t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qc-SNARE protein, putative

Species:

Leishmania mexicana

UniProt:

E9AY48_LEIMU

TriTrypDb:

LmxM.26.0690

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0012505	endomembrane system	2	1
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

E9AY48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY48

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0016192	vesicle-mediated transport	4	8
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0006886	intracellular protein transport	4	1
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	3
GO:0009987	cellular process	1	3
GO:0015031	protein transport	4	3
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	3
GO:0045184	establishment of protein localization	3	3
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	3
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	3
GO:0071702	organic substance transport	4	3
GO:0071705	nitrogen compound transport	4	3
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.384
CLV_NRD_NRD_1	215	217	PF00675	0.318
CLV_PCSK_KEX2_1	130	132	PF00082	0.383
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.445
CLV_PCSK_SKI1_1	202	206	PF00082	0.333
CLV_PCSK_SKI1_1	80	84	PF00082	0.367
DEG_Nend_UBRbox_3	1	3	PF02207	0.728
DOC_MAPK_gen_1	178	186	PF00069	0.612
DOC_MAPK_gen_1	228	236	PF00069	0.462
DOC_MAPK_MEF2A_6	228	236	PF00069	0.462
DOC_WW_Pin1_4	4	9	PF00397	0.563
LIG_14-3-3_CanoR_1	171	179	PF00244	0.691
LIG_Actin_RPEL_3	221	240	PF02755	0.541
LIG_AP2alpha_2	28	30	PF02296	0.563
LIG_EH1_1	237	245	PF00400	0.426
LIG_FHA_1	14	20	PF00498	0.553
LIG_FHA_1	54	60	PF00498	0.488
LIG_FHA_2	22	28	PF00498	0.720
LIG_FHA_2	83	89	PF00498	0.578
LIG_FHA_2	94	100	PF00498	0.562
LIG_GBD_Chelix_1	241	249	PF00786	0.381
LIG_SUMO_SIM_par_1	15	20	PF11976	0.556
LIG_TRAF2_1	96	99	PF00917	0.590
MOD_CK1_1	68	74	PF00069	0.573
MOD_CK2_1	21	27	PF00069	0.699
MOD_CK2_1	68	74	PF00069	0.571
MOD_CK2_1	82	88	PF00069	0.565
MOD_CK2_1	93	99	PF00069	0.559
MOD_GlcNHglycan	173	176	PF01048	0.493
MOD_GSK3_1	13	20	PF00069	0.705
MOD_GSK3_1	51	58	PF00069	0.639
MOD_GSK3_1	89	96	PF00069	0.673
MOD_NEK2_1	221	226	PF00069	0.475
MOD_NEK2_1	51	56	PF00069	0.665
MOD_NEK2_1	65	70	PF00069	0.446
MOD_PIKK_1	189	195	PF00454	0.635
MOD_PKA_1	216	222	PF00069	0.529
MOD_PKA_2	170	176	PF00069	0.669
MOD_Plk_1	165	171	PF00069	0.651
MOD_Plk_2-3	165	171	PF00069	0.651
MOD_Plk_4	13	19	PF00069	0.696
MOD_Plk_4	55	61	PF00069	0.590
MOD_ProDKin_1	4	10	PF00069	0.565
TRG_DiLeu_BaEn_2	145	151	PF01217	0.646
TRG_ER_diArg_1	129	132	PF00400	0.607
TRG_NES_CRM1_1	198	212	PF08389	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C8	Leptomonas seymouri	28%	100%
A0A0N1IK90	Leptomonas seymouri	74%	97%
A0A0S4JJL1	Bodo saltans	41%	100%
A0A1X0NSP4	Trypanosomatidae	55%	100%
A0A3Q8IDN9	Leishmania donovani	90%	100%
A0A3R7KG01	Trypanosoma rangeli	57%	100%
A4HES4	Leishmania braziliensis	83%	100%
A4I201	Leishmania infantum	90%	100%
O43752	Homo sapiens	26%	98%
O60499	Homo sapiens	26%	100%
Q4Q9C5	Leishmania major	89%	100%
Q5R6Q2	Pongo abelii	26%	98%
Q63635	Rattus norvegicus	28%	98%
Q946Y7	Arabidopsis thaliana	28%	100%
Q9HGN3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q9JKK1	Mus musculus	28%	98%
V5BUP0	Trypanosoma cruzi	55%	100%