Centrosome-associated protein 350

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AY56_LEIMU

TriTrypDb:

LmxM.26.0770

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	360	364	PF00656	0.556
CLV_C14_Caspase3-7	482	486	PF00656	0.387
CLV_NRD_NRD_1	250	252	PF00675	0.628
CLV_NRD_NRD_1	283	285	PF00675	0.663
CLV_NRD_NRD_1	326	328	PF00675	0.569
CLV_NRD_NRD_1	331	333	PF00675	0.559
CLV_NRD_NRD_1	54	56	PF00675	0.611
CLV_PCSK_KEX2_1	250	252	PF00082	0.628
CLV_PCSK_KEX2_1	283	285	PF00082	0.592
CLV_PCSK_KEX2_1	325	327	PF00082	0.564
CLV_PCSK_KEX2_1	331	333	PF00082	0.553
CLV_PCSK_KEX2_1	396	398	PF00082	0.469
CLV_PCSK_KEX2_1	478	480	PF00082	0.534
CLV_PCSK_KEX2_1	489	491	PF00082	0.429
CLV_PCSK_KEX2_1	54	56	PF00082	0.601
CLV_PCSK_KEX2_1	7	9	PF00082	0.570
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.596
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.524
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.534
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.429
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.570
CLV_PCSK_PC7_1	327	333	PF00082	0.505
CLV_PCSK_SKI1_1	369	373	PF00082	0.566
CLV_PCSK_SKI1_1	432	436	PF00082	0.677
CLV_PCSK_SKI1_1	451	455	PF00082	0.435
CLV_PCSK_SKI1_1	484	488	PF00082	0.382
CLV_PCSK_SKI1_1	506	510	PF00082	0.490
CLV_PCSK_SKI1_1	95	99	PF00082	0.650
CLV_Separin_Metazoa	51	55	PF03568	0.592
DEG_Nend_UBRbox_2	1	3	PF02207	0.609
DEG_SCF_FBW7_1	25	31	PF00400	0.480
DOC_CKS1_1	25	30	PF01111	0.543
DOC_CKS1_1	33	38	PF01111	0.588
DOC_MAPK_gen_1	456	465	PF00069	0.479
DOC_MAPK_MEF2A_6	459	467	PF00069	0.563
DOC_PP4_FxxP_1	354	357	PF00568	0.641
DOC_USP7_MATH_1	161	165	PF00917	0.776
DOC_USP7_MATH_1	357	361	PF00917	0.628
DOC_USP7_MATH_1	408	412	PF00917	0.573
DOC_USP7_MATH_1	438	442	PF00917	0.677
DOC_USP7_MATH_1	488	492	PF00917	0.580
DOC_USP7_MATH_1	504	508	PF00917	0.407
DOC_USP7_MATH_2	219	225	PF00917	0.633
DOC_WW_Pin1_4	114	119	PF00397	0.574
DOC_WW_Pin1_4	174	179	PF00397	0.673
DOC_WW_Pin1_4	185	190	PF00397	0.615
DOC_WW_Pin1_4	24	29	PF00397	0.580
DOC_WW_Pin1_4	32	37	PF00397	0.547
LIG_14-3-3_CanoR_1	121	129	PF00244	0.652
LIG_14-3-3_CanoR_1	155	163	PF00244	0.572
LIG_14-3-3_CanoR_1	298	303	PF00244	0.643
LIG_14-3-3_CanoR_1	351	355	PF00244	0.627
LIG_14-3-3_CanoR_1	459	464	PF00244	0.522
LIG_14-3-3_CanoR_1	54	60	PF00244	0.606
LIG_14-3-3_CanoR_1	95	104	PF00244	0.477
LIG_APCC_ABBA_1	373	378	PF00400	0.441
LIG_BRCT_BRCA1_1	2	6	PF00533	0.494
