RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania mexicana

UniProt:

E9AY55_LEIMU

TriTrypDb:

LmxM.26.0760

Length:

158

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0005686	U2 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071011	precatalytic spliceosome	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AY55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY55

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	29	31	PF00675	0.450
CLV_NRD_NRD_1	71	73	PF00675	0.282
CLV_PCSK_KEX2_1	29	31	PF00082	0.437
CLV_PCSK_SKI1_1	124	128	PF00082	0.533
CLV_PCSK_SKI1_1	29	33	PF00082	0.546
DEG_Kelch_Keap1_1	117	122	PF01344	0.590
DEG_Nend_UBRbox_1	1	4	PF02207	0.711
DOC_CKS1_1	11	16	PF01111	0.497
DOC_CYCLIN_RxL_1	26	33	PF00134	0.500
DOC_PP2B_PxIxI_1	23	29	PF00149	0.377
DOC_WW_Pin1_4	10	15	PF00397	0.530
DOC_WW_Pin1_4	42	47	PF00397	0.645
LIG_14-3-3_CanoR_1	29	35	PF00244	0.587
LIG_14-3-3_CterR_2	153	158	PF00244	0.539
LIG_Actin_WH2_2	24	39	PF00022	0.306
LIG_FHA_1	43	49	PF00498	0.413
LIG_FHA_1	78	84	PF00498	0.475
LIG_LIR_Gen_1	13	24	PF02991	0.402
LIG_LIR_Gen_1	55	64	PF02991	0.468
LIG_LIR_Gen_1	80	88	PF02991	0.465
LIG_LIR_Nem_3	13	19	PF02991	0.431
LIG_LIR_Nem_3	22	28	PF02991	0.353
LIG_LIR_Nem_3	55	60	PF02991	0.468
LIG_LIR_Nem_3	80	85	PF02991	0.454
LIG_PDZ_Class_2	153	158	PF00595	0.507
LIG_SH2_CRK	16	20	PF00017	0.417
LIG_SH2_STAP1	147	151	PF00017	0.437
LIG_SH2_STAT5	12	15	PF00017	0.469
LIG_SH3_3	131	137	PF00018	0.478
LIG_SH3_3	8	14	PF00018	0.530
LIG_SUMO_SIM_par_1	52	58	PF11976	0.534
MOD_CK1_1	117	123	PF00069	0.585
MOD_CK2_1	116	122	PF00069	0.651
MOD_GlcNHglycan	119	122	PF01048	0.589
MOD_GlcNHglycan	21	24	PF01048	0.303
MOD_GlcNHglycan	8	11	PF01048	0.517
MOD_GlcNHglycan	89	92	PF01048	0.259
MOD_GSK3_1	110	117	PF00069	0.574
MOD_GSK3_1	42	49	PF00069	0.559
MOD_GSK3_1	6	13	PF00069	0.518
MOD_NEK2_1	19	24	PF00069	0.456
MOD_NEK2_1	77	82	PF00069	0.465
MOD_PIKK_1	110	116	PF00454	0.621
MOD_PIKK_1	30	36	PF00454	0.512
MOD_PIKK_1	55	61	PF00454	0.454
MOD_PKA_2	71	77	PF00069	0.466
MOD_Plk_4	52	58	PF00069	0.454
MOD_ProDKin_1	10	16	PF00069	0.524
MOD_ProDKin_1	42	48	PF00069	0.550
MOD_SUMO_rev_2	117	126	PF00179	0.608
TRG_DiLeu_BaEn_1	15	20	PF01217	0.440
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.510
TRG_ENDOCYTIC_2	16	19	PF00928	0.416
TRG_ER_diArg_1	28	30	PF00400	0.437
TRG_ER_diArg_1	69	72	PF00400	0.479
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP8	Leptomonas seymouri	72%	99%
A0A0S4J184	Bodo saltans	38%	99%
A0A1X0NSD2	Trypanosomatidae	55%	98%
A0A3R7KI07	Trypanosoma rangeli	51%	100%
A0A3S7WZQ4	Leishmania donovani	94%	100%
A4HET1	Leishmania braziliensis	85%	100%
A4I207	Leishmania infantum	94%	100%
C9ZS05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	93%
Q4Q9B8	Leishmania major	94%	100%
V5BUP6	Trypanosoma cruzi	51%	100%