Regulator of chromosome condensation (RCC1) family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulator of chromosome condensation (RCC1) repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AY53_LEIMU

TriTrypDb:

LmxM.26.0740

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AY53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.429
CLV_NRD_NRD_1	357	359	PF00675	0.385
CLV_NRD_NRD_1	469	471	PF00675	0.430
CLV_NRD_NRD_1	835	837	PF00675	0.426
CLV_PCSK_KEX2_1	306	308	PF00082	0.280
CLV_PCSK_KEX2_1	469	471	PF00082	0.428
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.271
CLV_PCSK_SKI1_1	254	258	PF00082	0.459
CLV_PCSK_SKI1_1	492	496	PF00082	0.330
CLV_PCSK_SKI1_1	562	566	PF00082	0.351
CLV_PCSK_SKI1_1	726	730	PF00082	0.426
CLV_PCSK_SKI1_1	795	799	PF00082	0.452
CLV_PCSK_SKI1_1	83	87	PF00082	0.432
DEG_APCC_DBOX_1	82	90	PF00400	0.494
DEG_Nend_UBRbox_3	1	3	PF02207	0.558
DEG_SCF_FBW7_2	728	735	PF00400	0.376
DOC_CKS1_1	5	10	PF01111	0.332
DOC_CKS1_1	55	60	PF01111	0.466
DOC_CKS1_1	678	683	PF01111	0.367
DOC_CKS1_1	727	732	PF01111	0.509
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.472
DOC_MAPK_DCC_7	625	634	PF00069	0.465
DOC_MAPK_gen_1	304	311	PF00069	0.434
DOC_MAPK_MEF2A_6	239	248	PF00069	0.498
DOC_MAPK_MEF2A_6	427	436	PF00069	0.355
DOC_PP1_RVXF_1	505	511	PF00149	0.343
DOC_PP1_RVXF_1	560	567	PF00149	0.330
DOC_PP2B_LxvP_1	423	426	PF13499	0.367
DOC_PP2B_LxvP_1	434	437	PF13499	0.368
DOC_USP7_MATH_1	137	141	PF00917	0.453
DOC_USP7_MATH_1	144	148	PF00917	0.396
DOC_USP7_MATH_1	181	185	PF00917	0.459
DOC_USP7_MATH_1	267	271	PF00917	0.365
DOC_USP7_MATH_1	312	316	PF00917	0.359
DOC_WW_Pin1_4	16	21	PF00397	0.328
DOC_WW_Pin1_4	230	235	PF00397	0.547
DOC_WW_Pin1_4	4	9	PF00397	0.477
DOC_WW_Pin1_4	54	59	PF00397	0.445
DOC_WW_Pin1_4	627	632	PF00397	0.456
DOC_WW_Pin1_4	677	682	PF00397	0.309
DOC_WW_Pin1_4	726	731	PF00397	0.499
LIG_14-3-3_CanoR_1	367	373	PF00244	0.329
LIG_14-3-3_CanoR_1	513	523	PF00244	0.341
LIG_14-3-3_CanoR_1	557	561	PF00244	0.354
LIG_14-3-3_CanoR_1	683	690	PF00244	0.426
LIG_Actin_WH2_2	438	453	PF00022	0.451
LIG_BRCT_BRCA1_1	770	774	PF00533	0.398
LIG_FHA_1	20	26	PF00498	0.517
LIG_FHA_1	275	281	PF00498	0.379
LIG_FHA_1	316	322	PF00498	0.291
LIG_FHA_1	368	374	PF00498	0.274
LIG_FHA_1	416	422	PF00498	0.412
LIG_FHA_1	427	433	PF00498	0.402
LIG_FHA_1	462	468	PF00498	0.370