LIG_BRCT_BRCA1_1	504	508	PF00533	0.486
LIG_FHA_1	186	192	PF00498	0.614
LIG_FHA_1	460	466	PF00498	0.451
LIG_FHA_1	491	497	PF00498	0.485
LIG_FHA_1	68	74	PF00498	0.466
LIG_FHA_2	290	296	PF00498	0.670
LIG_FHA_2	507	513	PF00498	0.482
LIG_Integrin_RGD_1	172	174	PF01839	0.549
LIG_Integrin_RGD_1	306	308	PF01839	0.539
LIG_LIR_Apic_2	352	357	PF02991	0.633
LIG_LIR_Apic_2	498	504	PF02991	0.503
LIG_LIR_Gen_1	259	268	PF02991	0.556
LIG_LIR_Gen_1	312	321	PF02991	0.560
LIG_LIR_Gen_1	370	379	PF02991	0.447
LIG_LIR_Gen_1	452	460	PF02991	0.479
LIG_LIR_Gen_1	507	518	PF02991	0.484
LIG_LIR_Nem_3	105	109	PF02991	0.611
LIG_LIR_Nem_3	3	9	PF02991	0.495
LIG_LIR_Nem_3	370	375	PF02991	0.455
LIG_LIR_Nem_3	452	457	PF02991	0.482
LIG_LIR_Nem_3	507	513	PF02991	0.480
LIG_LIR_Nem_3	78	83	PF02991	0.550
LIG_Rb_pABgroove_1	35	43	PF01858	0.548
LIG_RPA_C_Fungi	322	334	PF08784	0.541
LIG_SH2_CRK	11	15	PF00017	0.511
LIG_SH2_GRB2like	421	424	PF00017	0.507
LIG_SH2_NCK_1	11	15	PF00017	0.511
LIG_SH2_NCK_1	376	380	PF00017	0.431
LIG_SH2_NCK_1	41	45	PF00017	0.563
LIG_SH2_SRC	376	379	PF00017	0.433
LIG_SH2_STAP1	421	425	PF00017	0.509
LIG_SH2_STAP1	499	503	PF00017	0.470
LIG_SH2_STAT3	225	228	PF00017	0.652
LIG_SH2_STAT3	83	86	PF00017	0.525
LIG_SH2_STAT5	20	23	PF00017	0.502
LIG_SH2_STAT5	83	86	PF00017	0.663
LIG_SH3_3	22	28	PF00018	0.529
LIG_SH3_3	30	36	PF00018	0.588
LIG_SH3_3	402	408	PF00018	0.468
LIG_SH3_4	126	133	PF00018	0.565
LIG_TRAF2_1	108	111	PF00917	0.523
LIG_TRAF2_1	387	390	PF00917	0.459
LIG_TRAF2_1	474	477	PF00917	0.529
LIG_UBA3_1	392	396	PF00899	0.521
LIG_WRC_WIRS_1	103	108	PF05994	0.496
MOD_CDK_SPxxK_3	114	121	PF00069	0.578
MOD_CDK_SPxxK_3	174	181	PF00069	0.559
MOD_CDK_SPxxK_3	185	192	PF00069	0.601
MOD_CK1_1	128	134	PF00069	0.556
MOD_CK1_1	177	183	PF00069	0.685
MOD_CK1_1	185	191	PF00069	0.601
MOD_CK1_1	201	207	PF00069	0.631
MOD_CK1_1	31	37	PF00069	0.492
MOD_CK1_1	347	353	PF00069	0.637
MOD_CK2_1	201	207	PF00069	0.639
MOD_CK2_1	289	295	PF00069	0.669
MOD_CK2_1	425	431	PF00069	0.712
MOD_CK2_1	488	494	PF00069	0.485
MOD_CK2_1	508	514	PF00069	0.369
MOD_CK2_1	72	78	PF00069	0.534
MOD_DYRK1A_RPxSP_1	24	28	PF00069	0.543
MOD_GlcNHglycan	182	185	PF01048	0.771
MOD_GlcNHglycan	200	203	PF01048	0.549
MOD_GlcNHglycan	247	250	PF01048	0.563
MOD_GlcNHglycan	327	330	PF01048	0.635
MOD_GlcNHglycan	359	362	PF01048	0.700
MOD_GlcNHglycan	447	450	PF01048	0.536
MOD_GSK3_1	197	204	PF00069	0.680
