PPR_long domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AY40_LEIMU

TriTrypDb:

LmxM.26.0610

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AY40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AY40

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	387	391	PF00656	0.515
CLV_C14_Caspase3-7	73	77	PF00656	0.643
CLV_NRD_NRD_1	11	13	PF00675	0.545
CLV_NRD_NRD_1	139	141	PF00675	0.384
CLV_NRD_NRD_1	27	29	PF00675	0.560
CLV_NRD_NRD_1	271	273	PF00675	0.434
CLV_NRD_NRD_1	308	310	PF00675	0.394
CLV_NRD_NRD_1	326	328	PF00675	0.303
CLV_NRD_NRD_1	335	337	PF00675	0.358
CLV_PCSK_FUR_1	269	273	PF00082	0.459
CLV_PCSK_FUR_1	306	310	PF00082	0.421
CLV_PCSK_KEX2_1	11	13	PF00082	0.545
CLV_PCSK_KEX2_1	139	141	PF00082	0.394
CLV_PCSK_KEX2_1	232	234	PF00082	0.310
CLV_PCSK_KEX2_1	27	29	PF00082	0.560
CLV_PCSK_KEX2_1	271	273	PF00082	0.425
CLV_PCSK_KEX2_1	308	310	PF00082	0.413
CLV_PCSK_KEX2_1	335	337	PF00082	0.362
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.310
CLV_PCSK_SKI1_1	158	162	PF00082	0.353
DEG_COP1_1	75	86	PF00400	0.769
DEG_Nend_Nbox_1	1	3	PF02207	0.740
DEG_SCF_FBW7_1	345	352	PF00400	0.625
DEG_SPOP_SBC_1	385	389	PF00917	0.503
DEG_SPOP_SBC_1	86	90	PF00917	0.752
DOC_CKS1_1	114	119	PF01111	0.683
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.630
DOC_MAPK_gen_1	158	167	PF00069	0.562
DOC_MAPK_gen_1	306	314	PF00069	0.577
DOC_MAPK_MEF2A_6	306	314	PF00069	0.564
DOC_PP2B_LxvP_1	383	386	PF13499	0.269
DOC_USP7_MATH_1	349	353	PF00917	0.641
DOC_USP7_MATH_1	36	40	PF00917	0.805
DOC_USP7_MATH_1	386	390	PF00917	0.454
DOC_USP7_MATH_1	67	71	PF00917	0.709
DOC_USP7_MATH_1	82	86	PF00917	0.724
DOC_WW_Pin1_4	113	118	PF00397	0.641
DOC_WW_Pin1_4	165	170	PF00397	0.377
DOC_WW_Pin1_4	200	205	PF00397	0.518
DOC_WW_Pin1_4	345	350	PF00397	0.618
DOC_WW_Pin1_4	46	51	PF00397	0.774
DOC_WW_Pin1_4	56	61	PF00397	0.757
DOC_WW_Pin1_4	87	92	PF00397	0.733
LIG_14-3-3_CanoR_1	186	190	PF00244	0.395
LIG_14-3-3_CanoR_1	272	280	PF00244	0.626
LIG_14-3-3_CanoR_1	37	46	PF00244	0.757
LIG_Actin_WH2_2	150	168	PF00022	0.662
LIG_Actin_WH2_2	172	188	PF00022	0.515
LIG_Actin_WH2_2	354	372	PF00022	0.385
LIG_AP2alpha_2	291	293	PF02296	0.655
LIG_APCC_ABBA_1	105	110	PF00400	0.555
LIG_BRCT_BRCA1_1	351	355	PF00533	0.592
LIG_EH1_1	354	362	PF00400	0.465
LIG_FHA_1	160	166	PF00498	0.420
LIG_FHA_1	78	84	PF00498	0.795
LIG_FHA_1	95	101	PF00498	0.693
LIG_FHA_2	114	120	PF00498	0.553
LIG_FHA_2	71	77	PF00498	0.709
LIG_LIR_Gen_1	170	180	PF02991	0.563
LIG_LIR_Gen_1	190	200	PF02991	0.359
LIG_LIR_Gen_1	262	270	PF02991	0.579
LIG_LIR_Gen_1	279	288	PF02991	0.520
LIG_LIR_Gen_1	317	326	PF02991	0.520
LIG_LIR_Gen_1	342	350	PF02991	0.622
LIG_LIR_Gen_1	352	361	PF02991	0.513
LIG_LIR_Gen_1	364	373	PF02991	0.372
LIG_LIR_Nem_3	170	175	PF02991	0.563
LIG_LIR_Nem_3	262	267	PF02991	0.591
LIG_LIR_Nem_3	279	283	PF02991	0.512
LIG_LIR_Nem_3	294	298	PF02991	0.495
LIG_LIR_Nem_3	317	322	PF02991	0.519
LIG_LIR_Nem_3	342	347	PF02991	0.547
LIG_LIR_Nem_3	352	356	PF02991	0.482
LIG_LIR_Nem_3	364	368	PF02991	0.335
LIG_PCNA_yPIPBox_3	131	142	PF02747	0.580
LIG_PCNA_yPIPBox_3	351	361	PF02747	0.502
LIG_Pex14_1	295	299	PF04695	0.528
LIG_Pex14_2	68	72	PF04695	0.684
LIG_SH2_CRK	207	211	PF00017	0.482
LIG_SH2_CRK	280	284	PF00017	0.515
LIG_SH2_GRB2like	287	290	PF00017	0.523
LIG_SH2_SRC	141	144	PF00017	0.671
LIG_SH2_SRC	340	343	PF00017	0.561
LIG_SH2_STAP1	150	154	PF00017	0.609
