LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

DAGKc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DAGKc domain-containing protein
Gene product:
Sphingosine kinase
Species:
Leishmania mexicana
UniProt:
E9AY50_LEIMU
TriTrypDb:
LmxM.26.0710
Length:
916

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AY50
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY50

Function

Biological processes
Term Name Level Count
GO:0006066 alcohol metabolic process 3 1
GO:0006629 lipid metabolic process 3 1
GO:0006643 membrane lipid metabolic process 4 1
GO:0006665 sphingolipid metabolic process 4 1
GO:0006670 sphingosine metabolic process 6 1
GO:0006793 phosphorus metabolic process 3 3
GO:0006796 phosphate-containing compound metabolic process 4 3
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 3
GO:0008610 lipid biosynthetic process 4 1
GO:0009058 biosynthetic process 2 1
GO:0009987 cellular process 1 3
GO:0016310 phosphorylation 5 3
GO:0019751 polyol metabolic process 4 1
GO:0030148 sphingolipid biosynthetic process 5 1
GO:0034311 diol metabolic process 5 1
GO:0034312 diol biosynthetic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0044237 cellular metabolic process 2 3
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0044281 small molecule metabolic process 2 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0046165 alcohol biosynthetic process 4 1
GO:0046173 polyol biosynthetic process 5 1
GO:0046467 membrane lipid biosynthetic process 4 1
GO:0046512 sphingosine biosynthetic process 5 1
GO:0046519 sphingoid metabolic process 5 1
GO:0046520 sphingoid biosynthetic process 6 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
GO:1901615 organic hydroxy compound metabolic process 3 1
GO:1901617 organic hydroxy compound biosynthetic process 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0016301 kinase activity 4 9
GO:0016740 transferase activity 2 9
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 9
GO:0017050 D-erythro-sphingosine kinase activity 5 9
GO:0001727 lipid kinase activity 5 4
GO:0008481 sphinganine kinase activity 5 4
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 5
GO:0003951 NAD+ kinase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 49 53 PF00656 0.563
CLV_NRD_NRD_1 366 368 PF00675 0.391
CLV_NRD_NRD_1 406 408 PF00675 0.302
CLV_NRD_NRD_1 571 573 PF00675 0.479
CLV_NRD_NRD_1 576 578 PF00675 0.454
CLV_NRD_NRD_1 582 584 PF00675 0.445
CLV_NRD_NRD_1 848 850 PF00675 0.314
CLV_PCSK_KEX2_1 366 368 PF00082 0.391
CLV_PCSK_KEX2_1 406 408 PF00082 0.325
