RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9AY57_LEIMU

TriTrypDb:

LmxM.26.0780

Length:

154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY57

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.518
CLV_NRD_NRD_1	18	20	PF00675	0.498
CLV_PCSK_FUR_1	16	20	PF00082	0.493
CLV_PCSK_KEX2_1	15	17	PF00082	0.518
CLV_PCSK_KEX2_1	150	152	PF00082	0.585
CLV_PCSK_KEX2_1	18	20	PF00082	0.498
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.585
DEG_Nend_UBRbox_2	1	3	PF02207	0.613
DEG_SPOP_SBC_1	53	57	PF00917	0.450
DOC_USP7_MATH_1	38	42	PF00917	0.369
LIG_14-3-3_CanoR_1	18	27	PF00244	0.594
LIG_Clathr_ClatBox_1	97	101	PF01394	0.436
LIG_deltaCOP1_diTrp_1	43	49	PF00928	0.325
LIG_FHA_1	2	8	PF00498	0.434
LIG_FHA_2	20	26	PF00498	0.581
LIG_FHA_2	54	60	PF00498	0.427
LIG_LIR_Gen_1	22	30	PF02991	0.524
LIG_LIR_Gen_1	43	53	PF02991	0.267
LIG_LIR_LC3C_4	122	127	PF02991	0.407
LIG_LIR_Nem_3	22	27	PF02991	0.535
LIG_LIR_Nem_3	43	48	PF02991	0.328
LIG_LIR_Nem_3	74	79	PF02991	0.474
LIG_PCNA_PIPBox_1	58	67	PF02747	0.494
LIG_PCNA_yPIPBox_3	58	69	PF02747	0.494
LIG_Pex14_1	45	49	PF04695	0.361
LIG_SH2_NCK_1	95	99	PF00017	0.428
LIG_SH2_STAP1	106	110	PF00017	0.492
LIG_SH2_STAT5	64	67	PF00017	0.492
LIG_SH2_STAT5	75	78	PF00017	0.329
LIG_SH3_3	123	129	PF00018	0.489
LIG_SUMO_SIM_par_1	96	102	PF11976	0.412
LIG_TRAF2_1	56	59	PF00917	0.494
LIG_WRC_WIRS_1	65	70	PF05994	0.494
MOD_CK2_1	19	25	PF00069	0.527
MOD_CK2_1	53	59	PF00069	0.492
MOD_CK2_1	64	70	PF00069	0.498
MOD_GlcNHglycan	119	122	PF01048	0.508
MOD_GSK3_1	113	120	PF00069	0.472
MOD_N-GLC_1	113	118	PF02516	0.196
MOD_NEK2_1	1	6	PF00069	0.581
MOD_NEK2_1	113	118	PF00069	0.497
MOD_NEK2_1	47	52	PF00069	0.433
MOD_NEK2_2	64	69	PF00069	0.492
MOD_PIKK_1	19	25	PF00454	0.608
MOD_PIKK_1	54	60	PF00454	0.497
MOD_PKA_2	17	23	PF00069	0.501
MOD_Plk_4	113	119	PF00069	0.451
MOD_Plk_4	127	133	PF00069	0.385
TRG_ENDOCYTIC_2	24	27	PF00928	0.573
TRG_ENDOCYTIC_2	95	98	PF00928	0.428
TRG_ER_diArg_1	14	16	PF00400	0.521
TRG_ER_diArg_1	17	19	PF00400	0.492
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVV4	Leptomonas seymouri	75%	100%
A0A0S4J314	Bodo saltans	32%	100%
A0A3R7NI30	Trypanosoma rangeli	45%	95%
A0A3S7WZQ8	Leishmania donovani	96%	100%
A4HET3	Leishmania braziliensis	89%	100%
A4I209	Leishmania infantum	96%	100%
C9ZS03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	97%
Q21832	Caenorhabditis elegans	33%	100%
Q4Q9B6	Leishmania major	95%	100%