MOD_GSK3_1	20	27	PF00069	0.530
MOD_GSK3_1	28	35	PF00069	0.576
MOD_GSK3_1	289	296	PF00069	0.702
MOD_GSK3_1	298	305	PF00069	0.756
MOD_GSK3_1	357	364	PF00069	0.667
MOD_GSK3_1	415	422	PF00069	0.513
MOD_GSK3_1	455	462	PF00069	0.516
MOD_GSK3_1	490	497	PF00069	0.527
MOD_GSK3_1	502	509	PF00069	0.442
MOD_N-GLC_1	245	250	PF02516	0.526
MOD_N-GLC_1	269	274	PF02516	0.582
MOD_N-GLC_1	277	282	PF02516	0.588
MOD_N-GLC_1	344	349	PF02516	0.527
MOD_N-GLC_1	409	414	PF02516	0.607
MOD_NEK2_1	1	6	PF00069	0.606
MOD_NEK2_1	198	203	PF00069	0.590
MOD_NEK2_1	245	250	PF00069	0.526
MOD_NEK2_1	288	293	PF00069	0.786
MOD_NEK2_1	302	307	PF00069	0.572
MOD_NEK2_1	445	450	PF00069	0.441
MOD_NEK2_1	67	72	PF00069	0.504
MOD_NEK2_2	102	107	PF00069	0.495
MOD_PIKK_1	109	115	PF00454	0.679
MOD_PIKK_1	289	295	PF00454	0.528
MOD_PIKK_1	415	421	PF00454	0.622
MOD_PIKK_1	512	518	PF00454	0.467
MOD_PIKK_1	53	59	PF00454	0.618
MOD_PKA_1	325	331	PF00069	0.553
MOD_PKA_2	120	126	PF00069	0.639
MOD_PKA_2	154	160	PF00069	0.594
MOD_PKA_2	289	295	PF00069	0.679
MOD_PKA_2	302	308	PF00069	0.565
MOD_PKA_2	325	331	PF00069	0.543
MOD_PKA_2	350	356	PF00069	0.619
MOD_PKA_2	438	444	PF00069	0.579
MOD_PKA_2	455	461	PF00069	0.522
MOD_PKA_2	53	59	PF00069	0.602
MOD_PKA_2	67	73	PF00069	0.491
MOD_Plk_1	1	7	PF00069	0.571
MOD_Plk_1	269	275	PF00069	0.581
MOD_Plk_1	277	283	PF00069	0.592
MOD_Plk_1	430	436	PF00069	0.612
MOD_Plk_4	221	227	PF00069	0.713
MOD_Plk_4	350	356	PF00069	0.597
MOD_ProDKin_1	114	120	PF00069	0.576
MOD_ProDKin_1	174	180	PF00069	0.675
MOD_ProDKin_1	185	191	PF00069	0.617
MOD_ProDKin_1	24	30	PF00069	0.582
MOD_ProDKin_1	32	38	PF00069	0.545
MOD_SUMO_for_1	465	468	PF00179	0.554
MOD_SUMO_for_1	63	66	PF00179	0.595
MOD_SUMO_rev_2	363	371	PF00179	0.656
MOD_SUMO_rev_2	424	434	PF00179	0.595
MOD_SUMO_rev_2	480	488	PF00179	0.516
TRG_DiLeu_BaEn_1	388	393	PF01217	0.467
TRG_DiLeu_LyEn_5	388	393	PF01217	0.467
TRG_ENDOCYTIC_2	261	264	PF00928	0.556
TRG_ENDOCYTIC_2	314	317	PF00928	0.606
TRG_ER_diArg_1	250	252	PF00400	0.628
TRG_ER_diArg_1	282	284	PF00400	0.763
TRG_ER_diArg_1	53	55	PF00400	0.598
TRG_NLS_MonoExtN_4	283	288	PF00514	0.628
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	95	100	PF00026	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2U8	Leptomonas seymouri	34%	91%
A0A3Q8IP13	Leishmania donovani	80%	96%
A4HET2	Leishmania braziliensis	49%	100%
A4I208	Leishmania infantum	80%	96%
Q4Q9B7	Leishmania major	78%	100%