LIG_SH2_STAP1	172	176	PF00017	0.562
LIG_SH2_STAP1	207	211	PF00017	0.496
LIG_SH2_STAP1	242	246	PF00017	0.520
LIG_SH2_STAP1	381	385	PF00017	0.442
LIG_SH2_STAT5	141	144	PF00017	0.568
LIG_SH2_STAT5	2	5	PF00017	0.599
LIG_SH2_STAT5	319	322	PF00017	0.556
LIG_SH2_STAT5	333	336	PF00017	0.525
LIG_SH2_STAT5	340	343	PF00017	0.541
LIG_SH2_STAT5	362	365	PF00017	0.369
LIG_SH2_STAT5	375	378	PF00017	0.355
LIG_SH3_3	307	313	PF00018	0.651
LIG_SH3_3	57	63	PF00018	0.766
LIG_SH3_5	146	150	PF00018	0.690
LIG_SUMO_SIM_anti_2	364	371	PF11976	0.349
LIG_TYR_ITIM	373	378	PF00017	0.363
LIG_UBA3_1	226	232	PF00899	0.486
LIG_WRC_WIRS_1	362	367	PF05994	0.266
MOD_CDK_SPxK_1	345	351	PF00069	0.626
MOD_CK1_1	168	174	PF00069	0.591
MOD_CK1_1	178	184	PF00069	0.467
MOD_CK1_1	248	254	PF00069	0.554
MOD_CK1_1	273	279	PF00069	0.626
MOD_CK1_1	384	390	PF00069	0.474
MOD_CK1_1	39	45	PF00069	0.790
MOD_CK1_1	70	76	PF00069	0.736
MOD_CK1_1	85	91	PF00069	0.631
MOD_CK2_1	113	119	PF00069	0.610
MOD_CK2_1	167	173	PF00069	0.530
MOD_GlcNHglycan	180	183	PF01048	0.393
MOD_GlcNHglycan	20	23	PF01048	0.546
MOD_GlcNHglycan	272	275	PF01048	0.349
MOD_GlcNHglycan	42	45	PF01048	0.583
MOD_GlcNHglycan	84	87	PF01048	0.490
MOD_GSK3_1	174	181	PF00069	0.591
MOD_GSK3_1	244	251	PF00069	0.576
MOD_GSK3_1	32	39	PF00069	0.782
MOD_GSK3_1	345	352	PF00069	0.571
MOD_GSK3_1	381	388	PF00069	0.404
MOD_GSK3_1	42	49	PF00069	0.657
MOD_GSK3_1	50	57	PF00069	0.792
MOD_GSK3_1	66	73	PF00069	0.623
MOD_GSK3_1	78	85	PF00069	0.743
MOD_GSK3_1	87	94	PF00069	0.733
MOD_NEK2_1	124	129	PF00069	0.592
MOD_NEK2_1	175	180	PF00069	0.585
MOD_NEK2_1	18	23	PF00069	0.797
MOD_NEK2_1	244	249	PF00069	0.572
MOD_NEK2_1	40	45	PF00069	0.799
MOD_NEK2_2	67	72	PF00069	0.534
MOD_PKA_2	185	191	PF00069	0.394
MOD_PKA_2	270	276	PF00069	0.606
MOD_PKA_2	36	42	PF00069	0.721
MOD_Plk_1	381	387	PF00069	0.470
MOD_Plk_1	78	84	PF00069	0.662
MOD_Plk_4	100	106	PF00069	0.680
MOD_Plk_4	175	181	PF00069	0.591
MOD_Plk_4	315	321	PF00069	0.584
MOD_Plk_4	361	367	PF00069	0.406
MOD_Plk_4	368	374	PF00069	0.410
MOD_Plk_4	388	394	PF00069	0.400
MOD_Plk_4	67	73	PF00069	0.537
MOD_ProDKin_1	113	119	PF00069	0.638
MOD_ProDKin_1	165	171	PF00069	0.377
MOD_ProDKin_1	200	206	PF00069	0.518
MOD_ProDKin_1	345	351	PF00069	0.626
MOD_ProDKin_1	46	52	PF00069	0.775
MOD_ProDKin_1	56	62	PF00069	0.765
MOD_ProDKin_1	87	93	PF00069	0.732
TRG_ENDOCYTIC_2	172	175	PF00928	0.562
TRG_ENDOCYTIC_2	192	195	PF00928	0.350
TRG_ENDOCYTIC_2	207	210	PF00928	0.453
TRG_ENDOCYTIC_2	242	245	PF00928	0.574
TRG_ENDOCYTIC_2	280	283	PF00928	0.502
TRG_ENDOCYTIC_2	287	290	PF00928	0.523
TRG_ENDOCYTIC_2	302	305	PF00928	0.527
TRG_ENDOCYTIC_2	319	322	PF00928	0.517
TRG_ENDOCYTIC_2	362	365	PF00928	0.406
TRG_ENDOCYTIC_2	375	378	PF00928	0.355
TRG_ENDOCYTIC_2	380	383	PF00928	0.308
TRG_ER_diArg_1	138	140	PF00400	0.594
TRG_ER_diArg_1	26	28	PF00400	0.760
TRG_ER_diArg_1	305	308	PF00400	0.553
TRG_ER_diArg_1	309	312	PF00400	0.592
TRG_ER_diArg_1	334	336	PF00400	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW81	Leptomonas seymouri	65%	100%
A0A0S4JWX5	Bodo saltans	45%	100%
A0A1X0NSQ2	Trypanosomatidae	59%	100%
A0A3Q8ICT6	Leishmania donovani	90%	100%
A4HER6	Leishmania braziliensis	78%	100%
A4I1Z3	Leishmania infantum	90%	100%
C9ZS21	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
Q4Q9D3	Leishmania major	89%	100%
V5BUJ1	Trypanosoma cruzi	50%	100%