CLV_PCSK_KEX2_1 478 480 PF00082 0.673
CLV_PCSK_KEX2_1 570 572 PF00082 0.488
CLV_PCSK_KEX2_1 576 578 PF00082 0.477
CLV_PCSK_KEX2_1 582 584 PF00082 0.587
CLV_PCSK_KEX2_1 688 690 PF00082 0.402
CLV_PCSK_KEX2_1 848 850 PF00082 0.243
CLV_PCSK_PC1ET2_1 478 480 PF00082 0.651
CLV_PCSK_PC1ET2_1 582 584 PF00082 0.357
CLV_PCSK_PC1ET2_1 688 690 PF00082 0.402
CLV_PCSK_PC7_1 572 578 PF00082 0.437
CLV_PCSK_SKI1_1 172 176 PF00082 0.472
CLV_PCSK_SKI1_1 232 236 PF00082 0.469
CLV_PCSK_SKI1_1 350 354 PF00082 0.342
CLV_PCSK_SKI1_1 408 412 PF00082 0.355
CLV_PCSK_SKI1_1 416 420 PF00082 0.310
CLV_PCSK_SKI1_1 646 650 PF00082 0.365
CLV_PCSK_SKI1_1 685 689 PF00082 0.504
DEG_APCC_DBOX_1 405 413 PF00400 0.394
DEG_SCF_FBW7_1 254 260 PF00400 0.652
DEG_SCF_FBW7_1 759 764 PF00400 0.640
DEG_SPOP_SBC_1 240 244 PF00917 0.478
DEG_SPOP_SBC_1 25 29 PF00917 0.517
DOC_CKS1_1 254 259 PF01111 0.577
DOC_CKS1_1 63 68 PF01111 0.557
DOC_CYCLIN_yClb5_NLxxxL_5 429 438 PF00134 0.189
DOC_CYCLIN_yCln2_LP_2 175 181 PF00134 0.393
DOC_CYCLIN_yCln2_LP_2 823 829 PF00134 0.394
DOC_MAPK_gen_1 170 179 PF00069 0.498
DOC_MAPK_gen_1 323 331 PF00069 0.405
DOC_MAPK_gen_1 347 355 PF00069 0.372
DOC_MAPK_gen_1 599 608 PF00069 0.507
DOC_MAPK_gen_1 848 857 PF00069 0.309
DOC_MAPK_gen_1 876 884 PF00069 0.379
DOC_MAPK_gen_1 902 912 PF00069 0.394
DOC_MAPK_MEF2A_6 170 179 PF00069 0.512
DOC_MAPK_MEF2A_6 347 355 PF00069 0.394
DOC_MAPK_MEF2A_6 646 654 PF00069 0.428
DOC_MAPK_MEF2A_6 876 884 PF00069 0.459
DOC_PP1_RVXF_1 204 210 PF00149 0.567
DOC_PP1_RVXF_1 230 236 PF00149 0.461
DOC_PP1_RVXF_1 294 301 PF00149 0.457
DOC_PP1_RVXF_1 644 650 PF00149 0.386
DOC_PP1_SILK_1 691 696 PF00149 0.296
DOC_PP2B_LxvP_1 107 110 PF13499 0.521
DOC_PP2B_LxvP_1 175 178 PF13499 0.455
DOC_PP2B_LxvP_1 606 609 PF13499 0.466
DOC_PP2B_LxvP_1 823 826 PF13499 0.394
DOC_SPAK_OSR1_1 674 678 PF12202 0.408
DOC_USP7_MATH_1 25 29 PF00917 0.517
DOC_USP7_MATH_1 257 261 PF00917 0.797
DOC_USP7_MATH_1 274 278 PF00917 0.681
DOC_USP7_MATH_1 381 385 PF00917 0.356
DOC_USP7_MATH_1 420 424 PF00917 0.414
DOC_USP7_MATH_1 487 491 PF00917 0.617
DOC_USP7_MATH_1 521 525 PF00917 0.410
DOC_USP7_MATH_1 648 652 PF00917 0.332
DOC_USP7_MATH_1 698 702 PF00917 0.490
DOC_USP7_MATH_1 761 765 PF00917 0.756
DOC_USP7_MATH_1 828 832 PF00917 0.366
DOC_USP7_MATH_1 897 901 PF00917 0.394
DOC_USP7_MATH_1 91 95 PF00917 0.639
DOC_USP7_MATH_1 99 103 PF00917 0.621
DOC_USP7_UBL2_3 112 116 PF12436 0.532
DOC_USP7_UBL2_3 705 709 PF12436 0.497
DOC_WW_Pin1_4 116 121 PF00397 0.767
DOC_WW_Pin1_4 250 255 PF00397 0.751
