Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY42_LEIMU

TriTrypDb:

LmxM.26.0630

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AY42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY42

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	4
GO:0006629	lipid metabolic process	3	4
GO:0006631	fatty acid metabolic process	4	4
GO:0006633	fatty acid biosynthetic process	5	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0009058	biosynthetic process	2	4
GO:0009987	cellular process	1	4
GO:0016053	organic acid biosynthetic process	4	4
GO:0019752	carboxylic acid metabolic process	5	4
GO:0032787	monocarboxylic acid metabolic process	6	4
GO:0043436	oxoacid metabolic process	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0044281	small molecule metabolic process	2	4
GO:0044283	small molecule biosynthetic process	3	4
GO:0046394	carboxylic acid biosynthetic process	5	4
GO:0071704	organic substance metabolic process	2	4
GO:0072330	monocarboxylic acid biosynthetic process	6	4
GO:1901576	organic substance biosynthetic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0016790	thiolester hydrolase activity	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.373
CLV_C14_Caspase3-7	368	372	PF00656	0.625
CLV_C14_Caspase3-7	4	8	PF00656	0.473
CLV_C14_Caspase3-7	93	97	PF00656	0.304
CLV_NRD_NRD_1	253	255	PF00675	0.340
CLV_NRD_NRD_1	297	299	PF00675	0.298
CLV_NRD_NRD_1	310	312	PF00675	0.310
CLV_PCSK_FUR_1	295	299	PF00082	0.285
CLV_PCSK_KEX2_1	172	174	PF00082	0.317
CLV_PCSK_KEX2_1	253	255	PF00082	0.358
CLV_PCSK_KEX2_1	297	299	PF00082	0.298
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.333
CLV_PCSK_SKI1_1	145	149	PF00082	0.327
CLV_PCSK_SKI1_1	173	177	PF00082	0.356
CLV_PCSK_SKI1_1	283	287	PF00082	0.330
DEG_Nend_Nbox_1	1	3	PF02207	0.359
DEG_SPOP_SBC_1	347	351	PF00917	0.436
DOC_ANK_TNKS_1	2	9	PF00023	0.465
DOC_CKS1_1	162	167	PF01111	0.375
DOC_CKS1_1	50	55	PF01111	0.511
DOC_CYCLIN_RxL_1	104	114	PF00134	0.284
DOC_CYCLIN_RxL_1	142	150	PF00134	0.315
DOC_MAPK_FxFP_2	331	334	PF00069	0.307
DOC_MAPK_gen_1	107	117	PF00069	0.240
DOC_MAPK_gen_1	172	178	PF00069	0.294
DOC_MAPK_gen_1	396	405	PF00069	0.321
DOC_MAPK_MEF2A_6	110	119	PF00069	0.259
DOC_MAPK_RevD_3	299	312	PF00069	0.325
DOC_PP2B_LxvP_1	227	230	PF13499	0.455
DOC_PP2B_LxvP_1	58	61	PF13499	0.392
DOC_PP4_FxxP_1	102	105	PF00568	0.569
DOC_PP4_FxxP_1	331	334	PF00568	0.307
DOC_SPAK_OSR1_1	177	181	PF12202	0.254
DOC_USP7_MATH_1	143	147	PF00917	0.267
DOC_USP7_MATH_1	211	215	PF00917	0.404
DOC_USP7_MATH_1	347	351	PF00917	0.436
DOC_USP7_MATH_1	6	10	PF00917	0.400
DOC_USP7_UBL2_3	182	186	PF12436	0.395
DOC_WW_Pin1_4	161	166	PF00397	0.509
DOC_WW_Pin1_4	222	227	PF00397	0.599
DOC_WW_Pin1_4	49	54	PF00397	0.497
LIG_14-3-3_CanoR_1	197	205	PF00244	0.524
LIG_14-3-3_CanoR_1	398	404	PF00244	0.451
LIG_Actin_WH2_2	244	261	PF00022	0.490
LIG_APCC_Cbox_2	397	403	PF00515	0.349
LIG_BIR_III_4	62	66	PF00653	0.554
LIG_BRCT_BRCA1_1	206	210	PF00533	0.401
LIG_Clathr_ClatBox_1	276	280	PF01394	0.274
LIG_EVH1_2	231	235	PF00568	0.321
LIG_FHA_1	211	217	PF00498	0.471
LIG_FHA_1	272	278	PF00498	0.419
LIG_FHA_1	358	364	PF00498	0.535
LIG_FHA_1	382	388	PF00498	0.357
LIG_FHA_1	408	414	PF00498	0.451
LIG_FHA_2	133	139	PF00498	0.397
LIG_FHA_2	24	30	PF00498	0.297
LIG_FHA_2	259	265	PF00498	0.384
LIG_FHA_2	50	56	PF00498	0.443
LIG_LIR_Apic_2	101	105	PF02991	0.411
LIG_LIR_Apic_2	328	334	PF02991	0.429
LIG_LIR_Gen_1	128	137	PF02991	0.421
