Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pentapeptide repeats (9 copies), putative

Species:

Leishmania mexicana

UniProt:

E9AY49_LEIMU

TriTrypDb:

LmxM.26.0700

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AY49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.591
CLV_NRD_NRD_1	243	245	PF00675	0.487
CLV_NRD_NRD_1	25	27	PF00675	0.722
CLV_NRD_NRD_1	287	289	PF00675	0.666
CLV_NRD_NRD_1	369	371	PF00675	0.545
CLV_NRD_NRD_1	431	433	PF00675	0.602
CLV_NRD_NRD_1	65	67	PF00675	0.728
CLV_PCSK_KEX2_1	25	27	PF00082	0.722
CLV_PCSK_KEX2_1	287	289	PF00082	0.706
CLV_PCSK_KEX2_1	369	371	PF00082	0.545
CLV_PCSK_KEX2_1	431	433	PF00082	0.612
CLV_PCSK_KEX2_1	65	67	PF00082	0.728
CLV_PCSK_PC7_1	61	67	PF00082	0.518
CLV_PCSK_SKI1_1	244	248	PF00082	0.530
CLV_PCSK_SKI1_1	315	319	PF00082	0.527
CLV_PCSK_SKI1_1	355	359	PF00082	0.545
CLV_PCSK_SKI1_1	459	463	PF00082	0.520
CLV_PCSK_SKI1_1	8	12	PF00082	0.573
DEG_APCC_DBOX_1	243	251	PF00400	0.577
DEG_SPOP_SBC_1	143	147	PF00917	0.659
DEG_SPOP_SBC_1	298	302	PF00917	0.645
DOC_CYCLIN_RxL_1	326	337	PF00134	0.345
DOC_CYCLIN_RxL_1	352	362	PF00134	0.272
DOC_MAPK_DCC_7	194	202	PF00069	0.518
DOC_MAPK_gen_1	244	252	PF00069	0.578
DOC_MAPK_gen_1	431	439	PF00069	0.514
DOC_MAPK_MEF2A_6	194	202	PF00069	0.779
DOC_MAPK_MEF2A_6	431	439	PF00069	0.619
DOC_PP1_RVXF_1	199	205	PF00149	0.533
DOC_PP1_RVXF_1	243	250	PF00149	0.573
DOC_PP2B_LxvP_1	307	310	PF13499	0.580
DOC_USP7_MATH_1	113	117	PF00917	0.538
DOC_USP7_MATH_1	133	137	PF00917	0.489
DOC_USP7_MATH_1	143	147	PF00917	0.565
DOC_USP7_MATH_1	151	155	PF00917	0.742
DOC_USP7_MATH_1	171	175	PF00917	0.788
DOC_USP7_MATH_1	209	213	PF00917	0.733
DOC_USP7_MATH_1	219	223	PF00917	0.706
DOC_USP7_MATH_1	298	302	PF00917	0.515
DOC_USP7_MATH_1	409	413	PF00917	0.699
DOC_USP7_MATH_1	427	431	PF00917	0.478
DOC_USP7_MATH_1	79	83	PF00917	0.620
DOC_USP7_UBL2_3	413	417	PF12436	0.482
DOC_WW_Pin1_4	147	152	PF00397	0.754
DOC_WW_Pin1_4	164	169	PF00397	0.591
DOC_WW_Pin1_4	256	261	PF00397	0.725
DOC_WW_Pin1_4	59	64	PF00397	0.516
DOC_WW_Pin1_4	81	86	PF00397	0.811
DOC_WW_Pin1_4	95	100	PF00397	0.644
LIG_14-3-3_CanoR_1	32	36	PF00244	0.759
LIG_14-3-3_CanoR_1	329	334	PF00244	0.345
LIG_14-3-3_CanoR_1	342	348	PF00244	0.345
LIG_14-3-3_CanoR_1	384	393	PF00244	0.588
LIG_14-3-3_CanoR_1	8	13	PF00244	0.651
LIG_14-3-3_CanoR_1	81	85	PF00244	0.679
LIG_14-3-3_CanoR_1	97	103	PF00244	0.490
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BRCT_BRCA1_1	435	439	PF00533	0.562
LIG_FHA_1	125	131	PF00498	0.513
LIG_FHA_1	257	263	PF00498	0.581
LIG_FHA_1	372	378	PF00498	0.415
LIG_FHA_2	180	186	PF00498	0.570
LIG_FHA_2	345	351	PF00498	0.345
LIG_FHA_2	389	395	PF00498	0.448
LIG_FHA_2	9	15	PF00498	0.711
LIG_LIR_Gen_1	169	180	PF02991	0.636
LIG_LIR_Gen_1	337	346	PF02991	0.345
LIG_LIR_Nem_3	153	158	PF02991	0.780
LIG_LIR_Nem_3	169	175	PF02991	0.647
LIG_LIR_Nem_3	337	341	PF02991	0.345
LIG_OCRL_FandH_1	37	49	PF00620	0.539
LIG_SH2_PTP2	9	12	PF00017	0.502
LIG_SH2_STAP1	119	123	PF00017	0.572
LIG_SH2_STAT5	56	59	PF00017	0.530
LIG_SH2_STAT5	9	12	PF00017	0.502
LIG_SH3_3	137	143	PF00018	0.613
LIG_SH3_3	192	198	PF00018	0.675
LIG_SH3_3	215	221	PF00018	0.578
LIG_SUMO_SIM_par_1	109	116	PF11976	0.519
LIG_WRC_WIRS_1	152	157	PF05994	0.522
LIG_WRC_WIRS_1	232	237	PF05994	0.654
MOD_CDC14_SPxK_1	62	65	PF00782	0.507
MOD_CDK_SPxK_1	59	65	PF00069	0.517
MOD_CDK_SPxK_1	81	87	PF00069	0.746
MOD_CDK_SPxxK_3	59	66	PF00069	0.519
MOD_CK1_1	147	153	PF00069	0.601
MOD_CK1_1	212	218	PF00069	0.755
MOD_CK1_1	223	229	PF00069	0.660
MOD_CK1_1	254	260	PF00069	0.593
MOD_CK1_1	294	300	PF00069	0.690
MOD_CK1_1	31	37	PF00069	0.682
MOD_CK1_1	344	350	PF00069	0.410
MOD_CK1_1	386	392	PF00069	0.615
MOD_CK1_1	430	436	PF00069	0.459
MOD_CK1_1	80	86	PF00069	0.708
MOD_CK1_1	98	104	PF00069	0.497
MOD_CK2_1	14	20	PF00069	0.808
MOD_CK2_1	388	394	PF00069	0.466
MOD_Cter_Amidation	63	66	PF01082	0.717
MOD_DYRK1A_RPxSP_1	81	85	PF00069	0.623
MOD_GlcNHglycan	115	118	PF01048	0.551
MOD_GlcNHglycan	214	217	PF01048	0.780
MOD_GlcNHglycan	256	259	PF01048	0.587
MOD_GlcNHglycan	262	265	PF01048	0.684
MOD_GlcNHglycan	293	296	PF01048	0.661
MOD_GlcNHglycan	301	304	PF01048	0.448
MOD_GlcNHglycan	432	435	PF01048	0.470
MOD_GSK3_1	143	150	PF00069	0.714
MOD_GSK3_1	219	226	PF00069	0.714
MOD_GSK3_1	227	234	PF00069	0.690
MOD_GSK3_1	256	263	PF00069	0.670
MOD_GSK3_1	264	271	PF00069	0.654
MOD_GSK3_1	290	297	PF00069	0.728
MOD_GSK3_1	383	390	PF00069	0.626
MOD_GSK3_1	423	430	PF00069	0.559
MOD_GSK3_1	463	470	PF00069	0.579
MOD_GSK3_1	73	80	PF00069	0.827
MOD_LATS_1	327	333	PF00433	0.410
MOD_N-GLC_1	254	259	PF02516	0.570
MOD_N-GLC_1	371	376	PF02516	0.508
MOD_NEK2_1	112	117	PF00069	0.522
MOD_NEK2_1	353	358	PF00069	0.508
MOD_NEK2_1	387	392	PF00069	0.477
MOD_NEK2_1	449	454	PF00069	0.485
MOD_NEK2_1	86	91	PF00069	0.728
MOD_NEK2_2	124	129	PF00069	0.465
MOD_PIKK_1	268	274	PF00454	0.790
MOD_PIKK_1	449	455	PF00454	0.531
MOD_PKA_2	31	37	PF00069	0.768
MOD_PKA_2	341	347	PF00069	0.410
MOD_PKA_2	383	389	PF00069	0.598
MOD_PKA_2	430	436	PF00069	0.437
MOD_PKA_2	80	86	PF00069	0.717
MOD_Plk_1	336	342	PF00069	0.410
MOD_Plk_4	227	233	PF00069	0.554
MOD_Plk_4	362	368	PF00069	0.433
MOD_ProDKin_1	147	153	PF00069	0.753
MOD_ProDKin_1	164	170	PF00069	0.590
MOD_ProDKin_1	256	262	PF00069	0.733
MOD_ProDKin_1	59	65	PF00069	0.517
MOD_ProDKin_1	81	87	PF00069	0.813
MOD_ProDKin_1	95	101	PF00069	0.636
MOD_SUMO_rev_2	131	136	PF00179	0.609
MOD_SUMO_rev_2	239	247	PF00179	0.498
TRG_ENDOCYTIC_2	172	175	PF00928	0.657
TRG_ENDOCYTIC_2	9	12	PF00928	0.702
TRG_ER_diArg_1	24	26	PF00400	0.681
TRG_ER_diArg_1	368	370	PF00400	0.410
TRG_ER_diArg_1	474	477	PF00400	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5M8	Leptomonas seymouri	40%	100%
A0A3Q8IC33	Leishmania donovani	83%	95%
A4HES5	Leishmania braziliensis	67%	100%
A4I202	Leishmania infantum	83%	94%
Q4Q9C4	Leishmania major	83%	100%