DOC_WW_Pin1_4 289 294 PF00397 0.519
DOC_WW_Pin1_4 33 38 PF00397 0.635
DOC_WW_Pin1_4 428 433 PF00397 0.380
DOC_WW_Pin1_4 557 562 PF00397 0.465
DOC_WW_Pin1_4 617 622 PF00397 0.574
DOC_WW_Pin1_4 62 67 PF00397 0.733
DOC_WW_Pin1_4 757 762 PF00397 0.695
DOC_WW_Pin1_4 76 81 PF00397 0.654
LIG_14-3-3_CanoR_1 147 152 PF00244 0.544
LIG_14-3-3_CanoR_1 269 278 PF00244 0.566
LIG_14-3-3_CanoR_1 357 361 PF00244 0.394
LIG_14-3-3_CanoR_1 413 419 PF00244 0.406
LIG_APCC_ABBA_1 777 782 PF00400 0.498
LIG_APCC_ABBAyCdc20_2 454 460 PF00400 0.529
LIG_BIR_III_4 54 58 PF00653 0.651
LIG_BRCT_BRCA1_1 461 465 PF00533 0.542
LIG_BRCT_BRCA1_1 60 64 PF00533 0.574
LIG_BRCT_BRCA1_1 650 654 PF00533 0.339
LIG_Clathr_ClatBox_1 858 862 PF01394 0.189
LIG_eIF4E_1 678 684 PF01652 0.290
LIG_eIF4E_1 780 786 PF01652 0.484
LIG_FHA_1 129 135 PF00498 0.558
LIG_FHA_1 169 175 PF00498 0.598
LIG_FHA_1 202 208 PF00498 0.642
LIG_FHA_1 244 250 PF00498 0.819
LIG_FHA_1 25 31 PF00498 0.666
LIG_FHA_1 312 318 PF00498 0.275
LIG_FHA_1 357 363 PF00498 0.248
LIG_FHA_1 417 423 PF00498 0.381
LIG_FHA_1 425 431 PF00498 0.413
LIG_FHA_1 603 609 PF00498 0.377
LIG_FHA_1 618 624 PF00498 0.554
LIG_FHA_1 90 96 PF00498 0.652
LIG_FHA_2 185 191 PF00498 0.417
LIG_FHA_2 558 564 PF00498 0.536
LIG_FHA_2 612 618 PF00498 0.541
LIG_FHA_2 724 730 PF00498 0.436
LIG_LIR_Gen_1 467 476 PF02991 0.561
LIG_LIR_Gen_1 508 518 PF02991 0.384
LIG_LIR_Gen_1 836 845 PF02991 0.363
LIG_LIR_Nem_3 462 468 PF02991 0.449
LIG_LIR_Nem_3 508 513 PF02991 0.395
LIG_LIR_Nem_3 651 657 PF02991 0.244
LIG_LIR_Nem_3 836 842 PF02991 0.363
LIG_LIR_Nem_3 870 874 PF02991 0.394
LIG_PCNA_yPIPBox_3 310 323 PF02747 0.401
LIG_Pex14_2 465 469 PF04695 0.415
LIG_PTB_Apo_2 669 676 PF02174 0.391
LIG_SH2_CRK 690 694 PF00017 0.366
LIG_SH2_STAT3 284 287 PF00017 0.517
LIG_SH2_STAT3 780 783 PF00017 0.439
LIG_SH2_STAT5 153 156 PF00017 0.419
LIG_SH2_STAT5 284 287 PF00017 0.430
LIG_SH2_STAT5 374 377 PF00017 0.309
LIG_SH2_STAT5 588 591 PF00017 0.343
LIG_SH2_STAT5 678 681 PF00017 0.288
LIG_SH2_STAT5 696 699 PF00017 0.402
LIG_SH2_STAT5 737 740 PF00017 0.468
LIG_SH2_STAT5 780 783 PF00017 0.496
LIG_SH2_STAT5 839 842 PF00017 0.394
LIG_SH2_STAT5 874 877 PF00017 0.306
LIG_SH3_3 251 257 PF00018 0.764
LIG_SH3_3 426 432 PF00018 0.262
LIG_SH3_3 460 466 PF00018 0.599
LIG_SUMO_SIM_anti_2 531 536 PF11976 0.395
LIG_SUMO_SIM_anti_2 553 558 PF11976 0.454
LIG_SUMO_SIM_anti_2 834 839 PF11976 0.189
LIG_SUMO_SIM_par_1 533 539 PF11976 0.459
LIG_TYR_ITIM 837 842 PF00017 0.372
LIG_UBA3_1 328 335 PF00899 0.335
LIG_UBA3_1 683 688 PF00899 0.477