LIG_FHA_1	622	628	PF00498	0.466
LIG_FHA_1	729	735	PF00498	0.382
LIG_FHA_1	753	759	PF00498	0.427
LIG_FHA_1	819	825	PF00498	0.552
LIG_FHA_2	126	132	PF00498	0.551
LIG_FHA_2	528	534	PF00498	0.492
LIG_HCF-1_HBM_1	676	679	PF13415	0.343
LIG_IRF3_LxIS_1	463	468	PF10401	0.367
LIG_LIR_Apic_2	343	347	PF02991	0.343
LIG_LIR_Apic_2	676	681	PF02991	0.461
LIG_LIR_Gen_1	140	148	PF02991	0.431
LIG_LIR_Gen_1	191	200	PF02991	0.334
LIG_LIR_Gen_1	315	321	PF02991	0.399
LIG_LIR_Gen_1	771	781	PF02991	0.445
LIG_LIR_Nem_3	140	146	PF02991	0.431
LIG_LIR_Nem_3	191	196	PF02991	0.336
LIG_LIR_Nem_3	315	319	PF02991	0.393
LIG_LIR_Nem_3	406	411	PF02991	0.330
LIG_LIR_Nem_3	579	583	PF02991	0.440
LIG_LIR_Nem_3	593	597	PF02991	0.320
LIG_LIR_Nem_3	676	682	PF02991	0.472
LIG_LIR_Nem_3	76	82	PF02991	0.382
LIG_LIR_Nem_3	771	777	PF02991	0.415
LIG_Pex14_2	316	320	PF04695	0.316
LIG_PTB_Apo_2	98	105	PF02174	0.564
LIG_REV1ctd_RIR_1	508	517	PF16727	0.387
LIG_REV1ctd_RIR_1	687	696	PF16727	0.426
LIG_SH2_CRK	143	147	PF00017	0.444
LIG_SH2_CRK	174	178	PF00017	0.531
LIG_SH2_CRK	193	197	PF00017	0.362
LIG_SH2_CRK	266	270	PF00017	0.453
LIG_SH2_CRK	344	348	PF00017	0.414
LIG_SH2_CRK	53	57	PF00017	0.560
LIG_SH2_CRK	555	559	PF00017	0.351
LIG_SH2_CRK	679	683	PF00017	0.426
LIG_SH2_GRB2like	12	15	PF00017	0.431
LIG_SH2_NCK_1	143	147	PF00017	0.444
LIG_SH2_NCK_1	266	270	PF00017	0.370
LIG_SH2_NCK_1	344	348	PF00017	0.162
LIG_SH2_NCK_1	53	57	PF00017	0.560
LIG_SH2_STAP1	193	197	PF00017	0.426
LIG_SH2_STAP1	408	412	PF00017	0.441
LIG_SH2_STAP1	838	842	PF00017	0.484
LIG_SH2_STAT3	838	841	PF00017	0.524
LIG_SH2_STAT5	12	15	PF00017	0.511
LIG_SH2_STAT5	276	279	PF00017	0.351
LIG_SH2_STAT5	29	32	PF00017	0.319
LIG_SH2_STAT5	408	411	PF00017	0.336
LIG_SH2_STAT5	580	583	PF00017	0.409
LIG_SH2_STAT5	679	682	PF00017	0.327
LIG_SH2_STAT5	698	701	PF00017	0.351
LIG_SH2_STAT5	710	713	PF00017	0.256
LIG_SH2_STAT5	745	748	PF00017	0.320
LIG_SH2_STAT5	769	772	PF00017	0.314
LIG_SH3_3	113	119	PF00018	0.582
LIG_SH3_3	228	234	PF00018	0.460
LIG_SH3_3	343	349	PF00018	0.445
LIG_SH3_3	497	503	PF00018	0.327
LIG_SH3_3	625	631	PF00018	0.359
LIG_SH3_3	724	730	PF00018	0.454
LIG_SH3_3	96	102	PF00018	0.415
LIG_SUMO_SIM_par_1	441	447	PF11976	0.509
LIG_SUMO_SIM_par_1	463	468	PF11976	0.375
LIG_SUMO_SIM_par_1	630	636	PF11976	0.435
LIG_SUMO_SIM_par_1	804	811	PF11976	0.395
LIG_UBA3_1	633	638	PF00899	0.449
MOD_CDK_SPxK_1	677	683	PF00069	0.351
MOD_CDK_SPxxK_3	16	23	PF00069	0.384
MOD_CK1_1	19	25	PF00069	0.494
MOD_CK1_1	191	197	PF00069	0.367
MOD_CK1_1	233	239	PF00069	0.516
MOD_CK1_1	274	280	PF00069	0.402
MOD_CK1_1	315	321	PF00069	0.294
MOD_CK1_1	415	421	PF00069	0.400
MOD_CK1_1	444	450	PF00069	0.572
MOD_CK1_1	472	478	PF00069	0.351
MOD_CK1_1	576	582	PF00069	0.349
MOD_CK1_1	593	599	PF00069	0.459
MOD_CK1_1	621	627	PF00069	0.421
MOD_CK1_1	768	774	PF00069	0.497
MOD_CK2_1	181	187	PF00069	0.358
MOD_CK2_1	527	533	PF00069	0.485
MOD_CK2_1	776	782	PF00069	0.567
MOD_Cter_Amidation	304	307	PF01082	0.280
MOD_Cter_Amidation	356	359	PF01082	0.343
MOD_GlcNHglycan	139	142	PF01048	0.448
MOD_GlcNHglycan	200	203	PF01048	0.404
MOD_GlcNHglycan	260	263	PF01048	0.421
MOD_GlcNHglycan	269	272	PF01048	0.363
MOD_GlcNHglycan	282	285	PF01048	0.410
MOD_GlcNHglycan	30	33	PF01048	0.507
MOD_GlcNHglycan	414	417	PF01048	0.359
MOD_GlcNHglycan	585	588	PF01048	0.434
MOD_GlcNHglycan	620	623	PF01048	0.551
MOD_GlcNHglycan	758	761	PF01048	0.370
MOD_GlcNHglycan	765	768	PF01048	0.424
MOD_GSK3_1	267	274	PF00069	0.449
MOD_GSK3_1	315	322	PF00069	0.263
MOD_GSK3_1	406	413	PF00069	0.358
MOD_GSK3_1	415	422	PF00069	0.363
MOD_GSK3_1	461	468	PF00069	0.360
MOD_GSK3_1	511	518	PF00069	0.357
MOD_GSK3_1	523	530	PF00069	0.210
MOD_GSK3_1	722	729	PF00069	0.440
MOD_GSK3_1	744	751	PF00069	0.381
MOD_GSK3_1	752	759	PF00069	0.366
MOD_GSK3_1	776	783	PF00069	0.372
MOD_N-GLC_1	16	21	PF02516	0.440
MOD_N-GLC_1	167	172	PF02516	0.419
MOD_N-GLC_1	191	196	PF02516	0.355
MOD_N-GLC_1	352	357	PF02516	0.343
MOD_N-GLC_1	406	411	PF02516	0.370
MOD_N-GLC_1	427	432	PF02516	0.380
MOD_N-GLC_1	539	544	PF02516	0.437
MOD_N-GLC_1	618	623	PF02516	0.524
MOD_N-GLC_1	752	757	PF02516	0.355
MOD_N-GLC_2	158	160	PF02516	0.410
MOD_N-GLC_2	169	171	PF02516	0.407
MOD_NEK2_1	167	172	PF00069	0.370
MOD_NEK2_1	196	201	PF00069	0.336
MOD_NEK2_1	258	263	PF00069	0.482
MOD_NEK2_1	352	357	PF00069	0.386
MOD_NEK2_1	368	373	PF00069	0.380
MOD_NEK2_1	421	426	PF00069	0.384
MOD_NEK2_1	465	470	PF00069	0.380
MOD_NEK2_1	511	516	PF00069	0.342
MOD_NEK2_1	523	528	PF00069	0.303
MOD_NEK2_1	583	588	PF00069	0.362
MOD_NEK2_1	633	638	PF00069	0.544
MOD_NEK2_1	748	753	PF00069	0.337
MOD_NEK2_1	756	761	PF00069	0.326
MOD_NEK2_2	144	149	PF00069	0.355
MOD_NEK2_2	271	276	PF00069	0.411
MOD_NEK2_2	312	317	PF00069	0.351
MOD_PIKK_1	492	498	PF00454	0.378
MOD_PIKK_1	556	562	PF00454	0.426
MOD_PK_1	785	791	PF00069	0.496
MOD_PKA_1	469	475	PF00069	0.351
MOD_PKA_2	469	475	PF00069	0.351
MOD_PKA_2	556	562	PF00069	0.431
MOD_PKA_2	682	688	PF00069	0.343
MOD_Plk_1	181	187	PF00069	0.404
MOD_Plk_1	191	197	PF00069	0.354
MOD_Plk_1	208	214	PF00069	0.439
MOD_Plk_1	342	348	PF00069	0.457
MOD_Plk_1	406	412	PF00069	0.369
MOD_Plk_1	427	433	PF00069	0.380
MOD_Plk_1	539	545	PF00069	0.429
MOD_Plk_1	562	568	PF00069	0.327
MOD_Plk_1	752	758	PF00069	0.516
MOD_Plk_2-3	776	782	PF00069	0.436
MOD_Plk_4	181	187	PF00069	0.461
MOD_Plk_4	191	197	PF00069	0.286
MOD_Plk_4	208	214	PF00069	0.234
MOD_Plk_4	271	277	PF00069	0.401
MOD_Plk_4	315	321	PF00069	0.410
MOD_Plk_4	368	374	PF00069	0.314
MOD_Plk_4	376	382	PF00069	0.356
MOD_Plk_4	407	413	PF00069	0.391
MOD_Plk_4	427	433	PF00069	0.291
MOD_Plk_4	576	582	PF00069	0.354
MOD_Plk_4	74	80	PF00069	0.351
MOD_Plk_4	765	771	PF00069	0.293
MOD_ProDKin_1	16	22	PF00069	0.319
MOD_ProDKin_1	230	236	PF00069	0.546
MOD_ProDKin_1	4	10	PF00069	0.473
MOD_ProDKin_1	54	60	PF00069	0.448
MOD_ProDKin_1	627	633	PF00069	0.461
MOD_ProDKin_1	677	683	PF00069	0.309
MOD_ProDKin_1	726	732	PF00069	0.502
MOD_SUMO_for_1	784	787	PF00179	0.438
MOD_SUMO_rev_2	249	259	PF00179	0.508
MOD_SUMO_rev_2	605	611	PF00179	0.445
TRG_DiLeu_BaLyEn_6	628	633	PF01217	0.380
TRG_ENDOCYTIC_2	12	15	PF00928	0.449
TRG_ENDOCYTIC_2	143	146	PF00928	0.442
TRG_ENDOCYTIC_2	174	177	PF00928	0.490
TRG_ENDOCYTIC_2	193	196	PF00928	0.365
TRG_ENDOCYTIC_2	266	269	PF00928	0.452
TRG_ENDOCYTIC_2	408	411	PF00928	0.309
TRG_ENDOCYTIC_2	53	56	PF00928	0.557
TRG_ENDOCYTIC_2	555	558	PF00928	0.351
TRG_ENDOCYTIC_2	580	583	PF00928	0.383
TRG_ENDOCYTIC_2	679	682	PF00928	0.426
TRG_ENDOCYTIC_2	745	748	PF00928	0.340
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P531	Leptomonas seymouri	81%	98%
A0A1X0NSD6	Trypanosomatidae	49%	99%
A0A1X0NT20	Trypanosomatidae	27%	72%
A0A3S7WZR9	Leishmania donovani	97%	100%
A0A422NN30	Trypanosoma rangeli	48%	100%
A4HES9	Leishmania braziliensis	92%	100%
A4I206	Leishmania infantum	96%	100%
C9ZS06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	73%
C9ZS09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4Q9C0	Leishmania major	97%	100%
V5BPX5	Trypanosoma cruzi	49%	100%
V5BUH8	Trypanosoma cruzi	27%	74%