Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania mexicana

UniProt:

E9AY46_LEIMU

TriTrypDb:

LmxM.26.0670

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 5
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005788	endoplasmic reticulum lumen	5	1
GO:0016020	membrane	2	3
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9AY46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY46

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1

Molecular functions
Term	Name	Level	Count
GO:0003756	protein disulfide isomerase activity	3	5
GO:0003824	catalytic activity	1	7
GO:0016853	isomerase activity	2	6
GO:0016860	intramolecular oxidoreductase activity	3	5
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	5
GO:0140096	catalytic activity, acting on a protein	2	6
GO:0015035	protein-disulfide reductase activity	3	1
GO:0015036	disulfide oxidoreductase activity	4	1
GO:0016491	oxidoreductase activity	2	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.518
CLV_NRD_NRD_1	3	5	PF00675	0.430
CLV_NRD_NRD_1	34	36	PF00675	0.527
CLV_NRD_NRD_1	43	45	PF00675	0.510
CLV_PCSK_KEX2_1	118	120	PF00082	0.464
CLV_PCSK_KEX2_1	34	36	PF00082	0.530
CLV_PCSK_SKI1_1	11	15	PF00082	0.275
DEG_Nend_Nbox_1	1	3	PF02207	0.482
DOC_CDC14_PxL_1	25	33	PF14671	0.382
DOC_CYCLIN_yCln2_LP_2	130	133	PF00134	0.264
DOC_MAPK_gen_1	4	14	PF00069	0.388
DOC_MAPK_MEF2A_6	121	130	PF00069	0.207
DOC_MAPK_MEF2A_6	7	16	PF00069	0.393
DOC_MAPK_NFAT4_5	11	19	PF00069	0.176
DOC_PP2B_LxvP_1	130	133	PF13499	0.266
DOC_WW_Pin1_4	38	43	PF00397	0.353
LIG_eIF4E_1	125	131	PF01652	0.239
LIG_FHA_1	125	131	PF00498	0.223
LIG_FHA_1	20	26	PF00498	0.329
LIG_LIR_Gen_1	55	66	PF02991	0.293
LIG_LIR_Gen_1	81	89	PF02991	0.301
LIG_LIR_LC3C_4	101	105	PF02991	0.166
LIG_LIR_Nem_3	123	128	PF02991	0.321
LIG_LIR_Nem_3	54	60	PF02991	0.266
LIG_LIR_Nem_3	64	69	PF02991	0.264
LIG_LIR_Nem_3	70	74	PF02991	0.264
LIG_LIR_Nem_3	81	85	PF02991	0.330
LIG_LIR_Nem_3	87	92	PF02991	0.262
LIG_LYPXL_yS_3	125	128	PF13949	0.239
LIG_NBox_RRM_1	20	30	PF00076	0.176
LIG_PCNA_PIPBox_1	65	74	PF02747	0.202
LIG_Pex14_2	71	75	PF04695	0.264
LIG_SH2_CRK	58	62	PF00017	0.223
LIG_SH2_NCK_1	58	62	PF00017	0.223
LIG_SH2_PTP2	92	95	PF00017	0.202
LIG_SH2_SRC	58	61	PF00017	0.202
LIG_SH2_STAT5	78	81	PF00017	0.293
LIG_SH2_STAT5	92	95	PF00017	0.276
LIG_SH3_3	105	111	PF00018	0.264
LIG_SUMO_SIM_anti_2	127	132	PF11976	0.306
LIG_SUMO_SIM_par_1	14	19	PF11976	0.184
LIG_TRAF2_1	159	162	PF00917	0.235
MOD_CDC14_SPxK_1	41	44	PF00782	0.237
MOD_CDK_SPxK_1	38	44	PF00069	0.253
MOD_CDK_SPxxK_3	38	45	PF00069	0.258
MOD_GlcNHglycan	122	125	PF01048	0.461
MOD_GSK3_1	120	127	PF00069	0.321
MOD_NEK2_1	16	21	PF00069	0.326
MOD_Plk_2-3	81	87	PF00069	0.285
MOD_Plk_4	124	130	PF00069	0.282
MOD_Plk_4	16	22	PF00069	0.317
MOD_Plk_4	81	87	PF00069	0.267
MOD_ProDKin_1	38	44	PF00069	0.351
MOD_SUMO_for_1	159	162	PF00179	0.330
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.378
TRG_ENDOCYTIC_2	125	128	PF00928	0.239
TRG_ENDOCYTIC_2	57	60	PF00928	0.266
TRG_ENDOCYTIC_2	86	89	PF00928	0.380
TRG_ENDOCYTIC_2	92	95	PF00928	0.340
TRG_ER_diArg_1	118	120	PF00400	0.264
TRG_ER_diArg_1	93	96	PF00400	0.202

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJS7	Leptomonas seymouri	57%	100%
A0A1X0NT33	Trypanosomatidae	28%	100%
A0A3R7NHA8	Trypanosoma rangeli	25%	91%
A4HES2	Leishmania braziliensis	73%	100%
C9ZTP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
Q4Q9C7	Leishmania major	77%	100%