LIG_UBA3_1 693 702 PF00899 0.349
LIG_WRC_WIRS_1 220 225 PF05994 0.408
MOD_CDK_SPK_2 62 67 PF00069 0.557
MOD_CDK_SPxxK_3 289 296 PF00069 0.365
MOD_CDK_SPxxK_3 617 624 PF00069 0.499
MOD_CDK_SPxxK_3 62 69 PF00069 0.583
MOD_CDK_SPxxK_3 76 83 PF00069 0.597
MOD_CK1_1 102 108 PF00069 0.773
MOD_CK1_1 156 162 PF00069 0.442
MOD_CK1_1 212 218 PF00069 0.568
MOD_CK1_1 24 30 PF00069 0.616
MOD_CK1_1 253 259 PF00069 0.584
MOD_CK1_1 294 300 PF00069 0.500
MOD_CK1_1 3 9 PF00069 0.653
MOD_CK1_1 302 308 PF00069 0.524
MOD_CK1_1 33 39 PF00069 0.516
MOD_CK1_1 333 339 PF00069 0.302
MOD_CK1_1 356 362 PF00069 0.402
MOD_CK1_1 423 429 PF00069 0.377
MOD_CK1_1 586 592 PF00069 0.304
MOD_CK1_1 635 641 PF00069 0.561
MOD_CK1_1 745 751 PF00069 0.608
MOD_CK1_1 757 763 PF00069 0.668
MOD_CK1_1 76 82 PF00069 0.667
MOD_CK1_1 831 837 PF00069 0.237
MOD_CK2_1 184 190 PF00069 0.403
MOD_CK2_1 533 539 PF00069 0.462
MOD_CK2_1 557 563 PF00069 0.472
MOD_CK2_1 723 729 PF00069 0.545
MOD_CK2_1 888 894 PF00069 0.335
MOD_GlcNHglycan 101 104 PF01048 0.625
MOD_GlcNHglycan 198 201 PF01048 0.393
MOD_GlcNHglycan 211 214 PF01048 0.507
MOD_GlcNHglycan 223 226 PF01048 0.649
MOD_GlcNHglycan 23 26 PF01048 0.559
MOD_GlcNHglycan 302 305 PF01048 0.605
MOD_GlcNHglycan 332 335 PF01048 0.343
MOD_GlcNHglycan 448 451 PF01048 0.389
MOD_GlcNHglycan 523 526 PF01048 0.459
MOD_GlcNHglycan 60 63 PF01048 0.559
MOD_GlcNHglycan 70 73 PF01048 0.616
MOD_GlcNHglycan 756 759 PF01048 0.614
MOD_GlcNHglycan 765 768 PF01048 0.644
MOD_GlcNHglycan 771 774 PF01048 0.562
MOD_GlcNHglycan 862 865 PF01048 0.345
MOD_GlcNHglycan 97 100 PF01048 0.690
MOD_GSK3_1 13 20 PF00069 0.709
MOD_GSK3_1 156 163 PF00069 0.456
MOD_GSK3_1 164 171 PF00069 0.520
MOD_GSK3_1 2 9 PF00069 0.689
MOD_GSK3_1 21 28 PF00069 0.600
MOD_GSK3_1 235 242 PF00069 0.672
MOD_GSK3_1 253 260 PF00069 0.695
MOD_GSK3_1 270 277 PF00069 0.561
MOD_GSK3_1 416 423 PF00069 0.457
MOD_GSK3_1 424 431 PF00069 0.262
MOD_GSK3_1 58 65 PF00069 0.648
MOD_GSK3_1 723 730 PF00069 0.486
MOD_GSK3_1 74 81 PF00069 0.519
MOD_GSK3_1 742 749 PF00069 0.461
MOD_GSK3_1 757 764 PF00069 0.721
MOD_GSK3_1 897 904 PF00069 0.357
MOD_GSK3_1 91 98 PF00069 0.654
MOD_GSK3_1 99 106 PF00069 0.695
MOD_N-GLC_1 116 121 PF02516 0.596
MOD_N-GLC_1 20 25 PF02516 0.547
MOD_N-GLC_1 240 245 PF02516 0.680
MOD_N-GLC_1 432 437 PF02516 0.401
MOD_N-GLC_1 557 562 PF02516 0.452
MOD_N-GLC_1 752 757 PF02516 0.745
MOD_N-GLC_1 761 766 PF02516 0.776
MOD_N-GLC_1 95 100 PF02516 0.661
MOD_NEK2_1 160 165 PF00069 0.530
MOD_NEK2_1 196 201 PF00069 0.405
MOD_NEK2_1 209 214 PF00069 0.530
