD_GSK3_1	576	583	PF00069	0.629
MOD_GSK3_1	634	641	PF00069	0.735
MOD_GSK3_1	700	707	PF00069	0.770
MOD_GSK3_1	73	80	PF00069	0.645
MOD_GSK3_1	885	892	PF00069	0.585
MOD_GSK3_1	893	900	PF00069	0.614
MOD_GSK3_1	916	923	PF00069	0.698
MOD_N-GLC_1	102	107	PF02516	0.631
MOD_N-GLC_1	242	247	PF02516	0.775
MOD_N-GLC_1	45	50	PF02516	0.671
MOD_N-GLC_1	468	473	PF02516	0.643
MOD_N-GLC_1	580	585	PF02516	0.614
MOD_N-GLC_1	673	678	PF02516	0.748
MOD_N-GLC_1	718	723	PF02516	0.708
MOD_N-GLC_1	73	78	PF02516	0.752
MOD_N-GLC_1	812	817	PF02516	0.560
MOD_N-GLC_1	907	912	PF02516	0.579
MOD_N-GLC_2	778	780	PF02516	0.552
MOD_NEK2_1	20	25	PF00069	0.725
MOD_NEK2_1	230	235	PF00069	0.824
MOD_NEK2_1	259	264	PF00069	0.751
MOD_NEK2_1	429	434	PF00069	0.792
MOD_NEK2_1	580	585	PF00069	0.614
MOD_NEK2_1	587	592	PF00069	0.641
MOD_NEK2_1	774	779	PF00069	0.559
MOD_NEK2_1	851	856	PF00069	0.686
MOD_NEK2_1	893	898	PF00069	0.606
MOD_NEK2_2	701	706	PF00069	0.543
MOD_PIKK_1	230	236	PF00454	0.823
MOD_PKA_1	110	116	PF00069	0.770
MOD_PKA_2	110	116	PF00069	0.770
MOD_PKA_2	278	284	PF00069	0.686
MOD_PKA_2	344	350	PF00069	0.681
MOD_PKA_2	550	556	PF00069	0.617
MOD_PKA_2	896	902	PF00069	0.613
MOD_PKA_2	936	942	PF00069	0.672
MOD_PKB_1	895	903	PF00069	0.616
MOD_Plk_1	102	108	PF00069	0.640
MOD_Plk_1	430	436	PF00069	0.670
MOD_Plk_1	468	474	PF00069	0.633
MOD_Plk_1	580	586	PF00069	0.619
MOD_Plk_1	587	593	PF00069	0.646
MOD_Plk_1	673	679	PF00069	0.804
MOD_Plk_1	718	724	PF00069	0.706
MOD_Plk_1	753	759	PF00069	0.571
MOD_Plk_1	812	818	PF00069	0.563
MOD_Plk_1	907	913	PF00069	0.627
MOD_Plk_2-3	302	308	PF00069	0.847
MOD_Plk_2-3	753	759	PF00069	0.571
MOD_Plk_4	424	430	PF00069	0.717
MOD_Plk_4	587	593	PF00069	0.644
MOD_Plk_4	790	796	PF00069	0.616
MOD_Plk_4	813	819	PF00069	0.559
MOD_Plk_4	889	895	PF00069	0.553
MOD_Plk_4	920	926	PF00069	0.597
MOD_ProDKin_1	15	21	PF00069	0.695
MOD_ProDKin_1	209	215	PF00069	0.631
MOD_ProDKin_1	221	227	PF00069	0.697
MOD_ProDKin_1	318	324	PF00069	0.776
MOD_ProDKin_1	330	336	PF00069	0.635
MOD_ProDKin_1	434	440	PF00069	0.608
MOD_ProDKin_1	488	494	PF00069	0.611
MOD_ProDKin_1	617	623	PF00069	0.773
MOD_ProDKin_1	704	710	PF00069	0.749
MOD_ProDKin_1	874	880	PF00069	0.602
MOD_SUMO_for_1	802	805	PF00179	0.637
MOD_SUMO_rev_2	304	314	PF00179	0.765
MOD_SUMO_rev_2	699	704	PF00179	0.832
TRG_DiLeu_BaEn_1	455	460	PF01217	0.571
TRG_DiLeu_BaEn_1	759	764	PF01217	0.706
TRG_DiLeu_BaEn_1	805	810	PF01217	0.628
TRG_DiLeu_BaEn_2	919	925	PF01217	0.594
TRG_DiLeu_BaLyEn_6	566	571	PF01217	0.553
TRG_ENDOCYTIC_2	480	483	PF00928	0.552
TRG_ENDOCYTIC_2	65	68	PF00928	0.590
TRG_ENDOCYTIC_2	771	774	PF00928	0.583
TRG_ENDOCYTIC_2	835	838	PF00928	0.578
TRG_ER_diArg_1	109	111	PF00400	0.790
TRG_ER_diArg_1	592	594	PF00400	0.669
TRG_ER_diArg_1	62	64	PF00400	0.633
TRG_ER_diArg_1	733	735	PF00400	0.686
TRG_ER_diArg_1	894	897	PF00400	0.609
TRG_Pf-PMV_PEXEL_1	569	574	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	826	830	PF00026	0.659

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I256	Leptomonas seymouri	64%	96%
A0A3S7WZV1	Leishmania donovani	91%	100%
A4HET9	Leishmania braziliensis	82%	99%
A4I214	Leishmania infantum	91%	100%
Q4Q9B0	Leishmania major	91%	100%