LIG_LIR_Nem_3	125	130	PF02991	0.299
LIG_LIR_Nem_3	131	137	PF02991	0.307
LIG_LIR_Nem_3	379	385	PF02991	0.342
LIG_LIR_Nem_3	85	91	PF02991	0.302
LIG_PCNA_yPIPBox_3	270	283	PF02747	0.310
LIG_PTB_Apo_2	121	128	PF02174	0.337
LIG_PTB_Apo_2	35	42	PF02174	0.423
LIG_PTB_Phospho_1	121	127	PF10480	0.434
LIG_SH2_CRK	130	134	PF00017	0.325
LIG_SH2_CRK	224	228	PF00017	0.631
LIG_SH2_CRK	293	297	PF00017	0.494
LIG_SH2_SRC	136	139	PF00017	0.362
LIG_SH2_STAP1	130	134	PF00017	0.498
LIG_SH2_STAT5	134	137	PF00017	0.355
LIG_SH2_STAT5	317	320	PF00017	0.327
LIG_SH2_STAT5	39	42	PF00017	0.422
LIG_SH2_STAT5	79	82	PF00017	0.523
LIG_SH3_2	105	110	PF14604	0.326
LIG_SH3_2	334	339	PF14604	0.360
LIG_SH3_3	102	108	PF00018	0.515
LIG_SH3_3	13	19	PF00018	0.312
LIG_SH3_3	296	302	PF00018	0.396
LIG_SH3_3	331	337	PF00018	0.329
LIG_SH3_3	359	365	PF00018	0.595
LIG_SH3_3	382	388	PF00018	0.424
LIG_SH3_3	64	70	PF00018	0.432
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.370
LIG_SUMO_SIM_par_1	274	280	PF11976	0.422
LIG_SUMO_SIM_par_1	360	368	PF11976	0.441
LIG_TRFH_1	102	106	PF08558	0.453
LIG_WRC_WIRS_1	148	153	PF05994	0.351
LIG_WW_3	104	108	PF00397	0.423
MOD_CAAXbox	411	414	PF01239	0.371
MOD_CK1_1	125	131	PF00069	0.424
MOD_CK1_1	225	231	PF00069	0.602
MOD_CK1_1	346	352	PF00069	0.563
MOD_CK1_1	367	373	PF00069	0.474
MOD_CK1_1	82	88	PF00069	0.405
MOD_CK2_1	49	55	PF00069	0.369
MOD_GlcNHglycan	206	209	PF01048	0.368
MOD_GlcNHglycan	213	216	PF01048	0.438
MOD_GlcNHglycan	227	230	PF01048	0.621
MOD_GlcNHglycan	345	348	PF01048	0.480
MOD_GlcNHglycan	352	355	PF01048	0.640
MOD_GlcNHglycan	7	11	PF01048	0.302
MOD_GSK3_1	128	135	PF00069	0.327
MOD_GSK3_1	143	150	PF00069	0.359
MOD_GSK3_1	182	189	PF00069	0.528
MOD_GSK3_1	211	218	PF00069	0.451
MOD_GSK3_1	321	328	PF00069	0.385
MOD_GSK3_1	339	346	PF00069	0.341
MOD_GSK3_1	73	80	PF00069	0.632
MOD_N-GLC_1	123	128	PF02516	0.334
MOD_N-GLC_1	182	187	PF02516	0.450
MOD_N-GLC_1	211	216	PF02516	0.573
MOD_N-GLC_1	82	87	PF02516	0.564
MOD_N-GLC_2	38	40	PF02516	0.424
MOD_NEK2_1	147	152	PF00069	0.307
MOD_NEK2_1	204	209	PF00069	0.370
MOD_NEK2_1	210	215	PF00069	0.419
MOD_NEK2_1	235	240	PF00069	0.438
MOD_NEK2_1	399	404	PF00069	0.440
MOD_PIKK_1	128	134	PF00454	0.235
MOD_PIKK_1	23	29	PF00454	0.252
MOD_PIKK_1	339	345	PF00454	0.264
MOD_PKA_2	196	202	PF00069	0.389
MOD_PKA_2	258	264	PF00069	0.318
MOD_Plk_1	123	129	PF00069	0.331
MOD_Plk_1	211	217	PF00069	0.438
MOD_Plk_1	28	34	PF00069	0.309
MOD_Plk_1	82	88	PF00069	0.369
MOD_Plk_4	125	131	PF00069	0.472
MOD_Plk_4	132	138	PF00069	0.411
MOD_Plk_4	358	364	PF00069	0.496
MOD_Plk_4	82	88	PF00069	0.431
MOD_ProDKin_1	161	167	PF00069	0.508
MOD_ProDKin_1	222	228	PF00069	0.594
MOD_ProDKin_1	49	55	PF00069	0.501
TRG_ENDOCYTIC_2	130	133	PF00928	0.321
TRG_ENDOCYTIC_2	134	137	PF00928	0.345
TRG_ENDOCYTIC_2	224	227	PF00928	0.641
TRG_ENDOCYTIC_2	293	296	PF00928	0.491
TRG_ER_diArg_1	295	298	PF00400	0.270
TRG_NES_CRM1_1	376	391	PF08389	0.473
TRG_NLS_Bipartite_1	297	315	PF00514	0.233
TRG_NLS_MonoExtC_3	310	316	PF00514	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IG55	Leptomonas seymouri	56%	97%
A0A0S4JIW4	Bodo saltans	27%	100%
A0A0S4JK14	Bodo saltans	25%	93%
A0A1X0NSG4	Trypanosomatidae	36%	100%
A0A3Q8INZ4	Leishmania donovani	87%	100%
A0A3R7M5A1	Trypanosoma rangeli	34%	100%
A4HER8	Leishmania braziliensis	72%	100%
A4I1Z5	Leishmania infantum	87%	100%
C9ZS19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q9D1	Leishmania major	86%	100%
V5B9E8	Trypanosoma cruzi	34%	100%