MOD_NEK2_1 219 224 PF00069 0.550
MOD_NEK2_1 235 240 PF00069 0.651
MOD_NEK2_1 300 305 PF00069 0.555
MOD_NEK2_1 353 358 PF00069 0.335
MOD_NEK2_1 39 44 PF00069 0.660
MOD_NEK2_1 516 521 PF00069 0.340
MOD_NEK2_1 602 607 PF00069 0.373
MOD_NEK2_1 650 655 PF00069 0.340
MOD_NEK2_1 727 732 PF00069 0.603
MOD_NEK2_1 906 911 PF00069 0.394
MOD_NEK2_2 432 437 PF00069 0.288
MOD_NEK2_2 663 668 PF00069 0.492
MOD_NEK2_2 723 728 PF00069 0.517
MOD_NEK2_2 799 804 PF00069 0.466
MOD_NEK2_2 897 902 PF00069 0.394
MOD_OFUCOSY 725 731 PF10250 0.452
MOD_PIKK_1 583 589 PF00454 0.612
MOD_PKA_1 583 589 PF00069 0.416
MOD_PKA_2 156 162 PF00069 0.445
MOD_PKA_2 17 23 PF00069 0.681
MOD_PKA_2 356 362 PF00069 0.394
MOD_PKA_2 602 608 PF00069 0.513
MOD_PKA_2 68 74 PF00069 0.583
MOD_PKA_2 727 733 PF00069 0.578
MOD_PKA_2 901 907 PF00069 0.394
MOD_Plk_1 134 140 PF00069 0.411
MOD_Plk_1 201 207 PF00069 0.554
MOD_Plk_1 432 438 PF00069 0.256
MOD_Plk_1 459 465 PF00069 0.588
MOD_Plk_1 597 603 PF00069 0.441
MOD_Plk_1 6 12 PF00069 0.512
MOD_Plk_2-3 533 539 PF00069 0.459
MOD_Plk_4 26 32 PF00069 0.662
MOD_Plk_4 312 318 PF00069 0.474
MOD_Plk_4 383 389 PF00069 0.394
MOD_Plk_4 425 431 PF00069 0.402
MOD_Plk_4 464 470 PF00069 0.469
MOD_Plk_4 540 546 PF00069 0.382
MOD_ProDKin_1 116 122 PF00069 0.767
MOD_ProDKin_1 250 256 PF00069 0.750
MOD_ProDKin_1 289 295 PF00069 0.507
MOD_ProDKin_1 33 39 PF00069 0.639
MOD_ProDKin_1 428 434 PF00069 0.380
MOD_ProDKin_1 557 563 PF00069 0.472
MOD_ProDKin_1 617 623 PF00069 0.565
MOD_ProDKin_1 62 68 PF00069 0.734
MOD_ProDKin_1 757 763 PF00069 0.694
MOD_ProDKin_1 76 82 PF00069 0.654
MOD_SUMO_rev_2 490 495 PF00179 0.342
TRG_DiLeu_BaEn_2 852 858 PF01217 0.256
TRG_ENDOCYTIC_2 678 681 PF00928 0.359
TRG_ENDOCYTIC_2 690 693 PF00928 0.363
TRG_ENDOCYTIC_2 839 842 PF00928 0.366
TRG_ER_diArg_1 247 250 PF00400 0.530
TRG_ER_diArg_1 570 572 PF00400 0.538
TRG_ER_diArg_1 576 578 PF00400 0.450
TRG_ER_diArg_1 599 602 PF00400 0.545
TRG_ER_diArg_1 848 851 PF00400 0.243
TRG_ER_diArg_1 875 878 PF00400 0.250
TRG_NLS_Bipartite_1 570 586 PF00514 0.309
TRG_Pf-PMV_PEXEL_1 296 301 PF00026 0.457
TRG_Pf-PMV_PEXEL_1 503 507 PF00026 0.411
TRG_Pf-PMV_PEXEL_1 695 700 PF00026 0.388

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P530 Leptomonas seymouri 52% 94%
A0A3Q8IGX7 Leishmania donovani 82% 98%
A0A422NN92 Trypanosoma rangeli 32% 100%
A4HES6 Leishmania braziliensis 71% 100%
A4I203 Leishmania infantum 81% 98%
C9ZS12 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
Q4Q9C3 Leishmania major 80% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS